JP2016526885A5 - - Google Patents
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- Publication number
- JP2016526885A5 JP2016526885A5 JP2016522479A JP2016522479A JP2016526885A5 JP 2016526885 A5 JP2016526885 A5 JP 2016526885A5 JP 2016522479 A JP2016522479 A JP 2016522479A JP 2016522479 A JP2016522479 A JP 2016522479A JP 2016526885 A5 JP2016526885 A5 JP 2016526885A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- cancer
- polypeptide according
- amino acid
- ctla
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1311475.6 | 2013-06-27 | ||
| GBGB1311475.6A GB201311475D0 (en) | 2013-06-27 | 2013-06-27 | Polypeptides |
| PCT/EP2014/063442 WO2014207063A1 (en) | 2013-06-27 | 2014-06-25 | Cd86 variants with improved affinity for ctla-4 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016526885A JP2016526885A (ja) | 2016-09-08 |
| JP2016526885A5 true JP2016526885A5 (OSRAM) | 2017-08-03 |
| JP6621741B2 JP6621741B2 (ja) | 2019-12-18 |
Family
ID=48999077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016522479A Expired - Fee Related JP6621741B2 (ja) | 2013-06-27 | 2014-06-25 | Ｃｔｌａ−４に対する親和性が改善したｃｄ８６バリアント |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9834589B2 (OSRAM) |
| EP (1) | EP3013854B1 (OSRAM) |
| JP (1) | JP6621741B2 (OSRAM) |
| GB (1) | GB201311475D0 (OSRAM) |
| WO (1) | WO2014207063A1 (OSRAM) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112015013557B1 (pt) | 2012-12-11 | 2021-12-14 | Albert Einstein College Of Medicine | Sistema, método, método para determinar o efeito de um resíduo de aminoácido predeterminado de uma primeira proteína sobre a ligação da primeira proteína a uma segunda proteína e polipeptídeo pd-l1 mutante |
| PT3283508T (pt) | 2015-04-17 | 2021-06-21 | Alpine Immune Sciences Inc | Proteínas imuno modulatórias com afinidades afináveis |
| CN107709367A (zh) | 2015-05-21 | 2018-02-16 | 鳄鱼生物科学公司 | 新型多肽 |
| KR20180054713A (ko) * | 2015-09-14 | 2018-05-24 | 알파인 이뮨 사이언시즈, 인코포레이티드 | 조율가능한 변종 면역글로불린 수퍼패밀리 도메인 및 유전자 조작된 세포 치료법 |
| FI3423087T3 (fi) | 2016-03-04 | 2023-12-15 | Io Biotech Aps | Syövän vastainen yhdistelmähoito |
| IL310729A (en) | 2016-04-15 | 2024-04-01 | Alpine Immune Sciences Inc | Cd80 variant immunomodulatory proteins and uses thereof |
| WO2017181148A2 (en) | 2016-04-15 | 2017-10-19 | Alpine Immune Sciences, Inc. | Icos ligand variant immunomodulatory proteins and uses thereof |
| AU2017266905B2 (en) | 2016-05-18 | 2022-12-15 | Albert Einstein College Of Medicine, Inc. | Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof |
| CA3019005A1 (en) | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| US11471488B2 (en) | 2016-07-28 | 2022-10-18 | Alpine Immune Sciences, Inc. | CD155 variant immunomodulatory proteins and uses thereof |
| US11834490B2 (en) | 2016-07-28 | 2023-12-05 | Alpine Immune Sciences, Inc. | CD112 variant immunomodulatory proteins and uses thereof |
| GB201619652D0 (en) | 2016-11-21 | 2017-01-04 | Alligator Bioscience Ab | Novel polypeptides |
| JP7250677B2 (ja) | 2016-12-22 | 2023-04-03 | キュー バイオファーマ， インコーポレイテッド | Ｔ細胞調節多量体ポリペプチド及びその使用方法 |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| US20200009135A1 (en) | 2017-02-01 | 2020-01-09 | Medivir Ab | Therapeutic applications of malt1 inhibitors |
| KR102619015B1 (ko) | 2017-03-15 | 2023-12-28 | 큐 바이오파마, 인크. | 면역 반응을 조절하는 방법 |
| IL268781B2 (en) | 2017-03-16 | 2025-09-01 | Alpine Immune Sciences Inc | Cd80 variant immunomodulatory proteins and uses thereof |
| US11732022B2 (en) | 2017-03-16 | 2023-08-22 | Alpine Immune Sciences, Inc. | PD-L2 variant immunomodulatory proteins and uses thereof |
| WO2018202649A1 (en) | 2017-05-02 | 2018-11-08 | Alligator Bioscience Ab | Bispecific antibody against ox40 and ctla-4 |
