JP2015533490A5 - - Google Patents
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- Publication number
- JP2015533490A5 JP2015533490A5 JP2015532046A JP2015532046A JP2015533490A5 JP 2015533490 A5 JP2015533490 A5 JP 2015533490A5 JP 2015532046 A JP2015532046 A JP 2015532046A JP 2015532046 A JP2015532046 A JP 2015532046A JP 2015533490 A5 JP2015533490 A5 JP 2015533490A5
- Authority
- JP
- Japan
- Prior art keywords
- binding polypeptide
- residue
- glycan
- domain
- numbering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229920001184 polypeptide Polymers 0.000 claims 20
- 102000004196 processed proteins & peptides Human genes 0.000 claims 20
- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- 150000004676 glycans Chemical class 0.000 claims 11
- 239000012636 effector Substances 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 235000001014 amino acid Nutrition 0.000 claims 8
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 6
- 125000005647 linker group Chemical group 0.000 claims 5
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 4
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 4
- 108091033319 polynucleotide Proteins 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 125000005629 sialic acid group Chemical group 0.000 claims 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 3
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- 231100000599 cytotoxic agent Toxicity 0.000 claims 3
- 239000002619 cytotoxin Substances 0.000 claims 3
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
- 101710112752 Cytotoxin Proteins 0.000 claims 2
- 102000009490 IgG Receptors Human genes 0.000 claims 2
- 108010073807 IgG Receptors Proteins 0.000 claims 2
- 125000003172 aldehyde group Chemical group 0.000 claims 2
- 239000000611 antibody drug conjugate Substances 0.000 claims 2
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000013595 glycosylation Effects 0.000 claims 2
- 238000006206 glycosylation reaction Methods 0.000 claims 2
- 150000002923 oximes Chemical class 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- 102100029193 Low affinity immunoglobulin gamma Fc region receptor III-A Human genes 0.000 claims 1
- 101710099301 Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229930182830 galactose Chemical group 0.000 claims 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2012/003819 | 2012-09-12 | ||
| PCT/EP2012/003819 WO2013037484A2 (en) | 2011-09-12 | 2012-09-12 | Anti-aplhabetatcr antibody |
| US201361776715P | 2013-03-11 | 2013-03-11 | |
| US61/776,715 | 2013-03-11 | ||
| PCT/US2013/059481 WO2014043361A1 (en) | 2012-09-12 | 2013-09-12 | Fc containing polypeptides with altered glycosylation and reduced effector function |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533490A JP2015533490A (ja) | 2015-11-26 |
| JP2015533490A5 true JP2015533490A5 (cg-RX-API-DMAC7.html) | 2016-10-20 |
| JP6438397B2 JP6438397B2 (ja) | 2018-12-12 |
Family
ID=50278674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015532046A Active JP6438397B2 (ja) | 2012-09-12 | 2013-09-12 | 変更されたグリコシル化および低減されたエフェクター機能を有するＦｃ含有ポリペプチド |
Country Status (34)
Families Citing this family (42)
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| UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
| US9790268B2 (en) | 2012-09-12 | 2017-10-17 | Genzyme Corporation | Fc containing polypeptides with altered glycosylation and reduced effector function |
| WO2014164534A2 (en) | 2013-03-11 | 2014-10-09 | Genzyme Corporation | Site-specific antibody-drug conjugation through glycoengineering |
