JP2015532281A - 複数キナーゼ経路阻害剤 - Google Patents
複数キナーゼ経路阻害剤 Download PDFInfo
- Publication number
- JP2015532281A JP2015532281A JP2015534612A JP2015534612A JP2015532281A JP 2015532281 A JP2015532281 A JP 2015532281A JP 2015534612 A JP2015534612 A JP 2015534612A JP 2015534612 A JP2015534612 A JP 2015534612A JP 2015532281 A JP2015532281 A JP 2015532281A
- Authority
- JP
- Japan
- Prior art keywords
- dialkylamino
- compound
- alkyl
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261706084P | 2012-09-26 | 2012-09-26 | |
| US61/706,084 | 2012-09-26 | ||
| US201361757331P | 2013-01-28 | 2013-01-28 | |
| US61/757,331 | 2013-01-28 | ||
| US201361785992P | 2013-03-14 | 2013-03-14 | |
| US61/785,992 | 2013-03-14 | ||
| PCT/US2013/061548 WO2014052365A1 (en) | 2012-09-26 | 2013-09-25 | Multiple kinase pathway inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015532281A true JP2015532281A (ja) | 2015-11-09 |
| JP2015532281A5 JP2015532281A5 (enExample) | 2016-11-17 |
Family
ID=50388917
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015534612A Pending JP2015532281A (ja) | 2012-09-26 | 2013-09-25 | 複数キナーゼ経路阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9493454B2 (enExample) |
| EP (1) | EP2900668A4 (enExample) |
| JP (1) | JP2015532281A (enExample) |
| CN (1) | CN104812756A (enExample) |
| AU (1) | AU2013323736A1 (enExample) |
| CA (1) | CA2886275A1 (enExample) |
| HK (1) | HK1212683A1 (enExample) |
| WO (1) | WO2014052365A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020510083A (ja) * | 2016-12-16 | 2020-04-02 | シーストーン・ファーマスーティカルズCstone Pharmaceuticals | Cdk4/6阻害剤 |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2734205B1 (en) | 2011-07-21 | 2018-03-21 | Tolero Pharmaceuticals, Inc. | Heterocyclic protein kinase inhibitors |
| CN104812756A (zh) * | 2012-09-26 | 2015-07-29 | 曼凯德公司 | 多激酶通路抑制剂 |
| JP6433974B2 (ja) | 2013-03-14 | 2018-12-05 | トレロ ファーマシューティカルズ, インコーポレイテッド | Jak2およびalk2阻害剤およびその使用方法 |
| CN104418853B (zh) * | 2013-08-28 | 2016-09-07 | 北大方正集团有限公司 | 取代的萘啶-2-酮化合物、制备方法、用途及药物组合物 |
| CN105622638B (zh) * | 2014-10-29 | 2018-10-02 | 广州必贝特医药技术有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用 |
| WO2016161248A1 (en) * | 2015-04-02 | 2016-10-06 | Tolero Pharmaceuticals, Inc. | Targeting pim kinases in combination with btk inhibition |
| PL3298021T3 (pl) | 2015-05-18 | 2019-11-29 | Tolero Pharmaceuticals Inc | Proleki alvocidibu o zwiększonej biodostępności |
| WO2017024073A1 (en) | 2015-08-03 | 2017-02-09 | Tolero Pharmaceuticals, Inc. | Combination therapies for treatment of cancer |
| CN105130986B (zh) * | 2015-09-30 | 2017-07-18 | 广州科擎新药开发有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其应用 |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| CN108264511B (zh) * | 2017-01-03 | 2021-04-13 | 浙江海正药业股份有限公司 | 杂环类衍生物及其制备方法和其在医药上的用途 |
| US11174255B2 (en) * | 2017-05-15 | 2021-11-16 | University Of Houston System | Pyrido[2,3-d]pyrimidin-7-ones and related compounds as inhibitors of protein kinases |
| WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR |
| BR112020020246A8 (pt) | 2018-04-05 | 2022-10-18 | Sumitomo Dainippon Pharma Oncology Inc | Inibidores de cinase axl e uso dos mesmos |
| CA3095580A1 (en) | 2018-04-13 | 2019-10-17 | Sumitomo Dainippon Pharma Oncology, Inc. | Pim kinase inhibitors for treatment of myeloproliferative neoplasms and fibrosis associated with cancer |
| WO2020023910A1 (en) | 2018-07-26 | 2020-01-30 | Tolero Pharmaceuticals, Inc. | Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same |
| JP2022511029A (ja) | 2018-12-04 | 2022-01-28 | スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド | がんの処置のための薬剤としての使用のためのcdk9インヒビターおよびその多形 |
| MX2021005075A (es) * | 2018-12-07 | 2021-07-15 | Sumitomo Pharma Oncology Inc | Metodos para el tratamiento de cancer de prostata resistente a la castracion y sensible a la castracion. |
| AU2020221247B2 (en) | 2019-02-12 | 2024-12-12 | Sumitomo Pharma America, Inc. | Formulations comprising heterocyclic protein kinase inhibitors |
| JP2022525149A (ja) | 2019-03-20 | 2022-05-11 | スミトモ ダイニッポン ファーマ オンコロジー, インコーポレイテッド | ベネトクラクスが失敗した急性骨髄性白血病(aml)の処置 |
| CN117430597A (zh) * | 2022-07-14 | 2024-01-23 | 浙江同源康医药股份有限公司 | 用作cdk4激酶抑制剂的化合物及其应用 |
| JP2026509318A (ja) | 2022-10-31 | 2026-03-18 | スミトモ・ファーマ・アメリカ・インコーポレイテッド | 骨髄増殖性新生物を治療するためのpim1阻害剤 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001515078A (ja) * | 1997-08-20 | 2001-09-18 | ワーナー−ランバート・カンパニー | プロテインチロシンキナーゼおよび細胞周期キナーゼ仲介細胞増殖を阻害するためのナフチリジノン |
| JP2006516561A (ja) * | 2003-01-17 | 2006-07-06 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 細胞増殖の阻害剤としての2−アミノピリジン置換ヘテロ環類 |
| JP2007508310A (ja) * | 2003-10-08 | 2007-04-05 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| US5945422A (en) | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
| US6303652B1 (en) * | 1998-08-21 | 2001-10-16 | Hughes Institute | BTK inhibitors and methods for their identification and use |
| MX2008014618A (es) | 2006-05-15 | 2008-11-28 | Irm Llc | Composiciones y metodos para inhibidores de cinasas del receptor fgf. |
| AU2007254179B2 (en) | 2006-05-18 | 2013-03-21 | Pharmacyclics Llc | Intracellular kinase inhibitors |
| CN104812756A (zh) * | 2012-09-26 | 2015-07-29 | 曼凯德公司 | 多激酶通路抑制剂 |
-
2013
- 2013-09-25 CN CN201380060317.8A patent/CN104812756A/zh active Pending
- 2013-09-25 JP JP2015534612A patent/JP2015532281A/ja active Pending
- 2013-09-25 CA CA 2886275 patent/CA2886275A1/en active Pending
- 2013-09-25 WO PCT/US2013/061548 patent/WO2014052365A1/en not_active Ceased
- 2013-09-25 AU AU2013323736A patent/AU2013323736A1/en not_active Abandoned
- 2013-09-25 HK HK16100505.0A patent/HK1212683A1/zh unknown
- 2013-09-25 EP EP13840649.1A patent/EP2900668A4/en not_active Withdrawn
- 2013-09-25 US US14/431,476 patent/US9493454B2/en not_active Expired - Fee Related
-
2016
- 2016-09-26 US US15/276,604 patent/US9714247B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001515078A (ja) * | 1997-08-20 | 2001-09-18 | ワーナー−ランバート・カンパニー | プロテインチロシンキナーゼおよび細胞周期キナーゼ仲介細胞増殖を阻害するためのナフチリジノン |
