JP2015529462A5 - - Google Patents
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- Publication number
- JP2015529462A5 JP2015529462A5 JP2015530066A JP2015530066A JP2015529462A5 JP 2015529462 A5 JP2015529462 A5 JP 2015529462A5 JP 2015530066 A JP2015530066 A JP 2015530066A JP 2015530066 A JP2015530066 A JP 2015530066A JP 2015529462 A5 JP2015529462 A5 JP 2015529462A5
- Authority
- JP
- Japan
- Prior art keywords
- pressure
- bar
- high pressure
- microorganisms
- inactivation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 244000005700 microbiome Species 0.000 claims 12
- 239000012530 fluid Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- 230000002779 inactivation Effects 0.000 claims 8
- 210000003000 inclusion body Anatomy 0.000 claims 8
- 239000006285 cell suspension Substances 0.000 claims 7
- 241000588724 Escherichia coli Species 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 241000588832 Bordetella pertussis Species 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 239000004202 carbamide Substances 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 230000000415 inactivating effect Effects 0.000 claims 3
- 238000012544 monitoring process Methods 0.000 claims 3
- 230000001717 pathogenic effect Effects 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- 230000005847 immunogenicity Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229940066827 pertussis vaccine Drugs 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 229960005486 vaccine Drugs 0.000 claims 2
- 230000035899 viability Effects 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 241000206602 Eukaryota Species 0.000 claims 1
- 241000589902 Leptospira Species 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 238000004140 cleaning Methods 0.000 claims 1
- 238000007865 diluting Methods 0.000 claims 1
- 238000007599 discharging Methods 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002504 physiological saline solution Substances 0.000 claims 1
- 238000003825 pressing Methods 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 230000003381 solubilizing effect Effects 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261694968P | 2012-08-30 | 2012-08-30 | |
| US61/694,968 | 2012-08-30 | ||
| US201361830425P | 2013-06-03 | 2013-06-03 | |
| US61/830,425 | 2013-06-03 | ||
| PCT/US2013/057426 WO2014036345A2 (en) | 2012-08-30 | 2013-08-30 | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529462A JP2015529462A (ja) | 2015-10-08 |
| JP2015529462A5 true JP2015529462A5 (enExample) | 2016-09-15 |
| JP6438396B2 JP6438396B2 (ja) | 2018-12-12 |
Family
ID=49162270
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530066A Active JP6438396B2 (ja) | 2012-08-30 | 2013-08-30 | 不活化ワクチンを作製するための、ならびに組換えタンパク質をリフォールディング／可溶化させるための高圧デバイスおよび方法 |
| JP2015530070A Expired - Fee Related JP6405308B2 (ja) | 2012-08-30 | 2013-08-30 | キメラｋｓａｃタンパク質の発現及び高圧により可溶性タンパク質を製造する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015530070A Expired - Fee Related JP6405308B2 (ja) | 2012-08-30 | 2013-08-30 | キメラｋｓａｃタンパク質の発現及び高圧により可溶性タンパク質を製造する方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9169302B2 (enExample) |
| EP (2) | EP2890392B1 (enExample) |
