JP2015529657A5 - - Google Patents
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- Publication number
- JP2015529657A5 JP2015529657A5 JP2015525760A JP2015525760A JP2015529657A5 JP 2015529657 A5 JP2015529657 A5 JP 2015529657A5 JP 2015525760 A JP2015525760 A JP 2015525760A JP 2015525760 A JP2015525760 A JP 2015525760A JP 2015529657 A5 JP2015529657 A5 JP 2015529657A5
- Authority
- JP
- Japan
- Prior art keywords
- medicament
- conditions
- cancer
- diseases
- prevention
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drugs Substances 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 230000002265 prevention Effects 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 201000010099 diseases Diseases 0.000 claims 3
- 239000000203 mixtures Substances 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 241000222722 Leishmania <genus> Species 0.000 claims 2
- 210000002784 Stomach Anatomy 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 claims 1
- 206010027654 Allergic conditions Diseases 0.000 claims 1
- 206010001897 Alzheimer's diseases Diseases 0.000 claims 1
- 208000006673 Asthma Diseases 0.000 claims 1
- 210000004369 Blood Anatomy 0.000 claims 1
- 210000000988 Bone and Bones Anatomy 0.000 claims 1
- 210000004556 Brain Anatomy 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000008787 Cardiovascular Diseases Diseases 0.000 claims 1
- 208000005145 Cerebral Amyloid Angiopathy Diseases 0.000 claims 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 1
- 210000003679 Cervix Uteri Anatomy 0.000 claims 1
- 208000005243 Chondrosarcoma Diseases 0.000 claims 1
- 208000003407 Creutzfeldt-Jakob Syndrome Diseases 0.000 claims 1
- 201000010450 Creutzfeldt-Jakob diseases Diseases 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 201000010374 Down syndrome Diseases 0.000 claims 1
- 210000000981 Epithelium Anatomy 0.000 claims 1
- 210000003238 Esophagus Anatomy 0.000 claims 1
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 1
- 208000007465 Giant Cell Arteritis Diseases 0.000 claims 1
- 208000005017 Glioblastoma Diseases 0.000 claims 1
- 210000003128 Head Anatomy 0.000 claims 1
- 208000001258 Hemangiosarcoma Diseases 0.000 claims 1
- 241000711549 Hepacivirus C Species 0.000 claims 1
- 208000009889 Herpes Simplex Diseases 0.000 claims 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
- 241000725303 Human immunodeficiency virus Species 0.000 claims 1
- 201000001971 Huntington's diseases Diseases 0.000 claims 1
- 210000000987 Immune System Anatomy 0.000 claims 1
- 206010021972 Inflammatory bowel diseases Diseases 0.000 claims 1
- 206010022114 Injuries Diseases 0.000 claims 1
- 210000000936 Intestines Anatomy 0.000 claims 1
- 210000003734 Kidney Anatomy 0.000 claims 1
- 210000000867 Larynx Anatomy 0.000 claims 1
- 206010024229 Leprosy Diseases 0.000 claims 1
- 241000321541 Leptolegnia sp. Species 0.000 claims 1
- 206010024305 Leukaemia monocytic Diseases 0.000 claims 1
- 210000004185 Liver Anatomy 0.000 claims 1
- 210000004072 Lung Anatomy 0.000 claims 1
- 206010025135 Lupus erythematosus Diseases 0.000 claims 1
- 210000004324 Lymphatic System Anatomy 0.000 claims 1
- 206010025650 Malignant melanoma Diseases 0.000 claims 1
- 241000186359 Mycobacterium Species 0.000 claims 1
- 210000003739 Neck Anatomy 0.000 claims 1
- 206010053643 Neurodegenerative diseases Diseases 0.000 claims 1
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 1
- 206010061536 Parkinson's diseases Diseases 0.000 claims 1
- 210000002307 Prostate Anatomy 0.000 claims 1
