JP2016003207A - 外用組成物 - Google Patents
外用組成物 Download PDFInfo
- Publication number
- JP2016003207A JP2016003207A JP2014124415A JP2014124415A JP2016003207A JP 2016003207 A JP2016003207 A JP 2016003207A JP 2014124415 A JP2014124415 A JP 2014124415A JP 2014124415 A JP2014124415 A JP 2014124415A JP 2016003207 A JP2016003207 A JP 2016003207A
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- JP
- Japan
- Prior art keywords
- acid
- composition
- oil
- malassezia
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
Description
マラセチア属真菌に対する増殖抑制効果を評価するために、以下の拡散法(穿孔平板法)による試験を行った。先ず、1種類のマラセチア真菌(M.furfur(ATCC:46266))を用意し、その菌液を約106CFU/mL接種したATCC培地(1072 Pityrosporum medium)を作製した。別途、他の2種類のマラセチア真菌(M.restricta(ATCC:MYA−4611)、M.globosa(ATCC:MYA−4612))を用意し、各菌液を同様に約106CFU/mL接取したMLNA培地(modified Leeming and Notman Agar培地)を作製した。滅菌済みの穿孔カッター(TOYOBO製、バイオプシーパンチ8mm、ステンレス製)で各培地に直径8mmの穴を開けた。穴内一杯(約0.1mL)に5重量%クロタミトンを含む実施例1の被験試料を注入した。その後、M.furfurを接種したATCC培地は6日間33℃好気条件下で培養し、M.restricta又はM.globosaを接種したMLNA培地は8日間30℃好気条件下で培養した。培養期間終了後、それぞれの阻止円の直径(大きさ)を測定し、マラセチア真菌種毎に平均値を算出した。この結果を以下の表2に示す。
上記試験例1と実質的に同様の手順で、拡散法によりM.restrictaに対する増殖抑制効果について更に評価を行った。本試験例では、クロタミトンと共に配合濃度の異なるモノテルペン(1.0重量%又は3.5重量%)を組み合わせて調製した被験試料(実施例2及び実施例3)を用いて試験を実施した。この結果を以下の表3に示す。
(1)イオン交換水 残余
(2)クロタミトン 5重量%
(3)グリセリン 10重量%
(4)1,3−ブチレングリコール 5重量%
(5)パラベン 0.2重量%
(6)エデト酸2ナトリウム 0.05重量%
(7)カルボキシビニルポリマー 0.5重量%
(8)トリエタノールアミン 0.4重量%
(9)ステアリン酸ソルビタン 1.0重量%
(10)ポリソルベート60 1.0重量%
(11)流動パラフィン 10重量%
(12)パルミチン酸イソプロピル 5.0重量%
(13)セタノール 5.0重量%
(1)イオン交換水 残余
(2)クロタミトン 10重量%
(3)l−メントール 2.0重量%
(4)グリセリン 5重量%
(5)1,3−ブチレングリコール 5重量%
(6)パラベン 0.2重量%
(7)エデト酸2ナトリウム 0.05重量%
(8)カルボキシビニルポリマー 0.4重量%
(9)トリエタノールアミン 0.5重量%
(10)ポリオキシエチレンヤシ油脂肪酸ソルビタン 1.0重量%
(11)ステアリン酸グリセリル 1.0重量%
(12)流動パラフィン 5重量%
(13)パルミチン酸イソプロピル 3重量%
(14)べへニルアルコール 2重量%
(1)イオン交換水 残余
(2)無水エタノール 45重量%
(3)クロタミトン 5.0重量%
(4)l−メントール 3.5重量%
(5)1,3−ブチレングリコール 10重量%
(6)キサンタンガム 0.2重量%
(7)トリエタノールアミン 0.2重量%
Claims (6)
- クロタミトン及びその誘導体、並びにそれらの薬学的に許容される塩からなる群より選択される少なくとも1種を含有する、マラセチア属真菌の増殖を抑制するために用いられる外用組成物。
- 組成物全量に対して、2重量%以上のモノテルペンを含有する、請求項1に記載の外用組成物。
- 前記モノテルペンが、メントール、カンフル、ボルネオール、オイゲノール、シネオール、チモール、リモネン、ピネン、アネトール、シメン、テルピネオール、カンフェン、イソボルネオール、フェンチェン、ゲラニオール、ネロール、ミルセン、ミルセノール、リナロール、酢酸リナロール、及びラバンジュロールからなる群より選択される少なくとも1種である、請求項1又は2に記載の外用組成物。
- 前記マラセチア属真菌が、Malassezia restrictaである、請求項1〜3のいずれか1項に記載の外用組成物。
- 頭皮に対して用いられる、請求項1〜4のいずれか1項に記載の外用組成物。
- クロタミトン及びその誘導体、並びにそれらの薬学的に許容される塩からなる群より選択される少なくとも1種を含有する、マラセチア属真菌性の皮膚疾患又は皮膚症状の予防及び/又は治療剤。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2018052872A (ja) * | 2016-09-29 | 2018-04-05 | 花王株式会社 | 皮膚外用剤 |
JP2019523282A (ja) * | 2016-08-03 | 2019-08-22 | ゼルダ セラピューティクス オペレーションズ ピーティーワイ リミテッド | 大麻組成物 |
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JPH04316517A (ja) * | 1991-04-16 | 1992-11-06 | Yamanouchi Pharmaceut Co Ltd | トルナフテート含有液剤 |
JPH05306223A (ja) * | 1991-07-03 | 1993-11-19 | Takeda Chem Ind Ltd | 抗真菌性外用組成物 |
JPH09157161A (ja) * | 1995-12-13 | 1997-06-17 | Lion Corp | 皮膚疾患治療剤 |
JPH09208464A (ja) * | 1996-02-07 | 1997-08-12 | Takeda Chem Ind Ltd | 抗真菌性外用組成物 |
JP2000229852A (ja) * | 1999-02-04 | 2000-08-22 | Lion Corp | 皮膚外用剤 |
JP2003012501A (ja) * | 2001-06-27 | 2003-01-15 | Rohto Pharmaceut Co Ltd | 鎮痒エアゾール製剤 |
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2014
- 2014-06-17 JP JP2014124415A patent/JP6377423B2/ja active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH04316517A (ja) * | 1991-04-16 | 1992-11-06 | Yamanouchi Pharmaceut Co Ltd | トルナフテート含有液剤 |
JPH05306223A (ja) * | 1991-07-03 | 1993-11-19 | Takeda Chem Ind Ltd | 抗真菌性外用組成物 |
JPH09157161A (ja) * | 1995-12-13 | 1997-06-17 | Lion Corp | 皮膚疾患治療剤 |
JPH09208464A (ja) * | 1996-02-07 | 1997-08-12 | Takeda Chem Ind Ltd | 抗真菌性外用組成物 |
JP2000229852A (ja) * | 1999-02-04 | 2000-08-22 | Lion Corp | 皮膚外用剤 |
JP2003012501A (ja) * | 2001-06-27 | 2003-01-15 | Rohto Pharmaceut Co Ltd | 鎮痒エアゾール製剤 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2019523282A (ja) * | 2016-08-03 | 2019-08-22 | ゼルダ セラピューティクス オペレーションズ ピーティーワイ リミテッド | 大麻組成物 |
JP2018052872A (ja) * | 2016-09-29 | 2018-04-05 | 花王株式会社 | 皮膚外用剤 |
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