JP2016505006A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016505006A5 JP2016505006A5 JP2015550784A JP2015550784A JP2016505006A5 JP 2016505006 A5 JP2016505006 A5 JP 2016505006A5 JP 2015550784 A JP2015550784 A JP 2015550784A JP 2015550784 A JP2015550784 A JP 2015550784A JP 2016505006 A5 JP2016505006 A5 JP 2016505006A5
- Authority
- JP
- Japan
- Prior art keywords
- levonorgestrel
- drug delivery
- delivery system
- days
- transdermal drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000013271 transdermal drug delivery Methods 0.000 claims description 30
- ORKBYCQJWQBPFG-WOMZHKBXSA-N (8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one;(8r,9s,13s,14s,17r)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 ORKBYCQJWQBPFG-WOMZHKBXSA-N 0.000 claims description 22
- 239000011159 matrix material Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 18
- 229920000642 polymer Polymers 0.000 claims description 17
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 16
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 16
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 16
- 229960002826 levonorgestrel and ethinylestradiol Drugs 0.000 claims description 14
- 229920000058 polyacrylate Polymers 0.000 claims description 14
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims description 13
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 13
- 229960002568 ethinylestradiol Drugs 0.000 claims description 13
- WWYNJERNGUHSAO-XUDSTZEESA-N (+)-Norgestrel Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 WWYNJERNGUHSAO-XUDSTZEESA-N 0.000 claims description 10
- 229960004400 levonorgestrel Drugs 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 8
- 230000002459 sustained effect Effects 0.000 claims description 8
- 230000037317 transdermal delivery Effects 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 239000003961 penetration enhancing agent Substances 0.000 claims description 6
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 4
- 230000000699 topical effect Effects 0.000 claims description 4
- 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 claims description 2
- RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 claims description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 claims description 2
- 210000004877 mucosa Anatomy 0.000 claims description 2
- 238000012377 drug delivery Methods 0.000 claims 2
- 229940124558 contraceptive agent Drugs 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 230000004907 flux Effects 0.000 description 3
- KBFRRZPPJPKFHQ-WOMZHKBXSA-N (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-hydroxyimino-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-ol (8R,9S,13S,14S,17R)-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-3,17-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1.ON=C1CC[C@@H]2[C@H]3CC[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 KBFRRZPPJPKFHQ-WOMZHKBXSA-N 0.000 description 2
- 229940071844 ortho evra Drugs 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261747013P | 2012-12-28 | 2012-12-28 | |
| US61/747,013 | 2012-12-28 | ||
| PCT/US2013/077932 WO2014106014A1 (en) | 2012-12-28 | 2013-12-27 | Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016505006A JP2016505006A (ja) | 2016-02-18 |
| JP2016505006A5 true JP2016505006A5 (enExample) | 2017-02-09 |
Family
ID=49956517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015550784A Pending JP2016505006A (ja) | 2012-12-28 | 2013-12-27 | レボノルゲストレル及びエチニルエストラジオール用の経皮薬物送達システム |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9314470B2 (enExample) |
| JP (1) | JP2016505006A (enExample) |
| AR (1) | AR094289A1 (enExample) |
| TW (1) | TW201431554A (enExample) |
| WO (1) | WO2014106014A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9314470B2 (en) | 2012-12-28 | 2016-04-19 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol |
| EP2938335B1 (en) | 2012-12-28 | 2021-03-17 | Noven Pharmaceuticals, INC. | Multi-polymer compositions for transdermal drug delivery |
| WO2014159582A1 (en) | 2013-03-14 | 2014-10-02 | Noven Pharmaceuticals, Inc | Amphetamine transdermal compositions with acrylic block copolymer |
| AR095259A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria |
| AR095260A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones de anfetaminas transdérmicas estables y métodos de fabricación |
