JP2016505556A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016505556A5 JP2016505556A5 JP2015545935A JP2015545935A JP2016505556A5 JP 2016505556 A5 JP2016505556 A5 JP 2016505556A5 JP 2015545935 A JP2015545935 A JP 2015545935A JP 2015545935 A JP2015545935 A JP 2015545935A JP 2016505556 A5 JP2016505556 A5 JP 2016505556A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- antigen
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 148
- 239000012634 fragment Substances 0.000 claims description 103
- 239000000427 antigen Substances 0.000 claims description 97
- 102000036639 antigens Human genes 0.000 claims description 97
- 108091007433 antigens Proteins 0.000 claims description 97
- 238000006467 substitution reaction Methods 0.000 claims description 44
- 101000766907 Homo sapiens C-type lectin domain family 4 member C Proteins 0.000 claims description 41
- 102000057977 human CLEC4C Human genes 0.000 claims description 23
- 102100028668 C-type lectin domain family 4 member C Human genes 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 17
- 210000005134 plasmacytoid dendritic cell Anatomy 0.000 claims description 17
- 108010014726 Interferon Type I Proteins 0.000 claims description 12
- 208000027866 inflammatory disease Diseases 0.000 claims description 12
- 102000002227 Interferon Type I Human genes 0.000 claims description 11
- 108090001005 Interleukin-6 Proteins 0.000 claims description 10
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 10
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 102000004889 Interleukin-6 Human genes 0.000 claims description 9
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 8
- 108010055166 Chemokine CCL5 Proteins 0.000 claims description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 8
- 210000003169 central nervous system Anatomy 0.000 claims description 8
- 238000000338 in vitro Methods 0.000 claims description 8
- 206010025135 lupus erythematosus Diseases 0.000 claims description 8
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 6
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 208000023275 Autoimmune disease Diseases 0.000 claims description 4
- 208000005777 Lupus Nephritis Diseases 0.000 claims description 4
- 241000282560 Macaca mulatta Species 0.000 claims description 4
- 102000002689 Toll-like receptor Human genes 0.000 claims description 4
- 108020000411 Toll-like receptor Proteins 0.000 claims description 4
- ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 4
- 208000012263 renal involvement Diseases 0.000 claims description 4
- 239000011780 sodium chloride Substances 0.000 claims description 4
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 4
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims description 3
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims description 3
- 210000004027 cell Anatomy 0.000 claims description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- 241000282567 Macaca fascicularis Species 0.000 claims description 2
- 201000004681 Psoriasis Diseases 0.000 claims description 2
- 206010039710 Scleroderma Diseases 0.000 claims description 2
- 201000009594 Systemic Scleroderma Diseases 0.000 claims description 2
- 206010042953 Systemic sclerosis Diseases 0.000 claims description 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 230000034994 death Effects 0.000 claims description 2
- 201000001981 dermatomyositis Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000005987 polymyositis Diseases 0.000 claims description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 2
- 102000001327 Chemokine CCL5 Human genes 0.000 claims 3
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 description 26
- 108010021468 Fc gamma receptor IIA Proteins 0.000 description 20
- 102100029204 Low affinity immunoglobulin gamma Fc region receptor II-a Human genes 0.000 description 20
