JP2015529083A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015529083A5 JP2015529083A5 JP2015531224A JP2015531224A JP2015529083A5 JP 2015529083 A5 JP2015529083 A5 JP 2015529083A5 JP 2015531224 A JP2015531224 A JP 2015531224A JP 2015531224 A JP2015531224 A JP 2015531224A JP 2015529083 A5 JP2015529083 A5 JP 2015529083A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- mice
- mistrg
- cgy
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000699670 Mus sp. Species 0.000 description 4
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 3
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261698002P | 2012-09-07 | 2012-09-07 | |
| US61/698,002 | 2012-09-07 | ||
| US201361775171P | 2013-03-08 | 2013-03-08 | |
| US61/775,171 | 2013-03-08 | ||
| PCT/US2013/058448 WO2014039782A2 (en) | 2012-09-07 | 2013-09-06 | Genetically modified non-human animals and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018010192A Division JP6517958B2 (ja) | 2012-09-07 | 2018-01-25 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529083A JP2015529083A (ja) | 2015-10-05 |
| JP2015529083A5 true JP2015529083A5 (enExample) | 2017-10-05 |
| JP6283031B2 JP6283031B2 (ja) | 2018-02-21 |
Family
ID=50237767
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531224A Active JP6283031B2 (ja) | 2012-09-07 | 2013-09-06 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2018010192A Active JP6517958B2 (ja) | 2012-09-07 | 2018-01-25 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2019079029A Active JP6732998B2 (ja) | 2012-09-07 | 2019-04-18 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2020117482A Active JP7066785B2 (ja) | 2012-09-07 | 2020-07-08 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2022072893A Active JP7605789B2 (ja) | 2012-09-07 | 2022-04-27 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018010192A Active JP6517958B2 (ja) | 2012-09-07 | 2018-01-25 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2019079029A Active JP6732998B2 (ja) | 2012-09-07 | 2019-04-18 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2020117482A Active JP7066785B2 (ja) | 2012-09-07 | 2020-07-08 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2022072893A Active JP7605789B2 (ja) | 2012-09-07 | 2022-04-27 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US9820476B2 (enExample) |
| EP (3) | EP2892330B1 (enExample) |
| JP (5) | JP6283031B2 (enExample) |
| KR (7) | KR102287541B1 (enExample) |
| CN (4) | CN108782459B (enExample) |
| AU (3) | AU2013312359B8 (enExample) |
| CA (1) | CA2881468C (enExample) |
| DK (1) | DK2892330T3 (enExample) |
| ES (2) | ES3034290T3 (enExample) |
| FI (1) | FI2892330T3 (enExample) |
| IL (4) | IL307969B1 (enExample) |
| IN (1) | IN2015DN02032A (enExample) |
| MX (2) | MX385035B (enExample) |
| NZ (3) | NZ741951A (enExample) |
| PT (1) | PT2892330T (enExample) |
| RU (2) | RU2642319C2 (enExample) |
| SG (2) | SG11201500504RA (enExample) |
| WO (1) | WO2014039782A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2908587T3 (es) | 2009-10-06 | 2022-05-03 | Regeneron Pharma | Ratones modificados genéticamente e injerto |
| PT4233537T (pt) * | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| RU2642319C2 (ru) | 2012-09-07 | 2018-01-24 | Йель Юниверсити | Генетически модифицированные, не принадлежащие к человеческому роду животные и способ их использования |
| PT3939423T (pt) * | 2012-11-05 | 2024-05-29 | Regeneron Pharma | Animais não humanos geneticamente modificados e métodos de utilização dos mesmos |
