CA2900010A1 - Factor x mutants - Google Patents
Factor x mutants Download PDFInfo
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- CA2900010A1 CA2900010A1 CA2900010A CA2900010A CA2900010A1 CA 2900010 A1 CA2900010 A1 CA 2900010A1 CA 2900010 A CA2900010 A CA 2900010A CA 2900010 A CA2900010 A CA 2900010A CA 2900010 A1 CA2900010 A1 CA 2900010A1
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- Prior art keywords
- seq
- factor
- sequence
- fix
- thrombin
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1350930 | 2013-02-04 | ||
| FR1350930A FR3001729B1 (fr) | 2013-02-04 | 2013-02-04 | Mutants du facteur x |
| PCT/FR2014/050191 WO2014118481A1 (fr) | 2013-02-04 | 2014-02-03 | Mutants du facteur x |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2900010A1 true CA2900010A1 (en) | 2014-08-07 |
Family
ID=48083383
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2900010A Abandoned CA2900010A1 (en) | 2013-02-04 | 2014-02-03 | Factor x mutants |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10364424B2 (OSRAM) |
| EP (1) | EP2951297B1 (OSRAM) |
| JP (2) | JP2016506945A (OSRAM) |
| KR (1) | KR101942619B1 (OSRAM) |
| CN (1) | CN104995297B (OSRAM) |
| AU (1) | AU2014210986A1 (OSRAM) |
| CA (1) | CA2900010A1 (OSRAM) |
| DK (1) | DK2951297T3 (OSRAM) |
| ES (1) | ES2636162T3 (OSRAM) |
| FR (1) | FR3001729B1 (OSRAM) |
| IL (1) | IL239889A0 (OSRAM) |
| MX (1) | MX2015009867A (OSRAM) |
| WO (1) | WO2014118481A1 (OSRAM) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3001729B1 (fr) * | 2013-02-04 | 2015-03-06 | Lab Francais Du Fractionnement | Mutants du facteur x |
| FR3050992A1 (fr) * | 2016-05-06 | 2017-11-10 | Lab Francais Du Fractionnement | Mutants du facteur x |
| EP4299585A3 (en) * | 2016-05-13 | 2024-04-17 | The Scripps Research Institute | Compositions and methods for anti-thrombotic and hemostatic therapies |
| FR3077296A1 (fr) * | 2018-02-01 | 2019-08-02 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Dimeres de variants du facteur x |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5298599A (en) * | 1988-12-30 | 1994-03-29 | Oklahoma Medical Research Foundation | Expression and purification of recombinant soluble tissue factor |
| US5821088A (en) * | 1990-05-11 | 1998-10-13 | Siga Pharmaceuticals, Inc. | Use of gram-positive bacteria to express recombinant proteins |
| AT405516B (de) * | 1997-02-27 | 1999-09-27 | Immuno Ag | Faktor x-analoge mit modifizierter proteasespaltstelle |
| AT410216B (de) * | 1999-08-10 | 2003-03-25 | Baxter Ag | Faktor x-analogon mit verbesserter aktivierbarkeit |
| FR2831170B1 (fr) * | 2001-10-19 | 2004-03-19 | Inst Nat Sante Rech Med | Proteines c modifiees activables directement par la thrombine |
| FR2841904B1 (fr) * | 2002-07-03 | 2004-08-20 | Inst Nat Sante Rech Med | Analogues de facteurs x clivables par la thrombine |
| JP2007506416A (ja) * | 2003-09-26 | 2007-03-22 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | 合成ヘパラナーゼ分子及びその使用 |
| DK1781782T3 (da) * | 2004-08-17 | 2010-08-23 | Csl Behring Gmbh | Modificerede vitamin K-afhængige polypeptider |
| EP1728798A1 (en) * | 2005-06-01 | 2006-12-06 | ZLB Behring GmbH | Coagulation factor X polypeptides with modified activation properties |
| MX336958B (es) * | 2005-11-15 | 2016-02-05 | Philadelphia Children Hospital | Metodos y composiciones para modular la hemostasia. |
| EP1820508A1 (en) * | 2006-02-21 | 2007-08-22 | CSL Behring GmbH | Coagulation factor X polypeptides with modified activation properties |
| US9567382B2 (en) * | 2008-04-15 | 2017-02-14 | Genzyme Corporation | Methods to produce rod-derived cone viability factor (RdCVF) |
| KR20110114587A (ko) * | 2008-12-19 | 2011-10-19 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 세린 프로테아제 유도체 및 혈액응고 장애의 치료 또는 예방의 용도 |
| FR3001729B1 (fr) * | 2013-02-04 | 2015-03-06 | Lab Francais Du Fractionnement | Mutants du facteur x |
-
2013
- 2013-02-04 FR FR1350930A patent/FR3001729B1/fr not_active Expired - Fee Related
-
2014
- 2014-02-03 CN CN201480007229.6A patent/CN104995297B/zh not_active Expired - Fee Related
- 2014-02-03 JP JP2015555777A patent/JP2016506945A/ja not_active Ceased
- 2014-02-03 WO PCT/FR2014/050191 patent/WO2014118481A1/fr not_active Ceased
- 2014-02-03 ES ES14708609.4T patent/ES2636162T3/es active Active
- 2014-02-03 DK DK14708609.4T patent/DK2951297T3/en active
- 2014-02-03 US US14/765,073 patent/US10364424B2/en not_active Expired - Fee Related
- 2014-02-03 MX MX2015009867A patent/MX2015009867A/es unknown
- 2014-02-03 EP EP14708609.4A patent/EP2951297B1/fr not_active Not-in-force
- 2014-02-03 CA CA2900010A patent/CA2900010A1/en not_active Abandoned
- 2014-02-03 AU AU2014210986A patent/AU2014210986A1/en not_active Abandoned
- 2014-02-03 KR KR1020157024083A patent/KR101942619B1/ko not_active Expired - Fee Related
-
2015
- 2015-07-09 IL IL239889A patent/IL239889A0/en unknown
-
2018
- 2018-11-13 JP JP2018213037A patent/JP2019050819A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2636162T3 (es) | 2017-10-05 |
| KR101942619B1 (ko) | 2019-01-25 |
| AU2014210986A1 (en) | 2015-07-23 |
| WO2014118481A1 (fr) | 2014-08-07 |
| IL239889A0 (en) | 2015-08-31 |
| EP2951297A1 (fr) | 2015-12-09 |
| CN104995297A (zh) | 2015-10-21 |
| CN104995297B (zh) | 2018-10-26 |
| JP2019050819A (ja) | 2019-04-04 |
| EP2951297B1 (fr) | 2017-05-03 |
| DK2951297T3 (en) | 2017-08-28 |
| US20160145598A1 (en) | 2016-05-26 |
| MX2015009867A (es) | 2015-10-05 |
| FR3001729A1 (fr) | 2014-08-08 |
| JP2016506945A (ja) | 2016-03-07 |
| US10364424B2 (en) | 2019-07-30 |
| KR20150113205A (ko) | 2015-10-07 |
| FR3001729B1 (fr) | 2015-03-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20180828 |
|
| FZDE | Discontinued |
Effective date: 20220114 |
|
| FZDE | Discontinued |
Effective date: 20220114 |