- 238000000034 method Methods 0.000 description 11
- 210000004408 hybridoma Anatomy 0.000 description 10
- 102100032367 C-C motif chemokine 5 Human genes 0.000 description 7
- 229940100601 interleukin-6 Drugs 0.000 description 7
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 description 4
- 102000001326 Chemokine CCL4 Human genes 0.000 description 4
- 108010055165 Chemokine CCL4 Proteins 0.000 description 4
- 102000019034 Chemokines Human genes 0.000 description 4
- 108010012236 Chemokines Proteins 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 101001018097 Homo sapiens L-selectin Proteins 0.000 description 4
- 102100033467 L-selectin Human genes 0.000 description 4
- 102000009571 Macrophage Inflammatory Proteins Human genes 0.000 description 4
- 108010009474 Macrophage Inflammatory Proteins Proteins 0.000 description 4
- 108010018844 interferon type III Proteins 0.000 description 4
- 230000028327 secretion Effects 0.000 description 4
- 108010087819 Fc receptors Proteins 0.000 description 3
- 102000009109 Fc receptors Human genes 0.000 description 3
- 230000003915 cell function Effects 0.000 description 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 3
- 239000012636 effector Substances 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000013595 glycosylation Effects 0.000 description 3
- 238000006206 glycosylation reaction Methods 0.000 description 3
- 101710098275 C-X-C motif chemokine 10 Proteins 0.000 description 2
- 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 description 2
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 description 2
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 description 2
- 241000288906 Primates Species 0.000 description 2
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 description 2
- 102100039390 Toll-like receptor 7 Human genes 0.000 description 2
- 102100033117 Toll-like receptor 9 Human genes 0.000 description 2
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 102000014150 Interferons Human genes 0.000 description 1
- 108010050904 Interferons Proteins 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 229940079322 interferon Drugs 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019034198A JP6889741B2 (ja) | 2012-12-10 | 2019-02-27 | 抗血液樹状細胞抗原２抗体およびその使用 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261735362P | 2012-12-10 | 2012-12-10 | |
| US61/735,362 | 2012-12-10 | ||
| US201361763270P | 2013-02-11 | 2013-02-11 | |
| US61/763,270 | 2013-02-11 | ||
| PCT/US2013/074208 WO2014093396A1 (en) | 2012-12-10 | 2013-12-10 | Anti-blood dendritic cell antigen 2 antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019034198A Division JP6889741B2 (ja) | 2012-12-10 | 2019-02-27 | 抗血液樹状細胞抗原２抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016505556A JP2016505556A (ja) | 2016-02-25 |
| JP2016505556A5 true JP2016505556A5 (cg-RX-API-DMAC7.html) | 2017-01-26 |
| JP6490591B2 JP6490591B2 (ja) | 2019-03-27 |
Family
ID=49883267
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545935A Active JP6490591B2 (ja) | 2012-12-10 | 2013-12-10 | 抗血液樹状細胞抗原２抗体およびその使用 |
| JP2019034198A Active JP6889741B2 (ja) | 2012-12-10 | 2019-02-27 | 抗血液樹状細胞抗原２抗体およびその使用 |
| JP2021086053A Pending JP2021130677A (ja) | 2012-12-10 | 2021-05-21 | 抗血液樹状細胞抗原２抗体およびその使用 |
| JP2024006009A Pending JP2024045253A (ja) | 2012-12-10 | 2024-01-18 | 抗血液樹状細胞抗原２抗体およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019034198A Active JP6889741B2 (ja) | 2012-12-10 | 2019-02-27 | 抗血液樹状細胞抗原２抗体およびその使用 |
| JP2021086053A Pending JP2021130677A (ja) | 2012-12-10 | 2021-05-21 | 抗血液樹状細胞抗原２抗体およびその使用 |
| JP2024006009A Pending JP2024045253A (ja) | 2012-12-10 | 2024-01-18 | 抗血液樹状細胞抗原２抗体およびその使用 |
Country Status (25)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2968561B1 (fr) † | 2010-12-13 | 2013-08-09 | Lfb Biotechnologies | Utilisation d'un anticorps dirige contre une proteine membranaire |