- 206010072736 Rheumatic diseases Diseases 0.000 claims 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 1
- 241000700584 Simplexvirus Species 0.000 claims 1
- 206010040767 Sjogren's syndrome Diseases 0.000 claims 1
- 208000000587 Small Cell Lung Carcinoma Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 206010043207 Temporal arteritis Diseases 0.000 claims 1
- 210000001685 Thyroid Gland Anatomy 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 210000003932 Urinary Bladder Anatomy 0.000 claims 1
- 239000004480 active ingredients Substances 0.000 claims 1
- 239000011149 active materials Substances 0.000 claims 1
- 201000003076 angiosarcoma Diseases 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 201000003883 cystic fibrosis Diseases 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 239000003937 drug carriers Substances 0.000 claims 1
- 201000011240 frontotemporal dementia Diseases 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 230000000302 ischemic Effects 0.000 claims 1
- 201000005249 lung adenocarcinoma Diseases 0.000 claims 1
- 201000004792 malaria Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000002503 metabolic Effects 0.000 claims 1
- 201000006894 monocytic leukemia Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 201000004404 neurofibroma Diseases 0.000 claims 1
- 230000002314 neuroinflammatory Effects 0.000 claims 1
- 210000000056 organs Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 239000000546 pharmaceutic aids Substances 0.000 claims 1
- 201000004681 psoriasis Diseases 0.000 claims 1
- 230000000552 rheumatic Effects 0.000 claims 1
- 230000001732 thrombotic Effects 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 239000003981 vehicles Substances 0.000 claims 1
- 239000003435 antirheumatic agents Substances 0.000 description 2
- 239000002988 disease modifying antirheumatic drugs Substances 0.000 description 2
- 229940035676 ANALGESICS Drugs 0.000 description 1
- 230000000202 analgesic Effects 0.000 description 1
- 239000000730 antalgic agents Substances 0.000 description 1
- 230000003110 anti-inflammatory Effects 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 239000003862 glucocorticoids Substances 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12005716.1 | 2012-08-07 | ||
| EP12005716 | 2012-08-07 | ||
| PCT/EP2013/002032 WO2014023385A1 (en) | 2012-08-07 | 2013-07-10 | Pyridopyrimidine derivatives as protein kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529657A JP2015529657A (ja) | 2015-10-08 |
| JP2015529657A5 true JP2015529657A5 (it) | 2016-09-01 |
| JP6374384B2 JP6374384B2 (ja) | 2018-08-15 |
Family
ID=48782275
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015525760A Active JP6374384B2 (ja) | 2012-08-07 | 2013-07-10 | プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体 |
| JP2018076582A Pending JP2018150307A (ja) | 2012-08-07 | 2018-04-12 | プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018076582A Pending JP2018150307A (ja) | 2012-08-07 | 2018-04-12 | プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US9725462B2 (it) |
| EP (1) | EP2882746B1 (it) |
| JP (2) | JP6374384B2 (it) |
| CN (1) | CN104507942B (it) |
| AR (1) | AR092365A1 (it) |
| AU (1) | AU2013301865B2 (it) |
| CA (1) | CA2881279A1 (it) |
| ES (1) | ES2618004T3 (it) |
| IL (1) | IL237073A (it) |
| WO (1) | WO2014023385A1 (it) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104271576A (zh) * | 2012-02-23 | 2015-01-07 | 艾伯维公司 | 激酶的吡啶并嘧啶酮抑制剂 |
| JP6374384B2 (ja) * | 2012-08-07 | 2018-08-15 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体 |
