AU2012231293A1 - Piperidine carboxamide spirohydantoin CGRP receptor antagonists - Google Patents

Piperidine carboxamide spirohydantoin CGRP receptor antagonists Download PDF

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Publication number
AU2012231293A1
AU2012231293A1 AU2012231293A AU2012231293A AU2012231293A1 AU 2012231293 A1 AU2012231293 A1 AU 2012231293A1 AU 2012231293 A AU2012231293 A AU 2012231293A AU 2012231293 A AU2012231293 A AU 2012231293A AU 2012231293 A1 AU2012231293 A1 AU 2012231293A1
Authority
AU
Australia
Prior art keywords
methyl
hydrogen
compound
pharmaceutically acceptable
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2012231293A
Other languages
English (en)
Inventor
Ian M. Bell
Mark E. Fraley
Steven N. Gallicho
Helen J. Mitchell
Chang Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Publication of AU2012231293A1 publication Critical patent/AU2012231293A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2012231293A 2011-03-18 2012-03-14 Piperidine carboxamide spirohydantoin CGRP receptor antagonists Abandoned AU2012231293A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161453989P 2011-03-18 2011-03-18
US61/453,989 2011-03-18
PCT/US2012/028976 WO2012129014A1 (en) 2011-03-18 2012-03-14 Piperidine carboxamide spirohydantoin cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
AU2012231293A1 true AU2012231293A1 (en) 2013-08-29

Family

ID=46879681

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012231293A Abandoned AU2012231293A1 (en) 2011-03-18 2012-03-14 Piperidine carboxamide spirohydantoin CGRP receptor antagonists

Country Status (6)

Country Link
US (1) US20140005214A1 (enExample)
EP (1) EP2686324B1 (enExample)
JP (1) JP2014508170A (enExample)
AU (1) AU2012231293A1 (enExample)
CA (1) CA2830348A1 (enExample)
WO (1) WO2012129014A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2685826B1 (en) 2011-03-18 2016-02-03 Merck Sharp & Dohme Corp. Piperidinone carboxamide spirohydantoin cgrp receptor antagonists
GB201707938D0 (en) 2017-05-17 2017-06-28 Univ Sheffield Compounds
CN118834160B (zh) * 2023-04-23 2025-12-19 中国医学科学院药物研究所 Ubrelvy关键手性内酰胺中间体及其衍生物的不对称合成方法
CN119431222B (zh) * 2024-11-04 2025-10-17 杭州澳赛诺生物科技有限公司 一种不对称合成乌布吉泮手性中间体的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO2355B1 (en) * 2003-04-15 2006-12-12 ميرك شارب اند دوم كوربوريشن Hereditary calcitonin polypeptide receptor antagonists
WO2005072308A2 (en) * 2004-01-29 2005-08-11 Merck & Co., Inc. Cgrp receptor antagonists
AU2005282466B2 (en) * 2004-09-08 2011-03-10 Merck Sharp & Dohme Corp. Monocyclic anilide spirolactam CGRP receptor antagonists
US7384930B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
MX2008014353A (es) * 2006-05-09 2008-11-24 Merck & Co Inc Antagonistas de los receptores del peptido relacionado con el gen de calcitonina (cgrp) monociclicos sustituidos.
AU2007332898A1 (en) * 2006-12-08 2008-06-19 Merck Sharp & Dohme Corp. Constrained spirocyclic compounds as CGRP receptor antagonists
US8796260B2 (en) * 2008-02-19 2014-08-05 Merck Sharp & Dohme Corp. Imidazobenzazepine CGRP receptor antagonists
US8883807B2 (en) * 2010-11-12 2014-11-11 Merck Sharp & Dohme Corp. Piperidinone carboxamide indane CGRP receptor antagonists

Also Published As

Publication number Publication date
US20140005214A1 (en) 2014-01-02
WO2012129014A1 (en) 2012-09-27
JP2014508170A (ja) 2014-04-03
EP2686324A4 (en) 2014-11-19
EP2686324B1 (en) 2016-01-06
EP2686324A1 (en) 2014-01-22
CA2830348A1 (en) 2012-09-27

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Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period