JP2016500443A - 強固な血餅形成をモニタリングするための方法 - Google Patents

強固な血餅形成をモニタリングするための方法 Download PDF

Info

Publication number
JP2016500443A
JP2016500443A JP2015545852A JP2015545852A JP2016500443A JP 2016500443 A JP2016500443 A JP 2016500443A JP 2015545852 A JP2015545852 A JP 2015545852A JP 2015545852 A JP2015545852 A JP 2015545852A JP 2016500443 A JP2016500443 A JP 2016500443A
Authority
JP
Japan
Prior art keywords
blood sample
sample
algorithm
blood
clot
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015545852A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016500443A5 (enExample
Inventor
マッセフスキ，ウォルター，ダブリュ．
ロウェリー，トーマス，ジェイ
スクイス，リネル，アール．
Original Assignee
ティー２ バイオシステムズ，インコーポレーテッド
ティー２ バイオシステムズ，インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ティー２ バイオシステムズ，インコーポレーテッド, ティー２ バイオシステムズ，インコーポレーテッド filed Critical ティー２ バイオシステムズ，インコーポレーテッド
Publication of JP2016500443A publication Critical patent/JP2016500443A/ja
Publication of JP2016500443A5 publication Critical patent/JP2016500443A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/75—Fibrin; Fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/448—Relaxometry, i.e. quantification of relaxation times or spin density
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ecology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Genetics & Genomics (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2015545852A 2012-12-07 2013-12-05 強固な血餅形成をモニタリングするための方法 Pending JP2016500443A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261734579P 2012-12-07 2012-12-07
US61/734,579 2012-12-07
US201361837290P 2013-06-20 2013-06-20
US61/837,290 2013-06-20
US201361864322P 2013-08-09 2013-08-09
US61/864,322 2013-08-09
US201361870952P 2013-08-28 2013-08-28
US61/870,952 2013-08-28
PCT/US2013/073395 WO2014089346A1 (en) 2012-12-07 2013-12-05 Methods for monitoring tight clot formation

Publications (2)

Publication Number Publication Date
JP2016500443A true JP2016500443A (ja) 2016-01-12
JP2016500443A5 JP2016500443A5 (enExample) 2017-01-26

Family

ID=50884002

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015545852A Pending JP2016500443A (ja) 2012-12-07 2013-12-05 強固な血餅形成をモニタリングするための方法

Country Status (6)

Country Link
US (1) US9739733B2 (enExample)
EP (1) EP2929047A4 (enExample)
JP (1) JP2016500443A (enExample)
AU (1) AU2013355183A1 (enExample)
CA (1) CA2893591A1 (enExample)
WO (1) WO2014089346A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022510708A (ja) * 2018-12-07 2022-01-27 ディアグノスチカ・スタゴ 血液試料中で血液凝固酵素阻害剤である抗凝固薬の存在を検出する、同定する及び定量するための方法並びにその実装手段

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3218723B1 (en) * 2014-11-14 2021-10-06 Haemonetics Corporation Apparatus and method to determine stroke subtype
WO2018163188A1 (en) * 2017-03-09 2018-09-13 B.G. Negev Technologies And Applications Ltd., At Ben-Gurion University Generation of nuclear magnetic resonance multidimensional t1(spin-matrix)-t2(spin-spin) energy relaxation maps and uses thereof
JP6871839B2 (ja) * 2017-10-31 2021-05-12 信越化学工業株式会社 レジストの品質管理方法及びレジストの品質予測モデルを得る方法
CN109726430B (zh) * 2018-11-21 2023-04-25 中国石油天然气集团有限公司 一种基于t2谱拐点位置分段的核磁转伪毛管压力曲线方法
EP3919913A4 (en) * 2019-01-31 2022-11-09 Sekisui Medical Co., Ltd. PROCEDURE FOR ANALYZING BLOOD COAGULATION PROPERTIES OF A BLOOD SAMPLE
CN113740369B (zh) * 2020-05-29 2024-03-12 华东师范大学 基于原位低场核磁共振弛豫法检测重金属离子还原方法
WO2022048672A1 (en) 2020-09-04 2022-03-10 Shanghai United Imaging Healthcare Co., Ltd. Systems and methods for image processing
CN112200022A (zh) * 2020-09-23 2021-01-08 上海联影医疗科技股份有限公司 图像处理方法、医疗成像设备和存储介质
KR102964378B1 (ko) * 2021-01-08 2026-05-14 주식회사 엘지에너지솔루션 배터리 관리 장치 및 방법
CN117192141B (zh) * 2023-11-07 2024-01-23 北京众驰伟业科技发展有限公司 全自动凝血测试仪的质量控制系统及方法
CN121721678B (zh) * 2026-02-27 2026-05-26 陕西秦洲核与辐射安全技术有限公司 一种远程式氚在线监测系统

