JP2015526443A5 - - Google Patents
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- Publication number
- JP2015526443A5 JP2015526443A5 JP2015527569A JP2015527569A JP2015526443A5 JP 2015526443 A5 JP2015526443 A5 JP 2015526443A5 JP 2015527569 A JP2015527569 A JP 2015527569A JP 2015527569 A JP2015527569 A JP 2015527569A JP 2015526443 A5 JP2015526443 A5 JP 2015526443A5
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- indazol
- benzoyl
- trifluoromethyl
- cyclohex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QSERINUGEFDOOJ-UHFFFAOYSA-N CC(N1N(C)C1)S=O Chemical compound CC(N1N(C)C1)S=O QSERINUGEFDOOJ-UHFFFAOYSA-N 0.000 description 1
- 0 CCSc1cccc(*)c1C(N(*=C(C1=*S)C2=CCC(*)CC2)C1=**=*)=O Chemical compound CCSc1cccc(*)c1C(N(*=C(C1=*S)C2=CCC(*)CC2)C1=**=*)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/080133 WO2014026328A1 (en) | 2012-08-15 | 2012-08-15 | 3-cyclohexenyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof |
| CNPCT/CN2012/080133 | 2012-08-15 | ||
| PCT/US2013/054902 WO2014028597A2 (en) | 2012-08-15 | 2013-08-14 | 3-CYCLOHEXENYL AND CYCLOHEXYL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015526443A JP2015526443A (ja) | 2015-09-10 |
| JP2015526443A5 true JP2015526443A5 (https=) | 2016-09-23 |
| JP6232429B2 JP6232429B2 (ja) | 2017-11-15 |
Family
ID=50101186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527569A Expired - Fee Related JP6232429B2 (ja) | 2012-08-15 | 2013-08-14 | ＲＯＲγＴ阻害剤としての３−シクロヘキセニルおよびシクロヘキシル置換インドールおよびインダゾール化合物およびそれらの使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9487490B2 (https=) |
| EP (1) | EP2884976B1 (https=) |
| JP (1) | JP6232429B2 (https=) |
| KR (1) | KR20150041800A (https=) |
| CN (1) | CN104822376A (https=) |
| AU (1) | AU2013302644A1 (https=) |
| BR (1) | BR112015003332A2 (https=) |
| CA (1) | CA2881696A1 (https=) |
| CY (1) | CY1122272T1 (https=) |
| DK (1) | DK2884976T3 (https=) |
| ES (1) | ES2749713T3 (https=) |
| HR (1) | HRP20191654T1 (https=) |
| HU (1) | HUE045379T2 (https=) |
| LT (1) | LT2884976T (https=) |
| ME (1) | ME03579B (https=) |
| PL (1) | PL2884976T3 (https=) |
| PT (1) | PT2884976T (https=) |
| RS (1) | RS59364B1 (https=) |
| RU (1) | RU2015108898A (https=) |
| SI (1) | SI2884976T1 (https=) |
| SM (1) | SMT201900580T1 (https=) |
| WO (2) | WO2014026328A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2487159A1 (en) | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
| WO2014026330A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| WO2014026327A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof |
| WO2014026329A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof |
| LT3027603T (lt) * | 2013-08-02 | 2018-08-10 | Pfizer Inc. | Heterobicikloarilo rorc2 inhibitoriai ir jų panaudojimo būdai |
| EP3102576B8 (en) | 2014-02-03 | 2019-06-19 | Vitae Pharmaceuticals, LLC | Dihydropyrrolopyridine inhibitors of ror-gamma |
| JP2017507950A (ja) | 2014-02-27 | 2017-03-23 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | レチノイン酸受容体関連オーファン受容体ガンマのアゴニストを使用する養子細胞療法及び関連治療方法 |
| JP6523337B2 (ja) | 2014-05-05 | 2019-05-29 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγのアゴニストとしての使用及び疾患治療のためのベンゼンスルホンアミド及び関連化合物 |
| US9896441B2 (en) | 2014-05-05 | 2018-02-20 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
| WO2016014910A1 (en) * | 2014-07-25 | 2016-01-28 | Innov17 Llc | Sulfonamide retinoic acid receptor-related orphan receptor modulators and uses thereof |
