AU2013355183A1 - Methods for monitoring tight clot formation - Google Patents

Methods for monitoring tight clot formation Download PDF

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Publication number
AU2013355183A1
AU2013355183A1 AU2013355183A AU2013355183A AU2013355183A1 AU 2013355183 A1 AU2013355183 A1 AU 2013355183A1 AU 2013355183 A AU2013355183 A AU 2013355183A AU 2013355183 A AU2013355183 A AU 2013355183A AU 2013355183 A1 AU2013355183 A1 AU 2013355183A1
Authority
AU
Australia
Prior art keywords
blood sample
sample
clotting
clot
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2013355183A
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English (en)
Inventor
Thomas Jay Lowery
Walter W. Massefski
Lynell R. Skewis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
T2 Biosystems Inc
Original Assignee
T2 Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by T2 Biosystems Inc filed Critical T2 Biosystems Inc
Publication of AU2013355183A1 publication Critical patent/AU2013355183A1/en
Abandoned legal-status Critical Current

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/4905Determining clotting time of blood
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46NMR spectroscopy
    • G01R33/465NMR spectroscopy applied to biological material, e.g. in vitro testing
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745Assays involving non-enzymic blood coagulation factors
    • G01N2333/75Fibrin; Fibrinogen
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/22Haematology
    • G01N2800/224Haemostasis or coagulation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/448Relaxometry, i.e. quantification of relaxation times or spin density
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ecology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • Primary Health Care (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2013355183A 2012-12-07 2013-12-05 Methods for monitoring tight clot formation Abandoned AU2013355183A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201261734579P 2012-12-07 2012-12-07
US61/734,579 2012-12-07
US201361837290P 2013-06-20 2013-06-20
US61/837,290 2013-06-20
US201361864322P 2013-08-09 2013-08-09
US61/864,322 2013-08-09
US201361870952P 2013-08-28 2013-08-28
US61/870,952 2013-08-28
PCT/US2013/073395 WO2014089346A1 (en) 2012-12-07 2013-12-05 Methods for monitoring tight clot formation

Publications (1)

Publication Number Publication Date
AU2013355183A1 true AU2013355183A1 (en) 2015-06-11

Family

ID=50884002

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013355183A Abandoned AU2013355183A1 (en) 2012-12-07 2013-12-05 Methods for monitoring tight clot formation

Country Status (6)

Country Link
US (1) US9739733B2 (enExample)
EP (1) EP2929047A4 (enExample)
JP (1) JP2016500443A (enExample)
AU (1) AU2013355183A1 (enExample)
CA (1) CA2893591A1 (enExample)
WO (1) WO2014089346A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
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US12607641B2 (en) * 2014-11-14 2026-04-21 Haemonetics Corporation Apparatus and method to determine stroke subtype
WO2018163188A1 (en) * 2017-03-09 2018-09-13 B.G. Negev Technologies And Applications Ltd., At Ben-Gurion University Generation of nuclear magnetic resonance multidimensional t1(spin-matrix)-t2(spin-spin) energy relaxation maps and uses thereof
JP6871839B2 (ja) * 2017-10-31 2021-05-12 信越化学工業株式会社 レジストの品質管理方法及びレジストの品質予測モデルを得る方法
CN109726430B (zh) * 2018-11-21 2023-04-25 中国石油天然气集团有限公司 一种基于t2谱拐点位置分段的核磁转伪毛管压力曲线方法
FR3089634B1 (fr) * 2018-12-07 2020-12-25 Stago Diagnostica Methode pour la detection de la presence, l’identification et la quantification dans un echantillon sanguin d'anticoagulants inhibiteurs d’enzymes de la coagulation du sang, et moyens pour son implementation
EP3919913A4 (en) * 2019-01-31 2022-11-09 Sekisui Medical Co., Ltd. METHOD OF ANALYSIS OF BLOOD COAGULATION CHARACTERISTICS OF A BLOOD SAMPLE
CN113740369B (zh) * 2020-05-29 2024-03-12 华东师范大学 基于原位低场核磁共振弛豫法检测重金属离子还原方法
CN112200022A (zh) * 2020-09-23 2021-01-08 上海联影医疗科技股份有限公司 图像处理方法、医疗成像设备和存储介质
EP4193301A4 (en) 2020-09-04 2023-12-20 Shanghai United Imaging Healthcare Co., Ltd. SYSTEMS AND METHODS FOR IMAGE PROCESSING
JP2024501510A (ja) 2021-01-08 2024-01-12 エルジー エナジー ソリューション リミテッド バッテリー管理装置及び方法
CN117192141B (zh) * 2023-11-07 2024-01-23 北京众驰伟业科技发展有限公司 全自动凝血测试仪的质量控制系统及方法
CN121721678A (zh) * 2026-02-27 2026-03-24 陕西秦洲核与辐射安全技术有限公司 一种远程式氚在线监测系统

