JP2015528441A5 - - Google Patents
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- JP2015528441A5 JP2015528441A5 JP2015526733A JP2015526733A JP2015528441A5 JP 2015528441 A5 JP2015528441 A5 JP 2015528441A5 JP 2015526733 A JP2015526733 A JP 2015526733A JP 2015526733 A JP2015526733 A JP 2015526733A JP 2015528441 A5 JP2015528441 A5 JP 2015528441A5
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- JP
- Japan
- Prior art keywords
- composition
- item
- subject
- use according
- liposome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 claims description 69
- 239000002502 liposome Substances 0.000 claims description 63
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 40
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 35
- 235000012000 cholesterol Nutrition 0.000 claims description 20
- 229910052724 xenon Inorganic materials 0.000 claims description 19
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims description 18
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 18
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 claims description 18
- 239000002202 Polyethylene glycol Substances 0.000 claims description 16
- 229920001223 polyethylene glycol Polymers 0.000 claims description 16
- 230000000638 stimulation Effects 0.000 claims description 15
- SUHOOTKUPISOBE-UHFFFAOYSA-N O-phosphoethanolamine Chemical compound NCCOP(O)(O)=O SUHOOTKUPISOBE-UHFFFAOYSA-N 0.000 claims description 14
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims description 12
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims description 12
- 239000002577 cryoprotective agent Substances 0.000 claims description 12
- 150000002632 lipids Chemical class 0.000 claims description 12
- 238000002604 ultrasonography Methods 0.000 claims description 11
- 208000016988 Hemorrhagic Stroke Diseases 0.000 claims description 10
- 208000006011 Stroke Diseases 0.000 claims description 10
- 208000020658 intracerebral hemorrhage Diseases 0.000 claims description 10
- 239000000725 suspension Substances 0.000 claims description 10
- 206010043647 Thrombotic Stroke Diseases 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
- 229930195725 Mannitol Natural products 0.000 claims description 6
- 239000000594 mannitol Substances 0.000 claims description 6
- 235000010355 mannitol Nutrition 0.000 claims description 6
- 239000000523 sample Substances 0.000 claims description 4
- 238000010257 thawing Methods 0.000 claims description 4
- 230000001732 thrombotic effect Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 description 79
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 description 22
- BIABMEZBCHDPBV-UHFFFAOYSA-N dipalmitoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-UHFFFAOYSA-N 0.000 description 8
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 7
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 7
- 229960000187 tissue plasminogen activator Drugs 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 238000001802 infusion Methods 0.000 description 6
- 229940124597 therapeutic agent Drugs 0.000 description 6
- BIABMEZBCHDPBV-BEBVUIBBSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphoglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCCCCCCCCCC BIABMEZBCHDPBV-BEBVUIBBSA-N 0.000 description 5
- 229940012999 1,2-dipalmitoyl-sn-glycero-3-phospho-(1'-rac-glycerol) Drugs 0.000 description 5
- -1 PEG2000-DPPE Chemical compound 0.000 description 4
- 239000007789 gas Substances 0.000 description 3
- 230000002008 hemorrhagic effect Effects 0.000 description 3
- 238000001361 intraarterial administration Methods 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 101000801481 Homo sapiens Tissue-type plasminogen activator Proteins 0.000 description 2
