MX2020006476A - Vacuna contra el virus de lassa. - Google Patents

Vacuna contra el virus de lassa.

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Publication number
MX2020006476A
MX2020006476A MX2020006476A MX2020006476A MX2020006476A MX 2020006476 A MX2020006476 A MX 2020006476A MX 2020006476 A MX2020006476 A MX 2020006476A MX 2020006476 A MX2020006476 A MX 2020006476A MX 2020006476 A MX2020006476 A MX 2020006476A
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MX
Mexico
Prior art keywords
particles
virus
lassa
recombinant
recombinant infectious
Prior art date
Application number
MX2020006476A
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English (en)
Inventor
Frédéric Tangy
Mathieu Mateo
Sylvain Baize
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Pasteur Institut
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Publication date
Application filed by Pasteur Institut filed Critical Pasteur Institut
Publication of MX2020006476A publication Critical patent/MX2020006476A/es

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    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/76Viruses; Subviral particles; Bacteriophages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/155Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/165Mumps or measles virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • C12N2760/10022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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    • C12N2760/18011Paramyxoviridae
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    • C12N2760/18011Paramyxoviridae
    • C12N2760/18411Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18434Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/18011Paramyxoviridae
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    • C12N2760/18011Paramyxoviridae
    • C12N2760/18411Morbillivirus, e.g. Measles virus, canine distemper
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    • C12N2760/18011Paramyxoviridae
    • C12N2760/18411Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18471Demonstrated in vivo effect

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Abstract

La invención se refiere a un virus de sarampión recombinante que expresa los polipéptidos del virus de Lassa, y se refiere en particular a las partículas inmunogénicas del LASV que son expresadas por un virus del sarampión y/o a las partículas parecidas a virus (VLPs) que contienen las proteínas de un virus de Lassa. Estas partículas son partículas infecciosas recombinantes capaces de replicarse en un hospedero después de una administración. La invención proporciona los medios, en particular las construcciones de ácidos nucleicos, vectores, células y sistemas de rescate, para la producción de estas partículas infecciosas recombinantes. La invención también se refiere al uso de estas partículas infecciosas recombinantes, en particular bajo la forma de una composición, de una manera más particular en una formulación de vacuna, para el tratamiento o la prevención de una infección por el virus de Lassa.
MX2020006476A 2017-12-21 2018-12-20 Vacuna contra el virus de lassa. MX2020006476A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762609155P 2017-12-21 2017-12-21
PCT/IB2018/001620 WO2019123018A2 (en) 2017-12-21 2018-12-20 Lassa vaccine

Publications (1)

Publication Number Publication Date
MX2020006476A true MX2020006476A (es) 2020-12-10

Family

ID=65763665

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020006476A MX2020006476A (es) 2017-12-21 2018-12-20 Vacuna contra el virus de lassa.

Country Status (10)

Country Link
US (1) US11976305B2 (es)
EP (1) EP3727411A2 (es)
JP (2) JP2021507707A (es)
KR (1) KR20200104343A (es)
CN (1) CN111886342A (es)
AU (1) AU2018392826A1 (es)
CA (1) CA3085224A1 (es)
MX (1) MX2020006476A (es)
SG (1) SG11202004899SA (es)
WO (1) WO2019123018A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111206022A (zh) * 2020-02-20 2020-05-29 中国人民解放军军事科学院军事医学研究院 一种表达拉沙热病毒空衣壳的重组病毒及其制备方法
KR102404143B1 (ko) * 2020-04-21 2022-05-31 대한민국(질병관리청장) 라싸 바이러스 핵단백질에 특이적인 항체, 이를 생산하는 하이브리도마 세포주 및 이를 이용한 라싸 바이러스 검출 키트
TWI815572B (zh) * 2021-09-27 2023-09-11 美商圖策智能科技有限公司 特定病毒的突變耐受表位的推估方法及系統

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69510207T3 (de) 1995-08-09 2007-02-15 Schweiz. Serum- & Impfinstitut Bern Verfahren zur Herstellung von infektiösen minussträngigen RNA-Viren
ATE437175T1 (de) 2002-06-20 2009-08-15 Pasteur Institut Infektiöse cdna eines zugelassenen impfstammes des masern virus. verwendung in immunogenen zusammensetzungen
CA2534351C (en) * 2003-08-01 2018-10-02 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Accelerated vaccination
ES2423518T3 (es) 2006-12-22 2013-09-20 Institut Pasteur Células y metodología para generar virus de ARN de cadena de sentido negativo no segmentada
WO2011034953A2 (en) 2009-09-16 2011-03-24 The Administrators Of The Tulane Educational Fund Lassa virus-like particles and methods of production thereof
CA2841852C (en) 2011-07-11 2020-06-30 Inovio Pharmaceuticals, Inc. Cross-protective arenavirus vaccines and their method of use
US11701418B2 (en) * 2015-01-12 2023-07-18 Geovax, Inc. Replication-deficient modified vaccinia Ankara (MVA) expressing Ebola virus glycoprotein (GP) and matrix protein (VP40)
EP3103474A1 (en) * 2015-06-12 2016-12-14 Institut Pasteur Live recombinant measles-m2 virus and its use in eliciting immunity against influenza viruses

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Publication number Publication date
CN111886342A (zh) 2020-11-03
CA3085224A1 (en) 2019-06-27
JP2024009058A (ja) 2024-01-19
KR20200104343A (ko) 2020-09-03
WO2019123018A3 (en) 2019-08-01
WO2019123018A2 (en) 2019-06-27
US20200308555A1 (en) 2020-10-01
SG11202004899SA (en) 2020-06-29
EP3727411A2 (en) 2020-10-28
AU2018392826A1 (en) 2020-06-18
JP2021507707A (ja) 2021-02-25
US11976305B2 (en) 2024-05-07

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