| JP (2) | JP6438396B2 (enExample) |
| KR (1) | KR102208844B1 (enExample) |
| CN (3) | CN104768577B (enExample) |
| AP (1) | AP2015008331A0 (enExample) |
| AU (4) | AU2013308627B2 (enExample) |
| BR (1) | BR112015004463B8 (enExample) |
| CA (2) | CA2883303A1 (enExample) |
| EA (1) | EA031988B1 (enExample) |
| ES (1) | ES2744709T3 (enExample) |
| HK (1) | HK1211874A1 (enExample) |
| MD (1) | MD4608C1 (enExample) |
| MX (3) | MX381717B (enExample) |
| NZ (3) | NZ706288A (enExample) |
| PH (1) | PH12015500700B1 (enExample) |
| RU (1) | RU2647568C2 (enExample) |
| WO (2) | WO2014036349A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8968749B2 (en) * | 2006-07-21 | 2015-03-03 | Universidade Federal De Minas Gerais—Ufmg | Vaccine composition and immunization method |
| ZA201501696B (en) | 2012-08-30 | 2016-01-27 | Merial Ltd | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
| JP6438396B2 (ja) * | 2012-08-30 | 2018-12-12 | メリアル インコーポレイテッド | 不活化ワクチンを作製するための、ならびに組換えタンパク質をリフォールディング／可溶化させるための高圧デバイスおよび方法 |
| EP2978447B1 (en) * | 2013-03-28 | 2019-05-08 | Infectious Disease Research Institute | Vaccines comprising leishmania polypeptides for the treatment and diagnosis of leishmaniasis |
| CN104758944B (zh) * | 2015-04-02 | 2017-11-28 | 中国科学院过程工程研究所 | 一种疫苗制剂及其制备方法和用途 |
| JP2018082987A (ja) * | 2016-11-25 | 2018-05-31 | 株式会社日立製作所 | ウイルス不活化方法及びウイルス不活化装置 |
| JP2020152644A (ja) * | 2019-03-18 | 2020-09-24 | 国立大学法人愛媛大学 | Ｖｎａｒのリフォールディング方法およびｖｎａｒの製造方法 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| CN112120012B (zh) * | 2020-09-30 | 2022-03-22 | 广东康盾创新产业集团股份公司 | 一种car-t细胞冻存方法 |
| BR102021000794A2 (pt) * | 2021-01-15 | 2022-07-26 | Fundação Oswaldo Cruz | Proteína quimérica, kit, método para diagnóstico de leishmaniose, uso de uma proteína quimérica, composição vacinal contra leishmaniose visceral, e, uso de uma composição vacinal |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4708871A (en) | 1983-03-08 | 1987-11-24 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| JP2743177B2 (ja) * | 1987-04-24 | 1998-04-22 | 財団法人阪大微生物病研究会 | 百日咳菌の培養方法、及び百日咳トキソイドとその混合ワクチン |
| ATE292980T1 (de) | 1996-10-11 | 2005-04-15 | Univ California | Immunostimulierende oligonucleotidekonjugate |
| US5980912A (en) | 1997-03-25 | 1999-11-09 | Zonagen, Inc. | Chitosan induced immunopotentiation |
| FR2771011B1 (fr) | 1997-11-17 | 2000-01-28 | Hippocampe | Obtention de vaccins destines a prevenir les effets pathogenes associes a une infection retrovirale |
| FR2775601B1 (fr) | 1998-03-03 | 2001-09-21 | Merial Sas | Vaccins vivants recombines et adjuves |
| FR2776928B1 (fr) | 1998-04-03 | 2000-06-23 | Merial Sas | Vaccins adn adjuves |
| US6489450B2 (en) | 1998-07-09 | 2002-12-03 | University Technology Corporation | High pressure refolding of protein aggregates and inclusion bodies |
| EP1180945A1 (en) | 1999-05-28 | 2002-02-27 | Universite Laval | Inactivation of food spoilage and pathogenic microorganisms by dynamic high pressure |
| US6645740B1 (en) | 1999-06-10 | 2003-11-11 | Merial Limited | Nucleic acids encodings equine GM-CSF |
