AU2013323736A1 - Multiple kinase pathway inhibitors - Google Patents
Multiple kinase pathway inhibitors Download PDFInfo
- Publication number
- AU2013323736A1 AU2013323736A1 AU2013323736A AU2013323736A AU2013323736A1 AU 2013323736 A1 AU2013323736 A1 AU 2013323736A1 AU 2013323736 A AU2013323736 A AU 2013323736A AU 2013323736 A AU2013323736 A AU 2013323736A AU 2013323736 A1 AU2013323736 A1 AU 2013323736A1
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- AU
- Australia
- Prior art keywords
- dialkylamino
- compound
- alkyl
- pharmaceutically acceptable
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
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| US201261706084P | 2012-09-26 | 2012-09-26 | |
| US61/706,084 | 2012-09-26 | ||
| US201361757331P | 2013-01-28 | 2013-01-28 | |
| US61/757,331 | 2013-01-28 | ||
| US201361785992P | 2013-03-14 | 2013-03-14 | |
| US61/785,992 | 2013-03-14 | ||
| PCT/US2013/061548 WO2014052365A1 (en) | 2012-09-26 | 2013-09-25 | Multiple kinase pathway inhibitors |
Publications (2)
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| AU2013323736A1 true AU2013323736A1 (en) | 2015-04-09 |
| AU2013323736A8 AU2013323736A8 (en) | 2015-04-30 |
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| AU2013323736A Abandoned AU2013323736A1 (en) | 2012-09-26 | 2013-09-25 | Multiple kinase pathway inhibitors |
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| US (2) | US9493454B2 (enExample) |
| EP (1) | EP2900668A4 (enExample) |
| JP (1) | JP2015532281A (enExample) |
| CN (1) | CN104812756A (enExample) |
| AU (1) | AU2013323736A1 (enExample) |
| CA (1) | CA2886275A1 (enExample) |
| HK (1) | HK1212683A1 (enExample) |
| WO (1) | WO2014052365A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2671748T3 (es) | 2011-07-21 | 2018-06-08 | Tolero Pharmaceuticals, Inc. | Inhibidores heterocíclicos de proteína quinasas |
| WO2014052365A1 (en) * | 2012-09-26 | 2014-04-03 | Mannkind Corporation | Multiple kinase pathway inhibitors |
| JP6433974B2 (ja) | 2013-03-14 | 2018-12-05 | トレロ ファーマシューティカルズ， インコーポレイテッド | Ｊａｋ２およびａｌｋ２阻害剤およびその使用方法 |
| CN104418853B (zh) * | 2013-08-28 | 2016-09-07 | 北大方正集团有限公司 | 取代的萘啶-2-酮化合物、制备方法、用途及药物组合物 |
| CN105622638B (zh) * | 2014-10-29 | 2018-10-02 | 广州必贝特医药技术有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其制备方法和应用 |
| WO2016161248A1 (en) * | 2015-04-02 | 2016-10-06 | Tolero Pharmaceuticals, Inc. | Targeting pim kinases in combination with btk inhibition |
| RU2752729C2 (ru) | 2015-05-18 | 2021-07-30 | Сумитомо Даиниппон Фарма Онколоджи, Инк. | Пролекарства альвоцидиба, имеющие повышенную биодоступность |
| JP7083497B2 (ja) | 2015-08-03 | 2022-06-13 | スミトモ ファーマ オンコロジー， インコーポレイテッド | がんの処置のための併用療法 |
| CN105130986B (zh) * | 2015-09-30 | 2017-07-18 | 广州科擎新药开发有限公司 | 嘧啶或吡啶并吡啶酮类化合物及其应用 |
| US11279694B2 (en) | 2016-11-18 | 2022-03-22 | Sumitomo Dainippon Pharma Oncology, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| IL267299B (en) * | 2016-12-16 | 2022-09-01 | Cstone Pharmaceuticals | Cdk4/6 inhibitor |
| CN108264511B (zh) * | 2017-01-03 | 2021-04-13 | 浙江海正药业股份有限公司 | 杂环类衍生物及其制备方法和其在医药上的用途 |
| US11174255B2 (en) * | 2017-05-15 | 2021-11-16 | University Of Houston System | Pyrido[2,3-d]pyrimidin-7-ones and related compounds as inhibitors of protein kinases |
| JP7196160B2 (ja) | 2017-09-12 | 2022-12-26 | スミトモ ファーマ オンコロジー， インコーポレイテッド | Ｍｃｌ－１阻害剤アルボシジブを用いた、ｂｃｌ－２阻害剤に対して非感受性である癌の治療レジメン |
| AU2019247498A1 (en) | 2018-04-05 | 2020-11-26 | Sumitomo Pharma Oncology, Inc. | AXL kinase inhibitors and use of the same |