| RS64072B1 (sr) | 2014-03-19 | 2023-04-28 | Genzyme Corp | Mesto-specifični glikoinženjering ciljnih delova |
| CA2944539A1 (en) | 2014-04-08 | 2015-10-15 | University Of Georgia Research Foundation, Inc. | Site-specific antibody-drug glycoconjugates and methods |
| KR102451080B1 (ko) * | 2014-06-12 | 2022-10-06 | 씨에스피씨 메가리스 바이오파마슈티칼 씨오., 엘티디. | 효소적 방법을 통한 균일한 항체 약물 접합체 |
| PL3204425T3 (pl) * | 2014-10-09 | 2021-03-08 | Genzyme Corporation | Glikomodyfikowane koniugaty przeciwciał z lekami |
| TW202417497A (zh) | 2015-10-12 | 2024-05-01 | 美商再生元醫藥公司 | 活化瘦素受體的抗原結合蛋白 |
| EP3222292A1 (en) | 2016-03-03 | 2017-09-27 | Heidelberg Pharma GmbH | Amanitin conjugates |
| TW201815821A (zh) | 2016-07-18 | 2018-05-01 | 美商再生元醫藥公司 | 抗茲卡病毒抗體及使用方法 |
| KR102563568B1 (ko) | 2016-11-08 | 2023-08-04 | 리제너론 파마슈티칼스 인코포레이티드 | 렙틴 수용체에 길항하는 항원-결합 단백질 |
| WO2018107116A1 (en) * | 2016-12-09 | 2018-06-14 | Abbvie Stemcentrx Llc | Methods of reducing toxicity of antibody drug conjugates, and compositions produced thereby |
| GB201717446D0 (en) * | 2017-10-24 | 2017-12-06 | Evox Therapeutics Ltd | Affinity purification of engineering extracellular vesicles |
| CA3084385A1 (en) | 2017-12-18 | 2019-06-27 | Regeneron Pharmaceuticals, Inc. | Bispecific antigen binding molecules that bind leptin receptor and/or gp130, and methods of use thereof |
| EP4596043A3 (en) | 2018-04-06 | 2025-10-01 | Regeneron Pharmaceuticals, Inc. | A leptin receptor agonist antibody for use in increasing bone mass in a subject suffering from metabolic dysfunction or hypoleptinemia |
| JP1640846S (cg-RX-API-DMAC7.html) * | 2018-10-16 | 2019-09-09 | ||
| CA3110377A1 (en) | 2018-11-21 | 2020-05-28 | Regeneron Pharmaceuticals, Inc. | Anti-staphylococcus antibodies and uses thereof |
| US11666658B2 (en) | 2018-12-21 | 2023-06-06 | Regeneran Pharmaceuticals, Inc. | Rifamycin analogs and antibody-drug conjugates thereof |
| WO2020160242A1 (en) | 2019-02-01 | 2020-08-06 | Regeneron Pharmaceuticals, Inc. | Anti-il2 receptor gamma antigen-binding proteins |
| WO2020197400A1 (en) * | 2019-03-27 | 2020-10-01 | Umc Utrecht Holding B.V. | Engineered iga antibodies and methods of use |
| CN113939534B (zh) | 2019-04-03 | 2025-02-28 | 建新公司 | 具有降低的断裂的抗αβTCR结合多肽 |
| CA3182893A1 (en) | 2020-05-08 | 2021-11-11 | Regeneron Pharmaceuticals, Inc. | Vegf traps and mini-traps and methods for treating ocular disorders and cancer |
| KR20230069969A (ko) | 2020-09-15 | 2023-05-19 | 리제너론 파마슈티칼스 인코포레이티드 | 통증에 대한 lepr 아고니스트의 사용 |
| KR20220052098A (ko) | 2020-10-20 | 2022-04-27 | 주식회사 엘지에너지솔루션 | 마스킹 테이프를 이용한 전극 시편에 대한 물성 측정 시스템 및 이를 이용한 물성 측정 방법 |
| KR102576252B1 (ko) * | 2021-04-07 | 2023-09-11 | 아주대학교산학협력단 | 산화된 면역글로불린을 유효성분으로 포함하는 면역조절 기능 이상 관련 질환 예방 또는 치료용 약학적 조성물 |
| TW202325273A (zh) * | 2021-10-22 | 2023-07-01 | 美商杜夫特學院信託管理公司 | 靶向fap之中子捕獲劑及與其相關之用途及調配物 |
| EP4562041A2 (en) | 2022-07-29 | 2025-06-04 | Regeneron Pharmaceuticals, Inc. | Anti-tfr:payload fusions and methods of use thereof |
| IL318636A (en) | 2022-07-29 | 2025-03-01 | Regeneron Pharma | Viral particles retargeted to transferrin receptor 1 |
| EP4561636A1 (en) | 2022-07-29 | 2025-06-04 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle |
| US20240182561A1 (en) | 2022-11-04 | 2024-06-06 | Regeneron Pharmaceuticals, Inc. | Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle |
| EP4619438A2 (en) | 2022-11-14 | 2025-09-24 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes |
| CN120456916A (zh) | 2022-11-14 | 2025-08-08 | 瑞泽恩制药公司 | 抗fgfr3抗体和抗原结合片段及其使用方法 |