| US20160024086A1 (en) * | 2014-07-25 | 2016-01-28 | Innov17 Llc | Azaindole retinoic acid receptor-related orphan receptor modulators and uses thereof |
| US9884847B2 (en) | 2014-07-25 | 2018-02-06 | Innov17 Llc | Indazole retinoic acid receptor-related orphan receptor modulators and uses thereof |
| US20160024052A1 (en) * | 2014-07-25 | 2016-01-28 | Innov17 Llc | Benzimidazole retinoic acid receptor-related orphan receptor modulators and uses thereof |
| MA40759A (fr) | 2014-09-26 | 2017-08-01 | Pfizer | Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation |
| PT3207043T (pt) | 2014-10-14 | 2019-03-25 | Vitae Pharmaceuticals Llc | Inibidores de di-hidropirrolopiridina de ror-gama |
| GB201419015D0 (en) | 2014-10-24 | 2014-12-10 | Orca Pharmaceuticals Ltd | Compounds |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| EP3242878B1 (en) * | 2015-01-08 | 2020-10-14 | Impetis Biosciences Ltd. | Bicyclic compounds, compositions and medicinal applications thereof |
| CN105820103B (zh) * | 2015-01-28 | 2020-11-03 | 北京韩美药品有限公司 | N-苯甲酸基取代的苯并吡咯啉-2-酮类衍生物及其用途 |
| US10385036B2 (en) | 2015-01-30 | 2019-08-20 | Pfizer Inc. | Sulfonamide-substituted indole modulators of RORC2 and methods of use thereof |
| EP3256450B1 (en) | 2015-02-11 | 2020-12-02 | Merck Sharp & Dohme Corp. | Substituted pyrazole compounds as ror-gamma-t inhibitors and uses thereof |
| WO2016128908A1 (en) * | 2015-02-12 | 2016-08-18 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
| WO2016145298A1 (en) | 2015-03-12 | 2016-09-15 | The Regents Of The University Of California | METHODS FOR TREATING CANCER WITH RORgamma INHIBITORS |
| JP2018515491A (ja) | 2015-05-05 | 2018-06-14 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγの作動薬及び疾患の療法として使用するジヒドロ−２Ｈ−ベンゾ［ｂ］［１，４］オキサジンスルホンアミド及び関連化合物 |
| WO2016198908A1 (en) * | 2015-06-09 | 2016-12-15 | Abbvie Inc. | Ror nuclear receptor modulators |
| DK3307734T3 (da) * | 2015-06-09 | 2020-01-27 | Abbvie Inc | Nukleære receptormodulatorer (ror) til behandling af inflammatoriske og autoimmune sygdomme |
| KR20180025894A (ko) | 2015-06-11 | 2018-03-09 | 라이세라 코퍼레이션 | Rory의 작용제로서 사용하기 위한 아릴 디히드로-2h-벤조[b][1,4]옥사진 술폰아미드 및 관련 화합물 및 질환의 치료 |
| WO2017024018A1 (en) | 2015-08-05 | 2017-02-09 | Vitae Pharmaceuticals, Inc. | Modulators of ror-gamma |
| JO3638B1 (ar) * | 2015-09-09 | 2020-08-27 | Lilly Co Eli | مركبات مفيدة في تثبيط ror - جاما- t |
| WO2017075178A1 (en) * | 2015-10-27 | 2017-05-04 | Merck Sharp & Dohme Corp. | SUBSTITUTED BICYCLIC PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| RU2018117503A (ru) * | 2015-10-27 | 2019-11-28 | Мерк Шарп И Доум Корп. | ЗАМЕЩЕННЫЕ ИНДАЗОЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ RORγТ И ИХ ПРИМЕНЕНИЕ |
| AU2016344118A1 (en) | 2015-10-27 | 2018-05-10 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
| US11008340B2 (en) | 2015-11-20 | 2021-05-18 | Vitae Pharmaceuticals, Llc | Modulators of ROR-gamma |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| JP7111720B2 (ja) | 2016-12-28 | 2022-08-02 | ダート・ニューロサイエンス・エルエルシー | Ｐｄｅ２阻害剤としての置換ピラゾロピリミジノン化合物 |
| JP2020111510A (ja) * | 2017-03-29 | 2020-07-27 | 科研製薬株式会社 | インダゾール誘導体及びそれを含有する医薬 |
| JP7090639B2 (ja) * | 2017-04-11 | 2022-06-24 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | フッ素置換されたインダゾール化合物及びその使用 |
| RU2742770C1 (ru) * | 2017-07-06 | 2021-02-10 | Цзянсу Хэнжуй Медицин Ко., Лтд. | Производное индола и формамида, способ его получения и применение в медицине |
