JP2016006105A - アコニターゼ阻害による微生物増殖の阻害 - Google Patents
アコニターゼ阻害による微生物増殖の阻害 Download PDFInfo
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- aconitase
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/47—Quinolines; Isoquinolines
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
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- A61K8/22—Peroxides; Oxygen; Ozone
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4933—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having sulfur as an exocyclic substituent, e.g. pyridinethione
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
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- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
Description
一実施形態において、本発明は、ピリチオン又はピリチオンの多価金属塩を含んでもよい。血小板状及び針構造などの、いかなる形態の多価金属のピリチオン塩も用いてよい。更なる実施形態において、本明細書に用いる塩は、多価金属マグネシウム、バリウム、ビスマス、ストロンチウム、銅、亜鉛、カドミウム、ジルコニウム及びこれらの混合物から形成されるものを含み、更なる実施形態においては、亜鉛から形成されるものを含む。また更なる実施形態において、本明細書に用いるのは、1−ヒドロキシ−2−ピリジンチオンの亜鉛塩(「ジンクピリチオン」又は「ZPT」として既知)であり、別の実施形態においては、血小板状粒子形態のZPTであり、その中で、粒子は最大約20μmの平均粒径を有し、一実施形態では、最大約5μmの平均粒径を有し、また更なる実施形態では、最大約2.5μmの平均粒径を有する。
サッカロマイセス・セレヴィシエ菌株BY4741の培養菌を、30°で一晩、YPD(グルコース20グラム、ペプトン20グラム、酵母抽出物1リットルあたり10グラム)ブロス中で増殖させる。培養菌を、光学濃度0.1(600nm)で全容積100mLまでYPDで希釈する。培養菌を、光学濃度0.2に達するまで振盪させながらインキュベートし、それに試験物質を添加する。培養菌を一晩インキュベートし、細胞を遠心分離によって沈殿させる。細胞ペレットを、100mMのNaCl、20mMのトリスpH 7.4で洗浄し、100mMのNaCl 5mL、20mMのトリスpH 7.4中で再懸濁する。ガラスビーズ(0.5mm)を添加する。試料に、1分間のボルテックスと1分間氷上のインキュベートとを交互にかけ、合計10回処理する。遠心分離の後、上澄みを収集する。96ウェルプレート(紫外線透過性Corning 3679プレート)中で、30μLの細胞可溶化物を100mMのNaCl 20μL、20mMのトリスpH 7.4と混合し、説明書に従ってBioxytech Aconitase−340キット(OxisResearch)を使用してアッセイする。
ニトロイソクエン酸(nitroisocitrate)
4−ヒドロキシ−トランス−アコニターゼ
オキサロマラート(oxalomalate)(OMA、アルファ−ヒドロキシ−ベータ−オキサロコハク酸)
過酸化亜硝酸
一酸化窒素
過酸化水素
超酸化物
1,2,3−D,L−トリカルボキシシクロペンテン−1
トリメシン酸(1,3,5−トリカルボキシベンゼン)
トリメリット酸(1,2,4−トリカルボキシベンゼン)
ピロメリット酸(1,2,4,5−テトラカルボキシベンゼン)
1,2,3,4−テトラカルボキシシクロペンタン
オキサロスクシナート(oxalosuccinate)
トランス−アコニターゼ
シス−アコニターゼ
アルファ−ケトグルタル酸
2−オキソグルタレート
オキサロアセテート
アロキサン
1−メチル−4−フェニルピリジン
マンガン
ロンプロテアーゼ
デフェリプロン
ピリチオン又はピリチオンの金属塩
ジンクピリチオン
Claims (9)
- 個人における真菌細胞のアコニターゼ活性を阻害する方法であって、前記真菌細胞によるアコニターゼの活性を阻害するのに有効な量で、アコニターゼ活性の阻害物質を前記真菌細胞に投与する工程を含む、方法。
- 前記個人がふけ症患者である、請求項1に記載の真菌細胞のアコニターゼ活性を阻害する方法。
