JP2016505006A - レボノルゲストレル及びエチニルエストラジオール用の経皮薬物送達システム - Google Patents

レボノルゲストレル及びエチニルエストラジオール用の経皮薬物送達システム Download PDF

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Publication number
JP2016505006A
JP2016505006A JP2015550784A JP2015550784A JP2016505006A JP 2016505006 A JP2016505006 A JP 2016505006A JP 2015550784 A JP2015550784 A JP 2015550784A JP 2015550784 A JP2015550784 A JP 2015550784A JP 2016505006 A JP2016505006 A JP 2016505006A
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Prior art keywords
levonorgestrel
drug delivery
delivery system
transdermal drug
ethinyl estradiol
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JP2015550784A
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Japanese (ja)
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JP2016505006A5 (enExample
Inventor
プラシャント パテル
プラシャント パテル
ヴィエト グエン
ヴィエト グエン
ジュン リャオ
ジュン リャオ
Original Assignee
ノーヴェン ファーマシューティカルズ インコーポレイテッド
ノーヴェン ファーマシューティカルズ インコーポレイテッド
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Publication of JP2016505006A publication Critical patent/JP2016505006A/ja
Publication of JP2016505006A5 publication Critical patent/JP2016505006A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2015550784A 2012-12-28 2013-12-27 レボノルゲストレル及びエチニルエストラジオール用の経皮薬物送達システム Pending JP2016505006A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261747013P 2012-12-28 2012-12-28
US61/747,013 2012-12-28
PCT/US2013/077932 WO2014106014A1 (en) 2012-12-28 2013-12-27 Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol

Publications (2)

Publication Number Publication Date
JP2016505006A true JP2016505006A (ja) 2016-02-18
JP2016505006A5 JP2016505006A5 (enExample) 2017-02-09

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JP2015550784A Pending JP2016505006A (ja) 2012-12-28 2013-12-27 レボノルゲストレル及びエチニルエストラジオール用の経皮薬物送達システム

Country Status (5)

Country Link
US (2) US9314470B2 (enExample)
JP (1) JP2016505006A (enExample)
AR (1) AR094289A1 (enExample)
TW (1) TW201431554A (enExample)
WO (1) WO2014106014A1 (enExample)

Families Citing this family (9)

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US9314470B2 (en) 2012-12-28 2016-04-19 Noven Pharmaceuticals, Inc. Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol
EP2938335B1 (en) 2012-12-28 2021-03-17 Noven Pharmaceuticals, INC. Multi-polymer compositions for transdermal drug delivery
WO2014159582A1 (en) 2013-03-14 2014-10-02 Noven Pharmaceuticals, Inc Amphetamine transdermal compositions with acrylic block copolymer
AR095259A1 (es) 2013-03-15 2015-09-30 Noven Pharma Composiciones y métodos para la administración transdérmica de fármacos de amina terciaria
AR095260A1 (es) 2013-03-15 2015-09-30 Noven Pharma Composiciones de anfetaminas transdérmicas estables y métodos de fabricación
JP6807848B2 (ja) 2015-02-06 2021-01-06 ノーヴェン ファーマシューティカルズ インコーポレイテッド 経皮薬物送達のための感圧粘着剤
US10406116B2 (en) 2015-02-06 2019-09-10 Noven Pharmaceuticals, Inc. Pressure-sensitive adhesives for transdermal drug delivery
WO2017004507A1 (en) * 2015-07-02 2017-01-05 Noven Pharmaceuticals, Inc. Transdermal drug delivery systems for levonorgestrel and ethinyl estradiol
WO2019088010A1 (ja) * 2017-10-30 2019-05-09 帝國製薬株式会社 経皮投与製剤

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JPH01165529A (ja) * 1987-11-23 1989-06-29 Alza Corp 皮膚透過促進剤としてグリセロールモノオレエートを用いる治療系
JP2003533434A (ja) * 1999-11-24 2003-11-11 アジル・セラピユーテイクス・インコーポレーテツド 改良された経皮的避妊薬送達系および方法
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WO2011118683A1 (ja) * 2010-03-25 2011-09-29 東洋化学株式会社 医用貼付剤
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Title
寺原孝明: "９ 全身作用発現を期待した薬物の経皮吸収製剤の開発と応用", 難吸収性薬物の吸収性改善と新規投与製剤の開発, vol. 第１刷, JPN6018008940, 2012, pages 257 - 264, ISSN: 0003756486 *

Also Published As

Publication number Publication date
AR094289A1 (es) 2015-07-22
US10231977B2 (en) 2019-03-19
US20160296535A1 (en) 2016-10-13
TW201431554A (zh) 2014-08-16
US20140182597A1 (en) 2014-07-03
WO2014106014A1 (en) 2014-07-03
US9314470B2 (en) 2016-04-19

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