JP2015533810A5 - - Google Patents
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- JP2015533810A5 JP2015533810A5 JP2015533142A JP2015533142A JP2015533810A5 JP 2015533810 A5 JP2015533810 A5 JP 2015533810A5 JP 2015533142 A JP2015533142 A JP 2015533142A JP 2015533142 A JP2015533142 A JP 2015533142A JP 2015533810 A5 JP2015533810 A5 JP 2015533810A5
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- 150000001875 compounds Chemical class 0.000 claims description 54
- 150000003839 salts Chemical class 0.000 claims description 49
- VVVLTGMSHYUYEA-UHFFFAOYSA-N 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]acetic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NCC(O)=O)=C1 VVVLTGMSHYUYEA-UHFFFAOYSA-N 0.000 claims description 5
- JSESMWCLQOOOCY-UHFFFAOYSA-N 2-(4-methoxyphenyl)-n-(2,4,6-trimethoxyphenyl)ethanesulfonamide Chemical compound C1=CC(OC)=CC=C1CCS(=O)(=O)NC1=C(OC)C=C(OC)C=C1OC JSESMWCLQOOOCY-UHFFFAOYSA-N 0.000 claims description 4
- CHFLIEPNRSVIAP-UHFFFAOYSA-N 4-[2-(3,4-dimethoxyphenyl)ethylsulfanylmethyl]-2-methoxyphenol Chemical compound C1=C(OC)C(OC)=CC=C1CCSCC1=CC=C(O)C(OC)=C1 CHFLIEPNRSVIAP-UHFFFAOYSA-N 0.000 claims description 4
- UQCUBWLMEBNQAC-UHFFFAOYSA-N 4-[2-(3,4-dimethoxyphenyl)ethylsulfonylmethyl]-2-methoxyphenol Chemical compound C1=C(OC)C(OC)=CC=C1CCS(=O)(=O)CC1=CC=C(O)C(OC)=C1 UQCUBWLMEBNQAC-UHFFFAOYSA-N 0.000 claims description 4
- WJKRZBLORMSJFD-UHFFFAOYSA-N 4-methoxy-3-nitro-n-[2-(2,4,6-trimethoxyphenyl)ethyl]benzenesulfonamide Chemical compound COC1=CC(OC)=CC(OC)=C1CCNS(=O)(=O)C1=CC=C(OC)C([N+]([O-])=O)=C1 WJKRZBLORMSJFD-UHFFFAOYSA-N 0.000 claims description 4
- ACLZWBAKRRRYCE-UHFFFAOYSA-N 4-methoxy-n-[2-(2,4,6-trimethoxyphenyl)ethyl]benzenesulfonamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)NCCC1=C(OC)C=C(OC)C=C1OC ACLZWBAKRRRYCE-UHFFFAOYSA-N 0.000 claims description 4
- RELMLWSUAWYQCN-UHFFFAOYSA-N 4-methoxy-n-[2-(4-methoxyphenyl)ethyl]-3-nitrobenzenesulfonamide Chemical compound C1=CC(OC)=CC=C1CCNS(=O)(=O)C1=CC=C(OC)C([N+]([O-])=O)=C1 RELMLWSUAWYQCN-UHFFFAOYSA-N 0.000 claims description 4
- OBJJVDWZGCVDCO-UHFFFAOYSA-N 4-methoxy-n-[2-(4-methoxyphenyl)ethyl]benzenesulfonamide Chemical compound C1=CC(OC)=CC=C1CCNS(=O)(=O)C1=CC=C(OC)C=C1 OBJJVDWZGCVDCO-UHFFFAOYSA-N 0.000 claims description 4
- HKDHSJXMJYCZCI-UHFFFAOYSA-N 4-methyl-n-[2-(2,4,6-trimethoxyphenyl)ethyl]benzenesulfonamide Chemical compound COC1=CC(OC)=CC(OC)=C1CCNS(=O)(=O)C1=CC=C(C)C=C1 HKDHSJXMJYCZCI-UHFFFAOYSA-N 0.000 claims description 4
- QIAINPANZBVSKL-UHFFFAOYSA-N n-[2-(4-methoxyphenyl)ethyl]-4-methylbenzenesulfonamide Chemical compound C1=CC(OC)=CC=C1CCNS(=O)(=O)C1=CC=C(C)C=C1 QIAINPANZBVSKL-UHFFFAOYSA-N 0.000 claims description 4
- HEWJRHOJRHHIMM-UHFFFAOYSA-N 1,3,5-trimethoxy-2-[2-[(4-methoxyphenyl)methylsulfonyl]ethyl]benzene Chemical compound C1=CC(OC)=CC=C1CS(=O)(=O)CCC1=C(OC)C=C(OC)C=C1OC HEWJRHOJRHHIMM-UHFFFAOYSA-N 0.000 claims description 2
- VVNSAGFVOFCHEZ-UHFFFAOYSA-N 1-[2-[(4-chlorophenyl)methylsulfonyl]ethyl]-4-fluorobenzene Chemical compound C1=CC(F)=CC=C1CCS(=O)(=O)CC1=CC=C(Cl)C=C1 VVNSAGFVOFCHEZ-UHFFFAOYSA-N 0.000 claims description 2
- DZPCCAFPSYYZNT-UHFFFAOYSA-N 1-chloro-4-[2-(4-fluorophenyl)ethylsulfanylmethyl]benzene Chemical compound C1=CC(F)=CC=C1CCSCC1=CC=C(Cl)C=C1 DZPCCAFPSYYZNT-UHFFFAOYSA-N 0.000 claims description 2
- LOQFEVOQDUJSGR-UHFFFAOYSA-N 2-(4-chlorophenyl)-2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]acetic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C(O)=O)C=2C=CC(Cl)=CC=2)=C1 LOQFEVOQDUJSGR-UHFFFAOYSA-N 0.000 claims description 2
