JP2016503391A5 - - Google Patents
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- Publication number
- JP2016503391A5 JP2016503391A5 JP2015538050A JP2015538050A JP2016503391A5 JP 2016503391 A5 JP2016503391 A5 JP 2016503391A5 JP 2015538050 A JP2015538050 A JP 2015538050A JP 2015538050 A JP2015538050 A JP 2015538050A JP 2016503391 A5 JP2016503391 A5 JP 2016503391A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- compound
- fluoro
- item
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MZHRFHRSYBBMON-UHFFFAOYSA-N CC(C)(C)OCCONC(c(c(Nc(ccc(Br)c1)c1F)c1F)cc2c1nc[n]2C)=O Chemical compound CC(C)(C)OCCONC(c(c(Nc(ccc(Br)c1)c1F)c1F)cc2c1nc[n]2C)=O MZHRFHRSYBBMON-UHFFFAOYSA-N 0.000 description 2
- 0 *CNOCCOc1ccccc1 Chemical compound *CNOCCOc1ccccc1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261716169P | 2012-10-19 | 2012-10-19 | |
| US61/716,169 | 2012-10-19 | ||
| PCT/US2013/065633 WO2014063024A1 (en) | 2012-10-19 | 2013-10-18 | Preparation of and formulation comprising a mek inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018109486A Division JP6737838B2 (ja) | 2012-10-19 | 2018-06-07 | Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016503391A JP2016503391A (ja) | 2016-02-04 |
| JP2016503391A5 true JP2016503391A5 (enExample) | 2016-12-01 |
| JP6385939B2 JP6385939B2 (ja) | 2018-09-05 |
Family
ID=50488781
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015538050A Active JP6385939B2 (ja) | 2012-10-19 | 2013-10-18 | Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤 |
| JP2018109486A Active JP6737838B2 (ja) | 2012-10-19 | 2018-06-07 | Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤 |
| JP2019149828A Pending JP2019194272A (ja) | 2012-10-19 | 2019-08-19 | Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018109486A Active JP6737838B2 (ja) | 2012-10-19 | 2018-06-07 | Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤 |
| JP2019149828A Pending JP2019194272A (ja) | 2012-10-19 | 2019-08-19 | Ｍｅｋ阻害剤の調製およびｍｅｋ阻害剤を含む製剤 |
Country Status (23)
| Country | Link |
|---|---|
| US (7) | US9238627B2 (enExample) |
| EP (3) | EP3702351B1 (enExample) |
| JP (3) | JP6385939B2 (enExample) |
| CN (3) | CN109456272A (enExample) |
| AR (1) | AR099630A1 (enExample) |
| BR (1) | BR112015008623B1 (enExample) |
| CA (2) | CA3079071C (enExample) |
| CY (1) | CY1122670T1 (enExample) |
| DK (2) | DK2909182T3 (enExample) |
| ES (2) | ES2772498T3 (enExample) |
| FI (1) | FI3702351T3 (enExample) |
| HR (1) | HRP20240033T1 (enExample) |
| HU (2) | HUE065433T2 (enExample) |
| JO (1) | JOP20130304B1 (enExample) |
| LT (1) | LT3702351T (enExample) |
| PL (2) | PL3702351T3 (enExample) |
| PT (2) | PT2909182T (enExample) |
| RS (1) | RS65117B1 (enExample) |
| RU (2) | RU2018127873A (enExample) |
| SI (2) | SI2909182T1 (enExample) |
| SM (1) | SMT202400044T1 (enExample) |
| TW (1) | TWI650316B (enExample) |
| WO (1) | WO2014063024A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3079071C (en) * | 2012-10-19 | 2022-06-07 | Array Biopharma Inc. | Preparation of crystallized benzimidazole derivative as mek inhibitor and formulation comprising same |
| CN105566225A (zh) * | 2015-02-16 | 2016-05-11 | 苏州晶云药物科技有限公司 | 一种口服丝裂原活化蛋白激酶抑制剂的晶型及其制备方法 |
| BR112018074941A2 (pt) | 2016-06-03 | 2019-03-12 | Caponigro Giordano | combinações farmacêuticas |
| CN109438362B (zh) * | 2017-11-14 | 2020-07-21 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的苯并咪唑化合物及包含该化合物的组合物 |
| TW201938165A (zh) | 2017-12-18 | 2019-10-01 | 美商輝瑞股份有限公司 | 治療癌症的方法及組合療法 |
| WO2019139970A1 (en) * | 2018-01-09 | 2019-07-18 | Duke University | Topical administration of mek inhibiting agents for the treatment of skin disorders |
| WO2020212832A1 (en) * | 2019-04-16 | 2020-10-22 | Alembic Pharmaceuticals Limited | Process of preparation of benzimidazole compounds |
