JP2016500443A5 - - Google Patents
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- JP2016500443A5 JP2016500443A5 JP2015545852A JP2015545852A JP2016500443A5 JP 2016500443 A5 JP2016500443 A5 JP 2016500443A5 JP 2015545852 A JP2015545852 A JP 2015545852A JP 2015545852 A JP2015545852 A JP 2015545852A JP 2016500443 A5 JP2016500443 A5 JP 2016500443A5
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- JP
- Japan
- Prior art keywords
- blood sample
- algorithm
- water
- clot
- measurement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 210000004369 blood Anatomy 0.000 claims description 126
- 239000008280 blood Substances 0.000 claims description 126
- 238000000034 method Methods 0.000 claims description 85
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 45
- 238000005259 measurement Methods 0.000 claims description 42
- 206010053567 Coagulopathies Diseases 0.000 claims description 24
- 230000035602 clotting Effects 0.000 claims description 20
- 239000003999 initiator Substances 0.000 claims description 15
- 230000015271 coagulation Effects 0.000 claims description 12
- 238000005345 coagulation Methods 0.000 claims description 12
- 238000012544 monitoring process Methods 0.000 claims description 10
- 108010049003 Fibrinogen Proteins 0.000 claims description 9
- 102000008946 Fibrinogen Human genes 0.000 claims description 9
- 229940012952 fibrinogen Drugs 0.000 claims description 9
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- 102000003978 Tissue Plasminogen Activator Human genes 0.000 claims description 6
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 claims description 6
- 239000003130 blood coagulation factor inhibitor Substances 0.000 claims description 6
- 229960000187 tissue plasminogen activator Drugs 0.000 claims description 6
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims description 5
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 claims description 5
- 229920002079 Ellagic acid Polymers 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 5
- 108090000190 Thrombin Proteins 0.000 claims description 5
- 108010000499 Thromboplastin Proteins 0.000 claims description 5
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- 229960002852 ellagic acid Drugs 0.000 claims description 5
- 235000004132 ellagic acid Nutrition 0.000 claims description 5
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 claims description 5
- 210000004623 platelet-rich plasma Anatomy 0.000 claims description 5
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- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 claims description 3
- 229930182837 (R)-adrenaline Natural products 0.000 claims description 3
- 108010035532 Collagen Proteins 0.000 claims description 3
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- 101000783577 Dendroaspis angusticeps Thrombostatin Proteins 0.000 claims description 3
- 101000783578 Dendroaspis jamesoni kaimosae Dendroaspin Proteins 0.000 claims description 3
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- 229960005139 epinephrine Drugs 0.000 claims description 3
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- 108010039627 Aprotinin Proteins 0.000 claims description 2
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- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 claims description 2
- 239000003805 procoagulant Substances 0.000 claims description 2
- 229940107685 reopro Drugs 0.000 claims description 2
- 230000035939 shock Effects 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 201000005665 thrombophilia Diseases 0.000 claims description 2
- 230000001732 thrombotic effect Effects 0.000 claims description 2
- JVHIPYJQMFNCEK-UHFFFAOYSA-N cytochalasin Natural products N1C(=O)C2(C(C=CC(C)CC(C)CC=C3)OC(C)=O)C3C(O)C(=C)C(C)C2C1CC1=CC=CC=C1 JVHIPYJQMFNCEK-UHFFFAOYSA-N 0.000 claims 1
- ZMAODHOXRBLOQO-UHFFFAOYSA-N cytochalasin-A Natural products N1C(=O)C23OC(=O)C=CC(=O)CCCC(C)CC=CC3C(O)C(=C)C(C)C2C1CC1=CC=CC=C1 ZMAODHOXRBLOQO-UHFFFAOYSA-N 0.000 claims 1
- 231100000518 lethal Toxicity 0.000 claims 1
- 230000001665 lethal effect Effects 0.000 claims 1
- 238000007711 solidification Methods 0.000 claims 1
- 230000008023 solidification Effects 0.000 claims 1
- 239000000463 material Substances 0.000 description 13
- 239000000758 substrate Substances 0.000 description 8
- 102000009123 Fibrin Human genes 0.000 description 7
- 108010073385 Fibrin Proteins 0.000 description 7
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 7
- 229950003499 fibrin Drugs 0.000 description 7
- 239000011521 glass Substances 0.000 description 6
- 210000002381 plasma Anatomy 0.000 description 6
- HVAUUPRFYPCOCA-AREMUKBSSA-N 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](OC(C)=O)COP([O-])(=O)OCC[N+](C)(C)C HVAUUPRFYPCOCA-AREMUKBSSA-N 0.000 description 4
- 108010003541 Platelet Activating Factor Proteins 0.000 description 4