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110312002A1 (en) * 2008-10-29 2011-12-22 Sonia Taktak Nmr detection of coagulation time

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5913521B2 (ja) 1975-06-19 1984-03-30 メイトウサンギヨウ カブシキガイシヤ 磁性酸化鉄・デキストラン複合体の製造法
US4374360A (en) 1980-05-29 1983-02-15 Sepponen Raimo E NMR Diagnosis apparatus
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4920061A (en) 1984-03-02 1990-04-24 The University Of Texas System Biological magnetic colloids
US5262176A (en) 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
US4875486A (en) 1986-09-04 1989-10-24 Advanced Techtronics, Inc. Instrument and method for non-invasive in vivo testing for body fluid constituents
US5136095A (en) 1987-05-19 1992-08-04 Syntex (U.S.A.) Inc. Reversible agglutination mediators
US5042488A (en) 1987-09-29 1991-08-27 The Washington University Methods employing deuterium for obtaining direct, observable deuterium magnetic resonance images in vivo and in situ
CA2003508C (en) 1988-11-21 2000-01-25 Erik Hornes Monodisperse superparamagnetic particles for use in nucleic acid analyses
US5049819A (en) 1989-06-30 1991-09-17 Auburn International, Inc. Magnetic resonance analysis in real time, industrial usage mode
JP2726520B2 (ja) 1989-10-20 1998-03-11 名糖産業株式会社 有機磁性複合体
US5254460A (en) 1990-05-03 1993-10-19 Advanced Magnetics, Inc. Solvent mediated relaxation assay system
US5164297A (en) 1990-05-03 1992-11-17 Advanced Magnetics Inc. Solvent mediated relaxation assay system
IL98744A0 (en) 1990-07-06 1992-07-15 Gen Hospital Corp Method of studying biological tissue using monocrystalline particles
WO1992022586A1 (fr) 1991-06-11 1992-12-23 Meito Sangyo Kabushiki Kaisha Composite oxyde comprenant du carboxypolysaccharide hydrosoluble et de l'oxyde de fer magnetique
US5445970A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5445971A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
JP3362192B2 (ja) 1994-12-06 2003-01-07 味の素株式会社 検査方法及び検査薬
US6884357B2 (en) 1995-02-21 2005-04-26 Iqbal Waheed Siddiqi Apparatus and method for processing magnetic particles
US6500343B2 (en) 1995-02-21 2002-12-31 Iqbal W. Siddiqi Method for mixing and separation employing magnetic particles
US6297062B1 (en) 1996-03-07 2001-10-02 Bio-Magnetics Ltd. Separation by magnetic particles
IL126544A (en) 1996-04-25 2004-08-31 Genicon Sciences Inc Analyte assay using scattered-light detectable particles
AU3374597A (en) 1996-06-07 1998-01-05 Immunivest Corporation Magnetic separation employing external and internal gradients
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
WO1998004740A1 (en) 1996-07-29 1998-02-05 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
EP0928809B1 (en) 1996-08-30 2003-10-22 Meito Sangyo Kabushiki Kaisha Polysaccharide derivative/magnetic metal oxide composite
JP2001500501A (ja) 1996-09-12 2001-01-16 ニコムド イメージング エイエス マーカー組成物
JP3876022B2 (ja) 1996-09-26 2007-01-31 生化学工業株式会社 血液凝固時間に影響を与える物質の定量方法
FR2758884B1 (fr) 1997-01-30 1999-04-02 Bio Merieux Procede pour isoler, notamment detecter ou quantifier un analyte dans un milieu
JP3917239B2 (ja) 1997-06-05 2007-05-23 生化学工業株式会社 血液凝固時間の測定方法
DE19822123C2 (de) 1997-11-21 2003-02-06 Meinhard Knoll Verfahren und Vorrichtung zum Nachweis von Analyten
JP2000166897A (ja) 1998-12-11 2000-06-20 Toshiba Corp Ｍｒｉ装置およびｍｒイメージング方法
US6719973B1 (en) 1998-12-24 2004-04-13 National University Of Singapore Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