| JP2020528904A (ja) | 2017-07-24 | 2020-10-01 | ヴァイティー ファーマシューティカルズ，エルエルシー | ＲＯＲγの阻害剤 |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| CA3120971A1 (en) | 2017-11-27 | 2019-05-31 | Dart Neuroscience, Llc | Substituted furanopyrimidine compounds as pde1 inhibitors |
| WO2022117882A2 (en) * | 2020-12-03 | 2022-06-09 | Domain Therapeutics | Novel par-2 inhibitors |
| CN120418228A (zh) * | 2023-01-09 | 2025-08-01 | 康百达（四川）生物医药科技有限公司 | 一种杂环化合物及其在医药上的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT95899A (pt) * | 1989-11-17 | 1991-09-13 | Glaxo Group Ltd | Processo para a preparacao de derivados indole |
| WO1995027202A1 (en) * | 1994-03-30 | 1995-10-12 | Ciba-Geigy Ag | Screening method using the rzr receptor family |
| US5639780A (en) * | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
| US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| JP2008509138A (ja) * | 2004-08-03 | 2008-03-27 | ワイス | 心臓血管疾患の治療に有用なインダゾール類 |
| MX2007003336A (es) * | 2004-09-21 | 2007-06-05 | Athersys Inc | Acidos aceticos de indol que muestran antagonismo de receptor crth2 y usos de los mismos. |
| EP1828180A4 (en) * | 2004-12-08 | 2010-09-15 | Glaxosmithkline Llc | 1H-pyrrolo [2,3-BETA] PYRIDINE |
| EP2181710A1 (en) | 2008-10-28 | 2010-05-05 | Phenex Pharmaceuticals AG | Ligands for modulation of orphan receptor-gamma (NR1F3) activity |
| WO2011014775A1 (en) * | 2009-07-31 | 2011-02-03 | The Brigham And Women's Hospital, Inc. | Modulation of sgk1 expression in th17 cells to modulate th17-mediated immune responses |
| WO2011055270A1 (en) * | 2009-11-04 | 2011-05-12 | Wyeth Llc | Indole based receptor crth2 antagonists |
| EP2487159A1 (en) | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
| JP2014166961A (ja) * | 2011-06-20 | 2014-09-11 | Dainippon Sumitomo Pharma Co Ltd | 新規インダゾール誘導体 |
| WO2014026329A1 (en) * | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof |
| WO2014026327A1 (en) * | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof |
| WO2014026330A1 (en) * | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
-
2012
- 2012-08-15 WO PCT/CN2012/080133 patent/WO2014026328A1/en not_active Ceased
-
2013
- 2013-08-14 ME MEP-2019-276A patent/ME03579B/me unknown
- 2013-08-14 EP EP13829099.4A patent/EP2884976B1/en active Active
- 2013-08-14 DK DK13829099.4T patent/DK2884976T3/da active
- 2013-08-14 JP JP2015527569A patent/JP6232429B2/ja not_active Expired - Fee Related
- 2013-08-14 AU AU2013302644A patent/AU2013302644A1/en not_active Abandoned
- 2013-08-14 SI SI201331578T patent/SI2884976T1/sl unknown
- 2013-08-14 US US14/421,057 patent/US9487490B2/en active Active
- 2013-08-14 WO PCT/US2013/054902 patent/WO2014028597A2/en not_active Ceased
- 2013-08-14 RU RU2015108898A patent/RU2015108898A/ru unknown
- 2013-08-14 RS RSP20191289 patent/RS59364B1/sr unknown
- 2013-08-14 CA CA2881696A patent/CA2881696A1/en not_active Abandoned
- 2013-08-14 HU HUE13829099A patent/HUE045379T2/hu unknown
- 2013-08-14 BR BR112015003332A patent/BR112015003332A2/pt not_active IP Right Cessation
- 2013-08-14 HR HRP20191654 patent/HRP20191654T1/hr unknown
- 2013-08-14 PL PL13829099T patent/PL2884976T3/pl unknown
- 2013-08-14 ES ES13829099T patent/ES2749713T3/es active Active
- 2013-08-14 KR KR20157006342A patent/KR20150041800A/ko not_active Abandoned
- 2013-08-14 LT LTEP13829099.4T patent/LT2884976T/lt unknown
- 2013-08-14 SM SM20190580T patent/SMT201900580T1/it unknown
- 2013-08-14 CN CN201380053426.7A patent/CN104822376A/zh active Pending
- 2013-08-14 PT PT138290994T patent/PT2884976T/pt unknown
-
2019
- 2019-10-04 CY CY20191101047T patent/CY1122272T1/el unknown