JP2016506945A5 - - Google Patents
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- Publication number
- JP2016506945A5 JP2016506945A5 JP2015555777A JP2015555777A JP2016506945A5 JP 2016506945 A5 JP2016506945 A5 JP 2016506945A5 JP 2015555777 A JP2015555777 A JP 2015555777A JP 2015555777 A JP2015555777 A JP 2015555777A JP 2016506945 A5 JP2016506945 A5 JP 2016506945A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- seq
- protein
- mutation
- amino acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 235000018102 proteins Nutrition 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 230000035772 mutation Effects 0.000 claims 8
- 235000001014 amino acid Nutrition 0.000 claims 7
- 229940024606 amino acid Drugs 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 230000037431 insertion Effects 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 150000001508 asparagines Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 208000031169 hemorrhagic disease Diseases 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1350930A FR3001729B1 (fr) | 2013-02-04 | 2013-02-04 | Mutants du facteur x |
| FR1350930 | 2013-02-04 | ||
| PCT/FR2014/050191 WO2014118481A1 (fr) | 2013-02-04 | 2014-02-03 | Mutants du facteur x |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018213037A Division JP2019050819A (ja) | 2013-02-04 | 2018-11-13 | 第ｘ因子変異体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016506945A JP2016506945A (ja) | 2016-03-07 |
| JP2016506945A5 true JP2016506945A5 (OSRAM) | 2017-02-23 |
Family
ID=48083383
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015555777A Ceased JP2016506945A (ja) | 2013-02-04 | 2014-02-03 | 第ｘ因子変異体 |
| JP2018213037A Pending JP2019050819A (ja) | 2013-02-04 | 2018-11-13 | 第ｘ因子変異体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018213037A Pending JP2019050819A (ja) | 2013-02-04 | 2018-11-13 | 第ｘ因子変異体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10364424B2 (OSRAM) |
| EP (1) | EP2951297B1 (OSRAM) |
| JP (2) | JP2016506945A (OSRAM) |
| KR (1) | KR101942619B1 (OSRAM) |
| CN (1) | CN104995297B (OSRAM) |
| AU (1) | AU2014210986A1 (OSRAM) |
| CA (1) | CA2900010A1 (OSRAM) |
| DK (1) | DK2951297T3 (OSRAM) |
| ES (1) | ES2636162T3 (OSRAM) |
| FR (1) | FR3001729B1 (OSRAM) |
| IL (1) | IL239889A0 (OSRAM) |
| MX (1) | MX2015009867A (OSRAM) |
| WO (1) | WO2014118481A1 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3001729B1 (fr) * | 2013-02-04 | 2015-03-06 | Lab Francais Du Fractionnement | Mutants du facteur x |
| FR3050992A1 (fr) * | 2016-05-06 | 2017-11-10 | Lab Francais Du Fractionnement | Mutants du facteur x |
| EP3455636B1 (en) * | 2016-05-13 | 2023-08-23 | The Scripps Research Institute | Compositions and methods for anti-thrombotic and hemostatic therapies |
| FR3077296A1 (fr) * | 2018-02-01 | 2019-08-02 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Dimeres de variants du facteur x |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5298599A (en) * | 1988-12-30 | 1994-03-29 | Oklahoma Medical Research Foundation | Expression and purification of recombinant soluble tissue factor |
| US5821088A (en) * | 1990-05-11 | 1998-10-13 | Siga Pharmaceuticals, Inc. | Use of gram-positive bacteria to express recombinant proteins |
| AT405516B (de) * | 1997-02-27 | 1999-09-27 | Immuno Ag | Faktor x-analoge mit modifizierter proteasespaltstelle |
| AT410216B (de) * | 1999-08-10 | 2003-03-25 | Baxter Ag | Faktor x-analogon mit verbesserter aktivierbarkeit |
| FR2831170B1 (fr) * | 2001-10-19 | 2004-03-19 | Inst Nat Sante Rech Med | Proteines c modifiees activables directement par la thrombine |
| FR2841904B1 (fr) * | 2002-07-03 | 2004-08-20 | Inst Nat Sante Rech Med | Analogues de facteurs x clivables par la thrombine |
| EP1670917A1 (en) * | 2003-09-26 | 2006-06-21 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Synthetic heparanase molecules and uses thereof |
| MX2007001294A (es) * | 2004-08-17 | 2008-03-04 | Zlb Behring Gmbh | Polipeptidos modificados que dependen de vitamina k. |
| EP1728798A1 (en) * | 2005-06-01 | 2006-12-06 | ZLB Behring GmbH | Coagulation factor X polypeptides with modified activation properties |
| MX2008006313A (es) * | 2005-11-15 | 2008-11-06 | Philadelphia Children Hospital | Metodos y composiciones para modular la hemostasia. |
| EP1820508A1 (en) * | 2006-02-21 | 2007-08-22 | CSL Behring GmbH | Coagulation factor X polypeptides with modified activation properties |
| WO2009146183A1 (en) * | 2008-04-15 | 2009-12-03 | Genzyme Corporation | Methods to produce rod-derived cone viability factor (rdcvf) |
| CN104262479A (zh) * | 2008-12-19 | 2015-01-07 | 国家健康与医学研究院 | 丝氨酸蛋白酶衍生物及其在凝血功能障碍的预防或治疗中的用途 |
| FR3001729B1 (fr) * | 2013-02-04 | 2015-03-06 | Lab Francais Du Fractionnement | Mutants du facteur x |
-
2013
- 2013-02-04 FR FR1350930A patent/FR3001729B1/fr not_active Expired - Fee Related
-
2014
- 2014-02-03 DK DK14708609.4T patent/DK2951297T3/en active
- 2014-02-03 EP EP14708609.4A patent/EP2951297B1/fr not_active Not-in-force
- 2014-02-03 CA CA2900010A patent/CA2900010A1/en not_active Abandoned
- 2014-02-03 WO PCT/FR2014/050191 patent/WO2014118481A1/fr not_active Ceased
- 2014-02-03 MX MX2015009867A patent/MX2015009867A/es unknown
- 2014-02-03 AU AU2014210986A patent/AU2014210986A1/en not_active Abandoned
- 2014-02-03 ES ES14708609.4T patent/ES2636162T3/es active Active
- 2014-02-03 CN CN201480007229.6A patent/CN104995297B/zh not_active Expired - Fee Related
- 2014-02-03 US US14/765,073 patent/US10364424B2/en not_active Expired - Fee Related
- 2014-02-03 KR KR1020157024083A patent/KR101942619B1/ko not_active Expired - Fee Related
- 2014-02-03 JP JP2015555777A patent/JP2016506945A/ja not_active Ceased
-
2015
- 2015-07-09 IL IL239889A patent/IL239889A0/en unknown
-
2018
- 2018-11-13 JP JP2018213037A patent/JP2019050819A/ja active Pending
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