| WO2019200254A1 (en) | 2018-04-13 | 2019-10-17 | Tolero Pharmaceuticals, Inc. | Pim kinase inhibitors for treatment of myeloproliferative neoplasms and fibrosis associated with cancer |
| AU2019310590A1 (en) | 2018-07-26 | 2021-01-14 | Sumitomo Pharma Oncology, Inc. | Methods for treating diseases associated with abnormal acvr1 expression and acvr1 inhibitors for use in the same |
| CN113490499A (zh) | 2018-12-04 | 2021-10-08 | 大日本住友制药肿瘤公司 | 用作治疗癌症的活性剂的cdk9抑制剂及其多晶型物 |
| MX2021005075A (es) * | 2018-12-07 | 2021-07-15 | Sumitomo Pharma Oncology Inc | Metodos para el tratamiento de cancer de prostata resistente a la castracion y sensible a la castracion. |
| CA3127502A1 (en) | 2019-02-12 | 2020-08-20 | Sumitomo Dainippon Pharma Oncology, Inc. | Formulations comprising heterocyclic protein kinase inhibitors |
| US11793802B2 (en) | 2019-03-20 | 2023-10-24 | Sumitomo Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (AML) with venetoclax failure |
| CN117430597A (zh) * | 2022-07-14 | 2024-01-23 | 浙江同源康医药股份有限公司 | 用作cdk4激酶抑制剂的化合物及其应用 |
| CN120302975A (zh) | 2022-10-31 | 2025-07-11 | 住友制药美国公司 | 治疗骨髓增生性肿瘤的pim1抑制剂 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
| US5945422A (en) | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
| WO1999009030A1 (en) * | 1997-08-20 | 1999-02-25 | Warner-Lambert Company | Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation |
| US6303652B1 (en) * | 1998-08-21 | 2001-10-16 | Hughes Institute | BTK inhibitors and methods for their identification and use |
| JP2006516561A (ja) * | 2003-01-17 | 2006-07-06 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 細胞増殖の阻害剤としての２−アミノピリジン置換ヘテロ環類 |
| CN1863774B (zh) | 2003-10-08 | 2010-12-15 | Irm责任有限公司 | 用作蛋白激酶抑制剂的化合物和组合物 |
| BRPI0711628A2 (pt) * | 2006-05-15 | 2011-12-06 | Irm Llc | composto, composição farmacêutica, uso e processo para preparação do composto |
| CA2651732C (en) | 2006-05-18 | 2014-10-14 | Mannkind Corporation | Intracellular kinase inhibitors |
| WO2014052365A1 (en) * | 2012-09-26 | 2014-04-03 | Mannkind Corporation | Multiple kinase pathway inhibitors |
-
2013
- 2013-09-25 WO PCT/US2013/061548 patent/WO2014052365A1/en not_active Ceased
- 2013-09-25 US US14/431,476 patent/US9493454B2/en not_active Expired - Fee Related
- 2013-09-25 AU AU2013323736A patent/AU2013323736A1/en not_active Abandoned
- 2013-09-25 JP JP2015534612A patent/JP2015532281A/ja active Pending
- 2013-09-25 HK HK16100505.0A patent/HK1212683A1/zh unknown
- 2013-09-25 CA CA 2886275 patent/CA2886275A1/en active Pending
- 2013-09-25 CN CN201380060317.8A patent/CN104812756A/zh active Pending
- 2013-09-25 EP EP13840649.1A patent/EP2900668A4/en not_active Withdrawn
-
2016
- 2016-09-26 US US15/276,604 patent/US9714247B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HK1212683A1 (zh) | 2016-06-17 |
| JP2015532281A (ja) | 2015-11-09 |
| US9493454B2 (en) | 2016-11-15 |
| US20170107215A1 (en) | 2017-04-20 |
| US9714247B2 (en) | 2017-07-25 |
| EP2900668A4 (en) | 2016-04-20 |
| WO2014052365A1 (en) | 2014-04-03 |
| CN104812756A (zh) | 2015-07-29 |
| US20150266870A1 (en) | 2015-09-24 |
| CA2886275A1 (en) | 2014-04-03 |
| EP2900668A1 (en) | 2015-08-05 |
| AU2013323736A8 (en) | 2015-04-30 |
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Free format text: IN VOL 29 , NO 13 , PAGE(S) 2000 UNDER THE HEADING PCT APPLICATIONS THAT HAVE ENTERED THE NATIONAL PHASE - NAME INDEX UNDER THE NAME MANNKIND CORPORATION, TOLERO PHARMACEUTICALS, INC., APPLICATION NO. 2013323736, UNDER INID (71) CORRECT THE APPLICANT NAME TO MANNKIND CORPORATION, TOLERO PHARMACEUTICALS, INC. |
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