JP2015528441A5 - - Google Patents

Download PDF

Info

Publication number
JP2015528441A5
JP2015528441A5 JP2015526733A JP2015526733A JP2015528441A5 JP 2015528441 A5 JP2015528441 A5 JP 2015528441A5 JP 2015526733 A JP2015526733 A JP 2015526733A JP 2015526733 A JP2015526733 A JP 2015526733A JP 2015528441 A5 JP2015528441 A5 JP 2015528441A5
Authority
JP
Japan
Prior art keywords
composition
item
subject
use according
liposome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2015526733A
Other languages
English (en)
Japanese (ja)
Other versions
JP6297040B2 (ja
JP2015528441A (ja
Filing date
Publication date
Priority claimed from CN201210356929.9A external-priority patent/CN103565745A/zh
Application filed filed Critical
Publication of JP2015528441A publication Critical patent/JP2015528441A/ja
Publication of JP2015528441A5 publication Critical patent/JP2015528441A5/ja
Application granted granted Critical
Publication of JP6297040B2 publication Critical patent/JP6297040B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2015526733A 2012-08-10 2013-08-09 脳卒中の治療のための神経保護リポソーム組成物および方法 Active JP6297040B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261682130P 2012-08-10 2012-08-10
US61/682,130 2012-08-10
CN201210356929.9 2012-09-21
CN201210356929.9A CN103565745A (zh) 2012-08-10 2012-09-21 用于治疗中风的神经保护性脂质体组合物和方法
PCT/US2013/054349 WO2014026117A2 (en) 2012-08-10 2013-08-09 Neuroprotective liposome compositions and methods for treatment of stroke

Publications (3)

Publication Number Publication Date
JP2015528441A JP2015528441A (ja) 2015-09-28
JP2015528441A5 true JP2015528441A5 (enExample) 2016-09-29
JP6297040B2 JP6297040B2 (ja) 2018-03-20

Family

ID=50039028

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015526733A Active JP6297040B2 (ja) 2012-08-10 2013-08-09 脳卒中の治療のための神経保護リポソーム組成物および方法

Country Status (7)

Country Link
US (4) US10369103B2 (enExample)
EP (2) EP3932394B1 (enExample)
JP (1) JP6297040B2 (enExample)
CN (2) CN110464709A (enExample)
AU (1) AU2013299453B2 (enExample)
CA (2) CA3132444C (enExample)
WO (1) WO2014026117A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110464709A (zh) 2012-08-10 2019-11-19 德克萨斯州大学系统董事会 用于治疗中风的神经保护性脂质体组合物和方法
WO2014145443A2 (en) 2013-03-15 2014-09-18 The Board Of Regents Of The University Of Texas System Liquids rich in noble gas and methods of their preparation and use
US10456483B2 (en) 2014-12-03 2019-10-29 University Of Cincinnati Gas-encapsulated acoustically responsive stabilized microbubbles and methods for treating cardiovascular disease
US10500227B2 (en) * 2014-12-03 2019-12-10 University Of Cincinnati Bioactive gas-encapsulated echogenic liposomes and methods for treating cardiovascular disease
EP3313384A4 (en) * 2015-06-23 2019-04-03 Nobilis Therapeutics, Inc. THERAPEUTIC IMMUNE MODULATION USING NOBLE GAS COMPOSITIONS
EP3158992A1 (en) * 2015-10-21 2017-04-26 Universität Heidelberg Liposomes containing cell penetrating peptides and tetraetherlipids for the oral delivery of macromolecules
CZ307851B6 (cs) 2017-02-14 2019-06-26 Ústav experimentální medicíny AV ČR, v. v. i. Léčebný přípravek k prevenci a léčení zánětlivých a degenerativních onemocnění
JP2020033304A (ja) * 2018-08-30 2020-03-05 医療法人ふじいやさか 薬剤又はサプリメント、組成物、及び水素供給器の使用
EP3628309A1 (en) 2018-09-28 2020-04-01 Universität Heidelberg Method of making oral dosage forms
JP7716076B2 (ja) * 2021-02-04 2025-07-31 学校法人産業医科大学 血管内穿孔によるくも膜下出血モデルの血腫を可視化する方法
JP2022144013A (ja) * 2021-03-18 2022-10-03 橋本電子工業株式会社 抗血栓リポソーム