| KR102407354B1 (ko) | 2013-09-23 | 2022-06-10 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 신호-조절 단백질 유전자를 가지는 비-인간 동물 |
| SI3138397T1 (sl) | 2013-10-15 | 2019-04-30 | Regeneron Pharmaceuticals, Inc. | Humanizirane živali IL-15 |
| MX358206B (es) | 2013-11-19 | 2018-08-09 | Regeneron Pharma | Animales no humanos que tienen un gen humanizado de un ligando inductor de la proliferacion. |
| US9795121B2 (en) | 2014-05-05 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Humanized C3 animals |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| MX379268B (es) | 2014-05-19 | 2025-03-11 | Regeneron Pharma | Animales no humanos geneticamente modificados que expresan eritropoyetina de humano. |
| HUE064960T2 (hu) | 2014-12-05 | 2024-04-28 | Regeneron Pharma | Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok |
| AU2015360667B2 (en) | 2014-12-09 | 2021-09-23 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized cluster of differentiation 274 gene |
| KR102656470B1 (ko) | 2014-12-10 | 2024-04-09 | 리전츠 오브 더 유니버스티 오브 미네소타 | 질환을 치료하기 위한 유전적으로 변형된 세포, 조직 및 장기 |
| CN107896479B (zh) | 2015-04-13 | 2021-07-13 | 再生元制药公司 | 人源化SIRPα-IL15敲入小鼠及其使用方法 |
| EP3376857B1 (en) | 2015-11-20 | 2021-02-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a humanized lymphocyte-activation gene 3 |
| ES2908669T3 (es) | 2016-02-04 | 2022-05-03 | Regeneron Pharma | Animales no humanos que tienen un gen ANGPTL8 modificado genéticamente |
| PT3422845T (pt) | 2016-02-29 | 2021-08-26 | Regeneron Pharma | Roedores com um gene tmprss humanizado |
| CN106119284A (zh) * | 2016-06-27 | 2016-11-16 | 北京维通达生物技术有限公司 | 一种用于构建免疫缺陷动物模型的产品及其应用 |
| JP7458185B2 (ja) * | 2016-11-30 | 2024-03-29 | ザ ジャクソン ラボラトリー | 改善されたヒト自然免疫細胞の発生を有するヒト化マウスモデル |
| JP7129426B2 (ja) * | 2017-05-12 | 2022-09-01 | ザ ジャクソン ラボラトリー | Ｍｈｃクラスｉおよびｍｈｃクラスｉｉを欠損しているｎｓｇマウス |
| US11589562B2 (en) | 2018-07-16 | 2023-02-28 | Regeneran Pharmaceuticals, Inc. | Mouse model of DITRA disease and uses thereof |
| WO2020068615A1 (en) * | 2018-09-24 | 2020-04-02 | Albert Einstein College Of Medicine | Interleukin-8 for maintenance of human acute myeloid leukemia and myelodysplastic syndrome and uses thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN111073907B (zh) * | 2018-12-25 | 2025-07-29 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子csf1基因改造非人动物的构建方法及应用 |
| CN111118019B (zh) * | 2018-12-25 | 2021-03-16 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子il3基因改造非人动物的构建方法及应用 |
| US20220354098A1 (en) * | 2019-07-17 | 2022-11-10 | Yale University | Genetically Modified Non-Human Animals and Methods of Use Thereof |
| CN112779284B (zh) * | 2019-11-01 | 2022-12-20 | 百奥赛图(北京)医药科技股份有限公司 | Thpo基因人源化的非人动物的构建方法及应用 |
| US11339279B2 (en) * | 2020-04-01 | 2022-05-24 | Chevron Phillips Chemical Company Lp | Dual catalyst system for producing LLDPE and MDPE copolymers with long chain branching for film applications |
| CN114853871B (zh) * | 2021-04-20 | 2024-04-05 | 百奥赛图(北京)医药科技股份有限公司 | Csf1和/或csf1r基因人源化的非人动物及其构建方法和应用 |
| WO2024020057A1 (en) | 2022-07-19 | 2024-01-25 | Regeneron Pharmaceuticals, Inc. | Genetically modified animal model and its use to model the human immune system |
| AU2024304358A1 (en) | 2023-06-16 | 2025-11-06 | Regeneron Pharmaceuticals, Inc. | Vectors, genetically modified cells, and genetically modified non-human animals comprising the same |
| US20250255282A1 (en) | 2024-02-08 | 2025-08-14 | Regeneron Pharmaceuticals, Inc. | Vectors, genetically modified cells, and genetically modified non-human animals comprising the same |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
