JP2015535256A5 - - Google Patents
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- Publication number
- JP2015535256A5 JP2015535256A5 JP2015539867A JP2015539867A JP2015535256A5 JP 2015535256 A5 JP2015535256 A5 JP 2015535256A5 JP 2015539867 A JP2015539867 A JP 2015539867A JP 2015539867 A JP2015539867 A JP 2015539867A JP 2015535256 A5 JP2015535256 A5 JP 2015535256A5
- Authority
- JP
- Japan
- Prior art keywords
- syndrome
- usher
- compound
- pharmaceutically acceptable
- iii
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000011580 syndromic disease Diseases 0.000 claims 16
- 208000014769 Usher Syndromes Diseases 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 7
- 208000015122 neurodegenerative disease Diseases 0.000 claims 6
- 230000002207 retinal effect Effects 0.000 claims 6
- 206010007747 Cataract congenital Diseases 0.000 claims 2
- 206010011878 Deafness Diseases 0.000 claims 2
- 201000007737 Retinal degeneration Diseases 0.000 claims 2
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 2
- 206010064930 age-related macular degeneration Diseases 0.000 claims 2
- 238000010276 construction Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000010370 hearing loss Effects 0.000 claims 2
- 231100000888 hearing loss Toxicity 0.000 claims 2
- 208000016354 hearing loss disease Diseases 0.000 claims 2
- 208000002780 macular degeneration Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000004258 retinal degeneration Effects 0.000 claims 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261718593P | 2012-10-25 | 2012-10-25 | |
| US61/718,593 | 2012-10-25 | ||
| US201361775376P | 2013-03-08 | 2013-03-08 | |
| US61/775,376 | 2013-03-08 | ||
| PCT/US2013/066938 WO2014066835A1 (en) | 2012-10-25 | 2013-10-25 | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015535256A JP2015535256A (ja) | 2015-12-10 |
| JP2015535256A5 true JP2015535256A5 (enExample) | 2016-12-08 |
| JP6290910B2 JP6290910B2 (ja) | 2018-03-07 |
Family
ID=50545355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015539867A Active JP6290910B2 (ja) | 2012-10-25 | 2013-10-25 | ピラゾロピリダジンならびに網膜変性疾患およびアッシャー症候群に伴う聴力損失を処置するための方法 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2912038B1 (enExample) |
| JP (1) | JP6290910B2 (enExample) |
| AU (1) | AU2013334138B2 (enExample) |
| CA (1) | CA2889537C (enExample) |
| ES (1) | ES2693166T3 (enExample) |
| IL (1) | IL238287B (enExample) |
| PL (1) | PL2912038T3 (enExample) |
| TR (1) | TR201816028T4 (enExample) |
| WO (1) | WO2014066835A1 (enExample) |
| ZA (1) | ZA201502654B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5902293B2 (ja) | 2011-04-25 | 2016-04-13 | アッシャー・サード・イニシアティブ・インコーポレイテッド | ピラゾロピリダジンおよび網膜変性疾患およびアッシャー症候群に伴う聴覚損失を治療するための方法 |
| US9227976B2 (en) | 2012-10-25 | 2016-01-05 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
| CA2889494C (en) * | 2012-10-25 | 2018-12-18 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
| EP4178580B1 (en) | 2020-07-09 | 2025-11-05 | Usher III Initiative, Inc. | Bf 844 for use in the treatment of cancer |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2295550A3 (en) * | 2001-04-30 | 2011-12-14 | Vertex Pharmaceuticals Incorporated | Crystal structures of GSK-3beta protein and protein complexes and their use |
| ATE554087T1 (de) * | 2004-10-29 | 2012-05-15 | Abbott Lab | Neue kinaseinhibitoren |
| AR052559A1 (es) * | 2005-01-21 | 2007-03-21 | Astex Therapeutics Ltd | Derivados de pirazol para inhibir cdk's y gsk's |
| WO2009062118A2 (en) * | 2007-11-07 | 2009-05-14 | Foldrx Pharmaceuticals, Inc. | Modulation of protein trafficking |
| AU2009262068C1 (en) * | 2008-06-27 | 2015-07-02 | Celgene Car Llc | Heteroaryl compounds and uses thereof |
| JP5902293B2 (ja) * | 2011-04-25 | 2016-04-13 | アッシャー・サード・イニシアティブ・インコーポレイテッド | ピラゾロピリダジンおよび網膜変性疾患およびアッシャー症候群に伴う聴覚損失を治療するための方法 |
| CA2889494C (en) * | 2012-10-25 | 2018-12-18 | Usher Iii Initiative, Inc. | Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with usher syndrome |
-
2013
- 2013-10-25 JP JP2015539867A patent/JP6290910B2/ja active Active
- 2013-10-25 ES ES13849803.5T patent/ES2693166T3/es active Active
- 2013-10-25 CA CA2889537A patent/CA2889537C/en active Active
- 2013-10-25 AU AU2013334138A patent/AU2013334138B2/en active Active
- 2013-10-25 TR TR2018/16028T patent/TR201816028T4/tr unknown
- 2013-10-25 WO PCT/US2013/066938 patent/WO2014066835A1/en not_active Ceased
- 2013-10-25 EP EP13849803.5A patent/EP2912038B1/en active Active
- 2013-10-25 PL PL13849803T patent/PL2912038T3/pl unknown
-
2015
- 2015-04-14 IL IL238287A patent/IL238287B/en active IP Right Grant
- 2015-04-20 ZA ZA2015/02654A patent/ZA201502654B/en unknown
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