JP2015533154A5 - - Google Patents
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- Publication number
- JP2015533154A5 JP2015533154A5 JP2015536220A JP2015536220A JP2015533154A5 JP 2015533154 A5 JP2015533154 A5 JP 2015533154A5 JP 2015536220 A JP2015536220 A JP 2015536220A JP 2015536220 A JP2015536220 A JP 2015536220A JP 2015533154 A5 JP2015533154 A5 JP 2015533154A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound according
- acyclic
- lower alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000002015 acyclic group Chemical group 0.000 claims description 9
- 125000003342 alkenyl group Chemical group 0.000 claims description 6
- 125000004122 cyclic group Chemical group 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims 21
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 229920006395 saturated elastomer Polymers 0.000 claims 8
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000003710 aryl alkyl group Chemical group 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000001624 naphthyl group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 150000002148 esters Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 229940098113 Transglutaminase inhibitor Drugs 0.000 claims 2
- 150000001350 alkyl halides Chemical class 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000007536 Thrombosis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 208000037976 chronic inflammation Diseases 0.000 claims 1
- 208000037893 chronic inflammatory disorder Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000037390 scarring Effects 0.000 claims 1
- 0 *C(C(N(CC1)CCN1I)=O)N* Chemical compound *C(C(N(CC1)CCN1I)=O)N* 0.000 description 1
- 125000003358 C2-C20 alkenyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1218084.0A GB201218084D0 (en) | 2012-10-09 | 2012-10-09 | Novel compounds and methods for use in medicine |
| GB1218084.0 | 2012-10-09 | ||
| PCT/GB2013/052631 WO2014057266A1 (en) | 2012-10-09 | 2013-10-09 | Acylpiperazines as inhibitors of transglutaminase and their use in medicine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015533154A JP2015533154A (ja) | 2015-11-19 |
| JP2015533154A5 true JP2015533154A5 (enExample) | 2017-03-16 |
| JP6138950B2 JP6138950B2 (ja) | 2017-05-31 |
Family
ID=47294510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536220A Active JP6138950B2 (ja) | 2012-10-09 | 2013-10-09 | 新規化合物及び医薬における使用法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9656978B2 (enExample) |
| EP (1) | EP2906543B1 (enExample) |
| JP (1) | JP6138950B2 (enExample) |
| CN (1) | CN104837821B (enExample) |
| GB (1) | GB201218084D0 (enExample) |
| WO (1) | WO2014057266A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201218084D0 (en) | 2012-10-09 | 2012-11-21 | Univ Aston | Novel compounds and methods for use in medicine |
| EP3607948A1 (en) | 2018-08-07 | 2020-02-12 | Aarhus Universitet | Tissue transglutaminase modulators for medicinal use |
| WO2022213198A1 (en) * | 2021-04-08 | 2022-10-13 | University Of Ottawa | Arylacetyl inhibitors of tg2 and uses thereof |
| WO2023135425A1 (en) * | 2022-01-13 | 2023-07-20 | Aston University | Inhibitors of transglutaminase |
| GB202310246D0 (en) | 2023-07-04 | 2023-08-16 | Univ Aston | New compounds |
| GB202310233D0 (en) | 2023-07-04 | 2023-08-16 | Univ Aston | New compounds |
| WO2025153465A1 (en) | 2024-01-15 | 2025-07-24 | UCB Biopharma SRL | Method for the treatment of fibrotic-related disorder associated to ibd |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2628199B2 (ja) | 1988-09-26 | 1997-07-09 | 富士薬品工業株式会社 | 新規なアシルアミノ酸およびアシルペプチド化合物 |
| CA2022115A1 (en) * | 1989-07-31 | 1991-02-01 | David C. Remy | Imidazole compounds and their use as transglutaminase inhibitors |
| US5721365A (en) * | 1989-09-15 | 1998-02-24 | Us Health | N-substituted piperazine NONOates |
| WO1996030378A1 (en) * | 1995-03-31 | 1996-10-03 | Nippon Chemiphar Co., Ltd. | Bisphosphonic acid derivatives |
| TW438591B (en) * | 1995-06-07 | 2001-06-07 | Arris Pharm Corp | Reversible cysteine protease inhibitors |
| CA2226740A1 (en) | 1995-07-13 | 1997-01-30 | Mitsuyoshi Azuma | Piperazine derivative and its uses |
| DE69625575T2 (de) * | 1995-10-25 | 2003-09-25 | Senju Pharmaceutical Co., Ltd. | Angiogense-Inhibitor |
| GB9805520D0 (en) * | 1998-03-17 | 1998-05-13 | Zeneca Ltd | Chemical compounds |
| US6492408B1 (en) | 1999-07-21 | 2002-12-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
| US6861424B2 (en) * | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| EP1615698B1 (en) | 2003-04-11 | 2010-09-29 | High Point Pharmaceuticals, LLC | New amide derivatives and pharmaceutical use thereof |
| EP2607362B1 (en) * | 2005-02-17 | 2014-12-31 | Astellas Pharma Inc. | Piperidine and piperazine carboxylates as FAAH inhibitors |
| CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| WO2010075356A1 (en) * | 2008-12-23 | 2010-07-01 | Forest Laboratories Holdings Limited | Novel piperazine derivatives as inhibitors of stearoyl-coa desaturase |
| WO2013022550A2 (en) | 2011-08-10 | 2013-02-14 | President And Fellows Of Harvard College | Small molecule inhibitors of ebola and lassa fever viruses |
| GB201218084D0 (en) | 2012-10-09 | 2012-11-21 | Univ Aston | Novel compounds and methods for use in medicine |
-
2012
- 2012-10-09 GB GBGB1218084.0A patent/GB201218084D0/en not_active Ceased
-
2013
- 2013-10-09 JP JP2015536220A patent/JP6138950B2/ja active Active
- 2013-10-09 WO PCT/GB2013/052631 patent/WO2014057266A1/en not_active Ceased
- 2013-10-09 EP EP13802694.3A patent/EP2906543B1/en active Active
- 2013-10-09 US US14/431,472 patent/US9656978B2/en active Active
- 2013-10-09 CN CN201380052683.9A patent/CN104837821B/zh active Active
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