JP2016121171A - 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 - Google Patents

抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 Download PDF

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JP2016121171A
JP2016121171A JP2016015912A JP2016015912A JP2016121171A JP 2016121171 A JP2016121171 A JP 2016121171A JP 2016015912 A JP2016015912 A JP 2016015912A JP 2016015912 A JP2016015912 A JP 2016015912A JP 2016121171 A JP2016121171 A JP 2016121171A
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unsaturated
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membered saturated
pharmaceutically acceptable
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JP2016121171A5 (enrdf_load_stackoverflow
Inventor
エム・ダフィー エリン
M Duffy Erin
エム・ダフィー エリン
アショーク・バッタチャージー
Bhattacharjee Ashoke
ハードウィン・オダウド
O'dowd Hardwin
マルコ・デビーボ
Devivo Marco
ヤンミン・ドゥ
Yanming Du
サンドラ・シニシュタジ
Sinishtaj Sandra
ユアンチン・タン
Yuanqing Tang
ティー・ウィンバリー ブライアン
T Wimberly Brian
ティー・ウィンバリー ブライアン
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Melinta Subsidiary Corp
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Melinta Therapeutics Inc
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Publication of JP2016121171A publication Critical patent/JP2016121171A/ja
Publication of JP2016121171A5 publication Critical patent/JP2016121171A5/ja
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • A61K9/0048—Eye, e.g. artificial tears
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    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
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    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
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    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
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  • Biophysics (AREA)
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  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
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  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Materials For Medical Uses (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2016015912A 2009-10-16 2016-01-29 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法 Pending JP2016121171A (ja)

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Application Number Priority Date Filing Date Title
US25247809P 2009-10-16 2009-10-16
US61/252,478 2009-10-16
US31428710P 2010-03-16 2010-03-16
US61/314,287 2010-03-16
US35820110P 2010-06-24 2010-06-24
US61/358,201 2010-06-24

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JP2012534413A Division JP2013508299A (ja) 2009-10-16 2010-10-15 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法

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JP2016121171A true JP2016121171A (ja) 2016-07-07
JP2016121171A5 JP2016121171A5 (enrdf_load_stackoverflow) 2016-08-18

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JP2016015912A Pending JP2016121171A (ja) 2009-10-16 2016-01-29 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
JP2016037911A Withdrawn JP2016153405A (ja) 2009-10-16 2016-02-29 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
JP2016054375A Withdrawn JP2016172733A (ja) 2009-10-16 2016-03-17 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
JP2017148530A Pending JP2018024653A (ja) 2009-10-16 2017-07-31 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
JP2017148521A Pending JP2018039784A (ja) 2009-10-16 2017-07-31 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
JP2018182217A Pending JP2019038808A (ja) 2009-10-16 2018-09-27 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法

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JP2016037911A Withdrawn JP2016153405A (ja) 2009-10-16 2016-02-29 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
JP2016054375A Withdrawn JP2016172733A (ja) 2009-10-16 2016-03-17 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
JP2017148530A Pending JP2018024653A (ja) 2009-10-16 2017-07-31 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
JP2017148521A Pending JP2018039784A (ja) 2009-10-16 2017-07-31 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法
JP2018182217A Pending JP2019038808A (ja) 2009-10-16 2018-09-27 抗微生物性化合物および抗微生物性化合物の製造方法および使用方法

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JP (6) JP2016121171A (enrdf_load_stackoverflow)
KR (3) KR20120101392A (enrdf_load_stackoverflow)
CN (5) CN105646370A (enrdf_load_stackoverflow)
AR (3) AR080558A1 (enrdf_load_stackoverflow)
EA (1) EA201500913A1 (enrdf_load_stackoverflow)
MY (2) MY161870A (enrdf_load_stackoverflow)
NZ (2) NZ713357A (enrdf_load_stackoverflow)
PH (1) PH12012500732A1 (enrdf_load_stackoverflow)
SG (3) SG10201406634VA (enrdf_load_stackoverflow)
TW (8) TW201125566A (enrdf_load_stackoverflow)

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MX358697B (es) 2009-10-16 2018-08-31 Melinta Therapeutics Inc Compuestos antimicrobianos y metodos para fabricar y utilizar los mismos.
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