JP2016028068A5 - - Google Patents
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- Publication number
- JP2016028068A5 JP2016028068A5 JP2015176164A JP2015176164A JP2016028068A5 JP 2016028068 A5 JP2016028068 A5 JP 2016028068A5 JP 2015176164 A JP2015176164 A JP 2015176164A JP 2015176164 A JP2015176164 A JP 2015176164A JP 2016028068 A5 JP2016028068 A5 JP 2016028068A5
- Authority
- JP
- Japan
- Prior art keywords
- dry powder
- microparticles
- trans isomer
- diabetes
- insulin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18677909P | 2009-06-12 | 2009-06-12 | |
| US61/186,779 | 2009-06-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515175A Division JP5859432B2 (ja) | 2009-06-12 | 2010-06-11 | 規定された含量の異性体を有するジケトピペラジン微粒子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016028068A JP2016028068A (ja) | 2016-02-25 |
| JP2016028068A5 true JP2016028068A5 (cg-RX-API-DMAC10.html) | 2016-06-02 |
| JP6101326B2 JP6101326B2 (ja) | 2017-03-22 |
Family
ID=43306942
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515175A Active JP5859432B2 (ja) | 2009-06-12 | 2010-06-11 | 規定された含量の異性体を有するジケトピペラジン微粒子 |
| JP2015176164A Active JP6101326B2 (ja) | 2009-06-12 | 2015-09-07 | 規定された含量の異性体を有するジケトピペラジン微粒子 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012515175A Active JP5859432B2 (ja) | 2009-06-12 | 2010-06-11 | 規定された含量の異性体を有するジケトピペラジン微粒子 |
Country Status (17)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| JP4681231B2 (ja) | 2002-03-20 | 2011-05-11 | マンカインド コーポレイション | 吸入装置 |
| US20070027063A1 (en) * | 2004-01-12 | 2007-02-01 | Mannkind Corporation | Method of preserving the function of insulin-producing cells |
| ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| HUE025151T2 (en) | 2004-08-23 | 2016-01-28 | Mannkind Corp | Diceto-piperazine salts for drug delivery |
| MX373000B (es) | 2005-09-14 | 2020-05-21 | Mannkind Corp | Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas. |
| CN104383546B (zh) | 2006-02-22 | 2021-03-02 | 曼金德公司 | 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法 |
| ES2302448B1 (es) * | 2006-10-20 | 2009-05-08 | Vodafone España, S.A. | Sistema y metodo de difusion de informacion de area en entornos locales de tamaño reducido dentro de un sistema celular de comunicaciones moviles. |
| MY155524A (en) | 2008-06-13 | 2015-10-30 | Mannkind Corp | A dry powder inhaler and system for drug delivery |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| EP2609954B1 (en) | 2008-06-20 | 2021-12-29 | MannKind Corporation | An interactive apparatus for real-time profiling of inhalation efforts |
| TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| US8538707B2 (en) | 2009-03-11 | 2013-09-17 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
| AU2010259943C1 (en) | 2009-06-12 | 2016-03-03 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
| JP5784622B2 (ja) | 2009-11-03 | 2015-09-24 | マンカインド コーポレ−ション | 吸入活動をシミュレートするための装置及び方法 |
| RU2531455C2 (ru) | 2010-06-21 | 2014-10-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
| JP5964304B2 (ja) | 2010-08-25 | 2016-08-03 | エータイアー ファーマ， インコーポレイテッド | チロシルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| MX353285B (es) | 2011-04-01 | 2018-01-05 | Mannkind Corp | Paquete de blister para cartuchos farmaceuticos. |
| EP2714094B1 (en) | 2011-06-02 | 2016-02-24 | The University of Louisville Research Foundation, Inc. | Anti-nucleolin agent-conjugated nanoparticles |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| HK1201475A1 (en) | 2011-10-24 | 2015-09-04 | Mannkind Corporation | Methods and compositions for treating pain |
| AU2013289957B2 (en) | 2012-07-12 | 2017-02-23 | Mannkind Corporation | Dry powder drug delivery systems and methods |
| WO2014066856A1 (en) | 2012-10-26 | 2014-05-01 | Mannkind Corporation | Inhalable influenza vaccine compositions and methods |
| BR112015023168B1 (pt) * | 2013-03-15 | 2021-08-10 | Mannkind Corporation | Composição de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina cristalina, método de produção de partículas de 3,6-bis(n-fumaril-4-aminobutil)-2,5-dicetopiperazina e uso de uma composição de dicetopiperazina cristalina |
| BR122019026637B1 (pt) | 2013-07-18 | 2023-09-26 | Mannkind Corporation | Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco |
| CA2920488C (en) | 2013-08-05 | 2022-04-26 | Mannkind Corporation | Insufflation apparatus and methods |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| US9968125B2 (en) | 2015-01-09 | 2018-05-15 | Philip Morris Products S.A. | Nicotine—diketopiperazine microparticle formulations and methods of making the same |