Family Cites Families (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4870009A (en) | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| US5573930A (en) | 1985-02-05 | 1996-11-12 | Cetus Oncology Corporation | DNA encoding various forms of colony stimulating factor-1 |
| WO1988003173A2 (en) | 1986-10-24 | 1988-05-05 | Cetus Corporation | New forms of colony stimulating factor-1 |
| EP0322240B1 (en) | 1987-12-23 | 1995-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric immunocompromised mammals and their use |
| JP2981486B2 (ja) | 1988-06-14 | 1999-11-22 | メディカル・バイオロジー・インスティチュート | 哺乳動物の免疫系研究方法 |
| DK0438053T3 (da) | 1990-01-15 | 1999-11-22 | Yeda Res & Dev | Varig transplantation og udvikling af humane hæmopoietiske cellelinjer i normale pattedyr |
| US5849288A (en) | 1990-01-15 | 1998-12-15 | Yeda Research And Development Co. Ltd. | Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells |
| US5652373A (en) | 1990-01-15 | 1997-07-29 | Yeda Research And Development Co. Ltd. | Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems |
| AU637914B2 (en) | 1990-05-03 | 1993-06-10 | Systemix, Inc. | Human lymphoid tissue in an immunocompromised host |
| US5633426A (en) | 1990-05-25 | 1997-05-27 | Systemix, Inc. | In vivo use of human bone marrow for investigation and production |
| EP0484512A4 (en) | 1990-05-25 | 1993-05-05 | Systemix, Inc. | Human peripheral blood cells in an immunocompromised host |
| EP0571525A1 (en) | 1991-02-11 | 1993-12-01 | OMMAYA, Ayub K. | Spinal fluid driven artificial organ |
| US5222982A (en) | 1991-02-11 | 1993-06-29 | Ommaya Ayub K | Spinal fluid driven artificial organ |
| EP0517199A1 (en) | 1991-06-04 | 1992-12-09 | Yeda Research And Development Company, Ltd. | Durable engraftment of human tissue and cells in normal mammals |
| WO1993005796A1 (en) | 1991-09-19 | 1993-04-01 | The Scripps Research Institute | Method for producing human antibodies in a non-human animal, and animals therefor |
| DE69229254T2 (de) | 1991-10-30 | 1999-09-23 | Idemitsu Kosan Co. Ltd., Tokio/Tokyo | Verfahren zur Herstellung von menschlichen Lymphozyten und menschlichen Antikörpern; und so hergestellte Antikörper |
| US6353150B1 (en) | 1991-11-22 | 2002-03-05 | Hsc Research And Development Limited Partnership | Chimeric mammals with human hematopoietic cells |
| WO1993018144A1 (en) | 1992-03-05 | 1993-09-16 | The Trustees Of Columbia University Of The City Of New York | Recombination activating gene deficient animal |
| US5866757A (en) | 1992-06-02 | 1999-02-02 | Yeda Research And Development Co. Ltd. | Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems |
| US6018096A (en) | 1993-05-03 | 2000-01-25 | Surrogen, Inc. | Animal model for engraftment, proliferation and differentiation of human hematopoietic stem cells |
| CA2103693A1 (en) | 1993-08-06 | 1995-02-07 | Steven Gallinger | Animal model of the human immune system |
| CA2195678A1 (en) | 1994-07-27 | 1996-02-08 | Joseph A. Borkowski | Bradykinin b2 receptor modified transgenic non-human animals |
| US6455756B1 (en) | 1994-08-12 | 2002-09-24 | Novartis Ag | Long term xenogeneic myeloid and lymphoid cell production in chimeric immunocompromised mice |
| US7273753B2 (en) | 1996-08-02 | 2007-09-25 | Center Of Blood Research | Purification and uses of dendritic cells and monocytes |
