JP2015526444A5 - - Google Patents
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- Publication number
- JP2015526444A5 JP2015526444A5 JP2015527570A JP2015527570A JP2015526444A5 JP 2015526444 A5 JP2015526444 A5 JP 2015526444A5 JP 2015527570 A JP2015527570 A JP 2015527570A JP 2015527570 A JP2015527570 A JP 2015527570A JP 2015526444 A5 JP2015526444 A5 JP 2015526444A5
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- trifluoromethyl
- carboxylic acid
- indazol
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/080139 WO2014026330A1 (en) | 2012-08-15 | 2012-08-15 | 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| CNPCT/CN2012/080139 | 2012-08-15 | ||
| PCT/US2013/054911 WO2014028600A2 (en) | 2012-08-15 | 2013-08-14 | 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015526444A JP2015526444A (ja) | 2015-09-10 |
| JP2015526444A5 true JP2015526444A5 (https=) | 2016-09-23 |
| JP6204985B2 JP6204985B2 (ja) | 2017-09-27 |
Family
ID=50101188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527570A Expired - Fee Related JP6204985B2 (ja) | 2012-08-15 | 2013-08-14 | ＲＯＲγＴ阻害剤としての３−アミノシクロアルキル化合物およびその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9663522B2 (https=) |
| EP (1) | EP2920149B1 (https=) |
| JP (1) | JP6204985B2 (https=) |
| KR (1) | KR20150041660A (https=) |
| CN (1) | CN104822657A (https=) |
| AU (1) | AU2013302647A1 (https=) |
| BR (1) | BR112015003398A2 (https=) |
| CA (1) | CA2881699A1 (https=) |
| CY (1) | CY1122266T1 (https=) |
| DK (1) | DK2920149T3 (https=) |
| ES (1) | ES2742651T3 (https=) |
| HR (1) | HRP20191001T1 (https=) |
| HU (1) | HUE044300T2 (https=) |
| LT (1) | LT2920149T (https=) |
| PL (1) | PL2920149T3 (https=) |
| PT (1) | PT2920149T (https=) |
| RS (1) | RS58892B1 (https=) |
| RU (1) | RU2015108933A (https=) |
| SI (1) | SI2920149T1 (https=) |
| WO (2) | WO2014026330A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2487159A1 (en) | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
| WO2014026327A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof |
| WO2014026329A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof |
| WO2014026328A1 (en) * | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-cyclohexenyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof |
| EP3102576B8 (en) | 2014-02-03 | 2019-06-19 | Vitae Pharmaceuticals, LLC | Dihydropyrrolopyridine inhibitors of ror-gamma |
| JP2017507950A (ja) | 2014-02-27 | 2017-03-23 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | レチノイン酸受容体関連オーファン受容体ガンマのアゴニストを使用する養子細胞療法及び関連治療方法 |
| US20150252022A1 (en) * | 2014-03-10 | 2015-09-10 | Innov17 Llc | Retinoic acid receptor-related orphan receptor modulators and uses thereof |
| US9896441B2 (en) | 2014-05-05 | 2018-02-20 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
| JP6523337B2 (ja) | 2014-05-05 | 2019-05-29 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγのアゴニストとしての使用及び疾患治療のためのベンゼンスルホンアミド及び関連化合物 |
| US9884847B2 (en) * | 2014-07-25 | 2018-02-06 | Innov17 Llc | Indazole retinoic acid receptor-related orphan receptor modulators and uses thereof |
| PT3207043T (pt) | 2014-10-14 | 2019-03-25 | Vitae Pharmaceuticals Llc | Inibidores de di-hidropirrolopiridina de ror-gama |
| GB201419015D0 (en) | 2014-10-24 | 2014-12-10 | Orca Pharmaceuticals Ltd | Compounds |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| US10385036B2 (en) | 2015-01-30 | 2019-08-20 | Pfizer Inc. | Sulfonamide-substituted indole modulators of RORC2 and methods of use thereof |
| EP3256450B1 (en) | 2015-02-11 | 2020-12-02 | Merck Sharp & Dohme Corp. | Substituted pyrazole compounds as ror-gamma-t inhibitors and uses thereof |
| WO2016128908A1 (en) * | 2015-02-12 | 2016-08-18 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
| WO2016145298A1 (en) | 2015-03-12 | 2016-09-15 | The Regents Of The University Of California | METHODS FOR TREATING CANCER WITH RORgamma INHIBITORS |
