JP2015535174A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015535174A5 JP2015535174A5 JP2015531340A JP2015531340A JP2015535174A5 JP 2015535174 A5 JP2015535174 A5 JP 2015535174A5 JP 2015531340 A JP2015531340 A JP 2015531340A JP 2015531340 A JP2015531340 A JP 2015531340A JP 2015535174 A5 JP2015535174 A5 JP 2015535174A5
- Authority
- JP
- Japan
- Prior art keywords
- molecule
- pharmaceutically acceptable
- acceptable salt
- molecules
- ribonucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 29
- 125000003729 nucleotide group Chemical group 0.000 claims 14
- 125000002652 ribonucleotide group Chemical group 0.000 claims 14
- 239000002773 nucleotide Substances 0.000 claims 13
- 239000000203 mixture Substances 0.000 claims 12
- 108091081021 Sense strand Proteins 0.000 claims 9
- 230000000692 anti-sense effect Effects 0.000 claims 8
- 108091028664 Ribonucleotide Proteins 0.000 claims 7
- 239000002336 ribonucleotide Substances 0.000 claims 7
- HYCSHFLKPSMPGO-UHFFFAOYSA-N 3-hydroxypropyl dihydrogen phosphate Chemical group OCCCOP(O)(O)=O HYCSHFLKPSMPGO-UHFFFAOYSA-N 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 3
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims 3
- 230000014509 gene expression Effects 0.000 claims 3
- 208000016354 hearing loss disease Diseases 0.000 claims 3
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 3
- RXQZLSRIOOYKLF-UHFFFAOYSA-N 5H-pyrazolo[4,3-d]triazine Chemical compound N1=NN=C2C=NNC2=C1 RXQZLSRIOOYKLF-UHFFFAOYSA-N 0.000 claims 2
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 2
- 206010011878 Deafness Diseases 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 208000033626 Renal failure acute Diseases 0.000 claims 2
- 108091046915 Threose nucleic acid Proteins 0.000 claims 2
- 201000011040 acute kidney failure Diseases 0.000 claims 2
- 238000010322 bone marrow transplantation Methods 0.000 claims 2
- 208000020832 chronic kidney disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 230000010370 hearing loss Effects 0.000 claims 2
- 231100000888 hearing loss Toxicity 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical group OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 claims 1
- -1 5,6,7,8-tetrahydro-2-naphthalenebutyric acid phosphodiester Chemical class 0.000 claims 1
- 208000035657 Abasia Diseases 0.000 claims 1
- 208000007788 Acute Liver Failure Diseases 0.000 claims 1
- 206010000804 Acute hepatic failure Diseases 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000012639 Balance disease Diseases 0.000 claims 1
- 206010048610 Cardiotoxicity Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- KKZFLSZAWCYPOC-VPENINKCSA-N Deoxyribose 5-phosphate Chemical group O[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1 KKZFLSZAWCYPOC-VPENINKCSA-N 0.000 claims 1
- 206010020843 Hyperthermia Diseases 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 231100000836 acute liver failure Toxicity 0.000 claims 1
- 208000012998 acute renal failure Diseases 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 229940041181 antineoplastic drug Drugs 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 231100000259 cardiotoxicity Toxicity 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 208000022605 chemotherapy-induced alopecia Diseases 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 239000005547 deoxyribonucleotide Substances 0.000 claims 1
- 230000003828 downregulation Effects 0.000 claims 1
- 239000003814 drug Chemical group 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000002651 drug therapy Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 208000028329 epileptic seizure Diseases 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 230000036031 hyperthermia Effects 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 230000004768 organ dysfunction Effects 0.000 claims 1