- ARELIXMFRBREQS-UHFFFAOYSA-N 2-(4-fluorophenyl)-2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]acetic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C(O)=O)C=2C=CC(F)=CC=2)=C1 ARELIXMFRBREQS-UHFFFAOYSA-N 0.000 claims description 2
- REMLYGMYCSCYPB-UHFFFAOYSA-N 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]-2-(1h-pyrrol-3-yl)acetic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C(O)=O)C2=CNC=C2)=C1 REMLYGMYCSCYPB-UHFFFAOYSA-N 0.000 claims description 2
- DZEPLHZROPFQIZ-UHFFFAOYSA-N 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]-2-methylpropanoic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C)(C)C(O)=O)=C1 DZEPLHZROPFQIZ-UHFFFAOYSA-N 0.000 claims description 2
- HOKGDMRTJJNKKF-UHFFFAOYSA-N 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]-2-phenylacetic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C(O)=O)C=2C=CC=CC=2)=C1 HOKGDMRTJJNKKF-UHFFFAOYSA-N 0.000 claims description 2
- ZYNDYVNREASBDG-UHFFFAOYSA-N 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]-3-phenylpropanoic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(CC=2C=CC=CC=2)C(O)=O)=C1 ZYNDYVNREASBDG-UHFFFAOYSA-N 0.000 claims description 2
- JDNQNGHPXHOJQU-UHFFFAOYSA-N 2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]propanoic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C)C(O)=O)=C1 JDNQNGHPXHOJQU-UHFFFAOYSA-N 0.000 claims description 2
- MLVWKTZLSNWMMB-UHFFFAOYSA-N 2-cyclopropyl-2-[2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]anilino]acetic acid Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(NC(C2CC2)C(O)=O)=C1 MLVWKTZLSNWMMB-UHFFFAOYSA-N 0.000 claims description 2
- ORLOIZRWYPMTFC-UHFFFAOYSA-N 2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]aniline Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(N)=C1 ORLOIZRWYPMTFC-UHFFFAOYSA-N 0.000 claims description 2
- AOLIEXFAJQTCRI-UHFFFAOYSA-N 2-methoxy-5-[2-(2,4,6-trimethoxyphenyl)ethylsulfonylmethyl]phenol Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)CC1=CC=C(OC)C(O)=C1 AOLIEXFAJQTCRI-UHFFFAOYSA-N 0.000 claims description 2
- BGGSAZMFBNCKFE-UHFFFAOYSA-N 4-[2-[(4-chlorophenyl)methylsulfonyl]ethyl]benzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1CCS(=O)(=O)CC1=CC=C(Cl)C=C1 BGGSAZMFBNCKFE-UHFFFAOYSA-N 0.000 claims description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 claims description 2
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 claims description 2
- FESUOBZSNMUXOP-UHFFFAOYSA-N n-(3-amino-4-methoxyphenyl)-2-(2,4,6-trimethoxyphenyl)ethanesulfonamide Chemical compound COC1=CC(OC)=CC(OC)=C1CCS(=O)(=O)NC1=CC=C(OC)C(N)=C1 FESUOBZSNMUXOP-UHFFFAOYSA-N 0.000 claims description 2
- ITWHXUWPAYKSEL-UHFFFAOYSA-N n-(3-amino-4-methoxyphenyl)-3-(2,4,6-trimethoxyphenyl)propanamide Chemical compound COC1=CC(OC)=CC(OC)=C1CCC(=O)NC1=CC=C(OC)C(N)=C1 ITWHXUWPAYKSEL-UHFFFAOYSA-N 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 13
- 239000011541 reaction mixture Substances 0.000 claims 12
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 229920006395 saturated elastomer Polymers 0.000 claims 9
- 125000001424 substituent group Chemical group 0.000 claims 8
- 239000003814 drug Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 125000002015 acyclic group Chemical group 0.000 claims 6
- 125000004122 cyclic group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 125000002837 carbocyclic group Chemical group 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 4
- 230000002062 proliferating effect Effects 0.000 claims 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 3
- 230000003796 beauty Effects 0.000 claims 3
