JP2015529083A5 - - Google Patents
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- JP2015529083A5 JP2015529083A5 JP2015531224A JP2015531224A JP2015529083A5 JP 2015529083 A5 JP2015529083 A5 JP 2015529083A5 JP 2015531224 A JP2015531224 A JP 2015531224A JP 2015531224 A JP2015531224 A JP 2015531224A JP 2015529083 A5 JP2015529083 A5 JP 2015529083A5
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- JP
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- Prior art keywords
- cells
- mice
- mistrg
- cgy
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241000699670 Mus sp. Species 0.000 description 4
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 3
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261698002P | 2012-09-07 | 2012-09-07 | |
| US61/698,002 | 2012-09-07 | ||
| US201361775171P | 2013-03-08 | 2013-03-08 | |
| US61/775,171 | 2013-03-08 | ||
| PCT/US2013/058448 WO2014039782A2 (en) | 2012-09-07 | 2013-09-06 | Genetically modified non-human animals and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018010192A Division JP6517958B2 (ja) | 2012-09-07 | 2018-01-25 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015529083A JP2015529083A (ja) | 2015-10-05 |
| JP2015529083A5 true JP2015529083A5 (enExample) | 2017-10-05 |
| JP6283031B2 JP6283031B2 (ja) | 2018-02-21 |
Family
ID=50237767
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015531224A Active JP6283031B2 (ja) | 2012-09-07 | 2013-09-06 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2018010192A Active JP6517958B2 (ja) | 2012-09-07 | 2018-01-25 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2019079029A Active JP6732998B2 (ja) | 2012-09-07 | 2019-04-18 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2020117482A Active JP7066785B2 (ja) | 2012-09-07 | 2020-07-08 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2022072893A Active JP7605789B2 (ja) | 2012-09-07 | 2022-04-27 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018010192A Active JP6517958B2 (ja) | 2012-09-07 | 2018-01-25 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2019079029A Active JP6732998B2 (ja) | 2012-09-07 | 2019-04-18 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2020117482A Active JP7066785B2 (ja) | 2012-09-07 | 2020-07-08 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
| JP2022072893A Active JP7605789B2 (ja) | 2012-09-07 | 2022-04-27 | 遺伝学的に修飾された非ヒト動物およびその使用法 |
Country Status (18)
| Country | Link |
|---|---|
| US (6) | US9820476B2 (enExample) |
| EP (3) | EP2892330B1 (enExample) |
| JP (5) | JP6283031B2 (enExample) |
| KR (7) | KR102340059B1 (enExample) |
| CN (4) | CN108782459B (enExample) |
| AU (3) | AU2013312359B8 (enExample) |
| CA (1) | CA2881468C (enExample) |
| DK (1) | DK2892330T3 (enExample) |
| ES (2) | ES2938342T3 (enExample) |
| FI (1) | FI2892330T3 (enExample) |
| IL (4) | IL307969B1 (enExample) |
| IN (1) | IN2015DN02032A (enExample) |
| MX (2) | MX364714B (enExample) |
| NZ (3) | NZ741951A (enExample) |
| PT (1) | PT2892330T (enExample) |
| RU (2) | RU2768282C2 (enExample) |
| SG (2) | SG11201500504RA (enExample) |
| WO (1) | WO2014039782A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5874881B2 (ja) | 2009-10-06 | 2016-03-02 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 遺伝子改変されたマウスおよび移植方法 |