| WO2021116901A1 (en) * | 2019-12-09 | 2021-06-17 | Biocon Limited | Forms of binimetinib and process for preparation thereof |
| WO2022074011A1 (en) | 2020-10-05 | 2022-04-14 | Pierre Fabre Medicament | Combination of encorafenib and binimetinib as adjuvant treatment for resected stage ii melanoma |
| CN112679438A (zh) * | 2020-12-31 | 2021-04-20 | 武汉九州钰民医药科技有限公司 | 制备司美替尼的方法 |
| JP2024521788A (ja) | 2021-05-27 | 2024-06-04 | ミラティ セラピューティクス， インコーポレイテッド | 併用療法 |
| WO2023084489A1 (en) | 2021-11-15 | 2023-05-19 | Pfizer Inc. | Methods of treating coronavirus disease 2019 |
| US20250074882A1 (en) * | 2022-01-06 | 2025-03-06 | Msn Laboratories Private Limited, R&D Center | Improved process for the preparation of 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-n-(2hydroxyethoxy)-1-methyl-1h-benzimidazole-6-carboxamide |
| CN118973580A (zh) | 2022-04-08 | 2024-11-15 | 米拉蒂治疗股份有限公司 | 包含sos1抑制剂和mek抑制剂的组合疗法 |
| WO2024003942A1 (en) * | 2022-07-01 | 2024-01-04 | Natco Pharma Limited | An improved process for the preparation of selumetinib sulfate |
| KR20260019479A (ko) | 2023-05-04 | 2026-02-10 | 레볼루션 메디슨즈, 인크. | Ras 관련 질환 또는 장애를 위한 병용 요법 |
| CN121889155A (zh) | 2023-08-07 | 2026-04-17 | 锐新医药公司 | 用于治疗ras蛋白相关疾病或病症的rmc-6291 |
| AU2024360465A1 (en) | 2023-10-12 | 2026-04-09 | Revolution Medicines, Inc. | Macrocyclic ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| FR3159741A1 (fr) | 2024-03-04 | 2025-09-05 | Pierre Fabre Medicament | Formulation topique comprenant du binimetinib |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| US20250375445A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026072904A2 (en) | 2024-09-26 | 2026-04-02 | Revolution Medicines, Inc. | Compositions and methods for treating lung cancer |
| WO2026090116A2 (en) | 2024-10-21 | 2026-04-30 | Revolution Medicines, Inc. | Ras inhibitors |
| US20260108528A1 (en) | 2024-10-22 | 2026-04-23 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2026090245A1 (en) | 2024-10-22 | 2026-04-30 | Revolution Medicines, Inc. | Use of ras inhibitors for treating cancer |
| WO2026106912A1 (en) | 2024-11-12 | 2026-05-21 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026112260A1 (en) | 2024-11-21 | 2026-05-28 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026122764A2 (en) | 2024-12-06 | 2026-06-11 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026128688A2 (en) | 2024-12-13 | 2026-06-18 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026161839A1 (en) | 2025-01-27 | 2026-07-30 | Revolution Medicines, Inc. | Ras inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID30439A (id) * | 1999-01-13 | 2001-12-06 | Warner Lambert Co | Benzoheterosiklus dan penggunaannya sebagai penghambat mek |
| IL147150A0 (en) * | 1999-07-16 | 2002-08-14 | Warner Lambert Co | Method for treating chronic pain using mek inhibitors |
| SG2013013339A (en) * | 2002-03-13 | 2014-12-30 | Array Biopharma Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| CA2532067C (en) * | 2003-07-24 | 2010-12-21 | Stephen Douglas Barrett | N-methyle-substituted benzamidazoles |
| US8969379B2 (en) | 2004-09-17 | 2015-03-03 | Eisai R&D Management Co., Ltd. | Pharmaceutical compositions of 4-(3-chloro-4-(cyclopropylaminocarbonyl)aminophenoxy)-7=methoxy-6-quinolinecarboxide |
| KR101357361B1 (ko) | 2005-06-23 | 2014-02-03 | 아스트라제네카 아베 | 벤즈이미다졸 화합물의 ＳｎＡｒ 제조 방법 |
| EP1904481B1 (en) | 2005-06-23 | 2016-02-17 | Array Biopharma, Inc. | Process for preparing benzimidazole compounds |
| TWI405756B (zh) * | 2005-12-21 | 2013-08-21 | Array Biopharma Inc | 新穎硫酸氫鹽 |
| WO2007071951A1 (en) * | 2005-12-21 | 2007-06-28 | Astrazeneca Ab | Tosylate salt of 6- (4-br0m0-2-chl0r0phenylamin0) -7-fluoro-n- (2-hydroxyethoxy) -3-methyl-3h-benzimi dazole- 5 - carboxamide , mek inhibitor useful in the treatment of cancer |