| JP6807848B2 (ja) | 2015-02-06 | 2021-01-06 | ノーヴェン ファーマシューティカルズ インコーポレイテッド | 経皮薬物送達のための感圧粘着剤 |
| US10406116B2 (en) | 2015-02-06 | 2019-09-10 | Noven Pharmaceuticals, Inc. | Pressure-sensitive adhesives for transdermal drug delivery |
| WO2017004507A1 (en) * | 2015-07-02 | 2017-01-05 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol |
| WO2019088010A1 (ja) * | 2017-10-30 | 2019-05-09 | 帝國製薬株式会社 | 経皮投与製剤 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863738A (en) * | 1987-11-23 | 1989-09-05 | Alza Corporation | Skin permeation enhancer compositions using glycerol monooleate |
| US5446070A (en) | 1991-02-27 | 1995-08-29 | Nover Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5719197A (en) | 1988-03-04 | 1998-02-17 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5656286A (en) | 1988-03-04 | 1997-08-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5234957A (en) | 1991-02-27 | 1993-08-10 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US5474783A (en) | 1988-03-04 | 1995-12-12 | Noven Pharmaceuticals, Inc. | Solubility parameter based drug delivery system and method for altering drug saturation concentration |
| US5053227A (en) | 1989-03-22 | 1991-10-01 | Cygnus Therapeutic Systems | Skin permeation enhancer compositions, and methods and transdermal systems associated therewith |
| US5332576A (en) | 1991-02-27 | 1994-07-26 | Noven Pharmaceuticals, Inc. | Compositions and methods for topical administration of pharmaceutically active agents |
| US6024974A (en) | 1995-01-06 | 2000-02-15 | Noven Pharmaceuticals, Inc. | Composition and methods for transdermal delivery of acid labile drugs |
| US6316022B1 (en) | 1995-06-07 | 2001-11-13 | Noven Pharmaceuticals, Inc. | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures |
| CA2223588C (en) | 1995-06-07 | 2004-01-06 | Noven Pharmaceuticals, Inc. | Transdermal compositions containing low molecular weight drugs which are liquid at room temperatures |
| US20020102291A1 (en) | 1997-12-15 | 2002-08-01 | Noven Pharmaceuticals, Inc. | Compositions and method for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate |
| US6210705B1 (en) | 1997-12-15 | 2001-04-03 | Noven Pharmaceuticals, Nc. | Compositions and methods for treatment of attention deficit disorder and attention deficit/hyperactivity disorder with methylphenidate |
| US20030170195A1 (en) | 2000-01-10 | 2003-09-11 | Noven Pharmaceuticals, Inc. | Compositions and methods for drug delivery |
| WO2000041538A2 (en) | 1999-01-14 | 2000-07-20 | Noven Pharmaceuticals, Inc. | Dermal compositions |
| US7045145B1 (en) * | 1999-11-24 | 2006-05-16 | Agile Therapeutics, Inc. | Transdermal contraceptive delivery system and process |
| US7384650B2 (en) | 1999-11-24 | 2008-06-10 | Agile Therapeutics, Inc. | Skin permeation enhancement composition for transdermal hormone delivery system |
| DE60043621D1 (de) | 1999-11-24 | 2010-02-11 | Agile Therapeutics Inc | Verbessertes transdermales verabreichungssystem zur empfängnisverhütung und verfahren |
| AU3104301A (en) * | 2000-01-20 | 2001-07-31 | Noven Pharmaceuticals, Inc. | Compositions and methods to effect the release profile in the transdermal administration of active agents |
| CN100391462C (zh) | 2001-06-18 | 2008-06-04 | 诺芬药品公司 | 增强的透皮给药系统 |
| WO2005009417A1 (en) | 2003-07-21 | 2005-02-03 | Noven Pharmaceuticals, Inc. | Composition and method for controlling grug delivery from silicone adhesive blends |
| US8784874B2 (en) | 2003-09-10 | 2014-07-22 | Noven Pharmaceuticals, Inc. | Multi-layer transdermal drug delivery device |
| RS20060332A (sr) | 2003-10-28 | 2008-04-04 | Noven Pharmaceuticals Inc., | Kompozicije i postupci za kontrolisanje gubitka i oslobađanja leka u transdermalnim sistemima oslobađanja leka |
| US20060078602A1 (en) | 2004-10-08 | 2006-04-13 | Noven Pharmaceuticals, Inc. | Device for transdermal administration of drugs including acrylic polymers |
| US8343538B2 (en) | 2004-10-08 | 2013-01-01 | Noven Pharmaceuticals, Inc. | Compositions and methods for controlling the flux of a drug from a transdermal drug delivery systems |
| WO2006041908A2 (en) | 2004-10-08 | 2006-04-20 | Noven Pharmaceuticals, Inc. | Transdermal delivery of estradiol |
| JP4950510B2 (ja) * | 2006-02-16 | 2012-06-13 | 久光製薬株式会社 | 経皮吸収製剤 |
| EP1998756A2 (en) | 2006-02-27 | 2008-12-10 | Noven Pharmaceuticals, Inc. | Compositions and methods for delivery of amino-functional drugs |