| EP2675271B1 (en) * | 2011-02-15 | 2018-06-13 | Regeneron Pharmaceuticals, Inc. | Humanized m-csf mice |
| KR102340059B1 (ko) | 2012-09-07 | 2021-12-17 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
| US9901082B2 (en) * | 2012-11-05 | 2018-02-27 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals and methods of use thereof |
| SG11201601184UA (en) | 2013-09-23 | 2016-03-30 | Regeneron Pharma | Non-human animals having a humanized signal-regulatory protein gene |
| US9155290B2 (en) | 2013-10-15 | 2015-10-13 | Regeneron Pharmaceuticals, Inc. | Humanized IL-15 animals |
| CN105792647B (zh) | 2013-11-19 | 2018-10-02 | 瑞泽恩制药公司 | 具有人源化的增殖诱导配体基因的非人动物 |
| JP6598798B2 (ja) | 2014-05-05 | 2019-10-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化ｃ５およびｃ３動物 |
| NO2785538T3 (enExample) | 2014-05-07 | 2018-08-04 | ||
| KR102821645B1 (ko) * | 2014-05-19 | 2025-06-19 | 리제너론 파마슈티칼스 인코포레이티드 | 인간 epo를 발현하는 유전자 변형된 비-인간 동물 |
| TR201903891T4 (tr) | 2014-12-05 | 2019-04-22 | Regeneron Pharma | Bir insanlaştırılmış farklılaşma kümesi 47 genine sahip olan insan dışı hayvanlar. |
| HRP20202034T1 (hr) | 2014-12-09 | 2021-02-19 | Regeneron Pharmaceuticals, Inc. | Neljudske životinje s genom za humanizirani diferencijacijski biljeg cd274 |
| US9888673B2 (en) | 2014-12-10 | 2018-02-13 | Regents Of The University Of Minnesota | Genetically modified cells, tissues, and organs for treating disease |
| CN107896479B (zh) * | 2015-04-13 | 2021-07-13 | 再生元制药公司 | 人源化SIRPα-IL15敲入小鼠及其使用方法 |
| JP6997708B2 (ja) | 2015-11-20 | 2022-02-04 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヒト化されたｌｙｍｐｈｏｃｙｔｅ－ａｃｔｉｖａｔｉｏｎ ｇｅｎｅ ３遺伝子を有する非ヒト動物 |
| JP6843872B2 (ja) | 2016-02-04 | 2021-03-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 操作されたａｎｇｐｔｌ８遺伝子を有する非ヒト動物 |
| RU2749715C2 (ru) | 2016-02-29 | 2021-06-16 | Регенерон Фармасьютикалз, Инк. | Грызуны, характеризующиеся гуманизированным геном tmprss |
| CN106119284A (zh) * | 2016-06-27 | 2016-11-16 | 北京维通达生物技术有限公司 | 一种用于构建免疫缺陷动物模型的产品及其应用 |
| CN110740641A (zh) * | 2016-11-30 | 2020-01-31 | 杰克逊实验室 | 具有改善的人先天免疫细胞发育的人源化小鼠模型 |
| SG10202112528QA (en) * | 2017-05-12 | 2021-12-30 | Jackson Lab | Nsg mice lacking mhc class i and class ii |
| SMT202400300T1 (it) | 2018-07-16 | 2024-09-16 | Regeneron Pharma | Modelli di roditori della sindrome ditra e loro utilizzo |
| WO2020068615A1 (en) * | 2018-09-24 | 2020-04-02 | Albert Einstein College Of Medicine | Interleukin-8 for maintenance of human acute myeloid leukemia and myelodysplastic syndrome and uses thereof |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| CN111073907B (zh) * | 2018-12-25 | 2025-07-29 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子csf1基因改造非人动物的构建方法及应用 |
| CN111118019B (zh) * | 2018-12-25 | 2021-03-16 | 百奥赛图江苏基因生物技术有限公司 | 人源化细胞因子il3基因改造非人动物的构建方法及应用 |
| WO2021011853A2 (en) * | 2019-07-17 | 2021-01-21 | Yale University | Genetically modified non-human animals and methods of use thereof |
| WO2021083366A1 (en) * | 2019-11-01 | 2021-05-06 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with human or chimeric thpo |
| US11339279B2 (en) * | 2020-04-01 | 2022-05-24 | Chevron Phillips Chemical Company Lp | Dual catalyst system for producing LLDPE and MDPE copolymers with long chain branching for film applications |