| CA3198255A1 (en) | 2017-10-10 | 2019-04-18 | Alpine Immune Sciences, Inc. | Ctla-4 variant immunomodulatory proteins and uses thereof |
| EA202090974A1 (ru) | 2017-10-18 | 2020-08-05 | Элпайн Иммьюн Сайенсиз, Инк. | Вариантные иммуномодулирующие белки лиганда icos и сопутствующие композиции и способы |
| WO2019136179A1 (en) | 2018-01-03 | 2019-07-11 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| EP3737689A4 (en) | 2018-01-09 | 2021-12-01 | Cue Biopharma, Inc. | MULTIMER POLYPEPTIDES T-LYMPHOCYTE MODULATORS AND THEIR METHODS OF USE |
| JP7337855B2 (ja) | 2018-03-09 | 2023-09-04 | メディヴィル・アクチエボラーグ | （２，２－ビスヒドロキシメチル）メチレンシクロプロパンヌクレオチドを用いたがんの治療 |
| WO2019241758A1 (en) | 2018-06-15 | 2019-12-19 | Alpine Immune Sciences, Inc. | Pd-1 variant immunomodulatory proteins and uses thereof |
| US20220389037A1 (en) | 2019-07-04 | 2022-12-08 | Qilu Regor Therapeutics Inc. | Hpk1 inhibitors and uses thereof |
| JP7477182B2 (ja) * | 2019-10-08 | 2024-05-01 | ジーンフロンティア株式会社 | Ｃｔｌａ－４阻害活性を有する環状ペプチド、及びその用途 |
| CA3169949A1 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ， インコーポレイテッド | １型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法 |
| GB202103122D0 (en) | 2021-03-05 | 2021-04-21 | Univ London Queen Mary | Treatment |
| GB202103673D0 (en) | 2021-03-17 | 2021-04-28 | Io Biotech Aps | Combination therapy for cancer |
| EP4472734A1 (en) | 2022-02-03 | 2024-12-11 | C4X Discovery Limited | Heterocyclic derivatives as malt1 inhibitors |
| WO2023161350A1 (en) | 2022-02-24 | 2023-08-31 | Io Biotech Aps | Nucleotide delivery of cancer therapy |
| GB202207050D0 (en) | 2022-05-13 | 2022-06-29 | C4X Discovery Ltd | Therapeutic compounds |
| WO2025104411A1 (en) | 2023-11-15 | 2025-05-22 | C4X Discovery Limited | Therapeutic compounds |
| WO2025104412A1 (en) | 2023-11-15 | 2025-05-22 | C4X Discovery Limited | Therapeutic compounds |
| WO2025137168A2 (en) | 2023-12-19 | 2025-06-26 | Regor Pharmaceuticals, Inc. | Salt and solid forms of a hpk1 inhibitor |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5637481A (en) | 1993-02-01 | 1997-06-10 | Bristol-Myers Squibb Company | Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell |
| US6130316A (en) | 1993-07-26 | 2000-10-10 | Dana Farber Cancer Institute | Fusion proteins of novel CTLA4/CD28 ligands and uses therefore |
| EP1186300A1 (en) | 1996-03-20 | 2002-03-13 | Bristol-Myers Squibb Company | Pharmaceutical compositions useful for inhibiting an immune response by blocking the GP39/CD40 and CTLA4/CD28/B7 pathways |
| EE05627B1 (et) | 1998-12-23 | 2013-02-15 | Pfizer Inc. | CTLA-4 vastased inimese monoklonaalsed antikehad |
| US7183376B2 (en) | 2000-06-23 | 2007-02-27 | Maxygen, Inc. | Variant B7 co-stimulatory molecules |
| JP4430303B2 (ja) | 2000-12-12 | 2010-03-10 | アリゲーター・バイオサイエンス・アーベー | タンパク質機能のインビトロ分子進化方法 |
| US7262012B2 (en) | 2002-05-17 | 2007-08-28 | Alligator Bioscience Ab | Method for in vitro molecular evolution of protein function using varied exonuclease digestion in two polynucleotide populations |
| WO2006056464A2 (en) | 2004-11-26 | 2006-06-01 | Pieris Ag | Compound with affinity for the cytotoxic t lymphocyte-associated antigen (ctla-4) |
| GB2432366B (en) | 2005-11-19 | 2007-11-21 | Alligator Bioscience Ab | A method for in vitro molecular evolution of protein function |
| GB0920258D0 (en) * | 2009-11-19 | 2010-01-06 | Alligator Bioscience Ab | New medical agents and use thereof |
-
2013
- 2013-06-27 GB GBGB1311475.6A patent/GB201311475D0/en not_active Ceased
-
2014
- 2014-06-25 EP EP14732247.3A patent/EP3013854B1/en not_active Not-in-force
- 2014-06-25 JP JP2016522479A patent/JP6621741B2/ja not_active Expired - Fee Related
- 2014-06-25 WO PCT/EP2014/063442 patent/WO2014207063A1/en not_active Ceased
- 2014-06-25 US US14/901,202 patent/US9834589B2/en active Active
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