| WO2024259206A1 (en) | 2023-06-16 | 2024-12-19 | Regeneron Pharmaceuticals, Inc. | Cd40 x cd40 bispecific antigen-binding molecules and uses thereof |
| US20250049896A1 (en) | 2023-07-28 | 2025-02-13 | Regeneron Pharmaceuticals, Inc. | Anti-tfr:acid sphingomyelinase for treatment of acid sphingomyelinase deficiency |
| AR133385A1 (es) | 2023-07-28 | 2025-09-24 | Regeneron Pharma | Inserción anti-tfr:gaa y anti-cd63:gaa para el tratamiento de la enfermedad de pompe |
| US20250154262A1 (en) | 2023-10-25 | 2025-05-15 | Ablynx N.V. | Fc DOMAIN VARIANTS WITH ENHANCED Fc RECEPTOR BINDING |
| WO2025099632A1 (en) | 2023-11-08 | 2025-05-15 | Sanofi | Cd25 based lysosomal degrader and uses thereof |
| WO2025160340A2 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Combination immunosuppression for inhibiting an immune response and enabling immunogen administration and re-administration |
| US20250242056A1 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for using plasma cell depleting agents and/or b cell depleting agents to suppress host anti-aav antibody response and enable aav transduction and re-dosing |
| US20250277048A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | The use of cd40 inhibitors for inhibiting an immune response and enabling immunogen administration and re-administration |
| WO2025184567A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response |
| EP4616869A1 (en) * | 2024-03-15 | 2025-09-17 | Oncomatryx Biopharma, S.L. | Fap targeted antibody-drug conjugates |
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2013
- 2013-09-12 SG SG10201701831VA patent/SG10201701831VA/en unknown
- 2013-09-12 KR KR1020157009038A patent/KR102185151B1/ko active Active
- 2013-09-12 MA MA37949A patent/MA37949B1/fr unknown
- 2013-09-12 LT LTEP18166377.4T patent/LT3366705T/lt unknown
- 2013-09-12 EA EA201590545A patent/EA035987B1/ru unknown
- 2013-09-12 MX MX2015003234A patent/MX366103B/es active IP Right Grant
- 2013-09-12 CN CN201910721123.7A patent/CN110590953A/zh active Pending
- 2013-09-12 MY MYPI2015000513A patent/MY170126A/en unknown
- 2013-09-12 DK DK18166377.4T patent/DK3366705T5/da active
- 2013-09-12 EA EA202091166A patent/EA202091166A1/ru unknown
- 2013-09-12 DK DK13766833.1T patent/DK2895513T3/en active
- 2013-09-12 HU HUE18166377A patent/HUE062876T2/hu unknown
- 2013-09-12 ES ES13766833.1T patent/ES2684549T3/es active Active
- 2013-09-12 NZ NZ705983A patent/NZ705983A/en unknown
- 2013-09-12 WO PCT/US2013/059481 patent/WO2014043361A1/en not_active Ceased
- 2013-09-12 HU HUE13766833A patent/HUE039337T2/hu unknown
- 2013-09-12 RS RS20180981A patent/RS57748B1/sr unknown
- 2013-09-12 CA CA2884762A patent/CA2884762C/en active Active
- 2013-09-12 RS RS20230536A patent/RS64317B1/sr unknown
- 2013-09-12 SI SI201331144T patent/SI2895513T1/sl unknown
- 2013-09-12 EP EP13766833.1A patent/EP2895513B1/en active Active
- 2013-09-12 CN CN201380058863.8A patent/CN104797601B/zh active Active
- 2013-09-12 JP JP2015532046A patent/JP6438397B2/ja active Active
- 2013-09-12 ES ES18166377T patent/ES2950509T3/es active Active
- 2013-09-12 HR HRP20181354TT patent/HRP20181354T1/hr unknown
- 2013-09-12 SI SI201332053T patent/SI3366705T1/sl unknown
- 2013-09-12 PT PT181663774T patent/PT3366705T/pt unknown
- 2013-09-12 KR KR1020207033737A patent/KR102426488B1/ko active Active
- 2013-09-12 PL PL13766833T patent/PL2895513T3/pl unknown
- 2013-09-12 SG SG11201501521TA patent/SG11201501521TA/en unknown
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- 2013-09-12 FI FIEP18166377.4T patent/FI3366705T3/fi active
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