JP2016185168A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016185168A5 JP2016185168A5 JP2016149598A JP2016149598A JP2016185168A5 JP 2016185168 A5 JP2016185168 A5 JP 2016185168A5 JP 2016149598 A JP2016149598 A JP 2016149598A JP 2016149598 A JP2016149598 A JP 2016149598A JP 2016185168 A5 JP2016185168 A5 JP 2016185168A5
- Authority
- JP
- Japan
- Prior art keywords
- mouse
- pups
- cell
- genetic modification
- generation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 28
- 241000699666 Mus <mouse, genus> Species 0.000 claims 12
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 12
- 238000012239 gene modification Methods 0.000 claims 9
- 230000005017 genetic modification Effects 0.000 claims 9
- 235000013617 genetically modified food Nutrition 0.000 claims 9
- 239000007640 basal medium Substances 0.000 claims 8
- 150000007523 nucleic acids Chemical group 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 6
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims 6
- 235000017557 sodium bicarbonate Nutrition 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 210000001161 mammalian embryo Anatomy 0.000 claims 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 239000002609 medium Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 101100204227 Homo sapiens STEAP2 gene Proteins 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 210000000472 morula Anatomy 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000013589 supplement Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35389610P | 2010-06-11 | 2010-06-11 | |
| US61/353,896 | 2010-06-11 | ||
| US13/157,728 US9149026B2 (en) | 2010-06-11 | 2011-06-10 | Production of fertile XY animals from XY ES cells |
| US13/157,728 | 2011-06-10 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013514391A Division JP2013528062A (ja) | 2010-06-11 | 2011-06-10 | Ｘｙｅｓ細胞からの繁殖可能なｘｙ雌動物の生成 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016185168A JP2016185168A (ja) | 2016-10-27 |
| JP2016185168A5 true JP2016185168A5 (cg-RX-API-DMAC7.html) | 2017-03-09 |
| JP6310969B2 JP6310969B2 (ja) | 2018-04-11 |
Family
ID=45097380
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013514391A Withdrawn JP2013528062A (ja) | 2010-06-11 | 2011-06-10 | Ｘｙｅｓ細胞からの繁殖可能なｘｙ雌動物の生成 |
| JP2016149598A Active JP6310969B2 (ja) | 2010-06-11 | 2016-07-29 | Ｘｙ ｅｓ細胞からの繁殖可能なｘｙ雌動物の生成 |
| JP2016149597A Active JP6310968B2 (ja) | 2010-06-11 | 2016-07-29 | Ｘｙ ｅｓ細胞からの繁殖可能なｘｙ雌動物の生成 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013514391A Withdrawn JP2013528062A (ja) | 2010-06-11 | 2011-06-10 | Ｘｙｅｓ細胞からの繁殖可能なｘｙ雌動物の生成 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016149597A Active JP6310968B2 (ja) | 2010-06-11 | 2016-07-29 | Ｘｙ ｅｓ細胞からの繁殖可能なｘｙ雌動物の生成 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US9149026B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2579711B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2013528062A (cg-RX-API-DMAC7.html) |
| CN (2) | CN102933074B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2011265306C1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2800534C (cg-RX-API-DMAC7.html) |
| CY (1) | CY1121955T1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2579711T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2727738T3 (cg-RX-API-DMAC7.html) |
| MY (2) | MY191870A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2579711T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2579711T (cg-RX-API-DMAC7.html) |
