JP2016104045A5 - - Google Patents
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- JP2016104045A5 JP2016104045A5 JP2016043151A JP2016043151A JP2016104045A5 JP 2016104045 A5 JP2016104045 A5 JP 2016104045A5 JP 2016043151 A JP2016043151 A JP 2016043151A JP 2016043151 A JP2016043151 A JP 2016043151A JP 2016104045 A5 JP2016104045 A5 JP 2016104045A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- glycoprotein
- seq
- protein comprises
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18340009P | 2009-06-02 | 2009-06-02 | |
| US61/183,400 | 2009-06-02 | ||
| US34885810P | 2010-05-27 | 2010-05-27 | |
| US61/348,858 | 2010-05-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014251541A Division JP2015051021A (ja) | 2009-06-02 | 2014-12-12 | フコシル化欠損細胞 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016202634A Division JP2017006147A (ja) | 2009-06-02 | 2016-10-14 | フコシル化欠損細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016104045A JP2016104045A (ja) | 2016-06-09 |
| JP2016104045A5 true JP2016104045A5 (OSRAM) | 2016-12-01 |
| JP6211642B2 JP6211642B2 (ja) | 2017-10-11 |
Family
ID=42338231
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514045A Expired - Fee Related JP5744856B2 (ja) | 2009-06-02 | 2010-06-01 | フコシル化欠損細胞 |
| JP2014251541A Withdrawn JP2015051021A (ja) | 2009-06-02 | 2014-12-12 | フコシル化欠損細胞 |
| JP2016043151A Expired - Fee Related JP6211642B2 (ja) | 2009-06-02 | 2016-03-07 | フコシル化欠損細胞 |
| JP2016202634A Pending JP2017006147A (ja) | 2009-06-02 | 2016-10-14 | フコシル化欠損細胞 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514045A Expired - Fee Related JP5744856B2 (ja) | 2009-06-02 | 2010-06-01 | フコシル化欠損細胞 |
| JP2014251541A Withdrawn JP2015051021A (ja) | 2009-06-02 | 2014-12-12 | フコシル化欠損細胞 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016202634A Pending JP2017006147A (ja) | 2009-06-02 | 2016-10-14 | フコシル化欠損細胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (8) | US8409838B2 (OSRAM) |
| EP (3) | EP3279326B1 (OSRAM) |
| JP (4) | JP5744856B2 (OSRAM) |
| KR (2) | KR101641526B1 (OSRAM) |
| CN (1) | CN102459603B (OSRAM) |
| AU (1) | AU2010256753B2 (OSRAM) |
| BR (1) | BRPI1010035A2 (OSRAM) |
| CA (1) | CA2764370C (OSRAM) |
| DK (3) | DK2808393T3 (OSRAM) |
| ES (2) | ES2661074T3 (OSRAM) |
| HU (1) | HUE038596T2 (OSRAM) |
| IL (1) | IL216624A (OSRAM) |
| PL (3) | PL2808393T3 (OSRAM) |
| SG (1) | SG176251A1 (OSRAM) |
| TW (1) | TWI513818B (OSRAM) |
| WO (1) | WO2010141478A1 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140161782A1 (en) | 2008-06-09 | 2014-06-12 | Targazyme, Inc. | Augmentation of cell therapy efficacy including treatment with alpha 1-3 fucoslytransferase |
| ES2661074T3 (es) | 2009-06-02 | 2018-03-27 | Regeneron Pharmaceuticals, Inc. | Células deficientes de fucosilación |
| BR112013022832A2 (pt) | 2011-03-06 | 2016-11-22 | Merck Serono Sa | linhagens de células de baixo teor de fucose e usos das mesmas |
| WO2013013013A2 (en) * | 2011-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for producing modified glycoproteins |
| TWI641687B (zh) | 2012-05-29 | 2018-11-21 | 美商再生元醫藥公司 | 生產細胞株增強子 |
| EP2722673B1 (en) | 2012-10-17 | 2017-07-12 | Hexal AG | Improved method of mapping glycans of glycoproteins |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| WO2015033343A1 (en) | 2013-09-03 | 2015-03-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Compositions and methods for expressing recombinant polypeptides |
| US20150093782A1 (en) * | 2013-10-01 | 2015-04-02 | The University Of Wyoming | Compositions and methods for reducing fucosylation of glycoproteins in insect cells and methods of use thereof for production of recombinant glycoproteins |
| CN106459199B (zh) | 2014-03-11 | 2021-01-01 | 瑞泽恩制药公司 | 抗-egfrviii抗体及其用途 |