| JP2018515491A (ja) | 2015-05-05 | 2018-06-14 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγの作動薬及び疾患の療法として使用するジヒドロ−２Ｈ−ベンゾ［ｂ］［１，４］オキサジンスルホンアミド及び関連化合物 |
| KR20180025894A (ko) | 2015-06-11 | 2018-03-09 | 라이세라 코퍼레이션 | Rory의 작용제로서 사용하기 위한 아릴 디히드로-2h-벤조[b][1,4]옥사진 술폰아미드 및 관련 화합물 및 질환의 치료 |
| WO2017024018A1 (en) | 2015-08-05 | 2017-02-09 | Vitae Pharmaceuticals, Inc. | Modulators of ror-gamma |
| RU2018117503A (ru) | 2015-10-27 | 2019-11-28 | Мерк Шарп И Доум Корп. | ЗАМЕЩЕННЫЕ ИНДАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RORγТ И ИХ ПРИМЕНЕНИЕ |
| AU2016344118A1 (en) | 2015-10-27 | 2018-05-10 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
| WO2017075178A1 (en) | 2015-10-27 | 2017-05-04 | Merck Sharp & Dohme Corp. | SUBSTITUTED BICYCLIC PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| US11008340B2 (en) | 2015-11-20 | 2021-05-18 | Vitae Pharmaceuticals, Llc | Modulators of ROR-gamma |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| JP7090639B2 (ja) * | 2017-04-11 | 2022-06-24 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | フッ素置換されたインダゾール化合物及びその使用 |
| JP2020528904A (ja) | 2017-07-24 | 2020-10-01 | ヴァイティー ファーマシューティカルズ，エルエルシー | ＲＯＲγの阻害剤 |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| CN107698493A (zh) * | 2017-11-15 | 2018-02-16 | 上海皓伯化工科技有限公司 | 一种N‑Boc‑3‑哌啶酮的制备方法 |
| CN111116590B (zh) * | 2019-12-11 | 2021-07-06 | 广州医科大学 | 吲哚类化合物及其应用、制备方法 |
| CA3186628A1 (en) * | 2020-06-30 | 2022-01-06 | Dermira, Inc. | Ror.gamma.t inhibitors and topical uses thereof |
| EP4236928A4 (en) * | 2020-10-30 | 2024-08-28 | 1Cbio, Inc. | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP1) INHIBITORS AND THEIR USES |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4670447A (en) * | 1983-08-22 | 1987-06-02 | Hoechst-Roussel Pharmaceuticals Inc. | Antipsychotic 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles |
| PT95899A (pt) | 1989-11-17 | 1991-09-13 | Glaxo Group Ltd | Processo para a preparacao de derivados indole |
| US5532237A (en) * | 1995-02-15 | 1996-07-02 | Merck Frosst Canada, Inc. | Indole derivatives with affinity for the cannabinoid receptor |
| US5639780A (en) | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
| US6133290A (en) * | 1998-07-31 | 2000-10-17 | Eli Lilly And Company | 5-HT1F agonists |
| GB0117577D0 (en) * | 2001-02-16 | 2001-09-12 | Aventis Pharm Prod Inc | Novel heterocyclic substituted carbonyl derivatives and their use as dopamine D receptor ligands |
| US7355042B2 (en) * | 2001-10-16 | 2008-04-08 | Hypnion, Inc. | Treatment of CNS disorders using CNS target modulators |
| CA2528626A1 (en) * | 2003-07-09 | 2005-01-20 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| JP4525221B2 (ja) * | 2004-07-16 | 2010-08-18 | アステラス製薬株式会社 | 受容体リガンド同定法 |
| JP2008509138A (ja) | 2004-08-03 | 2008-03-27 | ワイス | 心臓血管疾患の治療に有用なインダゾール類 |
| US7605168B2 (en) | 2004-09-03 | 2009-10-20 | Plexxikon, Inc. | PDE4B inhibitors |
| SE0402762D0 (sv) * | 2004-11-11 | 2004-11-11 | Astrazeneca Ab | Indazole sulphonamide derivatives |
| CN100516049C (zh) | 2004-11-16 | 2009-07-22 | 永信药品工业股份有限公司 | 抗血管生成药n2-(取代的芳基甲基)-3-(取代的苯基)吲唑的合成 |
| EP1828180A4 (en) | 2004-12-08 | 2010-09-15 | Glaxosmithkline Llc | 1H-pyrrolo [2,3-BETA] PYRIDINE |
| CA2637531A1 (en) * | 2006-02-17 | 2007-08-30 | Memory Pharmaceuticals Corporation | Compounds having 5-ht6 receptor affinity |
| JP4675801B2 (ja) | 2006-03-06 | 2011-04-27 | 日本メナード化粧品株式会社 | Ｒｏｒ活性化剤 |
| CN101437820A (zh) * | 2006-03-07 | 2009-05-20 | 阿雷生物药品公司 | 杂二环吡唑化合物和使用方法 |
| BRPI0708615A2 (pt) * | 2006-03-07 | 2011-06-07 | Array Biopharma Inc | compostos de pirazol heterobicìclicos e métodos de uso |
| GB0611587D0 (en) | 2006-06-12 | 2006-07-19 | Glaxo Group Ltd | Novel compounds |
| MX2009011210A (es) | 2007-04-16 | 2009-10-30 | Abbott Lab | Inhibidores de mcl1 de indol 7-no sustituido. |
| GB0708141D0 (en) | 2007-04-26 | 2007-06-06 | Syngenta Participations Ag | Improvements in or relating to organic compounds |
