RU2669391C2 - Получение и составление композиции, содержащей ингибитор мек - Google Patents
Получение и составление композиции, содержащей ингибитор мек Download PDFInfo
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- RU2669391C2 RU2669391C2 RU2015118572A RU2015118572A RU2669391C2 RU 2669391 C2 RU2669391 C2 RU 2669391C2 RU 2015118572 A RU2015118572 A RU 2015118572A RU 2015118572 A RU2015118572 A RU 2015118572A RU 2669391 C2 RU2669391 C2 RU 2669391C2
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- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
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| US201261716169P | 2012-10-19 | 2012-10-19 | |
| US61/716,169 | 2012-10-19 | ||
| PCT/US2013/065633 WO2014063024A1 (en) | 2012-10-19 | 2013-10-18 | Preparation of and formulation comprising a mek inhibitor |
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| RU2018127873A Division RU2018127873A (ru) | 2012-10-19 | 2013-10-18 | Получение и составление композиции, содержащей ингибитор mek |
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| RU2018127873A RU2018127873A (ru) | 2012-10-19 | 2013-10-18 | Получение и составление композиции, содержащей ингибитор mek |
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| SI3702351T1 (sl) | 2012-10-19 | 2024-03-29 | Array Biopharma Inc., | Formulacija, ki obsega inhibitor mek |
| CN105566225A (zh) * | 2015-02-16 | 2016-05-11 | 苏州晶云药物科技有限公司 | 一种口服丝裂原活化蛋白激酶抑制剂的晶型及其制备方法 |
| FI3463345T3 (fi) | 2016-06-03 | 2023-01-31 | Farmaseuttisia yhdistelmiä | |
| WO2019096112A1 (zh) * | 2017-11-14 | 2019-05-23 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的苯并咪唑化合物及包含该化合物的组合物 |
| TW201938165A (zh) | 2017-12-18 | 2019-10-01 | 美商輝瑞股份有限公司 | 治療癌症的方法及組合療法 |
| WO2019139970A1 (en) * | 2018-01-09 | 2019-07-18 | Duke University | Topical administration of mek inhibiting agents for the treatment of skin disorders |
| WO2020212832A1 (en) * | 2019-04-16 | 2020-10-22 | Alembic Pharmaceuticals Limited | Process of preparation of benzimidazole compounds |
| WO2021116901A1 (en) * | 2019-12-09 | 2021-06-17 | Biocon Limited | Forms of binimetinib and process for preparation thereof |
| WO2022074011A1 (en) | 2020-10-05 | 2022-04-14 | Pierre Fabre Medicament | Combination of encorafenib and binimetinib as adjuvant treatment for resected stage ii melanoma |
| CN112679438A (zh) * | 2020-12-31 | 2021-04-20 | 武汉九州钰民医药科技有限公司 | 制备司美替尼的方法 |
| US12280055B2 (en) | 2021-05-27 | 2025-04-22 | Mirati Therapeutics, Inc. | Combination therapies |
| WO2023084489A1 (en) | 2021-11-15 | 2023-05-19 | Pfizer Inc. | Methods of treating coronavirus disease 2019 |
| WO2023131976A1 (en) * | 2022-01-06 | 2023-07-13 | Msn Laboratories Private Limited, R&D Center | Improved process for the preparation of 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-n-(2hydroxyethoxy)-1-methyl-1h-benzimidazole-6-carboxamide |
| WO2024003942A1 (en) * | 2022-07-01 | 2024-01-04 | Natco Pharma Limited | An improved process for the preparation of selumetinib sulfate |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ｒａｓ相關疾病或病症之組合療法 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| FR3159741A1 (fr) | 2024-03-04 | 2025-09-05 | Pierre Fabre Medicament | Formulation topique comprenant du binimetinib |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
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| WO2000042022A1 (en) * | 1999-01-13 | 2000-07-20 | Warner-Lambert Company | Benzoheterocycles and their use as mek inhibitors |
| RU2307831C9 (ru) * | 2002-03-13 | 2008-06-10 | Эррэй Биофарма, Инк. | N3-алкилированные бензимидазольные производные в качестве ингибиторов mek |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001005390A2 (en) * | 1999-07-16 | 2001-01-25 | Warner-Lambert Company | Method for treating chronic pain using mek inhibitors |
| US7235537B2 (en) * | 2002-03-13 | 2007-06-26 | Array Biopharma, Inc. | N3 alkylated benzimidazole derivatives as MEK inhibitors |
| BRPI0412851A (pt) * | 2003-07-24 | 2006-10-03 | Warner Lambert Co | benzamidazóis de n-metila-substituìdos |
| JP4834553B2 (ja) | 2004-09-17 | 2011-12-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 医薬組成物 |
| AU2006262375A1 (en) | 2005-06-23 | 2007-01-04 | Array Biopharma Inc. | SNAr process for preparing benzimidazole compounds |
| TWI391380B (zh) | 2005-06-23 | 2013-04-01 | Array Biopharma Inc | 製備苯并咪唑化合物之方法 |
| CN101341132A (zh) * | 2005-12-21 | 2009-01-07 | 阿斯利康(瑞典)有限公司 | 作为mek抑制剂用于治疗癌症的6-(4-溴-2-氯-苯基氨基)-7-氟-n-(2-羟基乙氧基)-3-甲基-3h-苯并咪唑-5-甲酰胺的甲苯磺酸盐 |
| TWI405756B (zh) * | 2005-12-21 | 2013-08-21 | Array Biopharma Inc | 新穎硫酸氫鹽 |
| CN101808516B (zh) * | 2007-07-30 | 2013-08-28 | 阿迪生物科学公司 | 作为mek抑制剂的包括多晶型物的n-(芳氨基)磺酰胺衍生物和组合物、其使用方法和制备方法 |
| CA2705452C (en) | 2007-11-12 | 2016-05-31 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors |
| CA2761108A1 (en) * | 2009-04-21 | 2010-10-28 | Novartis Ag | Heterocyclic compounds as mek inhibitors |
| WO2012145503A1 (en) | 2011-04-21 | 2012-10-26 | Novartis Ag | Pharmaceutical combinations |
| AU2012302106B2 (en) | 2011-09-01 | 2015-04-09 | Novartis Ag | Use of organic compound for the treatment of noonan syndrome |
| SI3702351T1 (sl) | 2012-10-19 | 2024-03-29 | Array Biopharma Inc., | Formulacija, ki obsega inhibitor mek |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2000042022A1 (en) * | 1999-01-13 | 2000-07-20 | Warner-Lambert Company | Benzoheterocycles and their use as mek inhibitors |
| RU2307831C9 (ru) * | 2002-03-13 | 2008-06-10 | Эррэй Биофарма, Инк. | N3-алкилированные бензимидазольные производные в качестве ингибиторов mek |
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