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162282A (en) 1976-04-22 1979-07-24 Coulter Electronics, Inc. Method for producing uniform particles
US4310505A (en) 1979-11-08 1982-01-12 California Institute Of Technology Lipid vesicles bearing carbohydrate surfaces as lymphatic directed vehicles for therapeutic and diagnostic substances
US4533254A (en) 1981-04-17 1985-08-06 Biotechnology Development Corporation Apparatus for forming emulsions
US5030453A (en) 1983-03-24 1991-07-09 The Liposome Company, Inc. Stable plurilamellar vesicles
US4728575A (en) 1984-04-27 1988-03-01 Vestar, Inc. Contrast agents for NMR imaging
US4921706A (en) 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
IL79559A0 (en) 1986-07-29 1986-10-31 Univ Ramot Contrast agents for nmr medical imaging
US4728578A (en) 1986-08-13 1988-03-01 The Lubrizol Corporation Compositions containing basic metal salts and/or non-Newtonian colloidal disperse systems and vinyl aromatic containing polymers
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5305757A (en) 1989-12-22 1994-04-26 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5228446A (en) 1989-12-22 1993-07-20 Unger Evan C Gas filled liposomes and their use as ultrasonic contrast agents
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5639441A (en) 1992-03-06 1997-06-17 Board Of Regents Of University Of Colorado Methods for fine particle formation
US5858399A (en) 1992-04-09 1999-01-12 Northwestern University Acoustically reflective liposomes and methods to make and use the same
WO1993020802A1 (en) 1992-04-09 1993-10-28 Northwestern University Acoustically reflective liposomes and methods to make and use the same
CA2155947C (en) 1993-02-22 2007-08-21 Mark W. Grinstaff Methods for in vivo delivery of biologics and compositions useful therefor
US7083572B2 (en) * 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
US5545396A (en) 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US6123919A (en) 1994-04-08 2000-09-26 The Trustees Of Princeton University Magnetic resonance imaging using hyperpolarized noble gases
US5855911A (en) 1995-08-29 1999-01-05 Board Of Regents, The University Of Texas System Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
EP0855912B1 (fr) 1995-10-20 2001-12-05 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Composition a base de monoxyde d'azote en tant que medicament
EP0955999B1 (en) 1996-08-19 2001-12-05 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Novel liposome complexes for increased systemic delivery
US6770291B2 (en) 1996-08-30 2004-08-03 The United States Of America As Represented By The Department Of Health And Human Services Liposome complexes for increased systemic delivery
US5891467A (en) 1997-01-31 1999-04-06 Depotech Corporation Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes
DE19709704C2 (de) 1997-03-10 1999-11-04 Michael Georgieff Verwendung einer flüssigen Präparation von Xenon zur intravenösen Verabreichung bei Einleitung und/oder Aufrechterhaltung der Anaesthesie
US6548047B1 (en) * 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6050444A (en) 1998-07-22 2000-04-18 Sugg; James Wesley Consumable beverage dispenser with one-way valve
DE19910986C2 (de) 1999-03-11 2001-06-07 Aga Ab Verwendung von Xenon bei der Behandlung von Neurointoxikationen
GB9913677D0 (en) 1999-06-11 1999-08-11 Imperial College Formulation
DE19933704A1 (de) 1999-07-19 2001-01-25 Michael Georgieff Verwendung einer lipophile Gase enthaltenden Präparation zur Neuroprotektion und Neuroregeneration
GB9917822D0 (en) 1999-07-29 1999-09-29 Imperial College Nmda antagonist
US6653354B2 (en) 1999-07-29 2003-11-25 Protexeon Limited NMDA antagonist comprising xenon
US6680068B2 (en) 2000-07-06 2004-01-20 The General Hospital Corporation Drug delivery formulations and targeting
DE10054563A1 (de) 2000-11-03 2002-05-16 Messer Griesheim Gmbh Verfahren und Vorrichtung zur Betonherstellung
AU2002220881A1 (en) 2000-12-04 2002-06-18 Uws Ventures Limited Noble gas complexes
ES2243350T3 (es) 2001-01-31 2005-12-01 Bracco International B.V. Agente de contraste liofizable que comprende microburbujas de gas.
WO2002100435A1 (en) 2001-06-11 2002-12-19 Centre Hospitalier Universitaire De Montreal Compositions and methods for enhancing nucleic acid transfer into cells
WO2003015757A1 (en) 2001-08-16 2003-02-27 The Trustees Of The University Of Pennsylvania Synthesis and use of reagents for improved dna lipofection and/or slow release prodrug and drug therapies
US7202089B2 (en) 2001-09-14 2007-04-10 Alan Kleinfeld Early diagnosis of stroke
GB0209998D0 (en) 2002-05-01 2002-06-12 Protexeon Ltd Use
ES2321185T3 (es) 2002-06-12 2009-06-03 Air Liquide Deutschland Gmbh Proteccion cerebral con un gas que contiene xenon.
DE10328272A1 (de) 2002-06-22 2004-01-15 Messer Griesheim Gmbh Medikament mit Xenon und NO
