JP2016509009A5 - - Google Patents
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- JP2016509009A5 JP2016509009A5 JP2015557068A JP2015557068A JP2016509009A5 JP 2016509009 A5 JP2016509009 A5 JP 2016509009A5 JP 2015557068 A JP2015557068 A JP 2015557068A JP 2015557068 A JP2015557068 A JP 2015557068A JP 2016509009 A5 JP2016509009 A5 JP 2016509009A5
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- Prior art keywords
- cancer
- antibody
- antigen
- binding fragment
- composition
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| CN111920802B (zh) * | 2020-09-11 | 2024-01-23 | 华侨大学 | 穿心莲内酯在制备防治成人t细胞白血病药物的应用 |
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| WO2025049818A1 (en) | 2023-08-29 | 2025-03-06 | Enosi Therapeutics Corporation | Tnfr1 antagonists lacking agonist activity and uses thereof |
Family Cites Families (110)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4309418A (en) | 1980-03-25 | 1982-01-05 | Sloan-Kettering Research Institute For Cancer | Anti-tumor agent from human serum and process |
| SE8204382L (sv) | 1981-07-21 | 1983-01-22 | Hayashibara Biochem Lab | Sett att framstella malcellysfaktor och anvendning derav |
| US4457916A (en) | 1982-08-31 | 1984-07-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| DE3582183D1 (de) | 1984-03-06 | 1991-04-25 | Dainippon Pharmaceutical Co | Dns den menschlichen tumornekrosisfaktor kodierend und das menschliche tumornekronisfaktor-polypeptid. |
| US5288852A (en) | 1984-03-06 | 1994-02-22 | Dainippon Pharmaceutical Co., Ltd. | Human tumor necrosis factor polypeptides |
| US4879226A (en) | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
| DE3423234A1 (de) | 1984-06-23 | 1986-02-06 | Boehringer Ingelheim International GmbH, 6507 Ingelheim | Synergistische mischungen von interferonen und tumor-nekrose-faktor |
| GR851626B (OSRAM) | 1984-07-05 | 1985-11-26 | Genentech Inc | |
| EP0200748B1 (en) | 1984-10-15 | 1991-02-06 | Cetus Corporation | Human tumor necrosis factor |
| US4677064A (en) | 1984-11-09 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
| US4677063A (en) | 1985-05-02 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
| US4959314A (en) | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
| ATE73856T1 (de) | 1984-12-21 | 1992-04-15 | Biogen Inc | Reinigung, herstellung und verwendung von tumor- nekrosisfaktoren. |
| US4681760A (en) | 1985-04-17 | 1987-07-21 | The Board Of Trustees Of The Leland Stanford Junior University | Method of conferring immunotolerance to a specific antigen |
| US5059530A (en) | 1985-09-30 | 1991-10-22 | Suntory Ltd. | Expression vector for human TNF |
| US6150090A (en) | 1986-01-09 | 2000-11-21 | Massachusetts Institute Of Technology | Nuclear factors associated with transcriptional regulation |
| ATE107362T1 (de) | 1986-06-20 | 1994-07-15 | Dainippon Pharmaceutical Co | Polypeptid-mutanten des menschlichen tnf und für diese mutanten codierende dns. |
| US5002876A (en) | 1986-09-22 | 1991-03-26 | Phillips Petroleum Company | Yeast production of human tumor necrosis factor |
| US4985241A (en) | 1986-11-21 | 1991-01-15 | Cetus Corporation | Therapeutic combination of free-radical scavenger and tumor necrosis factor |
| US4963354A (en) | 1987-01-21 | 1990-10-16 | Genentech, Inc. | Use of tumor necrosis factor (TNF) as an adjuvant |
| WO1988006625A2 (en) | 1987-02-26 | 1988-09-07 | Cetus Corporation | Arginine-depleted human tumor necrosis factor |
| US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
| US5215743A (en) | 1988-04-13 | 1993-06-01 | Maninder Singh | Tumor necrosis factor formulations |
| JPH0797997B2 (ja) | 1988-04-28 | 1995-10-25 | 帝人株式会社 | 新規生理活性ポリペプチド |