- 238000010943 off-gassing Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261682130P | 2012-08-10 | 2012-08-10 | |
| US61/682,130 | 2012-08-10 | ||
| CN201210356929.9A CN103565745A (zh) | 2012-08-10 | 2012-09-21 | 用于治疗中风的神经保护性脂质体组合物和方法 |
| CN201210356929.9 | 2012-09-21 | ||
| PCT/US2013/054349 WO2014026117A2 (en) | 2012-08-10 | 2013-08-09 | Neuroprotective liposome compositions and methods for treatment of stroke |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015528441A JP2015528441A (ja) | 2015-09-28 |
| JP2015528441A5 true JP2015528441A5 (https=) | 2016-09-29 |
| JP6297040B2 JP6297040B2 (ja) | 2018-03-20 |
Family
ID=50039028
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015526733A Active JP6297040B2 (ja) | 2012-08-10 | 2013-08-09 | 脳卒中の治療のための神経保護リポソーム組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US10369103B2 (https=) |
| EP (2) | EP3932394B1 (https=) |
| JP (1) | JP6297040B2 (https=) |
| CN (2) | CN110464709A (https=) |
| AU (1) | AU2013299453B2 (https=) |
| CA (2) | CA2881096C (https=) |
| WO (1) | WO2014026117A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110464709A (zh) | 2012-08-10 | 2019-11-19 | 德克萨斯州大学系统董事会 | 用于治疗中风的神经保护性脂质体组合物和方法 |
| JP6625966B2 (ja) | 2013-03-15 | 2019-12-25 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 希ガスが豊富な液体ならびにその調製及び使用の方法 |
| US10456483B2 (en) | 2014-12-03 | 2019-10-29 | University Of Cincinnati | Gas-encapsulated acoustically responsive stabilized microbubbles and methods for treating cardiovascular disease |
| US10500227B2 (en) * | 2014-12-03 | 2019-12-10 | University Of Cincinnati | Bioactive gas-encapsulated echogenic liposomes and methods for treating cardiovascular disease |
| AU2016281656B2 (en) * | 2015-06-23 | 2019-05-30 | Nobilis Therapeutics, Inc. | Therapeutic immune modulation using noble gas compositions |
| EP3158992A1 (en) * | 2015-10-21 | 2017-04-26 | Universität Heidelberg | Liposomes containing cell penetrating peptides and tetraetherlipids for the oral delivery of macromolecules |
| CZ307851B6 (cs) | 2017-02-14 | 2019-06-26 | Ústav experimentální medicíny AV ČR, v. v. i. | Léčebný přípravek k prevenci a léčení zánětlivých a degenerativních onemocnění |
| JP2020033304A (ja) * | 2018-08-30 | 2020-03-05 | 医療法人ふじいやさか | 薬剤又はサプリメント、組成物、及び水素供給器の使用 |
| EP3628309A1 (en) | 2018-09-28 | 2020-04-01 | Universität Heidelberg | Method of making oral dosage forms |
| JP7716076B2 (ja) * | 2021-02-04 | 2025-07-31 | 学校法人産業医科大学 | 血管内穿孔によるくも膜下出血モデルの血腫を可視化する方法 |
| JP2022144013A (ja) * | 2021-03-18 | 2022-10-03 | 橋本電子工業株式会社 | 抗血栓リポソーム |
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| CN110464709A (zh) | 2012-08-10 | 2019-11-19 | 德克萨斯州大学系统董事会 | 用于治疗中风的神经保护性脂质体组合物和方法 |
-
2012
- 2012-09-21 CN CN201910643063.1A patent/CN110464709A/zh active Pending
- 2012-09-21 CN CN201210356929.9A patent/CN103565745A/zh active Pending
-
2013
- 2013-08-09 CA CA2881096A patent/CA2881096C/en active Active
- 2013-08-09 EP EP21170435.8A patent/EP3932394B1/en active Active
- 2013-08-09 WO PCT/US2013/054349 patent/WO2014026117A2/en not_active Ceased
- 2013-08-09 JP JP2015526733A patent/JP6297040B2/ja active Active
- 2013-08-09 AU AU2013299453A patent/AU2013299453B2/en active Active
- 2013-08-09 CA CA3132444A patent/CA3132444C/en active Active
- 2013-08-09 US US14/420,429 patent/US10369103B2/en active Active
- 2013-08-09 EP EP13828100.1A patent/EP2882422B1/en active Active
-
2019
- 2019-06-26 US US16/453,252 patent/US10973764B2/en active Active
-
2021
- 2021-04-13 US US17/229,627 patent/US11872312B2/en active Active
-
2023
- 2023-12-14 US US18/540,656 patent/US20240398708A1/en active Pending
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