| SG (1) | SG185703A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011156723A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102933074B (zh) | 2010-06-11 | 2015-04-08 | 瑞泽恩制药公司 | 由xy es细胞制备能育的xy雌性动物 |
| PT2847335T (pt) | 2012-04-25 | 2018-09-28 | Regeneron Pharma | Alvejamento mediado por nuclease com vetores de alvejamento grandes |
| HUE040575T2 (hu) | 2013-04-16 | 2019-03-28 | Regeneron Pharma | A patkány genom célzott módosítása |
| US9546384B2 (en) | 2013-12-11 | 2017-01-17 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for the targeted modification of a mouse genome |
| LT3152312T (lt) | 2014-06-06 | 2020-04-27 | Regeneron Pharmaceuticals, Inc. | Tikslinio lokuso modifikavimo būdai ir kompozicijos |
| EP3461885B1 (en) * | 2014-06-26 | 2021-10-20 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modifications and methods of use |
| JP2017536811A (ja) | 2014-10-15 | 2017-12-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 多能性細胞の樹立又は維持のための方法及び組成物 |
| HUE044907T2 (hu) | 2014-11-21 | 2019-11-28 | Regeneron Pharma | Módszerek és készítmények célzott genetikai módosításhoz, párosított mutató RNS-ek használatával |
| NZ732895A (en) | 2014-12-19 | 2022-05-27 | Regeneron Pharma | Methods and compositions for targeted genetic modification through single-step multiple targeting |
| US10893666B2 (en) * | 2015-09-17 | 2021-01-19 | Regeneron Pharmaceuticals, Inc. | Production of fertile XY female animals by silencing of genes on the Y chromosome |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2892997A (en) | 1996-04-29 | 1997-11-19 | Leuven Research & Development Vzw | Pluripotent rabbit embryonic stem (es) cell lines and their use in the generation of chimeric rabbits |
| JP2003517317A (ja) | 1999-12-20 | 2003-05-27 | ペリー、アンソニー、シー．エフ． | 培養細胞からクローン化胚及び成体を作製する方法 |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| GB0031744D0 (en) | 2000-12-28 | 2001-02-07 | Pig Improvement Co Uk Ltd | Methods |
| JP2004248505A (ja) * | 2001-09-21 | 2004-09-09 | Norio Nakatsuji | 移植抗原の一部または全てを欠除したｅｓ細胞由来の未分化な体細胞融合細胞およびその製造 |
| WO2003071869A1 (fr) | 2002-02-27 | 2003-09-04 | Yasumitsu Nagao | Procede de construction d'animal chimere a lignee germinale |
| AU2003210405A1 (en) * | 2002-03-05 | 2003-09-16 | Artemis Pharmaceuticals Gmbh | Inbred embryonic stem-cell derived mice |
| EP1516924A1 (en) | 2003-09-17 | 2005-03-23 | Fundacion IVI para el Estudio de la reproduccion Humana (FIVIER) | Generation of human embryonic stem cells from triploid zygotes |
| CA2560581C (en) | 2004-03-23 | 2013-06-11 | Toshihiro Akaike | Pluripotent stem cell growing method |
| PL1802193T3 (pl) | 2004-10-19 | 2014-09-30 | Regeneron Pharma | Sposób wytwarzania myszy homozygotycznej pod względem modyfikacji genetycznej |
| JP4595896B2 (ja) | 2006-07-14 | 2010-12-08 | パナソニック電工株式会社 | 静電霧化装置 |
| CA2660035A1 (en) | 2006-08-09 | 2008-02-14 | Vivalis | Method of production of transgenic avian using embryonic stem cells |
| GB0623635D0 (en) * | 2006-11-27 | 2007-01-03 | Stem Cell Sciences Uk Ltd | Pluripotent cell growth media |
| WO2011044684A1 (en) | 2009-10-13 | 2011-04-21 | Stemcell Technologies Inc. | Manipulation of osmolality for differentiating stem cells |