- 108700025694 p53 Genes Proteins 0.000 claims 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 150000003722 vitamin derivatives Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261699884P | 2012-09-12 | 2012-09-12 | |
| US61/699,884 | 2012-09-12 | ||
| PCT/US2013/059349 WO2014043292A1 (en) | 2012-09-12 | 2013-09-12 | Double-stranded oligonucleotide molecules to p53 and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015535174A JP2015535174A (ja) | 2015-12-10 |
| JP2015535174A5 true JP2015535174A5 (enExample) | 2016-11-04 |
| JP6364009B2 JP6364009B2 (ja) | 2018-07-25 |
Family
ID=49304313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531340A Expired - Fee Related JP6364009B2 (ja) | 2012-09-12 | 2013-09-12 | Ｐ５３に対する二本鎖オリゴヌクレオチド分子、およびその使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9932578B2 (enExample) |
| EP (1) | EP2895607B1 (enExample) |
| JP (1) | JP6364009B2 (enExample) |
| CN (1) | CN104619844A (enExample) |
| BR (1) | BR112015004747A2 (enExample) |
| CA (1) | CA2880290C (enExample) |
| DK (1) | DK2895607T3 (enExample) |
| ES (1) | ES2872349T3 (enExample) |
| HK (1) | HK1210216A1 (enExample) |
| WO (1) | WO2014043289A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014043289A2 (en) | 2012-09-12 | 2014-03-20 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide molecules to ddit4 and methods of use thereof |
| EP3019559A4 (en) | 2013-08-22 | 2017-04-05 | Sony Corporation | Water soluble fluorescent or colored dyes and methods for their use |
| IL316808A (en) | 2014-08-20 | 2025-01-01 | Alnylam Pharmaceuticals Inc | Modified double-stranded RNA materials and their uses |
| KR102646956B1 (ko) | 2015-02-26 | 2024-03-14 | 소니그룹주식회사 | 페닐에티닐나프탈렌 염료 및 이의 사용 방법 |
| WO2016138461A1 (en) | 2015-02-26 | 2016-09-01 | Sony Corporation | Water soluble fluorescent or colored dyes comprising conjugating groups |
| KR102765335B1 (ko) | 2015-05-11 | 2025-02-13 | 소니그룹주식회사 | 초휘도 이량체성 또는 중합체성 염료 |
| EP3436528B1 (en) | 2016-04-01 | 2025-07-02 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
| BR112018070164B1 (pt) | 2016-04-01 | 2022-09-27 | Sony Corporation Of America | Corantes diméricos ou poliméricos ultrabrilhantes |
| CN109153860B (zh) | 2016-04-06 | 2021-04-23 | 索尼公司 | 具有间隔连接体基团的超高亮二聚体或聚合物染料 |
| JP7527537B2 (ja) | 2016-05-10 | 2024-08-05 | ソニーグループ株式会社 | ペプチド骨格を有する超明色ポリマー染料 |
| US11390754B2 (en) | 2016-05-10 | 2022-07-19 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| BR112018073199A2 (pt) | 2016-05-11 | 2019-04-16 | Sony Corporation | corantes diméricos ou poliméricos ultrabrilhantes |
| EP3464477A1 (en) | 2016-06-06 | 2019-04-10 | Sony Corporation | Ionic polymers comprising fluorescent or colored reporter groups |
| WO2018022925A1 (en) | 2016-07-29 | 2018-02-01 | Sony Corporation | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
| US20180193270A1 (en) | 2016-11-29 | 2018-07-12 | PureTech Health LLC | Exosomes for delivery of therapeutic agents |
| KR20260011205A (ko) | 2017-10-05 | 2026-01-22 | 소니그룹주식회사 | 프로그램가능한 중합체성 약물 |
| US12290571B2 (en) | 2017-10-05 | 2025-05-06 | Sony Group Corporation | Programmable dendritic drugs |
| CN111836645A (zh) | 2017-11-16 | 2020-10-27 | 索尼公司 | 可编程的聚合药物 |
| EP3737417B1 (en) | 2018-01-12 | 2025-08-27 | Sony Group Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| WO2019140128A1 (en) | 2018-01-12 | 2019-07-18 | Sony Corporation | Phosphoalkyl polymers comprising biologically active compounds |
| US12076407B2 (en) | 2018-01-12 | 2024-09-03 | Sony Group Corporation | Polymers with rigid spacing groups comprising biologically active compounds |
| EP3769085B1 (en) | 2018-03-19 | 2022-08-24 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