| UA77152C2 (en) | 1999-09-25 | 2006-11-15 | Method for stimulation of immune response using nucleic acid-containing immunostimulating compositions, method for treatment of cancer and method for treatment or prophylaxis of allergy or asthma | |
| US7615617B2 (en) | 1999-10-25 | 2009-11-10 | University Of Delaware | Use of hydrostatic pressure to inhibit and reverse protein aggregation and facilitate protein refolding |
| WO2002056824A2 (en) | 2000-08-10 | 2002-07-25 | Boston Biomedica, Inc. | Pressure cycling inactivation of pathogens in biological materials used for therapeutics or vaccines |
| US6635223B2 (en) * | 2000-10-25 | 2003-10-21 | Andreas Maerz | Method for inactivating micro-organisms using high pressure processing |
| DK1434789T3 (da) * | 2000-10-31 | 2008-07-07 | Barofold Inc | Forbedret proteindisaggregering og refoldning under tryk |
| AU2003245416A1 (en) | 2002-06-07 | 2004-04-30 | University Of Florida | Endodontic files made using bulk metallic glasses |
| SE525457C2 (sv) * | 2002-06-24 | 2005-02-22 | Flow Holdings Sagl | Förfarande för åstadkommande av en tryckändring mellan två trycktillstånd, högtryckspressanordning samt användning av förfarande eller högtryckspressanordning |
| BRPI0416246B8 (pt) * | 2003-11-05 | 2021-05-25 | C B F Leti S L Unipersonal | usos de todas as quatro histonas de leishmania h2a, h2b, h3 ou h4, de um vetor e de anticorpos, composição farmacêutica e agente ou kit diagnóstico |
| US7993580B2 (en) | 2004-08-24 | 2011-08-09 | Baxter International Inc. | Methods for the inactivation of microorganisms in biological fluids, flow through reactors and methods of controlling the light sum dose to effectively inactivate microorganisms in batch reactors |
| JP2009519706A (ja) | 2005-11-21 | 2009-05-21 | バロフォールド， インコーポレイテッド | タンパク質の高圧リフォールディングのためのデバイスおよび方法 |
| CN200945252Y (zh) * | 2006-09-01 | 2007-09-12 | 天津市华泰森淼生物工程技术有限公司 | 手动开启式小型超高压生物处理设备 |
| US20080161242A1 (en) | 2006-09-15 | 2008-07-03 | Randolph Theodore W | High pressure treatment of proteins for reduced immunogenicity |
| US7829681B2 (en) * | 2007-04-05 | 2010-11-09 | Barofold Inc. | High-pressure inclusion body solubilization and protease clipping of recombinant fusion proteins |
| US20080249286A1 (en) | 2007-04-05 | 2008-10-09 | Seefeldt Matthew B | High-pressure refolding of proteins in the presence of binding partners |
| WO2009045553A1 (en) | 2007-10-05 | 2009-04-09 | Barofold, Inc. | High pressure treatment of aggregated interferons |
| CN106562927A (zh) * | 2007-12-21 | 2017-04-19 | 硕腾服务有限责任公司 | 经热处理的菌苗，及由这些经热处理的菌苗制备的乳剂疫苗 |
| BRPI0800357A2 (pt) | 2008-03-10 | 2009-10-27 | Fundacao Oswaldo Cruz | método para produção de uma vacina estabilizada |
| EP2283035B1 (en) | 2008-05-08 | 2015-07-29 | Merial Limited | Leishmania vaccine using sand fly salivary immunogen |
| BRPI0912768A2 (pt) * | 2008-05-21 | 2016-05-17 | Infectious Disease Res Inst | vacinas de poliproteínas recombinante para o tratamento e diagnóstico de leishmaniose |
| US8410258B2 (en) * | 2008-05-21 | 2013-04-02 | Infections Disease Research Institute | Recombinant polyprotein vaccines for the treatment and diagnosis of leishmaniasis |
| WO2009155102A2 (en) | 2008-05-30 | 2009-12-23 | Barofold, Inc. | Method for derivatization of proteins using hydrostatic pressure |