| CN114853871B (zh) * | 2021-04-20 | 2024-04-05 | 百奥赛图(北京)医药科技股份有限公司 | Csf1和/或csf1r基因人源化的非人动物及其构建方法和应用 |
| CN119654068A (zh) | 2022-07-19 | 2025-03-18 | 瑞泽恩制药公司 | 转基因动物模型及其模拟人类免疫系统的用途 |
| AU2024304358A1 (en) | 2023-06-16 | 2025-11-06 | Regeneron Pharmaceuticals, Inc. | Vectors, genetically modified cells, and genetically modified non-human animals comprising the same |
| US20250255282A1 (en) | 2024-02-08 | 2025-08-14 | Regeneron Pharmaceuticals, Inc. | Vectors, genetically modified cells, and genetically modified non-human animals comprising the same |
| WO2025212991A1 (en) | 2024-04-05 | 2025-10-09 | Regeneron Pharmaceuticals, Inc. | Rodent models of disease |
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| EP2675271B1 (en) | 2011-02-15 | 2018-06-13 | Regeneron Pharmaceuticals, Inc. | Humanized m-csf mice |
| PL2663575T3 (pl) | 2011-10-28 | 2015-03-31 | Regeneron Pharma | Humanizowane IL-6 i receptor IL-6 |
| KR102340059B1 (ko) | 2012-09-07 | 2021-12-17 | 예일 유니버시티 | 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 |
| US9901082B2 (en) * | 2012-11-05 | 2018-02-27 | Regeneron Pharmaceuticals, Inc. | Genetically modified non-human animals and methods of use thereof |
| SG11201601184UA (en) | 2013-09-23 | 2016-03-30 | Regeneron Pharma | Non-human animals having a humanized signal-regulatory protein gene |
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| KR102821645B1 (ko) | 2014-05-19 | 2025-06-19 | 리제너론 파마슈티칼스 인코포레이티드 | 인간 epo를 발현하는 유전자 변형된 비-인간 동물 |
| CN107896479B (zh) | 2015-04-13 | 2021-07-13 | 再生元制药公司 | 人源化SIRPα-IL15敲入小鼠及其使用方法 |
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2013
- 2013-09-06 KR KR1020217024519A patent/KR102340059B1/ko active Active
- 2013-09-06 MX MX2015002983A patent/MX364714B/es active IP Right Grant
- 2013-09-06 SG SG11201500504RA patent/SG11201500504RA/en unknown
- 2013-09-06 NZ NZ741951A patent/NZ741951A/en unknown
- 2013-09-06 RU RU2017145913A patent/RU2768282C2/ru active
- 2013-09-06 ES ES13834735T patent/ES2938342T3/es active Active
- 2013-09-06 IL IL307969A patent/IL307969B1/en unknown
- 2013-09-06 CN CN201810721840.5A patent/CN108782459B/zh active Active
- 2013-09-06 MX MX2019005251A patent/MX385035B/es unknown
- 2013-09-06 KR KR1020227041881A patent/KR102594390B1/ko active Active
- 2013-09-06 CA CA2881468A patent/CA2881468C/en active Active
- 2013-09-06 KR KR1020217040735A patent/KR102473555B1/ko active Active
- 2013-09-06 US US14/420,318 patent/US9820476B2/en active Active
- 2013-09-06 EP EP13834735.6A patent/EP2892330B1/en active Active
- 2013-09-06 EP EP25175812.4A patent/EP4606818A3/en active Pending
- 2013-09-06 EP EP22208636.5A patent/EP4193834B1/en active Active
- 2013-09-06 SG SG10201701759VA patent/SG10201701759VA/en unknown
- 2013-09-06 CN CN202510882358.XA patent/CN120718856A/zh active Pending
- 2013-09-06 NZ NZ704957A patent/NZ704957A/en unknown
- 2013-09-06 KR KR1020217010949A patent/KR102287541B1/ko active Active
- 2013-09-06 JP JP2015531224A patent/JP6283031B2/ja active Active
- 2013-09-06 FI FIEP13834735.6T patent/FI2892330T3/fi active
- 2013-09-06 CN CN202111215079.6A patent/CN113897398B/zh active Active
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2021
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