| KR102864292B1 (ko) | 2018-03-21 | 2025-09-26 | 소니그룹주식회사 | 링커 군을 갖는 중합체성 텐덤 염료 |
| JP7580689B2 (ja) | 2018-06-27 | 2024-11-12 | ソニーグループ株式会社 | デオキシリボースを含むリンカー基を有するポリマー色素 |
| US12578342B2 (en) | 2018-07-13 | 2026-03-17 | Sony Group Corporation | Polymeric dyes having a backbone comprising organophosphate units |
| EP3861074A2 (en) | 2019-09-26 | 2021-08-11 | Sony Group Corporation | Polymeric tandem dyes with linker groups |
| EP4038081A1 (en) | 2019-09-30 | 2022-08-10 | Sony Group Corporation | Nucleotide probes |
| CN110974804B (zh) * | 2019-11-13 | 2021-09-24 | 杭州师范大学 | p53信使RNA纳米粒及其制备方法和在制备治疗肿瘤药物中的应用 |
| EP4256078A1 (en) | 2020-12-07 | 2023-10-11 | Sony Group Corporation | Spacing linker group design for brightness enhancement in dimeric or polymeric dyes |
| KR20250043472A (ko) * | 2022-07-27 | 2025-03-28 | 이-테라퓨틱스 피엘씨 | 핵산 화합물 |
| US12454693B1 (en) | 2024-09-27 | 2025-10-28 | Dexcel Pharma Technologies Ltd. | Nucleic acids for inhibiting expression of transferrin receptor 2 |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
| US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
| US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
| US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
| US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
| US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US4959217A (en) | 1986-05-22 | 1990-09-25 | Syntex (U.S.A.) Inc. | Delayed/sustained release of macromolecules |
| US4925678A (en) | 1987-04-01 | 1990-05-15 | Ranney David F | Endothelial envelopment drug carriers |
| US5080646A (en) | 1988-10-03 | 1992-01-14 | Alza Corporation | Membrane for electrotransport transdermal drug delivery |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5270030A (en) | 1988-12-29 | 1993-12-14 | Bio-Technology General Corp. | Fibrin binding domain polypeptide and method of producing |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5167616A (en) | 1989-12-14 | 1992-12-01 | Alza Corporation | Iontophoretic delivery method |
| US6153737A (en) | 1990-01-11 | 2000-11-28 | Isis Pharmaceuticals, Inc. | Derivatized oligonucleotides having improved uptake and other properties |
| US5214136A (en) | 1990-02-20 | 1993-05-25 | Gilead Sciences, Inc. | Anthraquinone-derivatives oligonucleotides |
| US5138045A (en) | 1990-07-27 | 1992-08-11 | Isis Pharmaceuticals | Polyamine conjugated oligonucleotides |
| US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
| US6335434B1 (en) | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
| US5225182A (en) | 1991-10-31 | 1993-07-06 | Sharma Yash P | Vectored drug delivery system using a cephaloplastin linking agent and a methed of using the system |
| ATE515510T1 (de) | 1991-12-24 | 2011-07-15 | Isis Pharmaceuticals Inc | Durch dna-abschnitte unterbrochene modifizierte oligonukleotide |
| CA2135646A1 (en) | 1992-05-11 | 1993-11-25 | Kenneth G. Draper | Method and reagent for inhibiting viral replication |
| JPH07509133A (ja) | 1992-07-17 | 1995-10-12 | リボザイム・ファーマシューティカルズ・インコーポレイテッド | 動物疾患の処置のための方法および剤 |
| US6235886B1 (en) | 1993-09-03 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Methods of synthesis and use |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| CA2170869C (en) | 1993-09-03 | 1999-09-14 | Phillip Dan Cook | Amine-derivatized nucleosides and oligonucleosides |
| US6447796B1 (en) | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| US5998203A (en) | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
| US5898031A (en) | 1996-06-06 | 1999-04-27 | Isis Pharmaceuticals, Inc. | Oligoribonucleotides for cleaving RNA |
| US6251666B1 (en) | 1997-03-31 | 2001-06-26 | Ribozyme Pharmaceuticals, Inc. | Nucleic acid catalysts comprising L-nucleotide analogs |
| US6235310B1 (en) | 1997-04-04 | 2001-05-22 | Valentis, Inc. | Methods of delivery using cationic lipids and helper lipids |