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5913521B2 (ja) 1975-06-19 1984-03-30 メイトウサンギヨウ カブシキガイシヤ 磁性酸化鉄・デキストラン複合体の製造法
US4374360A (en) 1980-05-29 1983-02-15 Sepponen Raimo E NMR Diagnosis apparatus
US4452773A (en) 1982-04-05 1984-06-05 Canadian Patents And Development Limited Magnetic iron-dextran microspheres
US4920061A (en) 1984-03-02 1990-04-24 The University Of Texas System Biological magnetic colloids
US5262176A (en) 1986-07-03 1993-11-16 Advanced Magnetics, Inc. Synthesis of polysaccharide covered superparamagnetic oxide colloids
US4875486A (en) 1986-09-04 1989-10-24 Advanced Techtronics, Inc. Instrument and method for non-invasive in vivo testing for body fluid constituents
US5136095A (en) 1987-05-19 1992-08-04 Syntex (U.S.A.) Inc. Reversible agglutination mediators
US5042488A (en) 1987-09-29 1991-08-27 The Washington University Methods employing deuterium for obtaining direct, observable deuterium magnetic resonance images in vivo and in situ
WO1990006045A2 (en) 1988-11-21 1990-06-14 Dynal As Nucleic acid probes
US5049819A (en) 1989-06-30 1991-09-17 Auburn International, Inc. Magnetic resonance analysis in real time, industrial usage mode
JP2726520B2 (ja) 1989-10-20 1998-03-11 名糖産業株式会社 有機磁性複合体
US5254460A (en) 1990-05-03 1993-10-19 Advanced Magnetics, Inc. Solvent mediated relaxation assay system
US5164297A (en) 1990-05-03 1992-11-17 Advanced Magnetics Inc. Solvent mediated relaxation assay system
IL98744A0 (en) 1990-07-06 1992-07-15 Gen Hospital Corp Method of studying biological tissue using monocrystalline particles
CA2089148C (en) 1991-06-11 2003-08-05 Masakatsu Hasegawa Oxidized complex comprising water-soluble carboxypolysaccaride and magnetic iron oxide
US5445971A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5445970A (en) 1992-03-20 1995-08-29 Abbott Laboratories Magnetically assisted binding assays using magnetically labeled binding members
US5637469A (en) 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
JP3362192B2 (ja) 1994-12-06 2003-01-07 味の素株式会社 検査方法及び検査薬
US6884357B2 (en) 1995-02-21 2005-04-26 Iqbal Waheed Siddiqi Apparatus and method for processing magnetic particles
US6500343B2 (en) 1995-02-21 2002-12-31 Iqbal W. Siddiqi Method for mixing and separation employing magnetic particles
US6297062B1 (en) 1996-03-07 2001-10-02 Bio-Magnetics Ltd. Separation by magnetic particles
IL126544A (en) 1996-04-25 2004-08-31 Genicon Sciences Inc Analyte assay using scattered-light detectable particles
JP3996644B2 (ja) 1996-06-07 2007-10-24 イムニベスト・コーポレイション 外部及び内部勾配を有する磁気分離
WO1998004740A1 (en) 1996-07-29 1998-02-05 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
EP0928809B1 (en) 1996-08-30 2003-10-22 Meito Sangyo Kabushiki Kaisha Polysaccharide derivative/magnetic metal oxide composite
ATE253943T1 (de) 1996-09-12 2003-11-15 Amersham Health As Markerzusammensetzungen
JP3876022B2 (ja) 1996-09-26 2007-01-31 生化学工業株式会社 血液凝固時間に影響を与える物質の定量方法
FR2758884B1 (fr) 1997-01-30 1999-04-02 Bio Merieux Procede pour isoler, notamment detecter ou quantifier un analyte dans un milieu
JP3917239B2 (ja) 1997-06-05 2007-05-23 生化学工業株式会社 血液凝固時間の測定方法
DE19822123C2 (de) 1997-11-21 2003-02-06 Meinhard Knoll Verfahren und Vorrichtung zum Nachweis von Analyten
JP2000166897A (ja) 1998-12-11 2000-06-20 Toshiba Corp Mri装置およびmrイメージング方法
US6719973B1 (en) 1998-12-24 2004-04-13 National University Of Singapore Recombinant proteins and peptides for endotoxin biosensors, endotoxin removal, and anti-microbial and anti-endotoxin therapeutics
US7179652B2 (en) 1999-02-22 2007-02-20 Haemoscope Corporation Protocol for monitoring platelet inhibition