- 229910052794 bromium Inorganic materials 0.000 claims 3
- 229910052801 chlorine Inorganic materials 0.000 claims 3
- 229910052740 iodine Inorganic materials 0.000 claims 3
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000005239 aroylamino group Chemical group 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- -1 cyano, carboxy Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 1
- CSXHUONYHRDYGM-UHFFFAOYSA-N 2-(hydroxyamino)-2-oxoacetic acid Chemical compound ONC(=O)C(O)=O CSXHUONYHRDYGM-UHFFFAOYSA-N 0.000 claims 1
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 241000255925 Diptera Species 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 241001553014 Myrsine salicina Species 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000001246 bromo group Chemical group Br* 0.000 claims 1
- 150000003857 carboxamides Chemical class 0.000 claims 1
- 150000001767 cationic compounds Chemical class 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 150000002892 organic cations Chemical class 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- JRTAMQDKIGNMEI-UHFFFAOYSA-N 4-methoxy-3-nitro-n-[2-(2,4,6-trimethoxyphenyl)ethyl]benzamide Chemical compound COC1=CC(OC)=CC(OC)=C1CCNC(=O)C1=CC=C(OC)C([N+]([O-])=O)=C1 JRTAMQDKIGNMEI-UHFFFAOYSA-N 0.000 description 2
- PXESUFRTUNJEIN-UHFFFAOYSA-N 4-methoxy-n-[2-(2,4,6-trimethoxyphenyl)ethyl]benzamide Chemical compound C1=CC(OC)=CC=C1C(=O)NCCC1=C(OC)C=C(OC)C=C1OC PXESUFRTUNJEIN-UHFFFAOYSA-N 0.000 description 2
- PVVVTRASHPXKOI-UHFFFAOYSA-N 4-methoxy-n-[2-(4-methoxyphenyl)ethyl]-3-nitrobenzamide Chemical compound C1=CC(OC)=CC=C1CCNC(=O)C1=CC=C(OC)C([N+]([O-])=O)=C1 PVVVTRASHPXKOI-UHFFFAOYSA-N 0.000 description 2
- LLRIWSIYZIKQEN-UHFFFAOYSA-N 4-methoxy-n-[2-(4-methoxyphenyl)ethyl]benzamide Chemical compound C1=CC(OC)=CC=C1CCNC(=O)C1=CC=C(OC)C=C1 LLRIWSIYZIKQEN-UHFFFAOYSA-N 0.000 description 2
- 0 *C(*)C(*)NS(*)(=O)=O Chemical compound *C(*)C(*)NS(*)(=O)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261703368P | 2012-09-20 | 2012-09-20 | |
| US61/703,368 | 2012-09-20 | ||
| PCT/US2013/060294 WO2014047110A2 (en) | 2012-09-20 | 2013-09-18 | Substituted alkyl diaryl derivatives, methods of preparation and uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533810A JP2015533810A (ja) | 2015-11-26 |
| JP2015533810A5 true JP2015533810A5 (cg-RX-API-DMAC7.html) | 2016-11-04 |
| JP6348904B2 JP6348904B2 (ja) | 2018-06-27 |
Family
ID=50342061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015533142A Active JP6348904B2 (ja) | 2012-09-20 | 2013-09-18 | 置換アルキルジアリール誘導体、その製造方法及び使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10207989B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2897599B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6348904B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101992929B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN110776447A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2013318206B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2885217C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2863538T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL237699B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014047110A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| KR20130056244A (ko) | 2010-04-22 | 2013-05-29 | 버텍스 파마슈티칼스 인코포레이티드 | 시클로알킬카르복스아미도-인돌 화합물의 제조 방법 |
| ES2885181T3 (es) | 2014-04-15 | 2021-12-13 | Vertex Pharma | Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística |
| CN105085436B (zh) | 2014-04-19 | 2019-08-16 | 广东东阳光药业有限公司 | 磺酰胺类衍生物及其在药物上的应用 |
| JP6768662B2 (ja) * | 2014-12-16 | 2020-10-14 | グルソックス・バイオテック・アーベー | Ｎａｄｐｈオキシダーゼに関連する状態の処置に使用するための化合物 |