| US6248721B1 (en) | 1997-04-09 | 2001-06-19 | Lung-Ji Chang | Method of using mouse model for evaluation of HIV vaccines |
| CA2284689C (en) | 1997-04-09 | 2009-10-06 | Lung-Ji Chang | Animal model for evaluation of vaccines |
| WO2001015521A1 (en) | 1999-08-31 | 2001-03-08 | Genencor International, Inc. | Transgenic mammal capable of facilitating production of donor-specific functional immunity |
| US20030028911A1 (en) | 1999-08-31 | 2003-02-06 | Manley Huang | Transgenic mammal capable of facilitating production of donor-specific functional immunity |
| CA2392740A1 (en) | 1999-12-09 | 2001-06-14 | Human Genome Sciences, Inc. | Il-6 like polynucleotides, polypeptides, and antibodies |
| US6864061B2 (en) | 2000-09-14 | 2005-03-08 | Genetrol Biotherapeutics, Inc. | Method for screening compounds for anti-inflammatory activity |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| BR0211079A (pt) * | 2001-07-10 | 2005-08-30 | Johnson & Johnson Res Pty Ltd | Processos para a modificação genética de células hematopoiéticas progenitoras e empregos das células modificadas |
| US20030124091A1 (en) | 2001-10-26 | 2003-07-03 | Large Scale Biology Corporation | Endothelial cell derived hematopoietic growth factor |
| EP1994824A1 (en) | 2001-11-15 | 2008-11-26 | Kirin Pharma Kabushiki Kaisha | Chimeric non-human animal |
| WO2004005496A1 (ja) | 2002-07-05 | 2004-01-15 | Kirin Beer Kabushiki Kaisha | 臍帯血、骨髄、末梢血等に含まれる新規な未分化幹細胞集団 |
| CN101250553A (zh) | 2002-07-13 | 2008-08-27 | 上海医学遗传研究所 | 一种促人血小板生成素表达载体及其构建方法 |
| AU2003278790A1 (en) | 2002-09-09 | 2004-03-29 | California Institute Of Technology | Methods and compositions for the generation of humanized mice |
| EP1418185A1 (en) | 2002-11-11 | 2004-05-12 | Aventis Pharma Deutschland GmbH | Use of EDG2 receptor in an animal model of heart failure |
| KR20050084317A (ko) | 2002-12-16 | 2005-08-26 | 제넨테크, 인크. | 인간 ｃｄ２０ 및(또는) ｃｄ１６을 발현하는 트랜스제닉마우스 |
| DK1802193T3 (da) | 2004-10-19 | 2014-06-10 | Regeneron Pharma | Fremgangsmåde til frembringelse af en homozygot mus til genetisk modifikation |
| US7759541B2 (en) | 2004-12-13 | 2010-07-20 | Iti Life Sciences | Transgenic animals for assessing drug metabolism and toxicity |
| GB2434578A (en) | 2006-01-26 | 2007-08-01 | Univ Basel | Transgenic animals |
| PT2019683T (pt) | 2006-04-25 | 2017-03-17 | Univ California | Administração de fatores de crescimento para o tratamento de distúrbios do snc |
| EP1878342A1 (en) | 2006-07-13 | 2008-01-16 | Institut Pasteur | Immunodeficient mice transgenic for HLA class I and HLA class II molecules and their uses |
| WO2008060360A2 (en) | 2006-09-28 | 2008-05-22 | Surmodics, Inc. | Implantable medical device with apertures for delivery of bioactive agents |
| EP2088854A1 (en) | 2006-12-05 | 2009-08-19 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Improved xenogenic immune system in a non-human mammal |
| JP5666903B2 (ja) | 2007-05-23 | 2015-02-12 | サンガモ バイオサイエンシーズ， インコーポレイテッド | 導入遺伝子の発現を増強するための方法および組成物 |
| GB0718029D0 (en) | 2007-09-14 | 2007-10-24 | Iti Scotland Ltd | Two step cluster deletion and humanisation |
| WO2009042917A1 (en) | 2007-09-28 | 2009-04-02 | The General Hospital Corporation | Methods and compositions for antibody production |
| EP2207797A4 (en) * | 2007-10-11 | 2010-12-22 | Univ Health Network | MODULATION OF THE SIRPALPHA CD47 INTERACTION TO IMPROVE TRANSPLANTATION OF HUMAN HEMATOPOETIC STEM CELLS AND COMPOUNDS THEREOF |
| WO2009097468A2 (en) | 2008-01-29 | 2009-08-06 | Kliman Gilbert H | Drug delivery devices, kits and methods therefor |