EP1519714B1 (en) 2002-06-28 2010-10-20 Protiva Biotherapeutics Inc. Method and apparatus for producing liposomes
US20050255169A1 (en) 2002-07-05 2005-11-17 Messer Griesheim Adjuvant containing xenon
GB0218153D0 (en) 2002-08-05 2002-09-11 Ic Innovations Ltd An analgesic agent for newborn or retal subjects
DE10336778B4 (de) 2002-08-10 2010-09-16 Air Liquide Deutschland Gmbh Stabilisierung eines Patienten mit einem xenonhaltigen Gas
DE10336768B4 (de) 2002-08-10 2010-09-09 Air Liquide Deutschland Gmbh Medikament zur Verbesserung der Sauerstoffutilation
EP1658304A4 (en) 2002-09-28 2009-01-14 Massachusetts Inst Technology THERAPY ANTIGRIPPALE
AU2003298749A1 (en) 2002-11-26 2004-06-18 Seacoast Neuroscience, Inc. Buoyant polymer particles delivering therapeutic agents
US20040208921A1 (en) 2003-01-14 2004-10-21 Ho Rodney J. Y. Lipid-drug formulations and methods for targeted delivery of lipid-drug complexes to lymphoid tissues
FR2849779B1 (fr) 2003-01-15 2006-07-14 Air Liquide Sante Sa Utilisation de xenon ou de n2o dans le traitement des deteriorations cellulaires cerebrales post-ischemiques
US7198179B2 (en) 2003-02-25 2007-04-03 Therox, Inc. System for storing and dispensing a gas-solubilized product
US20060019868A1 (en) 2004-01-30 2006-01-26 Pendharkar Sanyog M Hemostatic compositions and devices
CA2538104C (en) 2003-10-10 2013-12-10 Protexeon Limited Use of xenon with hypothermia for treating neonatal asphyxia
EP1552840A1 (en) 2004-01-07 2005-07-13 Aga Ab Use of a xenon/carbon monoxide mixture for the protection of cells
GB0418540D0 (en) 2004-08-19 2004-09-22 Protexeon Ltd Use
EP1714642A1 (en) * 2005-04-18 2006-10-25 Bracco Research S.A. Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
WO2006126244A1 (ja) 2005-05-23 2006-11-30 Mebiopharm Co., Ltd. ガス封入リポソームの製造法
RU2008148329A (ru) 2006-05-09 2010-06-20 Колгейт-Палмолив Компани (US) Система ухода за ротовой полостью
US7976743B2 (en) * 2006-10-16 2011-07-12 Northwestern University Gas-containing liposomes
US20080187605A1 (en) 2007-02-02 2008-08-07 Olney John W Preventing pathological nerve cell suicide (neuroapoptosis) in immature nervous systems
US9814672B2 (en) * 2007-03-09 2017-11-14 Susan T. Laing Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
EP1980260A1 (en) 2007-04-10 2008-10-15 Nicholas Peter Franks Use of hyperbaric conditions to provide neuroprotection
US8435569B2 (en) 2007-04-30 2013-05-07 Nnoxe Pharmaceutiques Inc. Pharmaceutical composition comprising at least one thrombolytic agent (A) and at least one gas (B) selected from the group consisting of nitrous oxide, argon, xenon, helium, neon
ITMI20071031A1 (it) 2007-05-22 2008-11-23 Acetilene & Deriv Ati Siad Spa Uso di xenon per la protezione di organi da danno ischemico
WO2009073193A2 (en) * 2007-12-03 2009-06-11 The Johns Hopkins University Methods of synthesis and use of chemospheres
EP2222279A2 (en) 2007-12-10 2010-09-01 Epitarget AS Acoustically sensitive drug delivery particles comprising non-lamellar forming lipids
CL2007003772A1 (es) 2007-12-21 2008-04-25 Vulco Sa Procedimiento para la fabricacion de un mandril flexible de poliuretano, que contiene un alma metalica que comprende recubrir con goma un alma metalica, aplicar desmoldante, precalentar el conjunto, curar el poliuretano y enfriar el codo.
US8618056B2 (en) * 2007-12-22 2013-12-31 Cuthbert O. Simpkins Methods and compositions for treating conditions related to lack of blood supply, shock and neuronal injuries
ES2758830T3 (es) 2008-11-10 2020-05-06 Moleac Pte Ltd Terapia combinada para el tratamiento de pacientes con trastornos neurológicos e infarto cerebral
CA2749698C (en) * 2009-01-30 2017-08-01 Cuthbert O. Simpkins Resuscitation fluid
FR2944969B1 (fr) 2009-04-29 2011-08-26 Air Liquide Utilisation de n2o gazeux dans le traitement des douleurs chroniques
PL3100728T3 (pl) * 2009-05-13 2020-05-18 Cydex Pharmaceuticals, Inc. Kompozycje farmaceutyczne zawierające prasugrel i pochodne cyklodekstryny oraz sposoby ich wytwarzania i zastosowania
KR101875843B1 (ko) * 2009-06-22 2018-07-06 디퓨젼 파마슈티컬즈 엘엘씨 확산 촉진 화합물 및 그 화합물 단독 또는 혈전 용해제와 합쳐진 화합물의 용도
WO2011091160A1 (en) 2010-01-20 2011-07-28 Henry Wu Custom-formulated phospholipid microbubbles and methods and uses thereof
FR2956323B1 (fr) 2010-02-15 2013-12-20 Air Liquide Medicament gazeux inhalable a base d'argon contre les deficiences ou defaillances d'organes peripheriques
ES2673277T3 (es) * 2010-08-09 2018-06-21 Bracco Suisse Sa Microvesículas dirigidas llenas de gas
CN103491976B (zh) * 2011-01-14 2015-04-01 卡思伯特·O·辛普金斯 用于处理与缺乏血液供给、休克和神经损伤相关的疾病的方法和组合物
US20130247924A1 (en) 2012-03-23 2013-09-26 Mark Scatterday Electronic cigarette having a flexible and soft configuration
CN110464709A (zh) 2012-08-10 2019-11-19 德克萨斯州大学系统董事会 用于治疗中风的神经保护性脂质体组合物和方法