- 229920005601 base polymer Polymers 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
- 239000003112 inhibitor Substances 0.000 description 4
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 3
- 238000001208 nuclear magnetic resonance pulse sequence Methods 0.000 description 3
- 229910000077 silane Inorganic materials 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 2
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- 239000004793 Polystyrene Substances 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
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- SDZRWUKZFQQKKV-JHADDHBZSA-N cytochalasin D Chemical compound C([C@H]1[C@@H]2[C@@H](C([C@@H](O)[C@H]\3[C@]2([C@@H](/C=C/[C@@](C)(O)C(=O)[C@@H](C)C/C=C/3)OC(C)=O)C(=O)N1)=C)C)C1=CC=CC=C1 SDZRWUKZFQQKKV-JHADDHBZSA-N 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
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- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 102000040430 polynucleotide Human genes 0.000 description 2
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- -1 polypropylene Polymers 0.000 description 2
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- 229920002223 polystyrene Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000003331 prothrombotic effect Effects 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000004879 turbidimetry Methods 0.000 description 2
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- 208000007536 Thrombosis Diseases 0.000 description 1
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- 230000036039 immunity Effects 0.000 description 1
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Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261734579P | 2012-12-07 | 2012-12-07 | |
| US61/734,579 | 2012-12-07 | ||
| US201361837290P | 2013-06-20 | 2013-06-20 | |
| US61/837,290 | 2013-06-20 | ||
| US201361864322P | 2013-08-09 | 2013-08-09 | |
| US61/864,322 | 2013-08-09 | ||
| US201361870952P | 2013-08-28 | 2013-08-28 | |
| US61/870,952 | 2013-08-28 | ||
| PCT/US2013/073395 WO2014089346A1 (en) | 2012-12-07 | 2013-12-05 | Methods for monitoring tight clot formation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016500443A JP2016500443A (ja) | 2016-01-12 |
| JP2016500443A5 true JP2016500443A5 (enExample) | 2017-01-26 |
Family
ID=50884002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015545852A Pending JP2016500443A (ja) | 2012-12-07 | 2013-12-05 | 強固な血餅形成をモニタリングするための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9739733B2 (enExample) |
| EP (1) | EP2929047A4 (enExample) |
| JP (1) | JP2016500443A (enExample) |
| AU (1) | AU2013355183A1 (enExample) |
| CA (1) | CA2893591A1 (enExample) |
| WO (1) | WO2014089346A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12607641B2 (en) * | 2014-11-14 | 2026-04-21 | Haemonetics Corporation | Apparatus and method to determine stroke subtype |
| WO2018163188A1 (en) * | 2017-03-09 | 2018-09-13 | B.G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Generation of nuclear magnetic resonance multidimensional t1(spin-matrix)-t2(spin-spin) energy relaxation maps and uses thereof |
| JP6871839B2 (ja) * | 2017-10-31 | 2021-05-12 | 信越化学工業株式会社 | レジストの品質管理方法及びレジストの品質予測モデルを得る方法 |
| CN109726430B (zh) * | 2018-11-21 | 2023-04-25 | 中国石油天然气集团有限公司 | 一种基于t2谱拐点位置分段的核磁转伪毛管压力曲线方法 |
| FR3089634B1 (fr) * | 2018-12-07 | 2020-12-25 | Stago Diagnostica | Methode pour la detection de la presence, l’identification et la quantification dans un echantillon sanguin d'anticoagulants inhibiteurs d’enzymes de la coagulation du sang, et moyens pour son implementation |
| EP3919913A4 (en) * | 2019-01-31 | 2022-11-09 | Sekisui Medical Co., Ltd. | METHOD OF ANALYSIS OF BLOOD COAGULATION CHARACTERISTICS OF A BLOOD SAMPLE |
| CN113740369B (zh) * | 2020-05-29 | 2024-03-12 | 华东师范大学 | 基于原位低场核磁共振弛豫法检测重金属离子还原方法 |
| CN112200022A (zh) * | 2020-09-23 | 2021-01-08 | 上海联影医疗科技股份有限公司 | 图像处理方法、医疗成像设备和存储介质 |
| EP4193301A4 (en) | 2020-09-04 | 2023-12-20 | Shanghai United Imaging Healthcare Co., Ltd. | SYSTEMS AND METHODS FOR IMAGE PROCESSING |
| JP2024501510A (ja) | 2021-01-08 | 2024-01-12 | エルジー エナジー ソリューション リミテッド | バッテリー管理装置及び方法 |
| CN117192141B (zh) * | 2023-11-07 | 2024-01-23 | 北京众驰伟业科技发展有限公司 | 全自动凝血测试仪的质量控制系统及方法 |
| CN121721678A (zh) * | 2026-02-27 | 2026-03-24 | 陕西秦洲核与辐射安全技术有限公司 | 一种远程式氚在线监测系统 |
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2013
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- 2013-12-05 JP JP2015545852A patent/JP2016500443A/ja active Pending
- 2013-12-05 US US14/648,124 patent/US9739733B2/en not_active Expired - Fee Related
- 2013-12-05 CA CA2893591A patent/CA2893591A1/en not_active Abandoned
- 2013-12-05 AU AU2013355183A patent/AU2013355183A1/en not_active Abandoned
- 2013-12-05 EP EP13860819.5A patent/EP2929047A4/en not_active Withdrawn
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