| WO2017023912A1 (en) | 2015-08-03 | 2017-02-09 | Temple University - Of The Commonwealth System Of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
| CA3099093A1 (en) | 2018-05-09 | 2019-11-14 | Glucox Biotech Ab | Novel sulfonamide derivatives having selective nox inhibiting activity |
| PT4069691T (pt) | 2019-12-06 | 2024-12-18 | Vertex Pharma | Tetrahidrofuranos substituídos como moduladores dos canais de sódio |
| JP7785005B2 (ja) | 2020-01-31 | 2025-12-12 | レズメド センサー テクノロジーズ リミテッド | 無呼吸－低呼吸指数計算のための睡眠状態検出 |
| GEAP202416430A (en) | 2021-06-04 | 2024-03-25 | Vertex Pharma | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
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|---|---|---|---|---|
| DE3000377A1 (de) * | 1980-01-07 | 1981-07-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| US5142056A (en) | 1989-05-23 | 1992-08-25 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| GB8311678D0 (en) * | 1983-04-28 | 1983-06-02 | Ici Plc | Phenol derivatives |
| US5070099A (en) | 1988-10-31 | 1991-12-03 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use |
| JP3660395B2 (ja) | 1995-06-22 | 2005-06-15 | 大鵬薬品工業株式会社 | フェニルスルホン誘導体及びその製造方法 |
| GB9717576D0 (en) | 1997-08-19 | 1997-10-22 | Xenova Ltd | Pharmaceutical compounds |
| US6548553B2 (en) | 1997-10-03 | 2003-04-15 | Temple University-Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
| US6359013B1 (en) | 1997-10-03 | 2002-03-19 | Temple University-Of The Commonwealth System Of Higher Education | Styryl sulfone anticancer agents |
| US6201154B1 (en) | 1999-03-31 | 2001-03-13 | Temple University-Of The Commonwealth Of Higher Education | Z-styryl sulfone anticancer agents |
| US6762207B1 (en) | 1999-04-02 | 2004-07-13 | Temple University - Of The Commonwealth System Of Higher Education | (E)-styryl sulfone anticancer agents |
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| US6767926B1 (en) | 1999-10-12 | 2004-07-27 | Temple University - Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
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| US6486210B2 (en) | 2000-04-14 | 2002-11-26 | Temple University—Of the Commonwealth System of Higher Education | Substituted styryl benzylsulfones for treating proliferative disorders |
| CA2424884C (en) | 2000-10-05 | 2009-12-15 | E. Premkumar Reddy | Substituted (e)-styryl benzylsulfones for treating proliferative disorders |
| WO2002067913A1 (en) | 2001-02-27 | 2002-09-06 | Temple University-Of The Commonwealth System Of Higher Education | (z)-styrylbenzylsulfones and pharmaceutical uses thereof |
| JP4302986B2 (ja) | 2001-02-28 | 2009-07-29 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 細胞及び組織をα，β不飽和アリールスルホンにより電離放射線から防護する方法 |
| EP1379508B9 (en) | 2001-02-28 | 2011-02-09 | Temple University - Of The Commonwealth System of Higher Education | N-(aryl)-2-arylethenesulfonamides and therapeutic uses thereof |
| IL163608A0 (en) | 2002-02-28 | 2005-12-18 | Univ Temple | Amino-substituted sulfonanilides and derivatives thereof for treating proliferative disorders |
| US7598232B2 (en) | 2002-02-28 | 2009-10-06 | Temple University - Of The Commonwealth System Of Higher Education | Amino-substituted (E)-2,6-dialkoxystyryl 4-substituted-benzylsulfones for treating proliferative disorders |
| EP1539675B1 (en) | 2002-08-29 | 2013-11-06 | Temple University - Of The Commonwealth System of Higher Education | Aryl and heteroaryl propene amides, derivatives thereof and therapeutic uses thereof |
| AU2003282726B2 (en) | 2002-10-03 | 2010-10-07 | Targegen, Inc. | Vasculostatic agents and methods of use thereof |
