JP2015533822A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015533822A5 JP2015533822A5 JP2015534689A JP2015534689A JP2015533822A5 JP 2015533822 A5 JP2015533822 A5 JP 2015533822A5 JP 2015534689 A JP2015534689 A JP 2015534689A JP 2015534689 A JP2015534689 A JP 2015534689A JP 2015533822 A5 JP2015533822 A5 JP 2015533822A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- pyrido
- pyrimidin
- cyclopropyl
- piperazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)c1c(C)c(*)nc(*)c1* Chemical compound CC(C)c1c(C)c(*)nc(*)c1* 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261707340P | 2012-09-28 | 2012-09-28 | |
| US61/707,340 | 2012-09-28 | ||
| US201361781364P | 2013-03-14 | 2013-03-14 | |
| US61/781,364 | 2013-03-14 | ||
| PCT/US2013/062085 WO2014052699A1 (en) | 2012-09-28 | 2013-09-27 | Azaquinazoline inhibitors of atypical protein kinase c |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533822A JP2015533822A (ja) | 2015-11-26 |
| JP2015533822A5 true JP2015533822A5 (enExample) | 2017-06-22 |
| JP6535430B2 JP6535430B2 (ja) | 2019-06-26 |
Family
ID=49326872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534689A Active JP6535430B2 (ja) | 2012-09-28 | 2013-09-27 | 非定型プロテインキナーゼｃのアザキナゾリン阻害薬 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US9914730B2 (enExample) |
| EP (1) | EP2900666B1 (enExample) |
| JP (1) | JP6535430B2 (enExample) |
| KR (1) | KR102215272B1 (enExample) |
| CN (1) | CN105102456B (enExample) |
| AU (1) | AU2013323360B2 (enExample) |
| BR (1) | BR112015007061B1 (enExample) |
| CA (1) | CA2886495C (enExample) |
| CL (1) | CL2015000781A1 (enExample) |
| EA (1) | EA030253B1 (enExample) |
| IL (1) | IL237918B (enExample) |
| MX (1) | MX372736B (enExample) |
| NZ (1) | NZ706857A (enExample) |
| PH (1) | PH12015500689A1 (enExample) |
| SG (1) | SG11201502301YA (enExample) |
| TW (1) | TWI663165B (enExample) |
| WO (1) | WO2014052699A1 (enExample) |
| ZA (1) | ZA201502783B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX372736B (es) * | 2012-09-28 | 2020-06-19 | Cancer Research Tech Ltd | Inhibidores de azaquinazolina de la proteina quinasa c atipica. |
| JP6391120B2 (ja) | 2012-12-20 | 2018-09-19 | サンフォード−バーンハム メディカル リサーチ インスティテュート | ニューロテンシン受容体１の小分子アゴニスト |
| GEP201706780B (en) | 2013-03-14 | 2017-11-27 | Boehringer Ingelheim Int | Substituted 2-aza-bicyclo [2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c |
| NZ718190A (en) | 2013-08-23 | 2017-10-27 | Neupharma Inc | Substituted quinazolines for inhibiting kinase activity |
| WO2015143376A1 (en) * | 2014-03-21 | 2015-09-24 | Nivalis Therapeutics, Inc. | Novel compounds for the treatment of cystic fibrosis |
| TWI675836B (zh) * | 2014-03-25 | 2019-11-01 | 美商伊格尼塔公司 | 非典型蛋白質激酶ｃ之氮雜喹唑啉抑制劑 |
| WO2015200534A2 (en) | 2014-06-25 | 2015-12-30 | Sanford-Burnham Medical Research Institute | Small molecule agonists of neurotensin receptor 1 |
| WO2016004272A1 (en) | 2014-07-02 | 2016-01-07 | Pharmacyclics Llc | Inhibitors of bruton's tyrosine kinase |
| WO2016037106A1 (en) * | 2014-09-05 | 2016-03-10 | Allosteros Therapeutics, Inc | CaMKII INHIBITORS AND USES THEREOF |
| UA118610C2 (uk) | 2014-09-12 | 2019-02-11 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | Спіроциклічні інгібітори катепсину c |
| SG11201702075QA (en) * | 2014-10-29 | 2017-04-27 | Dong A St Co Ltd | Novel pyridopyrimidinone compounds for modulating the catalytic activity of histone lysine demethylases (kdms) |
| CN105288512A (zh) * | 2015-12-08 | 2016-02-03 | 李野林 | 一种治疗肥胖症的中药组合物 |