US7179652B2 (en) 1999-02-22 2007-02-20 Haemoscope Corporation Protocol for monitoring platelet inhibition
JP5064612B2 (ja) 1999-04-09 2012-10-31 エーエムエージー ファーマシューティカルズ，インコーポレイテッド 還元された炭水化物類及び炭水化物誘導体で被覆された熱的に安定なコロイド状酸化鉄
ATE502117T1 (de) 1999-06-25 2011-04-15 Nanosphere Inc Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen
WO2001011360A2 (de) 1999-08-06 2001-02-15 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Relaxation der doppelbrechung magnetischer nanopartikel während bindungsreaktionen
DE10046508A1 (de) 1999-09-14 2001-04-05 Tridelta Bio Medical Gmbh Magnetische Nanoteilchen mit biochemischer Wikrsamkeit und Verfahren zu ihrer Herstellung sowie ihre Verwendung
US6294342B1 (en) 1999-09-29 2001-09-25 Abbott Laboratories Magnetically assisted binding assays utilizing a magnetically responsive reagent
US6307372B1 (en) 1999-11-02 2001-10-23 Glaxo Wellcome, Inc. Methods for high throughput chemical screening using magnetic resonance imaging
US6254830B1 (en) 1999-11-05 2001-07-03 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Magnetic focusing immunosensor for the detection of pathogens
FR2800635B1 (fr) 1999-11-05 2002-07-26 Bio Merieux Nanospheres composites, conjugues derives, procede de preparation et leurs utilisations
US6940378B2 (en) 2001-01-19 2005-09-06 Halliburton Energy Services Apparatus and method for magnetic resonance measurements in an interior volume
WO2002086478A2 (en) 2001-04-23 2002-10-31 Metabometrix Limited Methods for analysis of spectral data and their applications
FR2824563B1 (fr) 2001-05-10 2004-12-03 Bio Merieux Particules composites, conjugues derives, procede de preparation et applications
US20030092029A1 (en) 2001-06-06 2003-05-15 Lee Josephson Magneitc-nanoparticle conjugates and methods of use
US6849426B2 (en) 2001-06-28 2005-02-01 Cambrex Bio Science Walkersville, Inc. Methods and reagents for detecting endotoxin
FR2832507B1 (fr) 2001-11-20 2004-02-20 Stago Diagnostica Methode de detection d'analyte(s) a l'aide de particules magnetiques colloidales
US7018849B2 (en) 2002-01-15 2006-03-28 Piasio Roger N Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughtout
CA2418229A1 (en) 2002-05-16 2003-11-16 Rohan Dharmakumar Microbubble construct for sensitivity enhanced mr manometry
US6798200B2 (en) 2002-06-03 2004-09-28 Long-Sheng Fan Batch-fabricated gradient and RF coils for submicrometer resolution magnetic resonance imaging and manipulation
US7217542B2 (en) 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
US20080305048A1 (en) 2003-12-10 2008-12-11 The General Hospital Corporation Self-Assembling Nanoparticle Conjugates
WO2005099419A2 (en) 2004-04-13 2005-10-27 President And Fellows Of Harvard College Manipulation and/or detection of biological samples or other objects
EP1751534A1 (en) 2004-05-18 2007-02-14 Koninklijke Philips Electronics N.V. Magnetic rotation to improve signal-over-background in biosensing
DE102004059055A1 (de) 2004-12-07 2006-06-08 Dade Behring Marburg Gmbh Verfahren zur automatischen Bestimmung des endogenen Thrombinpotenzials
US7781228B2 (en) 2005-04-07 2010-08-24 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
CA2606924C (en) 2005-05-09 2013-04-16 The General Hospital Corporation Water relaxation-based sensors
CN101951982A (zh) * 2005-05-27 2011-01-19 德克萨斯大学体系董事会 细胞和组合物的光学相干断层扫描术检测
EP1932009B1 (en) 2005-08-31 2014-02-12 T2 Biosystems, Inc. Nmr device for detection of analytes involving magnetic particles
