JP2015528318A - 用量設定および投与を監視およびログ記録するペン型薬物注射デバイスおよび電子増設監視モジュール - Google Patents
用量設定および投与を監視およびログ記録するペン型薬物注射デバイスおよび電子増設監視モジュール Download PDFInfo
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Abstract
Description
プロセッサ装置(processor arrangement)と;
送達された薬剤の数量を判定する数量判定器(quantity determiner)とを含み、数量判定器は、薬剤送達中に注射デバイスの打込みねじの運動を検出するように配置されたセンサを含む。
取り付けられた注射デバイスにダイヤル設定された薬剤の用量を検出するように動作可能な用量ダイヤル設定式検出器(dose dialled detector)と;
薬剤の用量が送達されたことを判定する用量送達判定器(dose delivery determiner)とをさらに含むことができる。
事前に取り込まれた背景画像による分割;
さらなる評価のために画素数を低減させるための画像(複数可)のビニング;
照明の強度の変動を低減させるための画像(複数可)の正規化;
画像(複数可)のシャーリング(sheering);および/または
固定の閾値と比較することによる画像(複数可)の2値化。
ここで、一実施形態において、薬学的に活性な化合物は、最大1500Daまでの分子量を有し、および/または、ペプチド、タンパク質、多糖類、ワクチン、DNA、RNA、酵素、抗体もしくはそのフラグメント、ホルモンもしくはオリゴヌクレオチド、または上述の薬学的に活性な化合物の混合物であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病、または糖尿病性網膜症などの糖尿病関連の合併症、深部静脈血栓塞栓症または肺血栓塞栓症などの血栓塞栓症、急性冠症候群(ACS)、狭心症、心筋梗塞、がん、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症および/または関節リウマチの処置および/または予防に有用であり、
ここで、さらなる実施形態において、薬学的に活性な化合物は、糖尿病または糖尿病性網膜症などの糖尿病に関連する合併症の処置および/または予防のための少なくとも1つのペプチドを含み、
ここで、さらなる実施形態において、薬学的に活性な化合物は、少なくとも1つのヒトインスリンもしくはヒトインスリン類似体もしくは誘導体、グルカゴン様ペプチド(GLP−1)もしくはその類似体もしくは誘導体、またはエキセンジン−3もしくはエキセンジン−4もしくはエキセンジン−3もしくはエキセンジン−4の類似体もしくは誘導体を含む。
H−(Lys)4−desPro36,desPro37エキセンジン−4(1−39)−NH2、
H−(Lys)5−desPro36,desPro37エキセンジン−4(1−39)−NH2、
desPro36エキセンジン−4(1−39)、
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14Trp(O2)25,IsoAsp28]エキセンジン−4(1−39);または
desPro36[Asp28]エキセンジン−4(1−39)、
desPro36[IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,IsoAsp28]エキセンジン−(1−39)、
desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)、
desPro36[Met(O)14,Trp(O2)25,IsoAsp28]エキセンジン−4(1−39)、
(ここで、基−Lys6−NH2が、エキセンジン−4誘導体のC−末端に結合していてもよい);
desPro36エキセンジン−4(1−39)−Lys6−NH2(AVE0010)、
H−(Lys)6−desPro36[Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desAsp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28Pro36,Pro37,Pro38[Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36[Met(O)14,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
desMet(O)14,Asp28Pro36,Pro37,Pro38エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2;
desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Asn−(Glu)5desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−Lys6−desPro36[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−Lys6−NH2、
H−desAsp28,Pro36,Pro37,Pro38[Met(O)14,Trp(O2)25]エキセンジン−4(1−39)−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Asp28]エキセンジン−4(1−39)−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−NH2、
desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2、
H−(Lys)6−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(S1−39)−(Lys)6−NH2、
H−Asn−(Glu)5−desPro36,Pro37,Pro38[Met(O)14,Trp(O2)25,Asp28]エキセンジン−4(1−39)−(Lys)6−NH2;
または前述のいずれか1つのエキセンジン−4誘導体の薬学的に許容される塩もしくは溶媒和化合物
から選択される。
Claims (14)
- 注射デバイスに取り付けるための補足デバイスであって:
プロセッサ装置と;
送達された薬剤の数量を判定する数量判定器とを含み、ここで、該数量判定器は、薬剤送達中に注射デバイスの打込みねじの運動を検出するように配置されたセンサを含む、前記補足デバイス。 - 補足デバイスは、ディスプレイをさらに含み、プロセッサ装置は、送達された薬剤の数量を示すようにディスプレイを制御するように構成される、請求項1に記載の補足デバイス。
- 数量判定器は、カメラを含み、プロセッサ装置は、該カメラによって提供される信号を解釈して送達された薬剤の数量を判定するように構成される、請求項1または請求項2に記載の補足デバイス。
- 数量判定器は、2つまたはそれ以上のカメラを含み、プロセッサ装置は、該カメラによって提供される信号を解釈して送達された薬剤の数量を判定するように構成される、請求項1または請求項2に記載の補足デバイス。
- 数量判定器は、光源および光検出器を含み、プロセッサ装置は、該光検出器によって提供される信号を解釈して送達された薬剤の数量を判定するように構成される、請求項1または請求項2に記載の補足デバイス。
- 数量判定器は、誘導センサを含み、プロセッサ装置は、該誘導センサによって提供される信号を解釈して送達された薬剤の数量を判定するように構成される、請求項1または請求項2に記載の補足デバイス。
- 数量判定器は、打込みねじの回転と直線的前進との両方を検出するように構成される、請求項1〜6のいずれか1項に記載の補足デバイス。
- 取り付けられた注射デバイスにダイヤル設定された薬剤の用量を検出するように動作可能な用量ダイヤル設定式検出器と;
薬剤の用量が送達されたことを判定する用量送達判定器と:
をさらに含む、請求項1〜7のいずれか1項に記載の補足デバイス。 - 請求項1〜8のいずれか1項に記載の補足デバイスと、注射デバイスとを含む、システム。
- 注射デバイスの打込みねじは、その表面上に螺旋状のマーキングを含む、請求項3〜5のいずれか1項に従属するときの請求項9に記載のシステム。
- 注射デバイスの打込みねじは、その表面上に円周方向のマーキングを含む、請求項10、または請求項3〜5のいずれか1項に従属するときの請求項9に記載のシステム。
- 注射デバイスのカートリッジホルダは、補足デバイスによって打込みねじを見ることを可能にする光透過窓を含む、請求項10、請求項11、または請求項3〜5のいずれか1項に従属するときの請求項9に記載のシステム。
- 注射デバイスのハウジングは、補足デバイスによって打込みねじを見ることを可能にする光透過窓を含む、請求項10〜12のいずれか1項、または請求項3〜5のいずれか1項に従属するときの請求項9に記載のシステム。
- 注射デバイスの打込みねじは、その表面上に磁気のマーキングを含む、請求項4に従属するときの請求項9に記載のシステム。
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JP2022033898A (ja) * | 2016-03-01 | 2022-03-02 | ノボ・ノルデイスク・エー/エス | 電力効率の良いアクセサリデバイス |
JP7201435B2 (ja) | 2016-03-01 | 2023-01-10 | ノボ・ノルデイスク・エー/エス | 電力効率の良いアクセサリデバイス |
JP7201435B6 (ja) | 2016-03-01 | 2023-01-23 | ノボ・ノルデイスク・エー/エス | 電力効率の良いアクセサリデバイス |
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Publication number | Publication date |
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CN104519931B (zh) | 2017-10-20 |
JP2018149313A (ja) | 2018-09-27 |
US10471213B2 (en) | 2019-11-12 |
EP2882476A1 (en) | 2015-06-17 |
JP6590693B2 (ja) | 2019-10-16 |
JP2020114441A (ja) | 2020-07-30 |
HK1211507A1 (en) | 2016-05-27 |
JP6687665B2 (ja) | 2020-04-28 |
CN104519931A (zh) | 2015-04-15 |
US20150202375A1 (en) | 2015-07-23 |
EP2882476B1 (en) | 2024-05-22 |
WO2014023763A1 (en) | 2014-02-13 |
JP6922026B2 (ja) | 2021-08-18 |
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