| US5370870A (en) | 1989-10-06 | 1994-12-06 | Genentech, Inc. | Method for protection against reactive oxygen species |
| US5283058A (en) | 1990-08-30 | 1994-02-01 | The General Hospital Corporation | Methods for inhibiting rejection of transplanted tissue |
| US5593698A (en) | 1990-10-31 | 1997-01-14 | Autoimmune, Inc. | Suppression of proliferative response and induction of tolerance with polymorphic class II MHC allopeptides |
| CA2055168A1 (en) | 1990-11-21 | 1992-05-22 | Walter Fiers | Tnf-muteins |
| US5919452A (en) | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| DK0600930T3 (da) | 1991-08-02 | 2002-12-02 | Denise L Faustman | Diagnose og behandling af autoimmune sygdomme |
| US6984380B1 (en) | 1991-08-02 | 2006-01-10 | Denise L. Faustman | Treatment of diseases involving faulty MHC class I antigen complex presentation |
| US5139481A (en) | 1991-08-07 | 1992-08-18 | The General Hospital Corporation | Treatment for type II diabetes |
| US5843425A (en) | 1992-02-19 | 1998-12-01 | The General Hospital Corporation | Transplantation and graft-versus-host-disease |
| SK376492A3 (en) | 1992-04-02 | 1995-06-07 | Hoffmann La Roche | Tnf - muteins and method of their production |
| EP0639979B1 (en) | 1992-04-23 | 2001-10-04 | Sloan-Kettering Institute For Cancer Research | LIGAND FOR THE c-KIT RECEPTOR AND METHODS OF USE THEREOF |
| US5939532A (en) | 1993-09-07 | 1999-08-17 | Kyowa Hakko Kogyo Co., Ltd | Humanized antibodies to ganglioside GM2 |
| WO1994009137A1 (en) | 1992-10-15 | 1994-04-28 | Genentech, Inc. | Antibodies against type 2 tumor necrosis factor receptor |
| US5843452A (en) | 1992-11-09 | 1998-12-01 | Pharmagenesis, Inc. | Immunotherapy composition and method |
| US5560908A (en) | 1993-01-22 | 1996-10-01 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Therapeutic agent for NIDDM |
| AU7386094A (en) * | 1993-07-29 | 1995-02-28 | Bernhard Heising | T-lymphocyte-containing pharmaceutical composition for treating infections |
| US5728385A (en) | 1993-08-12 | 1998-03-17 | Classen Immunotherapies, Inc. | Method and composition for an early vaccine to protect against both common infectious diseases and chronic immune mediated disorders or their sequelae |
| US5693617A (en) | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
| US6660268B1 (en) | 1994-03-18 | 2003-12-09 | The President And Fellows Of Harvard College | Proteasome regulation of NF-KB activity |
| US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| AU7010996A (en) | 1995-08-30 | 1997-03-19 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Selective elimination of t cells that recognize specific preselected targets |
| GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
| US5874306A (en) | 1996-12-12 | 1999-02-23 | The Regents Of The University Of California | Culturing human pancreatic endocrine cells in medium containing extracellular matrix from human bladder carcinoma cells |
| US6046031A (en) | 1997-01-21 | 2000-04-04 | Human Genome Sciences, Inc. | Metalloproteinases |
| US6177076B1 (en) | 1997-12-09 | 2001-01-23 | Thomas Jefferson University | Method of treating bladder cancer with wild type vaccinia virus |
| US6617171B2 (en) | 1998-02-27 | 2003-09-09 | The General Hospital Corporation | Methods for diagnosing and treating autoimmune disease |
| US6284879B1 (en) | 1998-04-16 | 2001-09-04 | The General Hospital Corporation | Transport associated protein splice variants |
| US6165737A (en) | 1998-04-16 | 2000-12-26 | The University Of Texas System Board Of Regents | DNA fragmentation factor involved in apoptosis |
