JP2016121171A5 - - Google Patents
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- Publication number
- JP2016121171A5 JP2016121171A5 JP2016015912A JP2016015912A JP2016121171A5 JP 2016121171 A5 JP2016121171 A5 JP 2016121171A5 JP 2016015912 A JP2016015912 A JP 2016015912A JP 2016015912 A JP2016015912 A JP 2016015912A JP 2016121171 A5 JP2016121171 A5 JP 2016121171A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- infection
- pharmaceutically acceptable
- nitrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 28
- 229920006395 saturated elastomer Polymers 0.000 claims 27
- 125000000217 alkyl group Chemical group 0.000 claims 26
- 150000003839 salts Chemical class 0.000 claims 21
- 150000001875 compounds Chemical class 0.000 claims 19
- 229910052757 nitrogen Inorganic materials 0.000 claims 19
- 125000005842 heteroatom Chemical group 0.000 claims 17
- 238000006467 substitution reaction Methods 0.000 claims 16
- 208000015181 infectious disease Diseases 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 239000001301 oxygen Chemical group 0.000 claims 10
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 8
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 8
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 8
- 229910052717 sulfur Inorganic materials 0.000 claims 8
- 239000011593 sulfur Substances 0.000 claims 8
- 238000006902 nitrogenation reaction Methods 0.000 claims 6
- 238000006213 oxygenation reaction Methods 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 206010035664 Pneumonia Diseases 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 230000000813 microbial effect Effects 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 206010040872 skin infection Diseases 0.000 claims 4
- 206010062255 Soft tissue infection Diseases 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 206010057190 Respiratory tract infections Diseases 0.000 claims 2
- 125000003725 azepanyl group Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 claims 2
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000005942 tetrahydropyridyl group Chemical group 0.000 claims 2
- 206010056519 Abdominal infection Diseases 0.000 claims 1
- 206010060968 Arthritis infective Diseases 0.000 claims 1
- 208000031729 Bacteremia Diseases 0.000 claims 1
- 206010018612 Gonorrhoea Diseases 0.000 claims 1
- 208000008745 Healthcare-Associated Pneumonia Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 208000036209 Intraabdominal Infections Diseases 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 208000037942 Methicillin-resistant Staphylococcus aureus infection Diseases 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 206010058674 Pelvic Infection Diseases 0.000 claims 1
- 206010035148 Plague Diseases 0.000 claims 1
- 206010035737 Pneumonia viral Diseases 0.000 claims 1
- 208000032826 Ring chromosome 3 syndrome Diseases 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 206010058028 Shunt infection Diseases 0.000 claims 1
- 206010041925 Staphylococcal infections Diseases 0.000 claims 1
- 108010059993 Vancomycin Proteins 0.000 claims 1
- 208000009470 Ventilator-Associated Pneumonia Diseases 0.000 claims 1
- 241000607479 Yersinia pestis Species 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 208000022338 anthrax infection Diseases 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 150000001717 carbocyclic compounds Chemical class 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010014665 endocarditis Diseases 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 208000001786 gonorrhea Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 claims 1
- 229960003907 linezolid Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010034674 peritonitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 210000004872 soft tissue Anatomy 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 208000019206 urinary tract infection Diseases 0.000 claims 1
- 229960003165 vancomycin Drugs 0.000 claims 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 1
- MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- 208000009421 viral pneumonia Diseases 0.000 claims 1
- LZLIMYASODBPNN-UHFFFAOYSA-N CS(CCCNCc(cc1)ccc1C1=CNC(NC(Nc2ccccc2OC(F)(F)F)=O)=NC1=O)=O Chemical compound CS(CCCNCc(cc1)ccc1C1=CNC(NC(Nc2ccccc2OC(F)(F)F)=O)=NC1=O)=O LZLIMYASODBPNN-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25247809P | 2009-10-16 | 2009-10-16 | |