| US20110070219A1 (en) | 2009-04-27 | 2011-03-24 | Seefeldt Matthew B | High pressure protein crystallization |
| CA2787320A1 (en) * | 2010-02-01 | 2011-08-04 | Avure Technologies Ab | High-pressure arrangement with locking element preventing rotation of load basket |
| CN201781934U (zh) * | 2010-04-14 | 2011-04-06 | 中国农业大学 | 一种小型框架自动式超高压设备 |
| EP2600843B9 (en) | 2010-07-19 | 2020-03-11 | Pressure BioSciences, Inc. | Therapeutic protein compositions having reduced immunogenicity and/or improved efficacy |
| JP6438396B2 (ja) * | 2012-08-30 | 2018-12-12 | メリアル インコーポレイテッド | 不活化ワクチンを作製するための、ならびに組換えタンパク質をリフォールディング／可溶化させるための高圧デバイスおよび方法 |
| ZA201501696B (en) * | 2012-08-30 | 2016-01-27 | Merial Ltd | Hyperbaric device and methods for producing inactivated vaccines and for refolding/solubilizing recombinant proteins |
-
2013
- 2013-08-30 JP JP2015530066A patent/JP6438396B2/ja active Active
- 2013-08-30 CN CN201380054922.4A patent/CN104768577B/zh active Active
- 2013-08-30 NZ NZ706288A patent/NZ706288A/en not_active IP Right Cessation
- 2013-08-30 AU AU2013308627A patent/AU2013308627B2/en not_active Ceased
- 2013-08-30 EP EP13760212.4A patent/EP2890392B1/en not_active Not-in-force
- 2013-08-30 CA CA2883303A patent/CA2883303A1/en not_active Abandoned
- 2013-08-30 BR BR112015004463A patent/BR112015004463B8/pt active IP Right Grant
- 2013-08-30 KR KR1020157008190A patent/KR102208844B1/ko active Active
- 2013-08-30 JP JP2015530070A patent/JP6405308B2/ja not_active Expired - Fee Related
- 2013-08-30 RU RU2015111255A patent/RU2647568C2/ru active
- 2013-08-30 CN CN201810318137.XA patent/CN108578679A/zh active Pending
- 2013-08-30 WO PCT/US2013/057430 patent/WO2014036349A1/en not_active Ceased
- 2013-08-30 US US14/014,434 patent/US9169302B2/en active Active
- 2013-08-30 CN CN201380053720.8A patent/CN104717976A/zh active Pending
- 2013-08-30 US US14/014,437 patent/US9315553B2/en active Active
- 2013-08-30 NZ NZ705790A patent/NZ705790A/en unknown
- 2013-08-30 ES ES13760212T patent/ES2744709T3/es active Active
- 2013-08-30 MD MDA20150031A patent/MD4608C1/ro not_active IP Right Cessation
- 2013-08-30 AU AU2013308623A patent/AU2013308623B2/en active Active
- 2013-08-30 NZ NZ715459A patent/NZ715459A/en unknown
- 2013-08-30 MX MX2015002701A patent/MX381717B/es unknown
- 2013-08-30 EP EP13766420.7A patent/EP2890393A2/en active Pending
- 2013-08-30 HK HK16100050.9A patent/HK1211874A1/xx unknown
- 2013-08-30 MX MX2015002699A patent/MX358782B/es active IP Right Grant
- 2013-08-30 WO PCT/US2013/057426 patent/WO2014036345A2/en not_active Ceased
- 2013-08-30 CA CA2883296A patent/CA2883296A1/en not_active Abandoned
- 2013-08-30 EA EA201500275A patent/EA031988B1/ru unknown
- 2013-08-30 AP AP2015008331A patent/AP2015008331A0/xx unknown
-
2015
- 2015-02-27 MX MX2021004478A patent/MX2021004478A/es unknown
- 2015-03-27 PH PH12015500700A patent/PH12015500700B1/en unknown
-
2016
- 2016-02-05 US US15/017,486 patent/US10364274B2/en active Active
-
2017
- 2017-01-17 AU AU2017200301A patent/AU2017200301A1/en not_active Abandoned
- 2017-03-14 AU AU2017201724A patent/AU2017201724B2/en active Active
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