| ES2993451T3 (en) | 2016-06-13 | 2024-12-30 | Glaxosmithkline Ip Dev Ltd | Substituted pyridines as inhibitors of dnmt1 |
| AU2017312561B2 (en) * | 2016-08-15 | 2022-06-30 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| AU2017312970B2 (en) * | 2016-08-16 | 2021-08-12 | Merck Patent Gmbh | 2-oxo-imidazopyridines as reversible BTK inhibitors and uses thereof |
| WO2018051306A1 (en) | 2016-09-19 | 2018-03-22 | Novartis Ag | Therapeutic combinations comprising a raf inhibitor and a erk inhibitor |
| JOP20190257A1 (ar) * | 2017-04-28 | 2019-10-28 | Novartis Ag | مركبات أريل غير متجانسة ثنائية الحلقة مندمجة 6-6 واستخدامها كمثبطات lats |
| KR20240032157A (ko) | 2017-05-02 | 2024-03-08 | 노파르티스 아게 | 병용 요법 |
| KR102563325B1 (ko) | 2017-06-30 | 2023-08-03 | 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 | Ｒｈｏ-관련 단백질 키나아제 억제제, Ｒｈｏ-관련 단백질 키나아제 억제제를 함유하는 약학 조성물, 제조 방법 및 약학 조성물의 용도 |
| WO2019001572A1 (zh) | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho 相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| WO2019000683A1 (zh) | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
| KR102603203B1 (ko) | 2018-07-25 | 2023-11-16 | 파에스 파마, 에스.에이. | 히스타민 h4-수용체 저해제로서 피리도피리미딘류 |
| EP3831823A4 (en) * | 2018-08-01 | 2022-04-27 | Shanghai Ennovabio Pharmaceuticals Co., Ltd. | PREPARATION AND USE OF AN AROMATIC COMPOUND WITH IMMUNEGULATORY FUNCTION |
| CN111100063B (zh) * | 2018-10-25 | 2022-05-17 | 南京药石科技股份有限公司 | 一种合成2-氟甲基取代的吡咯烷、哌啶以及哌嗪衍生物的制备方法 |
| JP7603605B2 (ja) * | 2019-03-28 | 2024-12-20 | キャンサー・リサーチ・テクノロジー・リミテッド | 非定型プロテインキナーゼｃの阻害剤およびヘッジホッグ経路依存性癌の治療におけるその使用 |
| MX2021013817A (es) | 2019-05-13 | 2021-12-14 | Novartis Ag | Nuevas formas cristalinas de n-(3-(2-(2-hidroxietoxi)-6-morfolinop iridin-4-il)-4-metilfenil)-2-(trifluorometil)isonicotinamida como inhibidores de raf para el tratamiento del cancer. |
| CN116120243B (zh) * | 2021-11-15 | 2025-07-29 | 都创(上海)医药科技股份有限公司 | aPKC抑制剂化合物中间体片段及其制备方法和应用 |
| CN114349711B (zh) * | 2022-02-28 | 2023-08-15 | 四川依维欣医药科技有限公司 | 一种（R）-1-Boc-3-羟甲基哌嗪的合成方法 |
| CN117088898B (zh) * | 2022-05-13 | 2026-02-06 | 中国药科大学 | 稠环嘧啶类化合物及其制备方法、药物组合物和应用 |
| CN120882714A (zh) * | 2022-12-13 | 2025-10-31 | 风树疗法公司 | {5-环丙基-2-[2-(3,6-二氟-吡啶-2-基氨基)-吡啶-4-基]-吡啶并[3,4-d]嘧啶-4-基}-((s)-3,3-二甲基-哌啶-4-基)-胺的固体形式 |
| CN117343005A (zh) * | 2023-10-08 | 2024-01-05 | 上海泰坦科技股份有限公司 | 一种异烟酸衍生物的制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4936700A (enExample) | 1972-08-16 | 1974-04-05 | ||
| US6184226B1 (en) * | 1998-08-28 | 2001-02-06 | Scios Inc. | Quinazoline derivatives as inhibitors of P-38 α |
| JP2002080423A (ja) * | 2000-09-06 | 2002-03-19 | Daikin Ind Ltd | トリフルオロ酢酸エチルの合成方法 |
| DK1318997T3 (da) * | 2000-09-15 | 2006-09-25 | Vertex Pharma | Pyrazolforbindelser der er nyttige som proteinkinase-inhibitorer |
| FR2846657B1 (fr) | 2002-11-05 | 2004-12-24 | Servier Lab | Nouveaux composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP4895806B2 (ja) * | 2003-04-09 | 2012-03-14 | エクセリクシス， インク． | Ｔｉｅ−２モジュレータと使用方法 |
| US20050038047A1 (en) * | 2003-08-14 | 2005-02-17 | Edwards Paul John | Azaquinazoline derivatives |
| US7582631B2 (en) * | 2004-01-14 | 2009-09-01 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| JP2008531538A (ja) * | 2005-02-25 | 2008-08-14 | クドス ファーマシューティカルズ リミテッド | ２，４−ジアミノ−ピリドピリミジン誘導体とｍＴＯＲ阻害剤としてのその使用 |
| AU2007287430B2 (en) * | 2006-08-23 | 2011-07-21 | Kudos Pharmaceuticals Limited | 2-methylmorpholine pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors |
| RU2009108006A (ru) * | 2006-09-08 | 2010-10-20 | Пфайзер Продактс Инк. (Us) | Синтез 2-(пиридин-2-иламино)-пиридо[2, 3-d]пиримидин-7-онов |