| CA2324995A1 (en) | 1998-04-17 | 1999-10-28 | University Of Vermont And State Agricultural College | Methods and products related to metabolic interactions in disease |
| CA2328509A1 (en) | 1998-05-18 | 1999-11-25 | Applied Research Systems Ars Holding N.V | Methods and use of compositions comprising tnf-rii(p75) agonists for treating asthma and other allergic conditions |
| US7485293B1 (en) | 1999-02-18 | 2009-02-03 | Faustman Denise L | Method for inhibiting transplant rejection |
| US6599710B1 (en) | 1999-03-10 | 2003-07-29 | The General Hospital Corporation | Treatment of autoimmune disease |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| JP3589912B2 (ja) | 1999-09-03 | 2004-11-17 | 泰久 福井 | ホスファチジルイノシトール−3,4−二リン酸を認識するモノクローナル抗体 |
| WO2001039784A1 (en) | 1999-12-06 | 2001-06-07 | The General Hospital Corporation | Pancreatic stem cells and their use in transplantation |
| WO2001044472A1 (en) | 1999-12-16 | 2001-06-21 | Amgen, Inc. | Tnfr/opg-like molecules and uses thereof |
| US6414218B1 (en) | 2000-01-18 | 2002-07-02 | The General Hospital Corporation | Mouse model for rheumatoid arthritis |
| US20030215450A1 (en) | 2000-05-26 | 2003-11-20 | Blake Simon M | Anti-rank ligand monoclonal antibodies useful in treatment of rank ligand mediated disorders |
| AU2001294834A1 (en) | 2000-09-26 | 2002-04-08 | Beth Israel Deaconess Medical Center | Recombinant bcg vaccines for the prevention and treatment of cancer |
| US20040031066A9 (en) | 2001-01-18 | 2004-02-12 | Faustman Denise L. | Mouse model for rheumatoid arthritis |
| US7582313B2 (en) | 2002-06-27 | 2009-09-01 | The General Hospital Corporation | Methods of organ regeneration using Hox 11-expressing pluripotent cells |
| US7628988B2 (en) | 2002-06-27 | 2009-12-08 | The General Hospital Corporation | Methods and compositions for treating type 1 diabetes |
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| AU2003290948A1 (en) | 2002-11-15 | 2004-06-15 | The General Hospital Corporation | Screening methods to identify treatments for autoimmune disease |
| US7510877B2 (en) | 2003-09-26 | 2009-03-31 | The Regents Of The University Of Michigan | Hematopoietic stem cell identification and isolation |
| CA2548787A1 (en) | 2003-10-09 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | Antibody composition specifically binding to ganglioside gm2 |
| US8563308B2 (en) | 2004-03-10 | 2013-10-22 | The Rockefeller University | Culture-expanded T suppressor cells and methods of use thereof |
| EP1765988B1 (en) * | 2004-05-27 | 2017-09-20 | The Trustees of The University of Pennsylvania | Novel artificial antigen presenting cells and uses therefor |
| CN101084014A (zh) | 2004-10-08 | 2007-12-05 | 杜门蒂斯有限公司 | 抗肿瘤坏死因子受体1的单域抗体及其使用方法 |
| US20080102054A1 (en) | 2005-01-18 | 2008-05-01 | Faustman Denise L | Compositions Containing Agm Cells And Methods Of Use Thereof |
| EP1875247B1 (en) | 2005-04-11 | 2011-02-02 | Cambridge Enterprise Limited | Selective modulation of tumour necrosis factor receptors in therapy |
| EP2107115A1 (en) | 2007-01-24 | 2009-10-07 | Kyowa Hakko Kirin Co., Ltd. | Genetically recombinant antibody composition capable of binding specifically to ganglioside gm2 |
| JP2010531138A (ja) * | 2007-06-13 | 2010-09-24 | ラ ホヤ インスティテュート フォア アラージー アンド イムノロジー | 制御性t細胞ならびに同製造および使用方法 |
| US8900816B2 (en) | 2007-07-19 | 2014-12-02 | Duke University | Assay for anti-EGFRvIII antibodies |
| US8314213B2 (en) * | 2008-04-18 | 2012-11-20 | Xencor, Inc. | Human equivalent monoclonal antibodies engineered from nonhuman variable regions |
| CA2758542A1 (en) * | 2009-04-17 | 2010-10-21 | New York University | Peptides targeting tnf family receptors and antagonizing tnf action, compositions, methods and uses thereof |
