JP2015535225A5 - - Google Patents
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- Publication number
- JP2015535225A5 JP2015535225A5 JP2015538418A JP2015538418A JP2015535225A5 JP 2015535225 A5 JP2015535225 A5 JP 2015535225A5 JP 2015538418 A JP2015538418 A JP 2015538418A JP 2015538418 A JP2015538418 A JP 2015538418A JP 2015535225 A5 JP2015535225 A5 JP 2015535225A5
- Authority
- JP
- Japan
- Prior art keywords
- disorders
- alkyl
- halogen
- alkynyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052736 halogen Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 208000035475 disorder Diseases 0.000 claims 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- 230000033115 angiogenesis Effects 0.000 claims 2
- -1 2 -phenyl-6-((4-phenylpiperazin-1-yl) methyl) -1,3,5-triazine-2,4-diamine Chemical compound 0.000 claims 1
- DMIFRSNZEOKCMR-UHFFFAOYSA-N 2-n-(4-methylphenyl)-6-[(4-phenylpiperazin-1-yl)methyl]-1,3,5-triazine-2,4-diamine Chemical compound C1=CC(C)=CC=C1NC1=NC(N)=NC(CN2CCN(CC2)C=2C=CC=CC=2)=N1 DMIFRSNZEOKCMR-UHFFFAOYSA-N 0.000 claims 1
- PWEXPMWUXDFYTH-UHFFFAOYSA-N 4-(3,4-dimethylphenyl)-6-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-1H-1,3,5-triazine-2,4-diamine Chemical compound CC=1C=C(C=CC1C)C1(NC(=NC(=N1)N)CN1CCN(CC1)C1=CC(=CC=C1)OC)N PWEXPMWUXDFYTH-UHFFFAOYSA-N 0.000 claims 1
- DHAGONCJVDCCSN-UHFFFAOYSA-N 4-(3-chloro-4-methylphenyl)-6-[[4-(3-methoxyphenyl)piperazin-1-yl]methyl]-1H-1,3,5-triazine-2,4-diamine Chemical compound ClC=1C=C(C=CC1C)C1(NC(=NC(=N1)N)CN1CCN(CC1)C1=CC(=CC=C1)OC)N DHAGONCJVDCCSN-UHFFFAOYSA-N 0.000 claims 1
- GZVHEAJQGPRDLQ-UHFFFAOYSA-N 6-phenyl-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC(N)=NC(C=2C=CC=CC=2)=N1 GZVHEAJQGPRDLQ-UHFFFAOYSA-N 0.000 claims 1
- 206010002199 Anaphylactic shock Diseases 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 102100021217 Dual oxidase 2 Human genes 0.000 claims 1
- 208000017701 Endocrine disease Diseases 0.000 claims 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 claims 1
- 101000968308 Homo sapiens Dual oxidase 1 Proteins 0.000 claims 1
- 101000968305 Homo sapiens Dual oxidase 2 Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000036110 Neuroinflammatory disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 claims 1
- 206010040070 Septic Shock Diseases 0.000 claims 1
- 206010049771 Shock haemorrhagic Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010069351 acute lung injury Diseases 0.000 claims 1
- 230000000172 allergic effect Effects 0.000 claims 1
- 208000003455 anaphylaxis Diseases 0.000 claims 1
- 208000010668 atopic eczema Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 210000003027 ear inner Anatomy 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 claims 1
- 230000002008 hemorrhagic effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000002314 neuroinflammatory effect Effects 0.000 claims 1
- 230000000414 obstructive effect Effects 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 230000001850 reproductive effect Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 208000017520 skin disease Diseases 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261717803P | 2012-10-24 | 2012-10-24 | |
| EP12189823 | 2012-10-24 | ||
| EP12189823.3 | 2012-10-24 | ||
| US61/717,803 | 2012-10-24 | ||
| PCT/EP2013/072098 WO2014064118A1 (en) | 2012-10-24 | 2013-10-22 | Triazine derivatives for the treatment of conditions associated with nicotinamide adenine dinucleotide phosphate oxidase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015535225A JP2015535225A (ja) | 2015-12-10 |
| JP2015535225A5 true JP2015535225A5 (enExample) | 2016-12-08 |
Family
ID=47143564
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015538418A Pending JP2015535225A (ja) | 2012-10-24 | 2013-10-22 | ニコチンアミドアデニンジヌクレオチドリン酸オキシダーゼに関連する状態を処置するためのトリアジン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9687490B2 (enExample) |
| EP (1) | EP2911667B1 (enExample) |
| JP (1) | JP2015535225A (enExample) |
| CN (1) | CN104918616A (enExample) |
| CA (1) | CA2889029A1 (enExample) |
| IN (1) | IN2015DN03761A (enExample) |
| WO (1) | WO2014064118A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10195167B2 (en) | 2014-12-16 | 2019-02-05 | Glucox Biotech Ab | Compounds for use in the treatment of conditions associated with NADPH oxidase |
| JP2018505226A (ja) * | 2015-02-16 | 2018-02-22 | グルコックス・バイオテック・アーベー | Ｎ２−（３，４−ジメチルフェニル）−６−（（４−（ｐ−トリル）ピペラジン−１−イル）メチル）−１，３，５−トリアジン−２，４−ジアミン |
| CN110325516A (zh) | 2016-12-29 | 2019-10-11 | 米尼奥尔克斯治疗有限公司 | 杂芳基化合物和它们的用途 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| EP2166009A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as nadph oxidase inhibitors |
| EP2166008A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| EP2165707A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| EP2166010A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
| EP2305679A1 (en) | 2009-09-28 | 2011-04-06 | GenKyoTex SA | Pyrazoline dione derivatives as nadph oxidase inhibitors |
| EP2361911A1 (en) | 2010-02-18 | 2011-08-31 | GenKyoTex SA | Pyrazolo piperidine derivatives as NADPH oxidase inhibitors |
| EP2361912A1 (en) | 2010-02-18 | 2011-08-31 | GenKyoTex SA | Pyrazolo piperidine derivatives as NADPH oxidase inhibitors |
| CN102389430B (zh) * | 2011-09-07 | 2013-08-28 | 苏州大学 | 一种小分子化合物在制备抗肺癌药物中的应用 |
-
2013
- 2013-10-22 WO PCT/EP2013/072098 patent/WO2014064118A1/en not_active Ceased
- 2013-10-22 JP JP2015538418A patent/JP2015535225A/ja active Pending
- 2013-10-22 CA CA2889029A patent/CA2889029A1/en not_active Abandoned
- 2013-10-22 EP EP13789502.5A patent/EP2911667B1/en not_active Not-in-force
- 2013-10-22 IN IN3761DEN2015 patent/IN2015DN03761A/en unknown
- 2013-10-22 US US14/437,678 patent/US9687490B2/en not_active Expired - Fee Related
- 2013-10-22 CN CN201380055721.6A patent/CN104918616A/zh active Pending
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