| US8993552B2 (en) * | 2009-09-04 | 2015-03-31 | The Regents Of The University Of Michigan | Compositions and methods for treatment of leukemia |
| MX372736B (es) * | 2012-09-28 | 2020-06-19 | Cancer Research Tech Ltd | Inhibidores de azaquinazolina de la proteina quinasa c atipica. |
| WO2014164543A1 (en) * | 2013-03-13 | 2014-10-09 | The Regents Of The University Of Michigan | Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof |
| WO2016040330A1 (en) * | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Thienopyrimidine and thienopyridine compounds and methods of use thereof |
| KR20180103053A (ko) * | 2015-12-22 | 2018-09-18 | 비타이 파마슈티컬즈, 인코포레이티드 | 메닌-mll 상호작용의 억제제 |
-
2013
- 2013-09-27 MX MX2015004016A patent/MX372736B/es active IP Right Grant
- 2013-09-27 KR KR1020157010868A patent/KR102215272B1/ko active Active
- 2013-09-27 SG SG11201502301YA patent/SG11201502301YA/en unknown
- 2013-09-27 BR BR112015007061-2A patent/BR112015007061B1/pt active IP Right Grant
- 2013-09-27 EP EP13774578.2A patent/EP2900666B1/en active Active
- 2013-09-27 WO PCT/US2013/062085 patent/WO2014052699A1/en not_active Ceased
- 2013-09-27 CN CN201380062263.9A patent/CN105102456B/zh active Active
- 2013-09-27 TW TW102134928A patent/TWI663165B/zh active
- 2013-09-27 CA CA2886495A patent/CA2886495C/en active Active
- 2013-09-27 NZ NZ706857A patent/NZ706857A/en unknown
- 2013-09-27 JP JP2015534689A patent/JP6535430B2/ja active Active
- 2013-09-27 US US14/038,915 patent/US9914730B2/en active Active
- 2013-09-27 AU AU2013323360A patent/AU2013323360B2/en active Active
- 2013-09-27 EA EA201590661A patent/EA030253B1/ru not_active IP Right Cessation
-
2015
- 2015-03-24 IL IL237918A patent/IL237918B/en active IP Right Grant
- 2015-03-26 PH PH12015500689A patent/PH12015500689A1/en unknown
- 2015-03-27 CL CL2015000781A patent/CL2015000781A1/es unknown
- 2015-04-23 ZA ZA2015/02783A patent/ZA201502783B/en unknown
- 2015-12-18 US US14/975,605 patent/US9896446B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015533822A5 (enExample) | ||
| AU2013323360B2 (en) | Azaquinazoline inhibitors of atypical protein kinase C | |
| JP6545863B2 (ja) | Ｆｇｆｒ阻害剤としての置換三環式化合物 | |
| WO2024107686A1 (en) | Macrocyclic kras inhibitors and methods of use | |
| EP2558468B1 (en) | 5, 7-substituted-imidazo [1,2-c] pyrimidines as inhibitors of jak kinases | |
| CN117651700A (zh) | 2-氨基苯并噻唑化合物及使用方法 | |
| KR101812357B1 (ko) | Ｃｄｋ4/6의 억제제로서의 피롤로피리미딘 화합물 | |
| EP3768668A1 (en) | Shp2 phosphatase inhibitors and methods of use thereof | |
| JP2017518326A5 (enExample) | ||
| HRP20160649T1 (hr) | Novi derivati tienopirimidina, postupci za njihovo pripremanje i njihova terapeutska uporaba | |
| JP2015521600A5 (enExample) | ||
| CA2687035A1 (en) | Amino-heterocyclic compounds | |
| HRP20151442T1 (hr) | Spojevi heteroaril piridona i aza-piridona kao inhibitori btk-djelovanja | |
| JP2011511034A5 (enExample) | ||
| JP2015537010A5 (enExample) | ||
| RU2015122895A (ru) | Пуриновые ингибиторы человеческой фосфатидилинозит 3-киназы дельта | |
| JP2017505327A5 (enExample) | ||
| JP2015504057A5 (enExample) | ||
| KR20120102724A (ko) | 신규한 트리사이클릭 화합물 | |
| JP2021504380A5 (enExample) | ||
| JPWO2019156987A5 (enExample) | ||
| WO2025230862A1 (en) | Macrocyclic amino compounds as modulators of kras and uses therof | |
| WO2025230878A1 (en) | Macrocyclic compounds as modulators of kras and uses thereof | |
| WO2025194057A1 (en) | Macrocyclic compounds as modulators of kras and uses thereof | |
| CN117897159A (zh) | 杂环化合物及使用方法 |