FR2894970B1 (fr) 2005-12-15 2008-01-25 Biomerieux Sa Procede de preparation de particules composites, particules composites obtenues et leur utilisation dans un test diagnostic
US7274191B2 (en) 2005-12-29 2007-09-25 Intel Corporation Integrated on-chip NMR and ESR device and method for making and using the same
US20070166730A1 (en) 2006-01-19 2007-07-19 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
US20080261261A1 (en) 2006-03-31 2008-10-23 Kmg2 Sensors Corporation System/unit and method employing a plurality of magnetoelastic sensor elements for automatically quantifying parameters of whole blood and platelet-rich plasma
WO2008007270A2 (en) 2006-06-21 2008-01-17 Spinomix S.A. A method for manipulating magnetic particles in a liquid medium
US8339135B2 (en) 2006-08-21 2012-12-25 Stc.Unm Biological detector and method
TWI322793B (en) 2006-10-02 2010-04-01 Chung Cheng Inst Of Technology Nat Defense University Functionalized magnetizable microspheres and preparation thereof
US8368402B2 (en) * 2006-11-08 2013-02-05 T2 Biosystems, Inc. NMR systems for in vivo detection of analytes
RU2487338C2 (ru) 2006-12-12 2013-07-10 Конинклейке Филипс Электроникс Н.В. Микроэлектронное сенсорное устройство для обнаружения частиц-меток
WO2008127497A2 (en) 2007-02-21 2008-10-23 The Regents Of The University Of California Hemostatic compositions and methods of use
JP2008209350A (ja) 2007-02-28 2008-09-11 Matsushita Electric Ind Co Ltd 血液凝固時間測定装置
WO2008119054A1 (en) 2007-03-27 2008-10-02 Abqmr, Inc. System and method for detecting labeled entities using microcoil magnetic mri
WO2008137721A2 (en) 2007-05-03 2008-11-13 Abqmr, Inc. Microcoil nmr detectors
EP2186034A2 (en) 2007-07-26 2010-05-19 T2 Biosystems, Inc. Diagnostic information generation and use
WO2009026251A1 (en) 2007-08-17 2009-02-26 The General Hospital Corporation Detecting ions and measuring ion concentrations
EP2201398A1 (en) 2007-09-28 2010-06-30 T2 Biosystems, Inc. Nmr diagnostics by means of a plastic sample container
WO2009045551A1 (en) 2007-10-04 2009-04-09 The General Hospital Corporation Miniaturized magnetic resonance systems and methods
CA2703687C (en) 2007-10-23 2018-07-31 Abqmr, Inc. Microcoil magnetic resonance detectors
JP2011503541A (ja) 2007-11-06 2011-01-27 ティツー・バイオシステムズ・インコーポレーテッド 磁気共鳴緩和測定用の小型の磁石およびｒｆコイル
JP2011508213A (ja) 2007-12-21 2011-03-10 ティツー・バイオシステムズ・インコーポレーテッド 埋め込み可能な構成品を備えた磁気共鳴システムおよびその使用方法
US20110275985A1 (en) 2008-07-03 2011-11-10 T2 Biosystems, Inc. Magnetic nanosensor compositions and bioanalytical assays therefor
CA2638697C (en) 2008-08-15 2014-11-18 Schlumberger Canada Limited Methods for determining in situ the viscosity of heavy oil using nuclear magnetic resonance relaxation time measurements
CN101659202A (zh) 2008-08-28 2010-03-03 比亚迪股份有限公司 一种混合动力驱动系统及其驱动方法
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
EP3974831A1 (en) 2010-10-22 2022-03-30 T2 Biosystems, Inc. Methods for detecting the presence of a bacterium in a whole blood sample
AU2012281017B2 (en) 2011-07-13 2017-07-20 T2 Biosystems, Inc. NMR methods for monitoring blood clot formation
US10620205B2 (en) 2011-09-21 2020-04-14 T2 Biosystems, Inc. NMR methods for endotoxin analysis
EP2677037B1 (en) 2012-06-21 2016-04-13 Synapse B.V. Simultaneous measurement of thrombin generation and clot strength in plasma and whole blood
US20150130463A1 (en) 2012-06-25 2015-05-14 T2 Biosystems, Inc. Portable device for nmr based analysis of rheological changes in liquid samples