| KR20250012733A (ko) * | 2014-05-30 | 2025-01-24 | 뉴 잉글랜드 바이오랩스, 인크 | 탈당화 시약 및 방법 |
| CA2954534C (en) * | 2014-07-07 | 2023-04-04 | Targazyme, Inc. | Manufacture and cryopreservation of fucosylated cells for therapeutic use |
| CN105671109B (zh) * | 2014-11-20 | 2019-08-23 | 中国人民解放军军事医学科学院生物工程研究所 | 用糖基工程酵母制备具有动物细胞糖基化修饰流感血凝素糖蛋白的方法 |
| TWI710573B (zh) | 2015-01-26 | 2020-11-21 | 美商再生元醫藥公司 | 抗伊波拉病毒醣蛋白之人類抗體 |
| TWI870789B (zh) | 2015-08-04 | 2025-01-21 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| JP6983772B2 (ja) * | 2015-11-02 | 2021-12-17 | ジェネンテック， インコーポレイテッド | タンパク質のフコシル化及び脱フコシル化形態の作製方法 |
| JP6674028B2 (ja) | 2016-01-06 | 2020-04-01 | アウトルック セラピューティクス，インコーポレイティド | モノクローナル抗体組成物中のアフコシル化種の調節 |
| CA3013336A1 (en) | 2016-02-03 | 2017-08-10 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| CA3015371A1 (en) | 2016-04-20 | 2017-10-26 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for making antibodies based on use of an expression-enhancing locus |
| BR112018071283A2 (pt) * | 2016-04-20 | 2019-02-12 | Regeneron Pharma | célula, conjunto de vetores para expressar uma proteína de ligação a antígeno biespecífica em uma célula, conjunto de vetores, método, e, método para produção de uma proteína de ligação a antígeno. |
| EP3339444A1 (en) * | 2016-12-20 | 2018-06-27 | Mabxience Research, S.L. | Method for obtaining a glycoprotein with an increased percentage of afucosylated glycans |
| SG11202009216YA (en) | 2018-03-26 | 2020-10-29 | Amgen Inc | Total afucosylated glycoforms of antibodies produced in cell culture |
| US20210317499A1 (en) * | 2018-08-29 | 2021-10-14 | United Biopharma Inc. | Afucosylated antibodies and manufacture thereof |
| TWI861023B (zh) | 2018-10-29 | 2024-11-11 | 日商免疫生物研究所股份有限公司 | 抗hiv抗體及其製造方法 |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| EP4157868A1 (en) | 2020-05-26 | 2023-04-05 | Regeneron Pharmaceuticals, Inc. | Anti-sars-cov-2-spike glycoprotein antibodies and antigen-binding fragments |
| US11999777B2 (en) | 2020-06-03 | 2024-06-04 | Regeneron Pharmaceuticals, Inc. | Methods for treating or preventing SARS-CoV-2 infections and COVID-19 with anti-SARS-CoV-2 spike glycoprotein antibodies |
| CN112843234B (zh) * | 2021-01-20 | 2022-09-06 | 四川大学华西第二医院 | 一种调控生物机体内gdp-甘露糖的浓度的装置 |
| WO2022261021A1 (en) | 2021-06-07 | 2022-12-15 | Amgen Inc. | Using fucosidase to control afucosylation level of glycosylated proteins |
| EP4359440A1 (en) | 2021-06-22 | 2024-05-01 | Regeneron Pharmaceuticals, Inc. | Anti-egfrviii antibody drug conjugates and uses thereof |
| MX2024000563A (es) | 2021-07-14 | 2024-04-10 | Regeneron Pharma | Anticuerpos y fragmentos de union al antigeno anti-glicoproteína de la espícula de sars-cov-2. |
| WO2023081434A2 (en) | 2021-11-07 | 2023-05-11 | Regeneron Pharmaceuticals, Inc. | Methods for treating or preventing sars-cov-2 infections and covid-19 with anti-sars-cov-2 spike glycoprotein antibodies |
| CN119095875A (zh) | 2022-03-02 | 2024-12-06 | 瑞泽恩制药公司 | 高滴度抗体的制造工艺 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1006070A (en) | 1909-05-11 | 1911-10-17 | George Walter Durbrow | Method of and means for extracting micro-organisms and solids from water. |
| ES2568899T3 (es) | 1999-04-09 | 2016-05-05 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de una molécula inmunofuncional |
| JP2001145488A (ja) | 1999-11-19 | 2001-05-29 | Natl Inst Of Advanced Industrial Science & Technology Meti | シロイヌナズナ由来のｇｄｐ−４−ケト−６−デオキシ−ｄ−マンノース−３，５−エピメラーゼ−４−レダクターゼ遺伝子 |
| FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| EP1331266B1 (en) | 2000-10-06 | 2017-01-04 | Kyowa Hakko Kirin Co., Ltd. | Cells producing antibody compositions |
| US20020150968A1 (en) | 2001-01-10 | 2002-10-17 | Wang Peng G. | Glycoconjugate and sugar nucleotide synthesis using solid supports |