US6599498B1 (en) 1999-04-09 2003-07-29 Advanced Magnetics, Inc. Heat stable colloidal iron oxides coated with reduced carbohydrates and carbohdrate derivatives
EP1198591B1 (en) 1999-06-25 2011-03-16 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
EP1200825B1 (de) 1999-08-06 2005-08-24 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Relaxation der doppelbrechung magnetischer nanopartikel während bindungsreaktionen
DE10046508A1 (de) 1999-09-14 2001-04-05 Tridelta Bio Medical Gmbh Magnetische Nanoteilchen mit biochemischer Wikrsamkeit und Verfahren zu ihrer Herstellung sowie ihre Verwendung
US6294342B1 (en) 1999-09-29 2001-09-25 Abbott Laboratories Magnetically assisted binding assays utilizing a magnetically responsive reagent
US6307372B1 (en) 1999-11-02 2001-10-23 Glaxo Wellcome, Inc. Methods for high throughput chemical screening using magnetic resonance imaging
US6254830B1 (en) 1999-11-05 2001-07-03 The Board Of Governors For Higher Education, State Of Rhode Island And Providence Plantations Magnetic focusing immunosensor for the detection of pathogens
FR2800635B1 (fr) 1999-11-05 2002-07-26 Bio Merieux Nanospheres composites, conjugues derives, procede de preparation et leurs utilisations
US6940378B2 (en) 2001-01-19 2005-09-06 Halliburton Energy Services Apparatus and method for magnetic resonance measurements in an interior volume
US20040214348A1 (en) 2001-04-23 2004-10-28 Nicholson Jeremy Kirk Methods for analysis of spectral data and their applications: osteoarthritis
FR2824563B1 (fr) 2001-05-10 2004-12-03 Bio Merieux Particules composites, conjugues derives, procede de preparation et applications
US20030092029A1 (en) 2001-06-06 2003-05-15 Lee Josephson Magneitc-nanoparticle conjugates and methods of use
CN100390193C (zh) 2001-06-28 2008-05-28 拜奥维塔克尔公司 检测内毒素的方法和试剂
FR2832507B1 (fr) 2001-11-20 2004-02-20 Stago Diagnostica Methode de detection d'analyte(s) a l'aide de particules magnetiques colloidales
US7018849B2 (en) 2002-01-15 2006-03-28 Piasio Roger N Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughtout
CA2418229A1 (en) 2002-05-16 2003-11-16 Rohan Dharmakumar Microbubble construct for sensitivity enhanced mr manometry
US6798200B2 (en) 2002-06-03 2004-09-28 Long-Sheng Fan Batch-fabricated gradient and RF coils for submicrometer resolution magnetic resonance imaging and manipulation
US7217542B2 (en) 2002-10-31 2007-05-15 Hewlett-Packard Development Company, L.P. Microfluidic system for analyzing nucleic acids
WO2005061724A1 (en) 2003-12-10 2005-07-07 The General Hospital Corporation Self-assembling nanoparticle conjugates
EP1735668A2 (en) 2004-04-13 2006-12-27 President And Fellows Of Harvard College Methods and apparatus for manipulation and/or detection of biological samples and other objects
WO2005111596A1 (en) 2004-05-18 2005-11-24 Koninklijke Philips Electronics N.V. Magnetic rotation to improve signal-over-background in biosensing
DE102004059055A1 (de) 2004-12-07 2006-06-08 Dade Behring Marburg Gmbh Verfahren zur automatischen Bestimmung des endogenen Thrombinpotenzials
US7781228B2 (en) 2005-04-07 2010-08-24 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
EP1880228B1 (en) 2005-05-09 2011-07-06 The General Hospital Corporation Water relaxation-based sensors
CN101951982A (zh) 2005-05-27 2011-01-19 德克萨斯大学体系董事会 细胞和组合物的光学相干断层扫描术检测
JP5295769B2 (ja) 2005-08-31 2013-09-18 ティツー・バイオシステムズ・インコーポレーテッド 分析物を検出するためのnmr装置
FR2894970B1 (fr) 2005-12-15 2008-01-25 Biomerieux Sa Procede de preparation de particules composites, particules composites obtenues et leur utilisation dans un test diagnostic
US7274191B2 (en) 2005-12-29 2007-09-25 Intel Corporation Integrated on-chip NMR and ESR device and method for making and using the same