| CN102933074B (zh) | 2010-06-11 | 2015-04-08 | 瑞泽恩制药公司 | 由xy es细胞制备能育的xy雌性动物 |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| EP3461885B1 (en) | 2014-06-26 | 2021-10-20 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modifications and methods of use |
| JP2017536811A (ja) | 2014-10-15 | 2017-12-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 多能性細胞の樹立又は維持のための方法及び組成物 |
-
2011
- 2011-06-10 CN CN201180028717.1A patent/CN102933074B/zh active Active
- 2011-06-10 ES ES11729215T patent/ES2727738T3/es active Active
- 2011-06-10 AU AU2011265306A patent/AU2011265306C1/en active Active
- 2011-06-10 US US13/157,728 patent/US9149026B2/en active Active
- 2011-06-10 MY MYPI2018702421A patent/MY191870A/en unknown
- 2011-06-10 EP EP11729215.1A patent/EP2579711B1/en active Active
- 2011-06-10 PT PT11729215T patent/PT2579711T/pt unknown
- 2011-06-10 CN CN201510101534.8A patent/CN104711218B/zh active Active
- 2011-06-10 CA CA2800534A patent/CA2800534C/en active Active
- 2011-06-10 PL PL11729215T patent/PL2579711T3/pl unknown
- 2011-06-10 MY MYPI2012005043A patent/MY172702A/en unknown
- 2011-06-10 DK DK11729215.1T patent/DK2579711T3/da active
- 2011-06-10 WO PCT/US2011/039997 patent/WO2011156723A1/en not_active Ceased
- 2011-06-10 SG SG2012085916A patent/SG185703A1/en unknown
- 2011-06-10 JP JP2013514391A patent/JP2013528062A/ja not_active Withdrawn
-
2014
- 2014-11-11 US US14/538,209 patent/US9398762B2/en active Active
-
2016
- 2016-06-22 US US15/189,767 patent/US9655351B2/en active Active
- 2016-07-29 JP JP2016149598A patent/JP6310969B2/ja active Active
- 2016-07-29 JP JP2016149597A patent/JP6310968B2/ja active Active
-
2017
- 2017-04-12 US US15/486,210 patent/US9885058B2/en active Active
-
2019
- 2019-06-21 CY CY20191100649T patent/CY1121955T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016185168A5 (cg-RX-API-DMAC7.html) | ||
| CN107475300B (zh) | Ifit3-eKO1基因敲除小鼠动物模型的构建方法和应用 | |
| CN107287245B (zh) | 一种基于CRISPR/Cas9技术的Glrx1基因敲除动物模型的构建方法 | |
| Mussgnug | Genetic tools and techniques for Chlamydomonas reinhardtii | |
| Sattar et al. | Induced genetic variations in fruit trees using new breeding tools: food security and climate resilience | |
| BR112015019950A2 (pt) | Método para gerar linhagem de células-tronco embrionárias (es) de rato, e, cultura in vitro | |
| MY191870A (en) | Production of fertile xy female animals from xy es cells | |
| JP2017538428A5 (cg-RX-API-DMAC7.html) | ||
| WO2017049240A8 (en) | Selection of pluripotent cells for production of fertile xy female mice | |
| US20160208214A1 (en) | Methods and compositions for generation of developmentally-incompetent eggs in recipients of nuclear genetic transfer | |
| CN110643636B (zh) | 一种团头鲂MSTNa&b基因敲除方法与应用 | |
| CN105505879B (zh) | 一种培养转基因动物胚胎细胞或转基因动物的方法及培养基 | |
| CN103975898A (zh) | 绿壳蛋鸡纯系的培育方法 | |
| JP2018527005A5 (cg-RX-API-DMAC7.html) | ||
| CN108300738B (zh) | 一种nod遗传背景的中性粒细胞缺失的人源化小鼠模型的制备方法 | |
| CN108368519A (zh) | 一种孤雄单倍体胚胎干细胞及其制备与应用 | |
| CN104186422A (zh) | 一种优质肉羊新品系的培育方法 | |
| CN108893495A (zh) | 一种Pdzd7基因突变动物模型的构建方法 | |
| JP2018506984A5 (cg-RX-API-DMAC7.html) | ||
| CN103103160B (zh) | 牛体外胚胎两段培养方法 | |
| WO2008084566A1 (ja) | モデルマウス、その製造方法およびその用途 | |
| CN112063654B (zh) | 一种点突变血小板无力症小鼠模型的构建方法 | |
| CN114958852A (zh) | 一种Ifnar1基因敲除小鼠动物模型的构建方法及其应用 | |
| Chai et al. | The gap in research on polyploidization between plants and vertebrates: model systems and strategic challenges | |
| CN114958908B (zh) | 基于CRISPR/Cas9构建Ets2基因超级增强子敲除动物模型的方法及其应用 |