| SG176117A1 (en) * | 2009-06-29 | 2011-12-29 | Ilya B Leskov | Non-human mammal model of human hematopoietic cancer |
| EP2449094A4 (en) | 2009-06-29 | 2013-07-10 | Qingfeng Chen | METHOD FOR PRODUCING HUMANIZED NON-MAMMAL MAMMALS |
| RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
| ES2908587T3 (es) | 2009-10-06 | 2022-05-03 | Regeneron Pharma | Ratones modificados genéticamente e injerto |
| WO2012040207A2 (en) * | 2010-09-20 | 2012-03-29 | Yale University | HUMAM SIRPAα TRANSGENIC ANIMALS AND THEIR METHODS OF USE |
| WO2012051572A1 (en) | 2010-10-15 | 2012-04-19 | Massachusetts Institute Of Technology | A humanized non-human mammal model of malaria and uses thereof |
| PT4233537T (pt) | 2011-02-15 | 2025-09-08 | Regeneron Pharma | Ratinhos humanizados para m-csf e utilizações dos mesmos |
| BR112014008529A2 (pt) | 2011-10-28 | 2017-04-18 | Regeneron Pharma | il-6 humanizado e receptor de il-6 |
| RU2642319C2 (ru) * | 2012-09-07 | 2018-01-24 | Йель Юниверсити | Генетически модифицированные, не принадлежащие к человеческому роду животные и способ их использования |
| PT3939423T (pt) * | 2012-11-05 | 2024-05-29 | Regeneron Pharma | Animais não humanos geneticamente modificados e métodos de utilização dos mesmos |
| KR102407354B1 (ko) | 2013-09-23 | 2022-06-10 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화된 신호-조절 단백질 유전자를 가지는 비-인간 동물 |
| SI3138397T1 (sl) | 2013-10-15 | 2019-04-30 | Regeneron Pharmaceuticals, Inc. | Humanizirane živali IL-15 |
| MX379268B (es) | 2014-05-19 | 2025-03-11 | Regeneron Pharma | Animales no humanos geneticamente modificados que expresan eritropoyetina de humano. |
| CN107896479B (zh) | 2015-04-13 | 2021-07-13 | 再生元制药公司 | 人源化SIRPα-IL15敲入小鼠及其使用方法 |
-
2013
- 2013-09-06 RU RU2015112607A patent/RU2642319C2/ru active
- 2013-09-06 CN CN201810721840.5A patent/CN108782459B/zh active Active
- 2013-09-06 EP EP13834735.6A patent/EP2892330B1/en active Active
- 2013-09-06 CN CN201380046265.9A patent/CN104955326B/zh active Active
- 2013-09-06 ES ES22208636T patent/ES3034290T3/es active Active
- 2013-09-06 CN CN202510882358.XA patent/CN120718856A/zh active Pending
- 2013-09-06 US US14/420,318 patent/US9820476B2/en active Active
- 2013-09-06 IL IL307969A patent/IL307969B1/en unknown
- 2013-09-06 KR KR1020217010949A patent/KR102287541B1/ko active Active
- 2013-09-06 CN CN202111215079.6A patent/CN113897398B/zh active Active
- 2013-09-06 KR KR1020217024519A patent/KR102340059B1/ko active Active
- 2013-09-06 ES ES13834735T patent/ES2938342T3/es active Active
- 2013-09-06 KR KR1020227041881A patent/KR102594390B1/ko active Active
- 2013-09-06 NZ NZ741951A patent/NZ741951A/en unknown
- 2013-09-06 MX MX2019005251A patent/MX385035B/es unknown
- 2013-09-06 CA CA2881468A patent/CA2881468C/en active Active
- 2013-09-06 KR KR1020237036218A patent/KR102645622B1/ko active Active
- 2013-09-06 NZ NZ746089A patent/NZ746089A/en unknown
- 2013-09-06 IN IN2032DEN2015 patent/IN2015DN02032A/en unknown
- 2013-09-06 NZ NZ704957A patent/NZ704957A/en unknown
- 2013-09-06 KR KR1020217040735A patent/KR102473555B1/ko active Active
- 2013-09-06 WO PCT/US2013/058448 patent/WO2014039782A2/en not_active Ceased
- 2013-09-06 SG SG11201500504RA patent/SG11201500504RA/en unknown
- 2013-09-06 EP EP25175812.4A patent/EP4606818A3/en active Pending
- 2013-09-06 PT PT138347356T patent/PT2892330T/pt unknown
- 2013-09-06 KR KR1020247007446A patent/KR20240045263A/ko active Pending
- 2013-09-06 EP EP22208636.5A patent/EP4193834B1/en active Active