| CN106029874B (zh) * | 2013-12-16 | 2020-09-15 | 北卡罗来纳-查佩尔山大学 | 浆细胞样树突状细胞的耗竭 |
| US10294301B2 (en) * | 2013-12-24 | 2019-05-21 | Astellas Pharma Inc. | Anti-human BDCA-2 antibody |
| FR3034420A1 (fr) | 2015-03-31 | 2016-10-07 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-cd303 |
| FR3045386B1 (fr) | 2015-12-16 | 2018-02-02 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Nouvelle utilisation d'un anticorps dirige contre une proteine membranaire |
| MX2018012945A (es) * | 2016-04-28 | 2019-03-06 | Biogen Ma Inc | Composiciones farmacéuticas y regímenes de dosificación para uso clínico de anticuerpos del antigeno 2 de las células dendríticas de la sangre. |
| CN110283803B (zh) * | 2016-06-02 | 2021-08-03 | 天津科技大学 | 一种磷脂酶d及其制备磷脂酸、磷脂酰丝氨酸的方法 |
| EP3606952A1 (en) | 2017-04-07 | 2020-02-12 | Miltenyi Biotec GmbH | POLYPEPTIDES WITH MUTANT HUMAN IgG4 |
| EP3785029A1 (en) * | 2018-04-27 | 2021-03-03 | Advaxis, Inc. | Compositions and methods for evaluating potency of listeria-based immunotherapeutics |
| KR102848349B1 (ko) * | 2018-06-04 | 2025-08-21 | 바이오젠 엠에이 인코포레이티드 | 감소된 효과기 기능을 갖는 항-ｖｌａ-4 항체 |
| EP3890773A4 (en) * | 2018-11-08 | 2022-11-09 | Orionis Biosciences, Inc. | MODULATION OF DENDRITIC CELL LINES |
| CA3147096A1 (en) * | 2019-08-05 | 2021-02-11 | Steve Holmes | Anti bdca-2 antibodies |
| AR124247A1 (es) | 2020-12-03 | 2023-03-01 | Biogen Ma Inc | Métodos de tratamiento del lupus eritematoso cutáneo y lupus eritematoso sistémico |
| JP7326584B2 (ja) | 2020-12-17 | 2023-08-15 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | 抗ｈｌａ－ｇ抗体及びその使用 |
| CN113484512B (zh) * | 2021-06-01 | 2023-06-27 | 中国农业科学院油料作物研究所 | 黄曲霉毒素风险预警智能感知卡及其应用 |
| TW202400652A (zh) * | 2022-05-25 | 2024-01-01 | 大陸商映恩生物製藥（蘇州）有限公司 | 抗ｂｄｃａ２抗體及其用途 |
| WO2024010118A1 (ko) * | 2022-07-07 | 2024-01-11 | 주식회사 유틸렉스 | 항 bdca-2 항체 및 이의 용도 |
| TW202432188A (zh) | 2022-12-28 | 2024-08-16 | 大陸商映恩生物製藥（蘇州）有限公司 | 抗ｂｄｃａ２抗體－藥物偶聯物及其用途 |
| AU2024270449A1 (en) * | 2023-05-10 | 2025-12-18 | Inmagene Pte. Ltd. | Bdca2-targeting antibodies and uses thereof |
| CN119119267A (zh) * | 2023-06-12 | 2024-12-13 | 三生国健药业（上海）股份有限公司 | 抗bdca2抗体 |
| WO2025051083A1 (zh) * | 2023-09-05 | 2025-03-13 | 上海宏成药业有限公司 | 抗bdca-2特异性抗体及其用途 |
| WO2025091023A1 (en) * | 2023-10-27 | 2025-05-01 | Northwestern University | Engineered cell transfected by all-in-one vector for therapeutic agents production and delivery and applications thereof |
| CN120098124A (zh) * | 2023-12-05 | 2025-06-06 | 苏州普乐康医药科技有限公司 | 一种抗bdca-2抗体及其制备方法和应用 |
| CN118638234B (zh) * | 2024-07-04 | 2025-10-14 | 杭州博之锐生物制药有限公司 | 抗bdca2抗体及其制备方法和应用 |
| CN119591712B (zh) * | 2024-11-27 | 2025-11-21 | 纽迈生物科技(苏州)有限公司 | 靶向人类浆细胞样树突状细胞的单克隆抗体及其应用 |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US5156840A (en) | 1982-03-09 | 1992-10-20 | Cytogen Corporation | Amine-containing porphyrin derivatives |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| WO1987005330A1 (en) | 1986-03-07 | 1987-09-11 | Michel Louis Eugene Bergh | Method for enhancing glycoprotein stability |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| AU665190B2 (en) | 1990-07-10 | 1995-12-21 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| DK0564531T3 (da) | 1990-12-03 | 1998-09-28 | Genentech Inc | Berigelsesfremgangsmåde for variantproteiner med ændrede bindingsegenskaber |
| US5370901A (en) | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
| DK1279731T3 (da) | 1991-03-01 | 2007-09-24 | Dyax Corp | Fremgangsmåde til udvikling af bindende miniproteiner |
| DK1471142T3 (da) | 1991-04-10 | 2009-03-09 | Scripps Research Inst | Heterodimere receptor-biblioteker under anvendelse af fagemider |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| DK1136556T3 (da) | 1991-11-25 | 2005-10-03 | Enzon Inc | Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner |
| DE69233745D1 (de) | 1991-12-02 | 2008-10-23 | Cambridge Antibody Tech | Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
| SE9201984D0 (sv) | 1992-06-29 | 1992-06-29 | Pharmacia Biosensor Ab | Improvement in optical assays |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US6210671B1 (en) | 1992-12-01 | 2001-04-03 | Protein Design Labs, Inc. | Humanized antibodies reactive with L-selectin |
| CA2163345A1 (en) | 1993-06-16 | 1994-12-22 | Susan Adrienne Morgan | Antibodies |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| ATE390933T1 (de) | 1995-04-27 | 2008-04-15 | Amgen Fremont Inc | Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8 |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| DK1143006T3 (da) | 1995-08-18 | 2008-07-14 | Morphosys Ip Gmbh | Vektorer/DNA-sekvenser fra humane kombinatoriske antistofbiblioteker |
| CA2722378C (en) | 1996-12-03 | 2015-02-03 | Amgen Fremont Inc. | Human antibodies that bind tnf.alpha. |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| US6242195B1 (en) | 1998-04-02 | 2001-06-05 | Genentech, Inc. | Methods for determining binding of an analyte to a receptor |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| US6201671B1 (en) | 1998-12-04 | 2001-03-13 | International Business Machines Corporation | Seed layer for a nickel oxide pinning layer for increasing the magnetoresistance of a spin valve sensor |
| ATE352559T1 (de) | 1998-12-08 | 2007-02-15 | Biovation Ltd | Verfahren zur verminderung der immunogenität von proteinen |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
| PL209786B1 (pl) | 1999-01-15 | 2011-10-31 | Genentech Inc | Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna |
| US7030228B1 (en) * | 1999-11-15 | 2006-04-18 | Miltenyi Biotec Gmbh | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
| CN1454215B (zh) * | 1999-11-15 | 2013-01-02 | 米勒腾尼生物技术有限公司 | 树突状细胞特异的抗原结合片段、组合物及其使用方法、被其识别的抗原及由其获得的细胞 |
| US20070148171A1 (en) | 2002-09-27 | 2007-06-28 | Xencor, Inc. | Optimized anti-CD30 antibodies |
| US8188231B2 (en) | 2002-09-27 | 2012-05-29 | Xencor, Inc. | Optimized FC variants |
| US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
| AU2003254019A1 (en) * | 2002-07-18 | 2004-02-09 | Dana-Farber Cancer Institute, Inc. | Compositions and methods to select dendritic cells from a heterogeneous cell population |
| US20060235208A1 (en) | 2002-09-27 | 2006-10-19 | Xencor, Inc. | Fc variants with optimized properties |
| US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| ES2897506T3 (es) | 2003-01-09 | 2022-03-01 | Macrogenics Inc | Identificación y modificación de anticuerpos con regiones Fc variantes y métodos de utilización de los mismos |
| EP1585767A2 (en) | 2003-01-16 | 2005-10-19 | Genentech, Inc. | Synthetic antibody phage libraries |
| WO2004072266A2 (en) | 2003-02-13 | 2004-08-26 | Kalobios Inc. | Antibody affinity engineering by serial epitope-guided complementarity replacement |
| JP2006517802A (ja) | 2003-02-14 | 2006-08-03 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 外来性分子の一過性の発現もしくは安定な発現のための発現カセットおよび発現ベクター |
| EP2239271A1 (en) | 2003-06-13 | 2010-10-13 | Biogen Idec MA Inc. | Aglycosyl anti-CD154 (CD40 ligand) antibodies and uses thereof |
| CN1871259A (zh) | 2003-08-22 | 2006-11-29 | 比奥根艾迪克Ma公司 | 具有改变的效应物功能的经改进的抗体和制备它的方法 |
| US20060134105A1 (en) | 2004-10-21 | 2006-06-22 | Xencor, Inc. | IgG immunoglobulin variants with optimized effector function |
| WO2005035557A2 (en) * | 2003-10-14 | 2005-04-21 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin | Adenylate cyclase in the treatment and/or prophylaxis of immune-medicated disease |
| GB0324368D0 (en) | 2003-10-17 | 2003-11-19 | Univ Cambridge Tech | Polypeptides including modified constant regions |
| WO2005063815A2 (en) | 2003-11-12 | 2005-07-14 | Biogen Idec Ma Inc. | Fcϝ receptor-binding polypeptide variants and methods related thereto |