| AU2002245272B2 (en) | 2001-01-16 | 2006-06-29 | Regeneron Pharmaceuticals, Inc. | Isolating cells expressing secreted proteins |
| ES2326964T3 (es) | 2001-10-25 | 2009-10-22 | Genentech, Inc. | Composiciones de glicoproteina. |
| KR100585140B1 (ko) | 2004-04-26 | 2006-05-30 | 삼성전자주식회사 | 와이어 본딩 장치 및 이를 이용한 반도체 패키지의 와이어본딩 방법 |
| US20060223147A1 (en) | 2004-08-05 | 2006-10-05 | Kyowa Hakko Kogyo Co., Ltd., | Process for producing glycoprotein composition |
| US20090208500A1 (en) | 2005-06-03 | 2009-08-20 | Genentech, Inc. | Method of producing antibodies with improved function |
| ES2402591T3 (es) | 2006-08-14 | 2013-05-07 | Xencor Inc. | Anticuerpos optimizados que seleccionan como diana CD19 |
| RU2479629C2 (ru) | 2007-03-07 | 2013-04-20 | Гликофи, Инк. | Продукция гликопротеинов с модифицированным фукозилированием |
| WO2008151219A1 (en) | 2007-06-04 | 2008-12-11 | Regeneron Pharmaceuticals, Inc. | Enhanced expression and stability regions |
| WO2010018847A1 (ja) | 2008-08-13 | 2010-02-18 | 協和発酵キリン株式会社 | 遺伝子組換えプロテインs組成物 |
| ES2661074T3 (es) * | 2009-06-02 | 2018-03-27 | Regeneron Pharmaceuticals, Inc. | Células deficientes de fucosilación |
| BR112013022832A2 (pt) | 2011-03-06 | 2016-11-22 | Merck Serono Sa | linhagens de células de baixo teor de fucose e usos das mesmas |
-
2010
- 2010-06-01 ES ES14179885.0T patent/ES2661074T3/es active Active
- 2010-06-01 US US12/791,637 patent/US8409838B2/en active Active
- 2010-06-01 KR KR1020147007025A patent/KR101641526B1/ko not_active Expired - Fee Related
- 2010-06-01 DK DK14179885.0T patent/DK2808393T3/en active
- 2010-06-01 EP EP17192430.1A patent/EP3279326B1/en active Active
- 2010-06-01 EP EP14179885.0A patent/EP2808393B1/en active Active
- 2010-06-01 HU HUE14179885A patent/HUE038596T2/hu unknown
- 2010-06-01 SG SG2011087517A patent/SG176251A1/en unknown
- 2010-06-01 CA CA2764370A patent/CA2764370C/en active Active
- 2010-06-01 AU AU2010256753A patent/AU2010256753B2/en not_active Ceased
- 2010-06-01 BR BRPI1010035-0A patent/BRPI1010035A2/pt not_active Application Discontinuation
- 2010-06-01 PL PL14179885T patent/PL2808393T3/pl unknown
- 2010-06-01 PL PL17192430T patent/PL3279326T3/pl unknown
- 2010-06-01 JP JP2012514045A patent/JP5744856B2/ja not_active Expired - Fee Related
- 2010-06-01 WO PCT/US2010/036914 patent/WO2010141478A1/en not_active Ceased
- 2010-06-01 PL PL10721096T patent/PL2438171T3/pl unknown
- 2010-06-01 DK DK10721096.5T patent/DK2438171T3/en active
- 2010-06-01 KR KR1020117031320A patent/KR101441437B1/ko not_active Expired - Fee Related
- 2010-06-01 DK DK17192430.1T patent/DK3279326T3/da active
- 2010-06-01 TW TW099117652A patent/TWI513818B/zh not_active IP Right Cessation
- 2010-06-01 CN CN2010800294912A patent/CN102459603B/zh not_active Expired - Fee Related
- 2010-06-01 ES ES10721096.5T patent/ES2527173T3/es active Active
- 2010-06-01 EP EP10721096.5A patent/EP2438171B1/en active Active
-
2011
- 2011-11-27 IL IL216624A patent/IL216624A/en active IP Right Grant
-
2013
- 2013-02-28 US US13/779,952 patent/US9206455B2/en active Active
-
2014
- 2014-12-12 JP JP2014251541A patent/JP2015051021A/ja not_active Withdrawn
-
2015
- 2015-12-08 US US14/963,178 patent/US9550823B2/en active Active
-
2016
- 2016-03-07 JP JP2016043151A patent/JP6211642B2/ja not_active Expired - Fee Related
- 2016-10-14 JP JP2016202634A patent/JP2017006147A/ja active Pending
- 2016-12-14 US US15/378,670 patent/US10006070B2/en active Active
-
2018
- 2018-05-23 US US15/987,286 patent/US20190024129A1/en not_active Abandoned
-
2019
- 2019-08-30 US US16/556,334 patent/US20200080124A1/en not_active Abandoned
-
2021
- 2021-05-04 US US17/307,255 patent/US11560550B2/en active Active
-
2022
- 2022-12-15 US US18/066,303 patent/US12054751B2/en active Active
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