| DK1689706T3 (da) | 2003-11-14 | 2017-04-03 | Temple Univ - Of The Commonwealth System Of Higher Education | Alfa, beta-umættede sulfoxider til behandling af proliferative forstyrrelser |
| US7932242B2 (en) | 2004-03-16 | 2011-04-26 | Temple University - Of The Commonwealth System Of Higher Education | Substituted phenoxy-and phenylthio-derivatives for treating proliferative disorders |
| CA2569705A1 (en) | 2004-06-08 | 2005-12-29 | Temple University - Of The Commonwealth System Of Higher Education | Heteroaryl sulfones and sulfonamides and therapeutic uses thereof |
| ATE529106T1 (de) | 2004-06-24 | 2011-11-15 | Univ Temple | Alpha-, beta-ungesättigte sulfone, sulfonoxide, sulfonimide, sulfinimide, acylsulfonamide und acylsulfinamide und therapeutische verwendungen damit |
| AU2006204103B2 (en) | 2005-01-05 | 2011-11-24 | Temple University Of The Commonwealth System Of Higher Education | Treatment of drug-resistant proliferative disorders |
| EP1896401B1 (en) * | 2005-02-25 | 2013-04-10 | Temple University - Of The Commonwealth System of Higher Education | Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis |
| WO2006104668A2 (en) | 2005-03-11 | 2006-10-05 | Temple University - Of The Commonwealth System Of Higher Education | Composition and methods for the treatment of proliferative diseases |
| US7691858B2 (en) | 2006-04-25 | 2010-04-06 | Targegen, Inc. | Kinase inhibitors and methods of use thereof |
| US8664272B2 (en) | 2006-08-30 | 2014-03-04 | Temple University—Of the Commonwealth System of Higher Education | Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
| CL2007003591A1 (es) | 2006-12-12 | 2008-02-29 | Wyeth Corp | Compuestos derivados de sulfonamida ciclicos, inhibidores de retoma de monoamina; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento o prevencion de disfuncion sexual, trastorno gastrointestinal, trastorno genitourinari |
| CL2007003874A1 (es) | 2007-01-03 | 2008-05-16 | Boehringer Ingelheim Int | Compuestos derivados de benzamida; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades cardiovasculares, hipertension, aterosclerosis, reestenosis, ictus, insuficiencia cardiaca, lesion isquemica, hipertensio |
| WO2009009041A2 (en) | 2007-07-06 | 2009-01-15 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
| CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2009126551A2 (en) | 2008-04-10 | 2009-10-15 | The Uab Research Foundation | Bis-aromatic anticancer agents |
| TWI403319B (zh) | 2008-07-03 | 2013-08-01 | Panmira Pharmaceuticals Llc | 前列腺素ｄ2受體之雜烷基拮抗劑 |
| EP2226329B1 (en) | 2009-03-02 | 2013-07-10 | Ruhr-Universität Bochum | Metal-containing platensimycin analogues |
| GB0908293D0 (en) | 2009-05-14 | 2009-06-24 | Syngenta Ltd | Herbicidal compounds |
-
2013
- 2013-09-18 WO PCT/US2013/060294 patent/WO2014047110A2/en not_active Ceased
- 2013-09-18 CA CA2885217A patent/CA2885217C/en active Active
- 2013-09-18 AU AU2013318206A patent/AU2013318206B2/en active Active
- 2013-09-18 US US14/429,223 patent/US10207989B2/en active Active
- 2013-09-18 CN CN201910975554.6A patent/CN110776447A/zh active Pending
- 2013-09-18 CN CN201380056016.8A patent/CN104812382A/zh active Pending
- 2013-09-18 JP JP2015533142A patent/JP6348904B2/ja active Active
- 2013-09-18 EP EP13839254.3A patent/EP2897599B1/en not_active Not-in-force
- 2013-09-18 KR KR1020157010016A patent/KR101992929B1/ko active Active
- 2013-09-18 ES ES13839254T patent/ES2863538T3/es active Active
-
2015
- 2015-03-12 IL IL237699A patent/IL237699B/en active IP Right Grant
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