| PT108368B (pt) * | 2015-03-31 | 2018-11-05 | Hovione Farm S A | Produção contínua de partículas |
| IL260823B2 (en) * | 2016-01-29 | 2024-08-01 | Mannkind Corp | Dry powder inhaler |
| WO2021202425A1 (en) | 2020-03-28 | 2021-10-07 | University Of Louisville Research Foundation, Inc. | Methods of inhibiting or treating coronavirus infection, and methods for delivering an anti-nucleolin agent |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT83613B (en) | 1985-10-28 | 1988-11-21 | Lilly Co Eli | Process for the selective chemical removal of a protein amino-terminal residue |
| US5693338A (en) | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
| US6331318B1 (en) | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
| US5352461A (en) | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
| US5888477A (en) | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
| US5506203C1 (en) | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
| US5547929A (en) | 1994-09-12 | 1996-08-20 | Eli Lilly And Company | Insulin analog formulations |
| US6428771B1 (en) | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| PL343342A1 (en) | 1998-04-09 | 2001-08-13 | Axiva Gmbh | Particulate active agent support for pulmonary application |
| ES2395096T3 (es) | 1999-06-29 | 2013-02-08 | Mannkind Corporation | Purificación y estabilización de agentes farmacéuticos a base de péptidos y proteínas |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| US7464706B2 (en) | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
| JP4681231B2 (ja) | 2002-03-20 | 2011-05-11 | マンカインド コーポレイション | 吸入装置 |
| WO2005092301A1 (en) | 2004-03-26 | 2005-10-06 | Universita' Degli Studi Di Parma | Insulin highly respirable microparticles |
| ATE486064T1 (de) | 2004-08-20 | 2010-11-15 | Mannkind Corp | Katalyse der diketopiperazinsynthese |
| HUE025151T2 (en) | 2004-08-23 | 2016-01-28 | Mannkind Corp | Diceto-piperazine salts for drug delivery |
| WO2006086107A2 (en) * | 2005-01-10 | 2006-08-17 | Mannkind Corporation | Methods and compositions for minimizing accrual of inhalable insulin in the lungs |
| MX373000B (es) * | 2005-09-14 | 2020-05-21 | Mannkind Corp | Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas. |
| CN104383546B (zh) * | 2006-02-22 | 2021-03-02 | 曼金德公司 | 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法 |
| RU2409349C2 (ru) | 2006-04-14 | 2011-01-20 | Маннкайнд Корпорейшн | Фармацевтические композиции, содержащие глюкагонподобный пептид(glp-1) |
| KR20100090692A (ko) * | 2007-10-24 | 2010-08-16 | 맨카인드 코포레이션 | 활성제의 전달 |
| KR101736502B1 (ko) * | 2007-10-24 | 2017-05-16 | 맨카인드 코포레이션 | Ｇｌｐ-1에 의한 유해 효과의 예방 방법 |
| MY155524A (en) * | 2008-06-13 | 2015-10-30 | Mannkind Corp | A dry powder inhaler and system for drug delivery |
-
2010
- 2010-06-11 SG SG10201403147SA patent/SG10201403147SA/en unknown
- 2010-06-11 TW TW099119045A patent/TWI513692B/zh active
- 2010-06-11 US US12/813,839 patent/US8227409B2/en active Active
- 2010-06-11 SG SG10201706995VA patent/SG10201706995VA/en unknown
- 2010-06-11 AU AU2010259939A patent/AU2010259939B2/en active Active
- 2010-06-11 EP EP10724973.2A patent/EP2440186B1/en active Active
- 2010-06-11 KR KR1020127000804A patent/KR101782174B1/ko active Active
- 2010-06-11 CA CA2765156A patent/CA2765156C/en active Active
- 2010-06-11 RU RU2012100785/15A patent/RU2490026C1/ru active
- 2010-06-11 SG SG2013076096A patent/SG195546A1/en unknown
- 2010-06-11 EP EP19175215.3A patent/EP3556356B1/en active Active
- 2010-06-11 BR BRPI1010722 patent/BRPI1010722B1/pt active IP Right Grant
- 2010-06-11 MY MYPI2011006016A patent/MY172858A/en unknown
- 2010-06-11 JP JP2012515175A patent/JP5859432B2/ja active Active
- 2010-06-11 SG SG2011091410A patent/SG176778A1/en unknown
- 2010-06-11 CN CN201080026117.7A patent/CN102458371B/zh active Active
- 2010-06-11 WO PCT/US2010/038287 patent/WO2010144785A2/en not_active Ceased
- 2010-06-11 ES ES19175215T patent/ES2880102T3/es active Active
- 2010-06-11 MX MX2011013313A patent/MX2011013313A/es active IP Right Grant
- 2010-06-11 ES ES10724973T patent/ES2751107T3/es active Active
- 2010-06-14 AR ARP100102093A patent/AR077087A1/es not_active Application Discontinuation
-
2011
- 2011-12-12 IL IL216910A patent/IL216910A/en active IP Right Grant
-
2015
- 2015-09-07 JP JP2015176164A patent/JP6101326B2/ja active Active
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