| WO2010124259A1 (en) | 2009-04-24 | 2010-10-28 | Centre Hospitalier Universitaire Sainte-Justine | Allosteramers for tnf receptors and uses thereof |
| CA2760305A1 (en) * | 2009-04-28 | 2010-11-04 | Boehringer Ingelheim International Gmbh | Ex-vivo treatment of immunological disorders with pkc-theta inhibitors |
| US8530392B2 (en) | 2009-05-13 | 2013-09-10 | Shionogi & Co., Ltd. | Test agent for visceral obesity and use thereof |
| WO2011107989A1 (en) | 2010-03-01 | 2011-09-09 | Lostam Biopharmaceuticals Ltd | Improved therapeutic antibodies against flagellated pseudomonas aeruginosa |
| JP6066732B2 (ja) | 2010-03-05 | 2017-01-25 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 標的免疫調節抗体および融合タンパク質に基づく組成物および方法 |
| US20130064831A1 (en) | 2010-05-17 | 2013-03-14 | Bristol-Myers Squibb Company | Immunotherapeutic dosing regimens and combinations thereof |
| CA2810465C (en) | 2010-09-16 | 2018-10-02 | Baliopharm Ag | Anti-hutnfr1 antibody |
| US20140121123A1 (en) | 2010-10-29 | 2014-05-01 | Kevin Caili Wang | Methods for diversifying antibodies, antibodies derived therefrom and uses thereof |
| EP2468764A1 (en) | 2010-12-24 | 2012-06-27 | Rijksuniversiteit te Groningen | TNF family ligand variants |
| WO2012122464A1 (en) | 2011-03-10 | 2012-09-13 | New York University | Methods and compositions for modulating tnf/tnfr signaling |
| GB201115280D0 (en) | 2011-09-05 | 2011-10-19 | Alligator Bioscience Ab | Antibodies, uses and methods |
| WO2013165982A2 (en) | 2012-04-30 | 2013-11-07 | Cell Signaling Technology, Inc. | Anti-human cytomegalvirus antibodies and use thereof |
| JP5922845B2 (ja) | 2012-07-18 | 2016-05-24 | 京セラ株式会社 | セルラ通信システムにおける装置間通信の干渉管理 |
| ES2885423T3 (es) | 2013-02-07 | 2021-12-13 | Massachusetts Gen Hospital | Procedimientos para la expansión o el empobrecimiento de células T reguladoras |
| EP3590967A1 (en) | 2014-03-24 | 2020-01-08 | Cancer Research Technology Limited | Modified antibodies containing modified igg2 domains which elicit agonist properties and use thereof |
| CN114099671A (zh) | 2014-08-12 | 2022-03-01 | 鳄鱼生物科学公司 | 利用抗cd40抗体的组合疗法 |
| US9172855B1 (en) | 2014-08-28 | 2015-10-27 | Avigilon Corporation | Pendant housing for a camera |
| WO2016187068A1 (en) | 2015-05-15 | 2016-11-24 | The General Hospital Corporation | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies |
| EP3340999A4 (en) | 2015-08-28 | 2019-06-12 | The General Hospital Corporation | AGONISTIC ANTI-TUMOR NECROSIS RECEPTOR 2 ANTIBODIES |
| CA3004830A1 (en) | 2015-11-11 | 2017-05-18 | Opi Vi- Ip Holdco Llc | Composition and methods for anti-tnfr2 antibodies |
| CN116715767A (zh) | 2016-05-13 | 2023-09-08 | 综合医院公司 | 拮抗性抗肿瘤坏死因子受体超家族抗体 |
| CA3033665A1 (en) | 2016-08-12 | 2018-02-15 | Janssen Biotech, Inc. | Fc engineered anti-tnfr superfamily member antibodies having enhanced agonistic activity and methods of using them |
| CA3038909A1 (en) | 2016-09-29 | 2018-04-05 | Amgen Inc. | Low-viscosity antigen binding proteins and methods of making them |
| JP7054209B2 (ja) | 2016-11-21 | 2022-04-13 | 国立研究開発法人医薬基盤・健康・栄養研究所 | エピトープ均質化抗体パネル、ならびにその作製方法および利用 |
| EA201991207A1 (ru) | 2016-12-19 | 2019-12-30 | Гленмарк Фармасьютикалс С.А. | Новые агонисты tnfr и их применение |
| EP3707163A4 (en) | 2017-11-09 | 2021-08-18 | The General Hospital Corporation | POLYPEPTIDES ANTAGONISTS OF THE TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY |
| KR20210061350A (ko) * | 2018-08-20 | 2021-05-27 | 더 제너럴 하스피탈 코포레이션 | 길항성 항-종양 괴사 인자 수용체 슈퍼패밀리 폴리펩티드 |
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