| US7989496B2 (en) | 2006-10-27 | 2011-08-02 | Noven Pharmaceuticals, Inc. | Transdermal delivery of ketoprofen polar derivatives |
| US8246978B2 (en) | 2007-07-10 | 2012-08-21 | Agile Therapeutics, Inc. | Dermal delivery device with reduced loss of its volatile components |
| US20090098191A1 (en) * | 2007-10-16 | 2009-04-16 | Anderson Christopher G | Use of bases to stabilize transdermal formulations |
| US8231906B2 (en) | 2008-07-10 | 2012-07-31 | Noven Pharmaceuticals, Inc. | Transdermal estrogen device and delivery |
| US8852628B1 (en) | 2009-07-13 | 2014-10-07 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery system for diclofenac |
| US9320742B2 (en) | 2009-12-01 | 2016-04-26 | Noven Pharmaceuticals, Inc. | Transdermal testosterone device and delivery |
| WO2011118683A1 (ja) * | 2010-03-25 | 2011-09-29 | 東洋化学株式会社 | 医用貼付剤 |
| WO2012092165A1 (en) * | 2010-12-29 | 2012-07-05 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery system comprising levonorgestrel acetate |
| CA2891467A1 (en) | 2012-10-15 | 2014-04-24 | Noven Pharmaceuticals, Inc. | Compositions and methods for the transdermal delivery of methylphenidate |
| JP2015535253A (ja) | 2012-10-25 | 2015-12-10 | ノーヴェン ファーマシューティカルズ インコーポレイテッド | アンフェタミンの組成物及びアンフェタミンを経皮送達する方法 |
| EP2934497B1 (en) | 2012-12-21 | 2016-11-23 | Teikoku Pharma USA, Inc. | Compositions and methods for transdermal delivery of hormones and other medicinal agents |
| EP2938335B1 (en) | 2012-12-28 | 2021-03-17 | Noven Pharmaceuticals, INC. | Multi-polymer compositions for transdermal drug delivery |
| KR20150103077A (ko) | 2012-12-28 | 2015-09-09 | 노벤 파머수티컬즈, 인코퍼레이티드 | 비스테로이드성 항염증제의 경피 전달을 위한 조성물 및 방법 |
| US9314470B2 (en) | 2012-12-28 | 2016-04-19 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol |
| WO2014159573A1 (en) | 2013-03-14 | 2014-10-02 | Noven Pharmaceuticals, Inc | Methylphenidate transdermal compositions with rubber-based adhesives |
| WO2014159582A1 (en) | 2013-03-14 | 2014-10-02 | Noven Pharmaceuticals, Inc | Amphetamine transdermal compositions with acrylic block copolymer |
| US20140276479A1 (en) | 2013-03-14 | 2014-09-18 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery system with overlay |
| US20140276483A1 (en) | 2013-03-14 | 2014-09-18 | Noven Pharmaceuticals, Inc. | Transdermal methylphenidate compositions with acrylic block copolymers |
| AR095260A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones de anfetaminas transdérmicas estables y métodos de fabricación |
| AR095259A1 (es) | 2013-03-15 | 2015-09-30 | Noven Pharma | Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria |
| WO2017004507A1 (en) | 2015-07-02 | 2017-01-05 | Noven Pharmaceuticals, Inc. | Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol |
-
2013
- 2013-12-27 US US14/141,935 patent/US9314470B2/en active Active
- 2013-12-27 AR ARP130105039A patent/AR094289A1/es unknown
- 2013-12-27 JP JP2015550784A patent/JP2016505006A/ja active Pending
- 2013-12-27 WO PCT/US2013/077932 patent/WO2014106014A1/en not_active Ceased
- 2013-12-27 TW TW102148839A patent/TW201431554A/zh unknown
-
2016
- 2016-03-14 US US15/069,425 patent/US10231977B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016505006A5 (enExample) | ||
| CN101940790B (zh) | 一种新型促渗剂组合物及其在透皮给药系统中的应用 | |
| JP2011527697A5 (enExample) | ||
| JP2016504368A5 (enExample) | ||
| JP2017039781A5 (enExample) | ||
| JP2016520638A5 (enExample) | ||
| NZ589542A (en) | Transdermal drug delivery system comprising an active agent in amorphous form and polyvinylpyrrolidone | |
| NZ610701A (en) | Once daily formulation of lacosamide | |
| JP2015531400A5 (enExample) | ||
| JP2013514984A5 (enExample) | ||
| CN103432104B (zh) | 一种含有普拉克索的透皮贴剂 | |
| JP2010507601A (ja) | 避妊及びホルモン補充のためのノルエルゲストロミンを含む経皮治療システム | |
| CN1652798A (zh) | 连续抑制硫酸酯酶的孕激素的激素替代疗法 | |
| US10231977B2 (en) | Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol | |
| JP2016502989A5 (enExample) | ||
| JP2009512658A5 (enExample) | ||
| RU2011101477A (ru) | Средство и способ трансдермальной доставки эстрогена | |
| US20160184246A1 (en) | Transdermal drug delivery systems for agomelatine | |
| JP2020536953A5 (enExample) | ||
| JP2016513665A5 (enExample) | ||
| NZ627242A (en) | Transdermal hormone delivery | |
| JP7625623B2 (ja) | レボノルゲストレルおよびエチニルエストラジオールのための経皮的薬物送達システム | |
| JP2002537257A5 (enExample) | ||
| US10335389B2 (en) | Beraprost-containing patch | |
| JP2018524348A5 (enExample) |