| AR067326A1 (es) | 2007-05-11 | 2009-10-07 | Novartis Ag | Imidazopiridinas y pirrolo -pirimidinas sustituidas como inhibidores de cinasa de lipido |
| US20100317863A1 (en) | 2007-07-25 | 2010-12-16 | Boehringer Ingelheim International Gmbh | Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof |
| EP2181710A1 (en) | 2008-10-28 | 2010-05-05 | Phenex Pharmaceuticals AG | Ligands for modulation of orphan receptor-gamma (NR1F3) activity |
| WO2010050837A1 (ru) | 2008-10-28 | 2010-05-06 | Haskin Lev Yakovlevich | Ветроэнергетическая установка |
| CA2744498C (en) | 2008-11-25 | 2017-10-24 | University Of Rochester | Mlk inhibitors and methods of use |
| MX2011009807A (es) * | 2009-03-19 | 2011-09-29 | Medical Res Council Technology | Compuestos. |
| WO2010150837A1 (ja) | 2009-06-25 | 2010-12-29 | 第一三共株式会社 | インドリン誘導体 |
| WO2011014775A1 (en) | 2009-07-31 | 2011-02-03 | The Brigham And Women's Hospital, Inc. | Modulation of sgk1 expression in th17 cells to modulate th17-mediated immune responses |
| JP2013514385A (ja) | 2009-12-18 | 2013-04-25 | ヤンセン ファーマシューティカ エヌ．ベー． | エストロゲン関連受容体αモジュレーターとしての置換アミノチアゾロンインダゾール |
| US9260382B2 (en) * | 2010-02-16 | 2016-02-16 | Uwm Research Foundation | Methods of reducing virulence in bacteria |
| GB201004311D0 (en) * | 2010-03-15 | 2010-04-28 | Proximagen Ltd | New enzyme inhibitor compounds |
| WO2011146313A1 (en) | 2010-05-19 | 2011-11-24 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| CA2816753A1 (en) | 2010-11-08 | 2012-05-18 | Lycera Corporation | N- sulfonylated tetrahydroquinolines and related bicyclic compounds inhibition of rory activity and the treatment of diseases |
| KR20120063283A (ko) * | 2010-12-07 | 2012-06-15 | 제일약품주식회사 | 신규한 피라졸로 피리딘 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 포함하는 약학적 조성물 |
| RU2620376C2 (ru) | 2010-12-22 | 2017-05-25 | Людвиг-Максимилианс-Университэт Мюнхен | Цинкорганические комплексы, способы их получения и применение |
| EP2487159A1 (en) | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
| JP2014166961A (ja) | 2011-06-20 | 2014-09-11 | Dainippon Sumitomo Pharma Co Ltd | 新規インダゾール誘導体 |
| WO2014026328A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-cyclohexenyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof |
| WO2014026327A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof |
| WO2014026329A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof |
-
2012
- 2012-08-15 WO PCT/CN2012/080139 patent/WO2014026330A1/en not_active Ceased
-
2013
- 2013-08-14 AU AU2013302647A patent/AU2013302647A1/en not_active Abandoned
- 2013-08-14 KR KR1020157006340A patent/KR20150041660A/ko not_active Ceased
- 2013-08-14 JP JP2015527570A patent/JP6204985B2/ja not_active Expired - Fee Related
- 2013-08-14 US US14/421,062 patent/US9663522B2/en active Active
- 2013-08-14 CA CA2881699A patent/CA2881699A1/en not_active Abandoned
- 2013-08-14 LT LTEP13829341.0T patent/LT2920149T/lt unknown
- 2013-08-14 HU HUE13829341 patent/HUE044300T2/hu unknown
- 2013-08-14 PL PL13829341T patent/PL2920149T3/pl unknown
- 2013-08-14 RU RU2015108933A patent/RU2015108933A/ru unknown
- 2013-08-14 EP EP13829341.0A patent/EP2920149B1/en active Active
- 2013-08-14 CN CN201380053416.3A patent/CN104822657A/zh active Pending
- 2013-08-14 DK DK13829341.0T patent/DK2920149T3/da active
- 2013-08-14 ES ES13829341T patent/ES2742651T3/es active Active
- 2013-08-14 WO PCT/US2013/054911 patent/WO2014028600A2/en not_active Ceased
- 2013-08-14 RS RS20190756A patent/RS58892B1/sr unknown
- 2013-08-14 SI SI201331469T patent/SI2920149T1/sl unknown
- 2013-08-14 HR HRP20191001TT patent/HRP20191001T1/hr unknown
- 2013-08-14 BR BR112015003398A patent/BR112015003398A2/pt not_active Application Discontinuation
- 2013-08-14 PT PT13829341T patent/PT2920149T/pt unknown
-
2019
- 2019-06-19 CY CY20191100630T patent/CY1122266T1/el unknown
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