JP2015533794A - 酸化ストレス障害を処置するためのベンゾキノン誘導体 - Google Patents
酸化ストレス障害を処置するためのベンゾキノン誘導体 Download PDFInfo
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- JP2015533794A JP2015533794A JP2015531266A JP2015531266A JP2015533794A JP 2015533794 A JP2015533794 A JP 2015533794A JP 2015531266 A JP2015531266 A JP 2015531266A JP 2015531266 A JP2015531266 A JP 2015531266A JP 2015533794 A JP2015533794 A JP 2015533794A
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- oxidative stress
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C66/00—Quinone carboxylic acids
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261698431P | 2012-09-07 | 2012-09-07 | |
| US61/698,431 | 2012-09-07 | ||
| US201361792797P | 2013-03-15 | 2013-03-15 | |
| US61/792,797 | 2013-03-15 | ||
| PCT/US2013/058637 WO2014039917A1 (en) | 2012-09-07 | 2013-09-06 | Benzoquinone derivatives for treating oxidative stress disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015533794A true JP2015533794A (ja) | 2015-11-26 |
| JP2015533794A5 JP2015533794A5 (enExample) | 2016-10-27 |
Family
ID=49170942
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531266A Ceased JP2015533794A (ja) | 2012-09-07 | 2013-09-06 | 酸化ストレス障害を処置するためのベンゾキノン誘導体 |
| JP2015531249A Expired - Fee Related JP6393684B2 (ja) | 2012-09-07 | 2013-09-06 | 個体のレドックス状態の調節において使用するためのキノン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531249A Expired - Fee Related JP6393684B2 (ja) | 2012-09-07 | 2013-09-06 | 個体のレドックス状態の調節において使用するためのキノン誘導体 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US9629815B2 (enExample) |
| EP (2) | EP2892516A1 (enExample) |
| JP (2) | JP2015533794A (enExample) |
| CA (2) | CA2883879A1 (enExample) |
| HK (1) | HK1211872A1 (enExample) |
| WO (2) | WO2014039917A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019504018A (ja) * | 2015-12-17 | 2019-02-14 | バイオエレクトロン テクノロジー コーポレイション | 酸化ストレス障害を処置するためのフルオロアルキル、フルオロアルコキシ、フェノキシ、ヘテロアリールオキシ、アルコキシ、およびアミノ1,4−ベンゾキノン誘導体 |
| JPWO2022030606A1 (enExample) * | 2020-08-07 | 2022-02-10 |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2610152C (en) | 2005-06-01 | 2018-04-10 | Edison Pharmaceuticals, Inc. | Redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| EA019675B1 (ru) | 2006-02-22 | 2014-05-30 | Эдисон Фармасьютикалз, Инк. | Редокс-активные терапевтические средства для лечения митохондриальных заболеваний и модуляции биомаркера коэнзима q |
| EP3018122B1 (en) | 2007-11-06 | 2018-10-10 | BioElectron Technology Corporation | 4-(p-quinonyl)-2-hydroxybutanamide derivatives for treatment of mitochondrial diseases |
| CA2708961C (en) | 2008-01-08 | 2017-03-28 | Ptc Therapeutics, Inc. | (het)aryl-p-quinone derivatives for treatment of mitochondrial diseases |
| WO2009111576A2 (en) | 2008-03-05 | 2009-09-11 | Edison Pharmaceuticals, Inc. | 2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES |
| BRPI0918139B1 (pt) | 2008-09-10 | 2024-04-30 | Ptc Therapeutics, Inc | Composição, alimento medicinal ou funcional, suplemento alimentar ou dietético para tratamento de distúrbios de desenvolvimento pervasivos com terapêuticos redox-ativos |
| CN102264730B (zh) | 2008-10-28 | 2016-04-13 | 爱迪生药物公司 | 用于生产生育三烯酚及衍生物的方法 |
| JP2012525399A (ja) | 2009-04-28 | 2012-10-22 | エジソン ファーマシューティカルズ, インコーポレイテッド | トコトリエノールキノンを用いる、レーバー遺伝性視神経症および優性遺伝性視神経萎縮症の治療 |
| WO2012174286A1 (en) | 2011-06-14 | 2012-12-20 | Edison Pharmaceuticals, Inc. | Catechol derivatives for treatment of oxidative stress diseases |
| JP2014520894A (ja) | 2011-07-19 | 2014-08-25 | エジソン ファーマシューティカルズ, インコーポレイテッド | 非アルファトコトリエノールの存在下でのアルファトコトリエノールの選択的酸化のための方法 |
| CA2883879A1 (en) * | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Quinone derivatives for use in the modulation of redox status of individuals |
| CA2906145A1 (en) | 2013-03-15 | 2014-09-18 | Ptc Therapeutics, Inc. | Alkyl-heteroaryl substituted quinone derivatives for treatment of oxidative stress disorders |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| US20160115141A1 (en) | 2013-05-31 | 2016-04-28 | Edison Pharmaceuticals, Inc. | Carboxylic acid derivatives for treatment of oxidative stress disorders |
| WO2015183963A2 (en) * | 2014-05-28 | 2015-12-03 | Stealth Peptides International, Inc. | Therapeutic compositions including redox-active parabenzoquinones and uses thereof |
| WO2016100579A1 (en) | 2014-12-16 | 2016-06-23 | Edison Pharmaceuticals, Inc., | Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide |
| US11267777B2 (en) | 2015-11-19 | 2022-03-08 | Concert Pharmaceuticals, Inc. | Deuterated EPI-743 |
| WO2017106786A1 (en) | 2015-12-16 | 2017-06-22 | Bioelectron Technology Corporation | Improved methods for enriching alpha-tocotrienol from mixed tocol compositions |
| WO2017123820A1 (en) * | 2016-01-12 | 2017-07-20 | Bioelectron Technology Corporation | Methods for diagnosing and treating oxidative stress disorders using biomarkers |
| US10707531B1 (en) | 2016-09-27 | 2020-07-07 | New Dominion Enterprises Inc. | All-inorganic solvents for electrolytes |
| JP2018083799A (ja) | 2016-11-15 | 2018-05-31 | バイオエレクトロン テクノロジー コーポレイション | 2−置換アミノ−ナフト[1,2−d]イミダゾール−5−オン化合物またはその製薬学上許容される塩 |
| WO2018129411A1 (en) | 2017-01-06 | 2018-07-12 | Bioelectron Technology Corporation | Aryl- and heteroaryl-resorufin derivatives for treatment of oxidative stress disorders and liver and kidney disorders |
| JP7586815B2 (ja) | 2018-10-17 | 2024-11-19 | ピーティーシー セラピューティクス, インコーポレイテッド | α-シヌクレイノパチー、タウオパチー、および他の障害を抑制および処置するための2,3,5-トリメチル-6-ノニルシクロヘキサ-2,5-ジエン-1,4-ジオン |
| WO2020252414A1 (en) | 2019-06-13 | 2020-12-17 | Ptc Therapeutics, Inc. | Naphthoquinone derivatives for treatment of oxidative stress disorders |
| IL291898A (en) | 2019-10-04 | 2022-06-01 | Stealth Biotherapeutics Inc | Quinone-, hydroquinone- and naphthoquinone-analogues of vatiquinone for treatment of mitochondrial disorder diseases |
| WO2021202986A1 (en) | 2020-04-03 | 2021-10-07 | Stealth Biotherapeutics Corp | Compositions and methods for the prevention and/or treatment of mitochondrial disease, including friedreich's ataxia |
| CN118175991A (zh) | 2021-07-08 | 2024-06-11 | Ptc医疗公司 | 包含2,3,5-三甲基-6-壬基环己-2,5-二烯-1,4-二酮的药物组合物 |
| US20250312360A1 (en) * | 2022-05-13 | 2025-10-09 | Virginia Tech Intellectual Properties, Inc. | Mitochondrial antioxidant treatment for cask-linked neurodevelopmental disorders |
| EP4727532A1 (en) * | 2023-06-16 | 2026-04-22 | PTC Therapeutics, Inc. | Methods for increasing vatiquinone plasma exposure with food |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57109739A (en) * | 1980-12-27 | 1982-07-08 | Takeda Chem Ind Ltd | Quinone compound and its preparation |
| JPS5910541A (ja) * | 1982-07-09 | 1984-01-20 | Takeda Chem Ind Ltd | キノン化合物 |
| JPS6143132A (ja) * | 1984-08-06 | 1986-03-01 | Takeda Chem Ind Ltd | キノン誘導体,その製造法およびそれを含んでなる医薬組成物 |
| US6133322A (en) * | 1998-10-29 | 2000-10-17 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Quinone derivatives for treating or preventing diseases associated with iron overload |
| JP2009527567A (ja) * | 2006-02-22 | 2009-07-30 | エジソン ファーマシューティカルズ, インコーポレイテッド | ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節 |
| JP2011503005A (ja) * | 2007-11-06 | 2011-01-27 | エジソン ファーマシューティカルズ, インコーポレイテッド | ミトコンドリア病を治療するための4−(p−キノリル)−2−ヒドロキシブタンアミド誘導体 |
| WO2012019032A1 (en) * | 2010-08-06 | 2012-02-09 | Ampere Life Sciences, Inc. | Treatment of mitochondrial diseases with vitamin k |
| WO2012019029A2 (en) * | 2010-08-06 | 2012-02-09 | Edison Pharmaceuticals, Inc. | Treatment of mitochondrial diseases with naphthoquinones |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5621021B2 (enExample) | 1973-12-19 | 1981-05-16 | ||
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- 2013-09-06 EP EP13762705.5A patent/EP2892515A1/en not_active Withdrawn
- 2013-09-06 JP JP2015531266A patent/JP2015533794A/ja not_active Ceased
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019504018A (ja) * | 2015-12-17 | 2019-02-14 | バイオエレクトロン テクノロジー コーポレイション | 酸化ストレス障害を処置するためのフルオロアルキル、フルオロアルコキシ、フェノキシ、ヘテロアリールオキシ、アルコキシ、およびアミノ1,4−ベンゾキノン誘導体 |
| JPWO2022030606A1 (enExample) * | 2020-08-07 | 2022-02-10 | ||
| JP7109705B2 (ja) | 2020-08-07 | 2022-07-29 | 大鵬薬品工業株式会社 | 新規なシクロアルケノン化合物又はその塩 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6393684B2 (ja) | 2018-09-19 |
| WO2014039917A1 (en) | 2014-03-13 |
| CA2883882A1 (en) | 2014-03-13 |
| JP2015527400A (ja) | 2015-09-17 |
| US20170209393A1 (en) | 2017-07-27 |
| US9629815B2 (en) | 2017-04-25 |
| US20150218079A1 (en) | 2015-08-06 |
| EP2892515A1 (en) | 2015-07-15 |
| US20150216820A1 (en) | 2015-08-06 |
| HK1211872A1 (en) | 2016-06-03 |
| EP2892516A1 (en) | 2015-07-15 |
| CA2883879A1 (en) | 2014-03-13 |
| WO2014039862A1 (en) | 2014-03-13 |
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