| US61/252,478 | 2009-10-16 | ||
| US31428710P | 2010-03-16 | 2010-03-16 | |
| US61/314,287 | 2010-03-16 | ||
| US35820110P | 2010-06-24 | 2010-06-24 | |
| US61/358,201 | 2010-06-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012534413A Division JP2013508299A (ja) | 2009-10-16 | 2010-10-15 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016121171A JP2016121171A (ja) | 2016-07-07 |
| JP2016121171A5 true JP2016121171A5 (enrdf_load_stackoverflow) | 2016-08-18 |
Family
ID=43876906
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016015912A Pending JP2016121171A (ja) | 2009-10-16 | 2016-01-29 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| JP2016037911A Withdrawn JP2016153405A (ja) | 2009-10-16 | 2016-02-29 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| JP2016054375A Withdrawn JP2016172733A (ja) | 2009-10-16 | 2016-03-17 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| JP2017148530A Pending JP2018024653A (ja) | 2009-10-16 | 2017-07-31 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| JP2017148521A Pending JP2018039784A (ja) | 2009-10-16 | 2017-07-31 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| JP2018182217A Pending JP2019038808A (ja) | 2009-10-16 | 2018-09-27 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016037911A Withdrawn JP2016153405A (ja) | 2009-10-16 | 2016-02-29 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| JP2016054375A Withdrawn JP2016172733A (ja) | 2009-10-16 | 2016-03-17 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| JP2017148530A Pending JP2018024653A (ja) | 2009-10-16 | 2017-07-31 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| JP2017148521A Pending JP2018039784A (ja) | 2009-10-16 | 2017-07-31 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| JP2018182217A Pending JP2019038808A (ja) | 2009-10-16 | 2018-09-27 | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
Country Status (10)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX358697B (es) | 2009-10-16 | 2018-08-31 | Melinta Therapeutics Inc | Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos. |
| JP6274723B2 (ja) | 2009-10-16 | 2018-02-07 | メリンタ セラピューティクス，インコーポレイテッド | 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 |
| KR20120101392A (ko) * | 2009-10-16 | 2012-09-13 | 립-엑스 파마슈티칼즈, 인크. | 항미생물성 화합물 및 이의 제조 방법 및 사용 방법 |
| CN109053695A (zh) * | 2011-04-15 | 2018-12-21 | 梅琳塔治疗公司 | 抗微生物化合物及制备和使用所述化合物的方法 |
| WO2015035426A1 (en) | 2013-09-09 | 2015-03-12 | Melinta Therapeutics, Inc. | Antimicrobial compunds and methods of making and using the same |
| CA2923179A1 (en) | 2013-09-09 | 2015-03-12 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| AU2016228584A1 (en) | 2015-03-11 | 2017-10-05 | Melinta Therapeutics, Inc. | Antimicrobial compounds and methods of making and using the same |
| EP3452479A1 (en) | 2016-05-06 | 2019-03-13 | Melinta Therapeutics, Inc. | Antimicrobials and methods of making and using same |
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| US3980781A (en) * | 1966-03-31 | 1976-09-14 | Imperial Chemical Industries Limited | Fungicidal composition and method containing 2-amino-pyrimidines |
| US3673184A (en) * | 1970-09-02 | 1972-06-27 | Dainippon Pharmaceutical Co | Certain 2-substituted-5,8-dihydro-5-oxopyrido{8 2,3-d{9 pyrimidine-6-carboxylic acid derivatives |
| EP0067610A1 (en) * | 1981-06-16 | 1982-12-22 | Beecham Group Plc | Penicillins, a process for their preparation and compositions containing them |
| ZA835684B (en) * | 1982-08-27 | 1985-03-27 | Roussel Uclaf | Imidazo(1,2-a)pyrimidines |
| IT1197876B (it) * | 1986-10-15 | 1988-12-21 | Pharmachim Engineering Srl | Procedimento per la preparazione dell'acido 5,8-diidro-8-etil-5-osso-2-(1-piperazinil)pirido(2,3-d)pirimidin-6-carbossilico |
| JP2549931B2 (ja) * | 1990-01-12 | 1996-10-30 | 株式会社大塚製薬工場 | ピリミドベンズイミダゾール誘導体 |
| JP2991382B2 (ja) * | 1990-07-18 | 1999-12-20 | 大日本製薬株式会社 | 縮合三環式化合物およびその塩 |
| JP2811230B2 (ja) * | 1990-10-17 | 1998-10-15 | コニカ株式会社 | 新規な写真用カプラー |
| US5208141A (en) * | 1990-10-09 | 1993-05-04 | Konica Corporation | Silver halide color photographic light-sensitive material |
| US6451968B1 (en) * | 1991-05-24 | 2002-09-17 | Isis Pharmaceuticals, Inc. | Peptide nucleic acids |
| US5434257A (en) * | 1992-06-01 | 1995-07-18 | Gilead Sciences, Inc. | Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages |
| US5646163A (en) * | 1992-10-30 | 1997-07-08 | The Procter & Gamble Company | Quinolone 5-(N-heterosubstituted amino) antimicrobials |
| IT1263804B (it) * | 1993-01-22 | 1996-09-03 | Luso Farmaco Inst | Derivati pirimidinonici fusi con eterocicli azotati ad attivita' a ii antagonista |
| CA2162846A1 (en) * | 1993-05-12 | 1994-11-24 | James Francis Bereznak | Fungicidal fused bicyclic pyrimidinones |
| US5502177A (en) * | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
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| WO1999024452A2 (en) * | 1997-11-07 | 1999-05-20 | Isis Pharmaceuticals, Inc. | Pyrimidine derivatives for labeled binding partners |
| DE19838998A1 (de) * | 1998-08-27 | 2000-03-09 | Bayer Ag | Neue Naturstoffderivate |
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| DE60113450T2 (de) * | 2000-12-14 | 2006-07-13 | The Procter & Gamble Company, Cincinnati | Antimikrobielle chinolone |
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| JP2005504020A (ja) * | 2001-07-03 | 2005-02-10 | アイシス・ファーマシューティカルス・インコーポレーテッド | ヌクレアーゼ耐性キメラオリゴヌクレオチド |
| JP4306206B2 (ja) * | 2001-09-04 | 2009-07-29 | 住友化学株式会社 | イミダゾ［１，２−ａ］ピリミジン、その用途およびその製造中間体 |
| GB0205165D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
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| WO2007101871A1 (de) * | 2006-03-08 | 2007-09-13 | Basf Se | Substituierte imidazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel |
| WO2008082440A2 (en) * | 2006-08-25 | 2008-07-10 | Emory University | Fluorescent nucleoside analogues |
| EP1964841A1 (en) * | 2007-02-28 | 2008-09-03 | sanofi-aventis | Imidazo[1,2-a]azine and their use as pharmaceuticals |
| KR20090098710A (ko) * | 2008-03-14 | 2009-09-17 | 주식회사 씨티아이바이오 | 세포투과성과 핵산 결합력이 좋은 펩타이드 핵산 유도체 |
| KR20120101392A (ko) * | 2009-10-16 | 2012-09-13 | 립-엑스 파마슈티칼즈, 인크. | 항미생물성 화합물 및 이의 제조 방법 및 사용 방법 |
-
2010
- 2010-10-15 KR KR1020127012676A patent/KR20120101392A/ko not_active Ceased
- 2010-10-15 NZ NZ713357A patent/NZ713357A/en not_active IP Right Cessation
- 2010-10-15 NZ NZ623384A patent/NZ623384A/en not_active IP Right Cessation
- 2010-10-15 TW TW099135286A patent/TW201125566A/zh unknown
- 2010-10-15 TW TW106101234A patent/TW201726630A/zh unknown
- 2010-10-15 EA EA201500913A patent/EA201500913A1/ru unknown
- 2010-10-15 SG SG10201406634VA patent/SG10201406634VA/en unknown
- 2010-10-15 MY MYPI2012001696A patent/MY161870A/en unknown
- 2010-10-15 CN CN201610065325.7A patent/CN105646370A/zh active Pending
- 2010-10-15 KR KR1020127012700A patent/KR20120099435A/ko not_active Ceased
- 2010-10-15 KR KR1020127012702A patent/KR101857694B1/ko not_active Expired - Fee Related
- 2010-10-15 TW TW104131806A patent/TWI621439B/zh not_active IP Right Cessation
- 2010-10-15 CN CN201710499962.XA patent/CN107266470A/zh active Pending
- 2010-10-15 TW TW106102658A patent/TWI629277B/zh not_active IP Right Cessation
- 2010-10-15 TW TW099135283A patent/TWI589294B/zh not_active IP Right Cessation
- 2010-10-15 CN CN201710499688.6A patent/CN107445976A/zh active Pending
- 2010-10-15 SG SG10201406631TA patent/SG10201406631TA/en unknown
- 2010-10-15 MY MYPI2012001651A patent/MY165011A/en unknown
- 2010-10-15 CN CN201510018490.2A patent/CN104628729B/zh not_active Expired - Fee Related
- 2010-10-15 PH PH1/2012/500732A patent/PH12012500732A1/en unknown
- 2010-10-15 TW TW099135287A patent/TWI612048B/zh not_active IP Right Cessation
- 2010-10-15 CN CN201810372366.XA patent/CN108456211A/zh active Pending
- 2010-10-15 TW TW106131448A patent/TW201825495A/zh unknown
- 2010-10-15 TW TW104135849A patent/TWI618707B/zh not_active IP Right Cessation
- 2010-10-15 SG SG10201406635QA patent/SG10201406635QA/en unknown
- 2010-10-18 AR ARP100103804A patent/AR080558A1/es unknown
- 2010-10-18 AR ARP100103803A patent/AR080617A1/es unknown
- 2010-10-18 AR ARP100103805A patent/AR080559A1/es unknown
-
2016
- 2016-01-29 JP JP2016015912A patent/JP2016121171A/ja active Pending
- 2016-02-29 JP JP2016037911A patent/JP2016153405A/ja not_active Withdrawn
- 2016-03-17 JP JP2016054375A patent/JP2016172733A/ja not_active Withdrawn
-
2017
- 2017-07-31 JP JP2017148530A patent/JP2018024653A/ja active Pending
- 2017-07-31 JP JP2017148521A patent/JP2018039784A/ja active Pending
-
2018
- 2018-09-27 JP JP2018182217A patent/JP2019038808A/ja active Pending
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