- 2013-09-06 MX MX2015002983A patent/MX364714B/es active IP Right Grant
- 2013-09-06 SG SG10201701759VA patent/SG10201701759VA/en unknown
- 2013-09-06 IL IL282472A patent/IL282472B2/en unknown
- 2013-09-06 DK DK13834735.6T patent/DK2892330T3/da active
- 2013-09-06 FI FIEP13834735.6T patent/FI2892330T3/fi active
- 2013-09-06 KR KR1020157008697A patent/KR102241962B1/ko active Active
- 2013-09-06 JP JP2015531224A patent/JP6283031B2/ja active Active
- 2013-09-06 AU AU2013312359A patent/AU2013312359B8/en active Active
- 2013-09-06 RU RU2017145913A patent/RU2768282C2/ru active
-
2015
- 2015-01-22 IL IL236877A patent/IL236877A0/en active IP Right Grant
-
2017
- 2017-05-17 US US15/598,080 patent/US20180020647A1/en not_active Abandoned
-
2018
- 2018-01-25 JP JP2018010192A patent/JP6517958B2/ja active Active
- 2018-05-15 US US15/980,602 patent/US10433527B2/en active Active
-
2019
- 2019-03-24 IL IL265570A patent/IL265570B/en active IP Right Grant
- 2019-04-18 JP JP2019079029A patent/JP6732998B2/ja active Active
- 2019-08-13 AU AU2019216625A patent/AU2019216625B2/en active Active
- 2019-09-27 US US16/586,573 patent/US11026408B2/en active Active
-
2020
- 2020-07-08 JP JP2020117482A patent/JP7066785B2/ja active Active
-
2021
- 2021-05-10 US US17/316,266 patent/US12127537B2/en active Active
- 2021-10-04 AU AU2021240324A patent/AU2021240324B2/en active Active
-
2022
- 2022-04-27 JP JP2022072893A patent/JP7605789B2/ja active Active
-
2024
- 2024-09-23 US US18/893,356 patent/US20250072405A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015529083A5 (enExample) | ||
| Luhmann et al. | Bone targeting for the treatment of osteoporosis | |
| Marchini et al. | Overcoming barriers in oncolytic virotherapy with HDAC inhibitors and immune checkpoint blockade | |
| CY1123106T1 (el) | Αγωγη ανοσοσχετιζομενων και φλεγμονωδων νοσων | |
| EP4233537A3 (en) | Humanized m-csf mice and uses thereof | |
| BR212016030926U2 (pt) | conjugados de alvo e partículas e formulações dos mesmos | |
| MX2021008224A (es) | Combinacion de vacunacion e inhibicion de la trayectoria pd-1. | |
| Newcomer et al. | Approved and experimental countermeasures against pestiviral diseases: bovine viral diarrhea, classical swine fever and border disease | |
| HRP20211706T1 (hr) | Nukleazom posredovana regulacija ekspresije gena | |
| CY1118813T1 (el) | Φαρμακευτικες συνθεσεις συν-κρυσταλλων τραμαδολης και κοξιμπων | |
| SG10201902353UA (en) | Capturing specific nucleic acid materials from individual biological cells in a micro-fluidic device | |
| JP2016513953A5 (enExample) | ||
| JP2014513722A5 (enExample) | ||
| Calton et al. | Oncolytic viruses for multiple myeloma therapy | |
| BR112015017490A2 (pt) | uso de nanopartículas inorgânicas | |
| NZ741724A (en) | Renal cell populations and uses thereof | |
| MX2020003436A (es) | Inhalador de polvo seco y metodo de uso. | |
| WO2019098759A3 (ko) | 형질전환된 인간세포 및 이의 용도 | |
| JP2012518646A5 (enExample) | ||
| Callaway | How elephants avoid cancer | |
| MX375993B (es) | Tratamiento o prevencion de anemia en mamiferos no humanos preñados. | |
| Xu et al. | Zinc oxide–selenium nanoparticles for inhibiting the proliferation of Porcine Reproductive and Respiratory Syndrome Virus | |
| JP2016531853A5 (enExample) | ||
| Wang et al. | Effects of prenatal irradiation with an accelerated heavy-ion beam on postnatal development in rats: I. Neurophysiological alterations | |
| RU2011108858A (ru) | Средство для повышения роста и сохранности молодняка |