| US6395713B1 (en) | 1997-07-23 | 2002-05-28 | Ribozyme Pharmaceuticals, Inc. | Compositions for the delivery of negatively charged molecules |
| ATE293633T1 (de) | 1997-08-21 | 2005-05-15 | Quark Biotech Inc | Hypoxie-regulierte gene |
| EP1038016A2 (en) | 1997-12-16 | 2000-09-27 | Valentis Inc. | Needle-free injection of formulated nucleic acid molecules |
| ES2356342T3 (es) | 1998-01-05 | 2011-04-07 | The University Of Washington | Mejora de transporte utilizando agentes de alteración de membrana. |
| ATE237312T1 (de) | 1998-07-20 | 2003-05-15 | Protiva Biotherapeutics Inc | In liposomen verkapselte nukleinsäurekomplexe |
| AU771579B2 (en) | 1998-10-26 | 2004-03-25 | Avi Biopharma, Inc. | p53 antisense agent and method |
| WO2000053722A2 (en) | 1999-03-10 | 2000-09-14 | Phogen Limited | Delivery of nucleic acids and proteins to cells |
| GB9927444D0 (en) | 1999-11-19 | 2000-01-19 | Cancer Res Campaign Tech | Inhibiting gene expression |
| EP1360488B1 (en) | 2000-07-26 | 2016-04-13 | ChemoMetec A/S | Spatially resolved enzyme-linked assay |
| US6693187B1 (en) | 2000-10-17 | 2004-02-17 | Lievre Cornu Llc | Phosphinoamidite carboxlates and analogs thereof in the synthesis of oligonucleotides having reduced internucleotide charge |
| CN100523215C (zh) | 2000-12-01 | 2009-08-05 | 马普科技促进协会 | 介导rna干涉的小rna分子 |
| US20020130430A1 (en) | 2000-12-29 | 2002-09-19 | Castor Trevor Percival | Methods for making polymer microspheres/nanospheres and encapsulating therapeutic proteins and other products |
| WO2002087541A1 (en) | 2001-04-30 | 2002-11-07 | Protiva Biotherapeutics Inc. | Lipid-based formulations for gene transfer |
| US20040019001A1 (en) | 2002-02-20 | 2004-01-29 | Mcswiggen James A. | RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA |
| US6586524B2 (en) | 2001-07-19 | 2003-07-01 | Expression Genetics, Inc. | Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier |
| US7060498B1 (en) | 2001-11-28 | 2006-06-13 | Genta Salus Llc | Polycationic water soluble copolymer and method for transferring polyanionic macromolecules across biological barriers |
| US7141540B2 (en) | 2001-11-30 | 2006-11-28 | Genta Salus Llc | Cyclodextrin grafted biocompatible amphilphilic polymer and methods of preparation and use thereof |
| EP1857547B2 (en) * | 2002-08-05 | 2020-12-02 | Silence Therapeutics GmbH | Further novel forms of interfering RNA molecules |
| ES2319891T3 (es) | 2002-10-18 | 2009-05-14 | Silence Therapeutics Ag | Factor implicado en la metastasis y usos del mismo. |
| EP2305813A3 (en) | 2002-11-14 | 2012-03-28 | Dharmacon, Inc. | Fuctional and hyperfunctional sirna |
| US20050136437A1 (en) | 2003-08-25 | 2005-06-23 | Nastech Pharmaceutical Company Inc. | Nanoparticles for delivery of nucleic acids and stable double-stranded RNA |
| NZ553162A (en) | 2004-08-16 | 2010-03-26 | Quark Biotech Inc | Double stranded siRNA compounds that inhibit RRTP801 |
| UY30097A1 (es) | 2006-01-20 | 2007-08-31 | Atugen Ag | Usos terapeuticos de inhibidores de rtp801 |
| US8362229B2 (en) | 2006-02-08 | 2013-01-29 | Quark Pharmaceuticals, Inc. | Tandem siRNAS |
| EP2046964B1 (en) | 2006-07-12 | 2018-07-04 | The Regents of The University of California | Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups |
| WO2008106102A2 (en) | 2007-02-26 | 2008-09-04 | Quark Pharmaceuticals, Inc. | Inhibitors of rtp801 and their use in disease treatment |
| WO2008104978A2 (en) | 2007-02-28 | 2008-09-04 | Quark Pharmaceuticals, Inc. | Novel sirna structures |
| CA2701845A1 (en) | 2007-10-03 | 2009-04-09 | Quark Pharmaceuticals, Inc. | Novel sirna structures |
| RU2010138558A (ru) | 2008-03-20 | 2012-03-27 | Кварк Фармасьютикалс. Инк, (Us) | Новые соединения миphk для ингибирования rtp801 |