- 前記アコニターゼ活性の阻害物質が、フルオロクエン酸塩、4−ヒドロキシ−トランス−アコニターゼ、オキサロマラート、アルファ−ヒドロキシ−ベータ−オキサロコハク酸、活性酸素種又は酸化種、過酸化亜硝酸、一酸化窒素、過酸化水素、超酸化物、1,2,3−D,L−トリカルボキシシクロペンテン−1、トリメシン酸(1,3,5−トリカルボキシベンゼン)、トリメリット酸(1,2,4−トリカルボキシベンゼン)、ピロメリット酸(1,2,4,5−テトラカルボキシベンゼン)、1,2,3,4−テトラカルボキシシクロペンタン、クレブス回路物質、オキサロスクシナート、トランス−アコニターゼ、シス−アコニターゼ、アルファ−ケトグルタル酸、2−オキソグルタレート、オキサロアセテート、アロキサン、1−メチル−4−フェニルピリジン、マンガン、ロンプロテアーゼ、N−ヒドロキシ−6−オクチルオキシピリジン−2(1H)オン、エタノールアミン塩、ピリチオン及びピリチオンの金属塩、ジンクピリチオン、並びにこれらの混合物からなる群から選択される、請求項1又は2に記載の真菌細胞のアコニターゼ活性を阻害する方法。
- 前記アコニターゼ活性の阻害物質が、ジンクピリチオンである、請求項1〜3のいずれか一項に記載の真菌細胞のアコニターゼ活性を阻害する方法。
- 前記アコニターゼの阻害物質が、アコニターゼ活性を少なくとも70%阻害する、請求項1〜4のいずれか一項に記載の真菌細胞のアコニターゼ活性を阻害する方法。
- 抗真菌効果のためにアコニターゼ活性を阻害する方法であって、
a)細胞を物質に曝露する工程と、
b)細胞を開き、アコニターゼ活性を測定する工程と、
c)ベースライン又は対照/未処理の試料と比較してアコニターゼ活性の減少を測定する工程と、を含む、方法。 - 真菌細胞の増殖を阻害する方法であって、前記真菌細胞を、アコニターゼ活性を少なくとも70%阻害する物質と接触させる工程を含み、それによって前記真菌細胞の増殖の阻害を引き起こす、方法。
- アコニターゼ酵素に対する阻害活性を有する物質のうちの1つ以上を含むパーソナルケア組成物であって、前記物質が、抗真菌薬が媒介する症状を処置する有効性の増強をもたらすように、アコニターゼ活性を少なくとも70%阻害する、パーソナルケア組成物。
- 前記物質が、抗真菌薬が媒介する頭皮の症状を処置する有効性の増強をもたらすように、アコニターゼ活性を少なくとも70%阻害する、請求項8に記載のパーソナルケア組成物。
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JP (2) | JP2013543847A (ja) |
CN (2) | CN103167894A (ja) |
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US10543157B2 (en) * | 2016-04-29 | 2020-01-28 | The Procter And Gamble Company | Method of treating a hair disorder with N-hydroxypyridinones |
JP6988185B2 (ja) * | 2017-06-16 | 2022-01-05 | 住友ベークライト株式会社 | 防カビ剤、防カビ樹脂フィルム、防カビ積層フィルム及び防カビ包装体 |
WO2021123323A1 (en) * | 2019-12-20 | 2021-06-24 | Linnane Pharma Ab | Lon protease, alpha-hemolysin, ck1-alpha-1; c-myb inhibitor or a cebp-delta inhibitor as therapeutics |
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US20050202984A1 (en) * | 2003-03-18 | 2005-09-15 | Schwartz James R. | Composition comprising zinc-containing layered material with a high relative zinc lability |
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2011
- 2011-10-28 EP EP11782318.7A patent/EP2632552B1/en active Active
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MX2013004556A (es) | 2013-06-07 |
CN105168225A (zh) | 2015-12-23 |
CN103167894A (zh) | 2013-06-19 |
EP2632552B1 (en) | 2019-11-27 |
WO2012058526A1 (en) | 2012-05-03 |
BR112013008578A2 (pt) | 2016-07-12 |
EP2632552A1 (en) | 2013-09-04 |
MX361964B (es) | 2018-12-19 |
BR112013008578B1 (pt) | 2020-11-03 |
JP2013543847A (ja) | 2013-12-09 |
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