| CN103479604B (zh) * | 2007-07-30 | 2016-08-10 | 阿迪生物科学公司 | 作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法 |
| US8022057B2 (en) | 2007-11-12 | 2011-09-20 | Takeda Pharmaceutical Company Limited | MAPK/ERK kinase inhibitors |
| EP2421612A1 (en) | 2009-04-21 | 2012-02-29 | Novartis AG | Heterocyclic compounds as mek inhibitors |
| WO2012145503A1 (en) | 2011-04-21 | 2012-10-26 | Novartis Ag | Pharmaceutical combinations |
| RU2014112324A (ru) | 2011-09-01 | 2015-10-10 | Новартис Аг | Применение органического соединения для лечения синдрома нунан |
| CA3079071C (en) | 2012-10-19 | 2022-06-07 | Array Biopharma Inc. | Preparation of crystallized benzimidazole derivative as mek inhibitor and formulation comprising same |
-
2013
- 2013-10-18 CA CA3079071A patent/CA3079071C/en active Active
- 2013-10-18 RU RU2018127873A patent/RU2018127873A/ru not_active Application Discontinuation
- 2013-10-18 LT LTEP19211405.6T patent/LT3702351T/lt unknown
- 2013-10-18 ES ES13847106T patent/ES2772498T3/es active Active
- 2013-10-18 FI FIEP19211405.6T patent/FI3702351T3/fi active
- 2013-10-18 SI SI201331672T patent/SI2909182T1/sl unknown
- 2013-10-18 CN CN201810684986.7A patent/CN109456272A/zh active Pending
- 2013-10-18 PT PT138471065T patent/PT2909182T/pt unknown
- 2013-10-18 PT PT192114056T patent/PT3702351T/pt unknown
- 2013-10-18 BR BR112015008623-3A patent/BR112015008623B1/pt active IP Right Grant
- 2013-10-18 US US14/057,498 patent/US9238627B2/en active Active
- 2013-10-18 EP EP19211405.6A patent/EP3702351B1/en active Active
- 2013-10-18 WO PCT/US2013/065633 patent/WO2014063024A1/en not_active Ceased
- 2013-10-18 RU RU2015118572A patent/RU2669391C2/ru active
- 2013-10-18 HR HRP20240033TT patent/HRP20240033T1/hr unknown
- 2013-10-18 SM SM20240044T patent/SMT202400044T1/it unknown
- 2013-10-18 DK DK13847106.5T patent/DK2909182T3/da active
- 2013-10-18 SI SI201332074T patent/SI3702351T1/sl unknown
- 2013-10-18 TW TW102137813A patent/TWI650316B/zh active
- 2013-10-18 CA CA2888474A patent/CA2888474C/en active Active
- 2013-10-18 CN CN201811124073.6A patent/CN109336824B/zh active Active
- 2013-10-18 RS RS20240112A patent/RS65117B1/sr unknown
- 2013-10-18 EP EP13847106.5A patent/EP2909182B1/en active Active
- 2013-10-18 CN CN201380063271.5A patent/CN104870427B/zh active Active
- 2013-10-18 EP EP23211278.9A patent/EP4306171A3/en active Pending
- 2013-10-18 HU HUE19211405A patent/HUE065433T2/hu unknown
- 2013-10-18 AR ARP130103796A patent/AR099630A1/es not_active Application Discontinuation
- 2013-10-18 HU HUE13847106A patent/HUE047708T2/hu unknown
- 2013-10-18 PL PL19211405.6T patent/PL3702351T3/pl unknown
- 2013-10-18 ES ES19211405T patent/ES2971077T3/es active Active
- 2013-10-18 JP JP2015538050A patent/JP6385939B2/ja active Active
- 2013-10-18 DK DK19211405.6T patent/DK3702351T3/da active
- 2013-10-18 PL PL13847106T patent/PL2909182T3/pl unknown
- 2013-10-20 JO JOP/2013/0304A patent/JOP20130304B1/ar active
-
2015
- 2015-12-18 US US14/974,588 patent/US9382212B1/en active Active
- 2015-12-18 US US14/974,655 patent/US9562016B2/en active Active
-
2016
- 2016-02-25 US US15/053,441 patent/US9598376B2/en active Active
-
2017
- 2017-02-28 US US15/445,393 patent/US9980944B2/en active Active
- 2017-12-14 US US15/842,715 patent/US10398683B2/en active Active
-
2018
- 2018-06-07 JP JP2018109486A patent/JP6737838B2/ja active Active
-
2019
- 2019-07-16 US US16/512,823 patent/US10729678B2/en active Active
- 2019-08-19 JP JP2019149828A patent/JP2019194272A/ja active Pending
-
2020
- 2020-02-18 CY CY20201100148T patent/CY1122670T1/el unknown
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