| KR20140027714A (ko) * | 2012-08-27 | 2014-03-07 | 주식회사 홍인터내셔날 | 외부 디바이스와 연동하는 다트 게임 장치 |
| KR20180028521A (ko) * | 2015-07-21 | 2018-03-16 | 광저우 맥시노벨 파마수티컬스 씨오., 엘티디. | 축합고리 피리미딘계 화합물, 중간체, 이의 제조 방법, 조성물 및 응용 |
| CR20190339A (es) | 2016-12-22 | 2020-01-10 | Calithera Biosciences Inc | COMPOSITIONS AND METHODS TO INHIBIT THE ACTION OF ARGINASE |
| WO2019014513A1 (en) * | 2017-07-13 | 2019-01-17 | Syros Pharmaceuticals, Inc. | INHIBITORS OF KINASES TAM |
| WO2019100106A1 (en) * | 2017-11-24 | 2019-05-31 | The University Of Sydney | Antibacterial compounds and methods of use thereof |
| WO2020188015A1 (en) | 2019-03-21 | 2020-09-24 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3752141T2 (de) * | 1986-02-24 | 1998-03-26 | Mitsui Petrochemical Ind | Mittel zur behandlung von neuropathie |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| AT237596T (de) | 1996-02-13 | 2003-05-15 | Astrazeneca Ab | Chinazolinderivate und deren verwendung als vegf hemmer |
| KR100489174B1 (ko) | 1996-03-05 | 2005-09-30 | 제네카-파마 소시에떼아노님 | 4-아닐리노퀴나졸린유도체 |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| BR0111230A (pt) | 2000-05-31 | 2003-06-10 | Astrazeneca Ab | Composto, e, uso e processo para a preparação do mesmo |
| CN1255391C (zh) | 2000-07-07 | 2006-05-10 | 安吉奥金尼药品有限公司 | 作为血管破坏剂的colchinol衍生物 |
| MXPA02012903A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | COLQUINOL DERIVATIVES AS ANGIOGENESIS INHIBITORS. |
| US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| EP2024342A2 (en) * | 2006-05-01 | 2009-02-18 | Pfizer Products Incorporated | Substituted 2-amino-fused heterocyclic compounds |
| WO2008118823A2 (en) | 2007-03-26 | 2008-10-02 | Rigel Pharmaceuticals, Inc. | Compositions and methods for inhibition of the jak pathway |
| US20110160232A1 (en) | 2007-10-04 | 2011-06-30 | Pingda Ren | Certain chemical entities and therapeutic uses thereof |
| KR20170051521A (ko) | 2008-04-16 | 2017-05-11 | 포톨라 파마슈티컬스, 인코포레이티드 | ｓｙｋ 또는 ＪＡＫ 키나제 억제제로서의 ２,６－디아미노-피리미딘－５－일－카르복스아미드 |
| AU2009243006B2 (en) | 2008-05-01 | 2013-03-21 | Sirtris Pharmaceuticals, Inc. | Quinolines and related analogs as sirtuin modulators |
| TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶，其組合物及使用其之治療方法 |
| KR20110093923A (ko) | 2008-12-01 | 2011-08-18 | 메르크 파텐트 게엠베하 | 암에 대한 오토탁신 저해제로서의 ２,５-디아미노-치환된 피리도 ［４,３-ｄ］피리미딘 |
| CA2779105C (en) * | 2009-10-29 | 2016-08-16 | Hong Woo Kim | Kinase inhibitors |
| CA2784830C (en) | 2009-12-18 | 2018-03-27 | Sunovion Pharmaceuticals Inc. | Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof |
| JP6374384B2 (ja) * | 2012-08-07 | 2018-08-15 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | プロテインキナーゼ阻害剤としてのピリドピリミジン誘導体 |
-
2013
- 2013-07-10 JP JP2015525760A patent/JP6374384B2/ja active Active
- 2013-07-10 WO PCT/EP2013/002032 patent/WO2014023385A1/en active Application Filing
- 2013-07-10 CN CN201380041839.3A patent/CN104507942B/zh active IP Right Grant
- 2013-07-10 EP EP13735205.0A patent/EP2882746B1/en active Active
- 2013-07-10 AU AU2013301865A patent/AU2013301865B2/en active Active
- 2013-07-10 US US14/420,003 patent/US9725462B2/en active Active
- 2013-07-10 ES ES13735205.0T patent/ES2618004T3/es active Active
- 2013-07-10 CA CA2881279A patent/CA2881279A1/en active Pending
- 2013-08-07 AR ARP130102804A patent/AR092365A1/es unknown
-
2015
- 2015-02-03 IL IL237073A patent/IL237073A/en active IP Right Grant
-
2018
- 2018-04-12 JP JP2018076582A patent/JP2018150307A/ja active Pending
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