| US7276585B2 (en) | 2004-03-24 | 2007-10-02 | Xencor, Inc. | Immunoglobulin variants outside the Fc region |
| CN101001872A (zh) * | 2004-04-16 | 2007-07-18 | 宏观基因有限公司 | FcγRIIB－特异性抗体及其使用方法 |
| CA2566473A1 (en) * | 2004-05-17 | 2005-12-08 | Board Of Trustees Of The University Of Illinois | Uses of bispecific antibody (biab) coated dendritic cells pulsed with antigens |
| AU2005274905B2 (en) | 2004-08-04 | 2010-12-23 | Mentrik Biotech, Llc | Variant Fc regions |
| ES2526811T3 (es) | 2005-08-10 | 2015-01-15 | Macrogenics, Inc. | Identificación y modificación de anticuerpos con regiones Fc variantes y métodos de uso de estos |
| AU2008218184B2 (en) * | 2007-02-02 | 2013-01-10 | Baylor Research Institute | Activation of human antigen-presenting cells through CLEC-6 |
| US8282964B2 (en) * | 2007-10-27 | 2012-10-09 | Medical Diagnostic Laboratories, Llc | Ex-vivo treatment of peripheral plasmacytoid dendritic cells with IFN-lambda |
| EP2282773B2 (en) | 2008-05-02 | 2025-03-05 | Seagen Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
| BRPI0921433A2 (pt) * | 2008-10-31 | 2017-06-06 | Abbott Biotherapeutics Corp | uso de anticorpos anti-cs1 para o tratamento de linfomas raros |
| AR075989A1 (es) | 2009-04-10 | 2011-05-11 | Lilly Co Eli | Anticuerpo dkk -1 (dickkopf-1) humano disenado por ingenieria |
| TWI412375B (zh) | 2009-08-28 | 2013-10-21 | Roche Glycart Ag | 人類化抗ｃｄｃｐ１抗體 |
| FR2968561B1 (fr) * | 2010-12-13 | 2013-08-09 | Lfb Biotechnologies | Utilisation d'un anticorps dirige contre une proteine membranaire |
-
2013
- 2013-12-10 WO PCT/US2013/074208 patent/WO2014093396A1/en not_active Ceased
- 2013-12-10 CN CN201380071162.8A patent/CN105452295B/zh active Active
- 2013-12-10 US US14/649,297 patent/US9902775B2/en active Active
- 2013-12-10 PL PL13814340T patent/PL2928923T3/pl unknown
- 2013-12-10 NZ NZ708033A patent/NZ708033A/en active IP Right Revival
- 2013-12-10 MX MX2015007034A patent/MX363407B/es unknown
- 2013-12-10 KR KR1020207031486A patent/KR102344907B1/ko active Active
- 2013-12-10 AU AU2013359419A patent/AU2013359419B2/en active Active
- 2013-12-10 CA CA2893375A patent/CA2893375A1/en active Pending
- 2013-12-10 SI SI201331663T patent/SI2928923T1/sl unknown
- 2013-12-10 ES ES13814340T patent/ES2780398T3/es active Active
- 2013-12-10 KR KR1020157017299A patent/KR20150094658A/ko not_active Withdrawn
- 2013-12-10 DK DK13814340.9T patent/DK2928923T3/da active
- 2013-12-10 EA EA201591113A patent/EA034757B1/ru unknown
- 2013-12-10 RS RS20200365A patent/RS60084B1/sr unknown
- 2013-12-10 HU HUE13814340A patent/HUE047874T2/hu unknown
- 2013-12-10 EP EP19209959.6A patent/EP3686218A1/en active Pending
- 2013-12-10 SM SM20200193T patent/SMT202000193T1/it unknown
- 2013-12-10 HR HRP20200174TT patent/HRP20200174T1/hr unknown
- 2013-12-10 LT LTEP13814340.9T patent/LT2928923T/lt unknown
- 2013-12-10 JP JP2015545935A patent/JP6490591B2/ja active Active
- 2013-12-10 PT PT138143409T patent/PT2928923T/pt unknown
- 2013-12-10 BR BR122020023058-4A patent/BR122020023058B1/pt active IP Right Grant
- 2013-12-10 CN CN202010418430.0A patent/CN111961134B/zh active Active
- 2013-12-10 EP EP13814340.9A patent/EP2928923B1/en active Active
-
2015
- 2015-05-13 IL IL238804A patent/IL238804B/en unknown
- 2015-05-29 ZA ZA2015/03881A patent/ZA201503881B/en unknown
-
2018
- 2018-01-12 US US15/869,514 patent/US20180362652A1/en not_active Abandoned
-
2019
- 2019-02-27 JP JP2019034198A patent/JP6889741B2/ja active Active
-
2020
- 2020-03-19 CY CY20201100263T patent/CY1122956T1/el unknown
-
2021
- 2021-05-21 JP JP2021086053A patent/JP2021130677A/ja active Pending
- 2021-08-09 IL IL285475A patent/IL285475A/en unknown
-
2024
- 2024-01-18 JP JP2024006009A patent/JP2024045253A/ja active Pending
-
2025
- 2025-01-27 US US19/037,765 patent/US20250304700A1/en active Pending