JP2014508170A - ピペリジノンカルボキサミドスピロヒダントインｃｇｒｐ受容体アンタゴニスト - Google Patents

ピペリジノンカルボキサミドスピロヒダントインｃｇｒｐ受容体アンタゴニスト Download PDF

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Publication number
JP2014508170A
JP2014508170A JP2013558126A JP2013558126A JP2014508170A JP 2014508170 A JP2014508170 A JP 2014508170A JP 2013558126 A JP2013558126 A JP 2013558126A JP 2013558126 A JP2013558126 A JP 2013558126A JP 2014508170 A JP2014508170 A JP 2014508170A
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JP
Japan
Prior art keywords
methyl
hydrogen
pharmaceutically acceptable
acceptable salt
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013558126A
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English (en)
Japanese (ja)
Other versions
JP2014508170A5 (enExample
Inventor
ベル，イアン・エム
フレイリー，マーク・イー
ガリツチオ，ステイーブン・エヌ
ミツチエル，ヘレン，ジエイ
ワン，チヤン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of JP2014508170A publication Critical patent/JP2014508170A/ja
Publication of JP2014508170A5 publication Critical patent/JP2014508170A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2013558126A 2011-03-18 2012-03-14 ピペリジノンカルボキサミドスピロヒダントインｃｇｒｐ受容体アンタゴニスト Pending JP2014508170A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161453989P 2011-03-18 2011-03-18
US61/453,989 2011-03-18
PCT/US2012/028976 WO2012129014A1 (en) 2011-03-18 2012-03-14 Piperidine carboxamide spirohydantoin cgrp receptor antagonists

Publications (2)

Publication Number Publication Date
JP2014508170A true JP2014508170A (ja) 2014-04-03
JP2014508170A5 JP2014508170A5 (enExample) 2015-04-30

Family

ID=46879681

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013558126A Pending JP2014508170A (ja) 2011-03-18 2012-03-14 ピペリジノンカルボキサミドスピロヒダントインｃｇｒｐ受容体アンタゴニスト

Country Status (6)

Country Link
US (1) US20140005214A1 (enExample)
EP (1) EP2686324B1 (enExample)
JP (1) JP2014508170A (enExample)
AU (1) AU2012231293A1 (enExample)
CA (1) CA2830348A1 (enExample)
WO (1) WO2012129014A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012129013A1 (en) 2011-03-18 2012-09-27 Merck Sharp & Dohme Corp. Piperidinone carboxamide spirohydantoin cgrp receptor antagonists
GB201707938D0 (en) 2017-05-17 2017-06-28 Univ Sheffield Compounds
CN119431222B (zh) * 2024-11-04 2025-10-17 杭州澳赛诺生物科技有限公司 一种不对称合成乌布吉泮手性中间体的方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006523697A (ja) * 2003-04-15 2006-10-19 メルク　エンド　カムパニー　インコーポレーテッド Ｃｇｒｐ受容体拮抗薬
JP2007519729A (ja) * 2004-01-29 2007-07-19 メルク　エンド　カムパニー　インコーポレーテッド Ｃｇｒｐ受容体拮抗薬
JP2008512460A (ja) * 2004-09-08 2008-04-24 メルク エンド カムパニー インコーポレーテッド 単環式アニリドスピロラクタムｃｇｒｐ受容体拮抗薬
JP2008519074A (ja) * 2004-11-03 2008-06-05 ブリストル−マイヤーズ スクイブ カンパニー Ｃｇｒｐ受容体アンタゴニストとしての束縛された化合物
WO2009105348A1 (en) * 2008-02-19 2009-08-27 Merck & Co., Inc. Imidazobenzazepine cgrp receptor antagonists
JP2009536645A (ja) * 2006-05-09 2009-10-15 メルク エンド カムパニー インコーポレーテッド 置換スピロ環ｃｇｒｐ受容体アンタゴニスト
JP2010511714A (ja) * 2006-12-08 2010-04-15 メルク エンド カムパニー インコーポレーテッド Ｃｇｒｐ受容体アンタゴニストとしての束縛されたスピロ環式化合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011326455A1 (en) * 2010-11-12 2013-05-23 Merck Sharp & Dohme Corp. Piperidinone carboxamide indane CGRP receptor antagonists

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006523697A (ja) * 2003-04-15 2006-10-19 メルク　エンド　カムパニー　インコーポレーテッド Ｃｇｒｐ受容体拮抗薬
JP2007519729A (ja) * 2004-01-29 2007-07-19 メルク　エンド　カムパニー　インコーポレーテッド Ｃｇｒｐ受容体拮抗薬
JP2008512460A (ja) * 2004-09-08 2008-04-24 メルク エンド カムパニー インコーポレーテッド 単環式アニリドスピロラクタムｃｇｒｐ受容体拮抗薬
JP2008519074A (ja) * 2004-11-03 2008-06-05 ブリストル−マイヤーズ スクイブ カンパニー Ｃｇｒｐ受容体アンタゴニストとしての束縛された化合物
JP2009536645A (ja) * 2006-05-09 2009-10-15 メルク エンド カムパニー インコーポレーテッド 置換スピロ環ｃｇｒｐ受容体アンタゴニスト
JP2010511714A (ja) * 2006-12-08 2010-04-15 メルク エンド カムパニー インコーポレーテッド Ｃｇｒｐ受容体アンタゴニストとしての束縛されたスピロ環式化合物
WO2009105348A1 (en) * 2008-02-19 2009-08-27 Merck & Co., Inc. Imidazobenzazepine cgrp receptor antagonists

Also Published As

Publication number Publication date
WO2012129014A1 (en) 2012-09-27
EP2686324A4 (en) 2014-11-19
EP2686324A1 (en) 2014-01-22
US20140005214A1 (en) 2014-01-02
EP2686324B1 (en) 2016-01-06
AU2012231293A1 (en) 2013-08-29
CA2830348A1 (en) 2012-09-27

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