US20070166730A1 (en) 2006-01-19 2007-07-19 Menon & Associates, Inc. Magnetic resonance system and method to detect and confirm analytes
US20080261261A1 (en) 2006-03-31 2008-10-23 Kmg2 Sensors Corporation System/unit and method employing a plurality of magnetoelastic sensor elements for automatically quantifying parameters of whole blood and platelet-rich plasma
WO2008007270A2 (en) 2006-06-21 2008-01-17 Spinomix S.A. A method for manipulating magnetic particles in a liquid medium
US8339135B2 (en) 2006-08-21 2012-12-25 Stc.Unm Biological detector and method
TWI322793B (en) 2006-10-02 2010-04-01 Chung Cheng Inst Of Technology Nat Defense University Functionalized magnetizable microspheres and preparation thereof
US8368402B2 (en) * 2006-11-08 2013-02-05 T2 Biosystems, Inc. NMR systems for in vivo detection of analytes
ES2388110T3 (es) 2006-12-12 2012-10-09 Koninklijke Philips Electronics N.V. Dispositivo de sensor microelectrónico para detectar partículas de marcador
WO2008127497A2 (en) 2007-02-21 2008-10-23 The Regents Of The University Of California Hemostatic compositions and methods of use
JP2008209350A (ja) 2007-02-28 2008-09-11 Matsushita Electric Ind Co Ltd 血液凝固時間測定装置
US20100207631A1 (en) 2007-03-27 2010-08-19 Mcdowell Andrew F System and Method for Detecting Labeled Entities Using Microcoil Magnetic MRI
WO2008137721A2 (en) 2007-05-03 2008-11-13 Abqmr, Inc. Microcoil nmr detectors
US20110020785A1 (en) 2007-07-26 2011-01-27 T2 Biosystems, Inc. Diagnostic Information Generation and Use
WO2009026251A1 (en) 2007-08-17 2009-02-26 The General Hospital Corporation Detecting ions and measuring ion concentrations
US8421458B2 (en) 2007-09-28 2013-04-16 T2 Biosystems, Inc. NMR diagnostics by means of a plastic sample container
WO2009045551A1 (en) 2007-10-04 2009-04-09 The General Hospital Corporation Miniaturized magnetic resonance systems and methods
EP2208081A1 (en) 2007-10-23 2010-07-21 Abqmr, Inc. Microcoil magnetic resonance detectors
AU2008325088A1 (en) 2007-11-06 2009-05-14 T2 Biosystems, Inc. Small magnet and RF coil for magnetic resonance relaxometry
EP2905631A1 (en) 2007-12-21 2015-08-12 T2 Biosystems, Inc. Magnetic resonance system with implantable components and methods of use thereof
WO2010002479A1 (en) 2008-07-03 2010-01-07 Lowery Thomas Jay Jr Magnetic nanosensor compositions and bioanalytical assays therefor
CA2638697C (en) 2008-08-15 2014-11-18 Schlumberger Canada Limited Methods for determining in situ the viscosity of heavy oil using nuclear magnetic resonance relaxation time measurements
CN101659202A (zh) 2008-08-28 2010-03-03 比亚迪股份有限公司 一种混合动力驱动系统及其驱动方法
EP2348976B1 (en) * 2008-10-29 2020-12-02 T2 Biosystems, Inc. Nmr detection of coagulation time
CA2815085C (en) 2010-10-22 2022-06-21 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
CA2841484A1 (en) 2011-07-13 2013-01-17 T2 Biosystems, Inc. Nmr methods for monitoring blood clot formation
US10620205B2 (en) 2011-09-21 2020-04-14 T2 Biosystems, Inc. NMR methods for endotoxin analysis
EP2677037B1 (en) 2012-06-21 2016-04-13 Synapse B.V. Simultaneous measurement of thrombin generation and clot strength in plasma and whole blood
WO2014004573A1 (en) 2012-06-25 2014-01-03 T2 Biosystems, Inc. Portable device for nmr based analysis of rheological changes in liquid samples

Also Published As

Publication number Publication date
WO2014089346A1 (en) 2014-06-12
CA2893591A1 (en) 2014-06-12
US9739733B2 (en) 2017-08-22
EP2929047A4 (en) 2016-08-03
EP2929047A1 (en) 2015-10-14
US20150308970A1 (en) 2015-10-29
JP2016500443A (ja) 2016-01-12

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