| JP2006516561A (ja) * | 2003-01-17 | 2006-07-06 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 細胞増殖の阻害剤としての2−アミノピリジン置換ヘテロ環類 |
| JP2007508310A (ja) * | 2003-10-08 | 2007-04-05 | アイアールエム・リミテッド・ライアビリティ・カンパニー | タンパク質キナーゼ阻害剤としての化合物および組成物 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020510083A (ja) * | 2016-12-16 | 2020-04-02 | シーストーン・ファーマスーティカルズCstone Pharmaceuticals | Cdk4/6阻害剤 |
| JP7044801B2 (ja) | 2016-12-16 | 2022-03-30 | シーストーン・ファーマスーティカルズ・(スージョウ)・カンパニー・リミテッド | Cdk4/6阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| US9714247B2 (en) | 2017-07-25 |
| WO2014052365A1 (en) | 2014-04-03 |
| EP2900668A4 (en) | 2016-04-20 |
| US9493454B2 (en) | 2016-11-15 |
| US20170107215A1 (en) | 2017-04-20 |
| CA2886275A1 (en) | 2014-04-03 |
| HK1212683A1 (zh) | 2016-06-17 |
| CN104812756A (zh) | 2015-07-29 |
| EP2900668A1 (en) | 2015-08-05 |
| US20150266870A1 (en) | 2015-09-24 |
| AU2013323736A1 (en) | 2015-04-09 |
| AU2013323736A8 (en) | 2015-04-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9714247B2 (en) | Multiple kinase pathway inhibitors | |
| KR102797536B1 (ko) | PI3Kα 억제제 및 이의 사용 방법 | |
| TWI839363B (zh) | 嘧啶化合物及包括其之供預防或治療癌症的藥學組成物 | |
| JP6475158B2 (ja) | Mnk1およびmnk2調節剤としての二環式ヘテロアリール誘導体、およびその使用 | |
| AU2013235344B2 (en) | Substituted pyridopyrimidine compounds and their use as FLT3 inhibitors | |
| TW201831483A (zh) | Fgfr抑制劑及其應用 | |
| CN110603254A (zh) | 被取代的吡唑化合物以及使用其治疗过度增生性疾病的方法 | |
| JP2014528482A (ja) | Iii型受容体チロシンキナーゼの調節因子としての複素環式化合物及びその使用 | |
| US8912181B2 (en) | Bicyclic compound or salt thereof | |
| WO2023039532A1 (en) | Pi3k-alpha inhibitors and methods of use thereof | |
| JP2020523348A (ja) | プロテインキナーゼ阻害剤としてのアミノチアゾール化合物 | |
| WO2022272106A1 (en) | Cdk2 inhibitors and methods of using the same | |
| JP2018513214A (ja) | 新規なキナーゼ阻害剤の調製と使用 | |
| CN113840823B (zh) | 显示癌细胞生长抑制效果的新型杂环取代的嘧啶衍生物,以及包含其的药物组合物 | |
| RU2807277C2 (ru) | Соединения пиримидина и содержащие их фармацевтические композиции для предупреждения или лечения рака | |
| WO2023109540A1 (zh) | 具有akt激酶抑制活性的杂环化合物及其制备方法和医药用途 | |
| WO2024105363A1 (en) | Pyridone and pyrimidinone inhibitors of hematopoietic progenitor kinase 1 | |
| WO2024104244A1 (zh) | 草酸酰胺化合物、包含其的药物组合物及其制备方法和用途 | |
| KR20240054994A (ko) | AhR 시그널링의 조절에 유용한 화합물 | |
| HK40045058B (en) | Triazolo-pyrimidine compounds and uses thereof | |
| HK40009843A (en) | Fgfr inhibitor and application thereof | |
| HK1255833B (en) | Hpk1 inhibitors and methods of using same | |
| HK1255833A1 (en) | Hpk1 inhibitors and methods of using same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150526 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160926 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20160926 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20170825 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170830 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20180320 |