CN104619844A - 靶向p53的双链寡核苷酸分子及其使用方法 - Google Patents
靶向p53的双链寡核苷酸分子及其使用方法 Download PDFInfo
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- CN104619844A CN104619844A CN201380047225.6A CN201380047225A CN104619844A CN 104619844 A CN104619844 A CN 104619844A CN 201380047225 A CN201380047225 A CN 201380047225A CN 104619844 A CN104619844 A CN 104619844A
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- ribonucleotide
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- Biophysics (AREA)
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- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261699884P | 2012-09-12 | 2012-09-12 | |
| US61/699,884 | 2012-09-12 | ||
| PCT/US2013/059349 WO2014043292A1 (en) | 2012-09-12 | 2013-09-12 | Double-stranded oligonucleotide molecules to p53 and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104619844A true CN104619844A (zh) | 2015-05-13 |
Family
ID=49304313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380047225.6A Pending CN104619844A (zh) | 2012-09-12 | 2013-09-12 | 靶向p53的双链寡核苷酸分子及其使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9611474B2 (enExample) |
| EP (1) | EP2895607B1 (enExample) |
| JP (1) | JP6364009B2 (enExample) |
| CN (1) | CN104619844A (enExample) |
| BR (1) | BR112015004747A2 (enExample) |
| CA (1) | CA2880290C (enExample) |
| DK (1) | DK2895607T3 (enExample) |
| ES (1) | ES2872349T3 (enExample) |
| HK (1) | HK1210216A1 (enExample) |
| WO (1) | WO2014043289A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110974804A (zh) * | 2019-11-13 | 2020-04-10 | 杭州师范大学 | p53信使RNA纳米粒及其制备方法和在制备治疗肿瘤药物中的应用 |
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| CN105377994B (zh) | 2013-08-22 | 2018-03-02 | 索尼公司 | 水溶性荧光染料或有色染料及其使用方法 |
| IL316808A (en) | 2014-08-20 | 2025-01-01 | Alnylam Pharmaceuticals Inc | Modified double-stranded RNA materials and their uses |
| WO2016138461A1 (en) * | 2015-02-26 | 2016-09-01 | Sony Corporation | Water soluble fluorescent or colored dyes comprising conjugating groups |
| CN107406353A (zh) | 2015-02-26 | 2017-11-28 | 索尼公司 | 苯基乙炔基萘染料和用于它们用途的方法 |
| EP3294811B1 (en) | 2015-05-11 | 2024-02-28 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes |
| US11434377B2 (en) | 2016-04-01 | 2022-09-06 | Sony Corporation | Ultra bright dimeric or polymeric dyes with rigid spacing groups |
| EP3436529A1 (en) | 2016-04-01 | 2019-02-06 | Sony Corporation | Ultra bright dimeric or polymeric dyes |
| KR102756931B1 (ko) | 2016-04-06 | 2025-01-21 | 소니그룹주식회사 | 스페이싱 링커 그룹을 포함하는 초고명도 이량체성 또는 중합체성 염료 |
| WO2017197014A2 (en) | 2016-05-10 | 2017-11-16 | Sony Corporation | Compositions comprising a polymeric dye and a cyclodextrin and uses thereof |
| US11370922B2 (en) | 2016-05-10 | 2022-06-28 | Sony Corporation | Ultra bright polymeric dyes with peptide backbones |
| CN109071961B (zh) | 2016-05-11 | 2021-04-27 | 索尼公司 | 超亮二聚或聚合染料 |
| WO2017214165A1 (en) | 2016-06-06 | 2017-12-14 | Sony Corporation | Ionic polymers comprising fluorescent or colored reporter groups |
| US12018159B2 (en) | 2016-07-29 | 2024-06-25 | Sony Group Corporation | Ultra bright dimeric or polymeric dyes and methods for preparation of the same |
| AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
| EP3691689A1 (en) | 2017-10-05 | 2020-08-12 | Sony Corporation | Programmable dendritic drugs |
| KR20200067132A (ko) | 2017-10-05 | 2020-06-11 | 소니 주식회사 | 프로그램가능한 중합체성 약물 |
| CN111836645A (zh) | 2017-11-16 | 2020-10-27 | 索尼公司 | 可编程的聚合药物 |
| JP2021510696A (ja) | 2018-01-12 | 2021-04-30 | ソニー株式会社 | 生物学的に活性な化合物を含む剛性間隔基を有するポリマー |
| US12194104B2 (en) | 2018-01-12 | 2025-01-14 | Sony Group Corporation | Phosphoalkyl ribose polymers comprising biologically active compounds |
| EP4137818B1 (en) | 2018-03-19 | 2025-12-10 | Sony Group Corporation | Use of divalent metals for enhancement of fluorescent signals |
| CN118480073A (zh) | 2018-03-21 | 2024-08-13 | 索尼公司 | 具有连接体基团的聚合串联染料 |
| CN112313242A (zh) | 2018-06-27 | 2021-02-02 | 索尼公司 | 具有含脱氧核糖的连接体基团的聚合物染料 |
| JP7239904B2 (ja) | 2019-09-26 | 2023-03-15 | ソニーグループ株式会社 | リンカー基を有するポリマータンデム色素 |
| JP2023552448A (ja) | 2020-12-07 | 2023-12-15 | ソニーグループ株式会社 | 二量体色素又はポリマー色素における輝度を増強するためのスペーシングリンカー基の設計 |
| EP4562147A1 (en) * | 2022-07-27 | 2025-06-04 | E-Therapeutics plc | Nucleic acid compounds |
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| US10421962B2 (en) | 2019-09-24 |
| JP2015535174A (ja) | 2015-12-10 |
| BR112015004747A2 (pt) | 2017-11-21 |
| WO2014043289A3 (en) | 2014-06-05 |
| WO2014043289A2 (en) | 2014-03-20 |
| HK1210216A1 (en) | 2016-04-15 |
| EP2895607A2 (en) | 2015-07-22 |
| US20180010125A1 (en) | 2018-01-11 |
| US9932578B2 (en) | 2018-04-03 |
| US20150267194A1 (en) | 2015-09-24 |
| CA2880290C (en) | 2020-10-27 |
| JP6364009B2 (ja) | 2018-07-25 |
| CA2880290A1 (en) | 2014-03-20 |
| US9611474B2 (en) | 2017-04-04 |
| US20150203845A1 (en) | 2015-07-23 |
| ES2872349T3 (es) | 2021-11-02 |
| EP2895607B1 (en) | 2021-05-05 |
| US20180044671A9 (en) | 2018-02-15 |
| DK2895607T3 (da) | 2021-05-25 |
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