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110312002A1 (en) * 2008-10-29 2011-12-22 Sonia Taktak Nmr detection of coagulation time
JP2012507722A (ja) * 2008-10-29 2012-03-29 ティー２ バイオシステムズ，インコーポレーテッド 凝固時間のｎｍｒ検出

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLARK R.A. ET AL: "Acute Hematomas : Effects of Deoxygenation, Hamatocrit, and Fibrin-Clot Formation and retraction on", RADIOLOGY, vol. 175, no. 1, JPN7017002985, 1 April 1990 (1990-04-01), US, pages 201 - 206, XP009171040, ISSN: 0003797009, DOI: 10.1148/radiology.175.1.2315481 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022510708A (ja) * 2018-12-07 2022-01-27 ディアグノスチカ・スタゴ 血液試料中で血液凝固酵素阻害剤である抗凝固薬の存在を検出する、同定する及び定量するための方法並びにその実装手段
JP7459103B2 (ja) 2018-12-07 2024-04-01 ディアグノスチカ・スタゴ 血液試料中で血液凝固酵素阻害剤である抗凝固薬の存在を検出する、同定する及び定量するための方法並びにその実装手段
US12473584B2 (en) 2018-12-07 2025-11-18 Diagnostica Stago Method for detecting the presence, identification and quantification in a blood sample of anticoagulants which are blood coagulation enzymes inhibitors, and means for the implementation thereof

Also Published As

Publication number Publication date
EP2929047A1 (en) 2015-10-14
AU2013355183A1 (en) 2015-06-11
CA2893591A1 (en) 2014-06-12
WO2014089346A1 (en) 2014-06-12
EP2929047A4 (en) 2016-08-03
US9739733B2 (en) 2017-08-22
US20150308970A1 (en) 2015-10-29

Similar Documents

Publication Publication Date Title
JP6386510B2 (ja) 血餅形成をモニタリングするためのｎｍｒ法
US9739733B2 (en) Methods for monitoring tight clot formation
US20220082575A1 (en) Nmr detection of coagulation time
Van der Meel et al. Toward routine detection of extracellular vesicles in clinical samples
Taha Plasma versus serum for extracellular vesicle (EV) isolation: A duel for reproducibility and accuracy for CNS‐originating EVs biomarker analysis
Luo et al. New frontiers in in vitro medical diagnostics by low field T2 magnetic resonance relaxometry
US20180188195A1 (en) Systems and methods for multiplexed hemostasis test panels
Banno et al. Quantification of red blood cell fragmentation by the automated hematology analyzer XE‐2100 in patients with living donor liver transplantation
US20170045494A1 (en) Systems and methods for identifying coagulopathies
HK1198181B (en) Nmr methods for monitoring blood clot formation
JP6959143B2 (ja) 血液凝固障害の診断およびリスク階層化のためのマーカータンパク質の同定方法
AU2014240329B2 (en) Nmr detection of coagulation time

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161205

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20161205

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20170831

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170919

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171213

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20180522