Similar Documents

Publication Publication Date Title
JP5421322B2 (ja) 線維化抑制のための薬物担体および薬物担体キット
Szebeni et al. Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and AmBisome
JP5437790B2 (ja) 膜貫通薬物送達システムに適用するためのプロサポシン由来の融合タンパク質又はポリペプチドを含む組成物
CN1102045C (zh) 新的含类脂和稳定剂的组合物
JP6297040B2 (ja) 脳卒中の治療のための神経保護リポソーム組成物および方法
US20100196284A1 (en) Ultrasound Imaging with Targeted Microbubbles
CN104884065A (zh) 治疗癌症的方法
US11439688B2 (en) Synthetic platelets
KR20090130081A (ko) 2상 지질-소포 조성물 및 질내 송달에 의한 자궁경부 이형성증의 치료 방법
Kim et al. Polymer lung surfactants
CN115427064A (zh) 使用基于脂质结合蛋白的复合物治疗急性病况的方法
CN117120028A (zh) 使用载剂靶向递送治疗剂的组合物和方法
CN117295518A (zh) 使用免疫治疗剂的治疗的增强
CN107708742A (zh) 诊断治疗用气泡制剂(tb)及其使用方法
WO2018071837A1 (en) Radiofrequency field hyperthermia and solid tumor immunomodulation
JP2008050375A (ja) 線維化抑制のための薬物担体および薬物担体キット
US20230181759A1 (en) Compositions for treatment of viral respiratory infections and methods of use thereof
CN108883068A (zh) 使用紫杉烷的阳离子微脂体制剂、紫杉烷的非微脂体制剂和其他活性药剂合并治疗乳癌的方法
WO2005004914A1 (ja) NF-κBデコイを含む呼吸器疾患用治療および予防のための薬学的組成物およびその使用方法
WO2017070338A1 (en) Methods and compositions for treating lung disease of prematurity
JP2025538488A (ja) ペプチド修飾されたリポソーム用凍結乾燥緩衝液
CN116115770A (zh) 一种微环境重塑中药纳米气弹及其制备方法和应用
JP2024528010A (ja) 気管支肺異形成症（ｂｐｄ）及びｂｐｄ関連肺高血圧症の治療のための組成物及び方法
US20250332183A1 (en) Compositions and methods for the stimulation of intermediate macrophages and treatments therewith
EP4504233A1 (en) Methods for treating leukocytosis, endothelial dysfunction and carditis using lipid binding protein-based complexes