| US8431692B2 (en) | 2008-06-06 | 2013-04-30 | Quark Pharmaceuticals, Inc. | Compositions and methods for treatment of ear disorders |
| WO2010039543A2 (en) | 2008-09-23 | 2010-04-08 | Traversa Therapeutics, Inc. | Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating rna interference |
| ES2563984T3 (es) | 2008-10-22 | 2016-03-17 | Quark Pharmaceuticals, Inc. | Métodos para el tratamiento de trastornos oculares |
| US20110288155A1 (en) * | 2008-12-18 | 2011-11-24 | Elena Feinstein | Sirna compounds and methods of use thereof |
| EP2440214A4 (en) | 2009-06-08 | 2013-07-31 | Quark Pharmaceuticals Inc | METHOD FOR THE TREATMENT OF CHRONIC KIDNEY DISEASES |
| TW201124160A (en) | 2009-11-26 | 2011-07-16 | Quark Pharmaceuticals Inc | SiRNA compounds comprising terminal substitutions |
| WO2011084193A1 (en) | 2010-01-07 | 2011-07-14 | Quark Pharmaceuticals, Inc. | Oligonucleotide compounds comprising non-nucleotide overhangs |
| CA2818024C (en) | 2010-12-06 | 2019-09-24 | Quark Pharmaceuticals, Inc. | Double stranded oligonucleotide compounds comprising positional modifications |
| US20140323549A1 (en) | 2011-11-08 | 2014-10-30 | Quark Pharmaceuticals, Inc. | Methods and compositions for treating diseases, disorders or injury of the nervous system |
| WO2014043289A2 (en) | 2012-09-12 | 2014-03-20 | Quark Pharmaceuticals, Inc. | Double-stranded oligonucleotide molecules to ddit4 and methods of use thereof |
-
2013
- 2013-09-12 WO PCT/US2013/059341 patent/WO2014043289A2/en not_active Ceased
- 2013-09-12 DK DK13773450.5T patent/DK2895607T3/da active
- 2013-09-12 CA CA2880290A patent/CA2880290C/en not_active Expired - Fee Related
- 2013-09-12 JP JP2015531340A patent/JP6364009B2/ja not_active Expired - Fee Related
- 2013-09-12 US US14/421,845 patent/US9932578B2/en not_active Expired - Fee Related
- 2013-09-12 BR BR112015004747A patent/BR112015004747A2/pt not_active IP Right Cessation
- 2013-09-12 CN CN201380047225.6A patent/CN104619844A/zh active Pending
- 2013-09-12 US US14/426,513 patent/US9611474B2/en not_active Expired - Fee Related
- 2013-09-12 ES ES13773450T patent/ES2872349T3/es active Active
- 2013-09-12 EP EP13773450.5A patent/EP2895607B1/en active Active
- 2013-09-12 HK HK15110939.6A patent/HK1210216A1/xx unknown
-
2017
- 2017-02-15 US US15/433,400 patent/US10421962B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7129702B2 (ja) | オーバーハングを有する二本鎖核酸複合体 | |
| EP3227445B1 (en) | Cell penetrating molecule | |
| JP2011522036A5 (enExample) | ||
| JP2019504112A5 (enExample) | ||
| TWI723363B (zh) | 用於治療癌症之包含引導rna及內切酶的藥學組成物 | |
| JP2018513682A5 (enExample) | ||
| JP2017505623A5 (enExample) | ||
| JP2021533804A5 (enExample) | ||
| UA118014C2 (uk) | Спосіб модифікації днк-мішені | |
| JP2013121977A5 (enExample) | ||
| FI3310917T4 (fi) | Uusia crispr-entsyymejä ja -järjestelmiä | |
| JP2019503394A5 (enExample) | ||
| JP5559159B2 (ja) | 修飾オリゴヌクレオチドを使用するｈｒｐ−３の阻害 | |
| RU2017108757A (ru) | Лечение связанных с геном-супрессором опухолей заболеваний посредством ингибирования природного транскрипта в антисмысловой ориентации относительно этого гена | |
| RU2016123086A (ru) | Способы и композиции для лечения болезни хантингтона | |
| JP2014500723A5 (enExample) | ||
| JP2024122981A (ja) | ゲノム編集方法及び組成物 | |
| JP2019506862A5 (enExample) | ||
| JP6442941B2 (ja) | 血管内皮細胞増殖因子結合性核酸アプタマー及びその利用 | |
| WO2019181946A1 (ja) | 毒性が軽減した核酸 | |
| Bartas et al. | Bioinformatics analyses and in vitro evidence for five and six stacked G-quadruplex forming sequences | |
| CA3173610A1 (en) | Organic compositions to treat kras-related diseases | |
| de Franciscis | Challenging cancer targets for aptamer delivery | |
| CA3109740A1 (en) | Blood-brain barrier permeable aptamer and application thereof | |
| JPWO2019181305A1 (ja) | ｓｎｏＲＮＡの発現抑制剤を有効成分とするがん増殖抑制剤 |