JP2015526443A5 - - Google Patents
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- Publication number
- JP2015526443A5 JP2015526443A5 JP2015527569A JP2015527569A JP2015526443A5 JP 2015526443 A5 JP2015526443 A5 JP 2015526443A5 JP 2015527569 A JP2015527569 A JP 2015527569A JP 2015527569 A JP2015527569 A JP 2015527569A JP 2015526443 A5 JP2015526443 A5 JP 2015526443A5
- Authority
- JP
- Japan
- Prior art keywords
- chloro
- indazol
- benzoyl
- trifluoromethyl
- cyclohex
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QSERINUGEFDOOJ-UHFFFAOYSA-N CC(N1N(C)C1)S=O Chemical compound CC(N1N(C)C1)S=O QSERINUGEFDOOJ-UHFFFAOYSA-N 0.000 description 1
- 0 CCSc1cccc(*)c1C(N(*=C(C1=*S)C2=CCC(*)CC2)C1=**=*)=O Chemical compound CCSc1cccc(*)c1C(N(*=C(C1=*S)C2=CCC(*)CC2)C1=**=*)=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/080133 WO2014026328A1 (en) | 2012-08-15 | 2012-08-15 | 3-cyclohexenyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof |
| CNPCT/CN2012/080133 | 2012-08-15 | ||
| PCT/US2013/054902 WO2014028597A2 (en) | 2012-08-15 | 2013-08-14 | 3-CYCLOHEXENYL AND CYCLOHEXYL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015526443A JP2015526443A (ja) | 2015-09-10 |
| JP2015526443A5 true JP2015526443A5 (https=) | 2016-09-23 |
| JP6232429B2 JP6232429B2 (ja) | 2017-11-15 |
Family
ID=50101186
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015527569A Expired - Fee Related JP6232429B2 (ja) | 2012-08-15 | 2013-08-14 | ＲＯＲγＴ阻害剤としての３−シクロヘキセニルおよびシクロヘキシル置換インドールおよびインダゾール化合物およびそれらの使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9487490B2 (https=) |
| EP (1) | EP2884976B1 (https=) |
| JP (1) | JP6232429B2 (https=) |
| KR (1) | KR20150041800A (https=) |
| CN (1) | CN104822376A (https=) |
| AU (1) | AU2013302644A1 (https=) |
| BR (1) | BR112015003332A2 (https=) |
| CA (1) | CA2881696A1 (https=) |
| CY (1) | CY1122272T1 (https=) |
| DK (1) | DK2884976T3 (https=) |
| ES (1) | ES2749713T3 (https=) |
| HR (1) | HRP20191654T1 (https=) |
| HU (1) | HUE045379T2 (https=) |
| LT (1) | LT2884976T (https=) |
| ME (1) | ME03579B (https=) |
| PL (1) | PL2884976T3 (https=) |
| PT (1) | PT2884976T (https=) |
| RS (1) | RS59364B1 (https=) |
| RU (1) | RU2015108898A (https=) |
| SI (1) | SI2884976T1 (https=) |
| SM (1) | SMT201900580T1 (https=) |
| WO (2) | WO2014026328A1 (https=) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2487159A1 (en) | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
| WO2014026327A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof |
| WO2014026330A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| WO2014026329A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof |
| CA2919783C (en) * | 2013-08-02 | 2018-02-06 | Pfizer Inc. | Heterobicycloaryl rorc2 inhibitors and methods of use thereof |
| AU2015210833B2 (en) | 2014-02-03 | 2019-01-03 | Vitae Pharmaceuticals, Llc | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| JP2017507950A (ja) | 2014-02-27 | 2017-03-23 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | レチノイン酸受容体関連オーファン受容体ガンマのアゴニストを使用する養子細胞療法及び関連治療方法 |
| JP6523337B2 (ja) | 2014-05-05 | 2019-05-29 | リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ | ＲＯＲγのアゴニストとしての使用及び疾患治療のためのベンゼンスルホンアミド及び関連化合物 |
| EP3140291A4 (en) | 2014-05-05 | 2018-01-10 | Lycera Corporation | Tetrahydroquinoline sulfonamide and related compounds for use as agonists of rory and the treatment of disease |
| EP3172196A4 (en) * | 2014-07-25 | 2017-12-27 | Innov17 LLC | Azaindole retinoic acid receptor-related orphan receptor modulators and uses thereof |
| WO2016014913A1 (en) * | 2014-07-25 | 2016-01-28 | Innov17 Llc | Indazole retinoic acid receptor-related orphan receptor modulators and uses thereof |
| EP3172195A4 (en) * | 2014-07-25 | 2018-03-21 | Innov17 LLC | Sulfonamide retinoic acid receptor-related orphan receptor modulators and uses thereof |
| EP3172197A4 (en) * | 2014-07-25 | 2018-03-14 | Innov17 LLC | Benzimidazole retinoic acid receptor-related orphan receptor modulators and uses thereof |
| MA40759A (fr) | 2014-09-26 | 2017-08-01 | Pfizer | Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation |
| JP6564029B2 (ja) | 2014-10-14 | 2019-08-21 | ヴァイティー ファーマシューティカルズ，エルエルシー | Ｒｏｒ−ガンマのジヒドロピロロピリジン阻害剤 |
| GB201419015D0 (en) | 2014-10-24 | 2014-12-10 | Orca Pharmaceuticals Ltd | Compounds |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| WO2016110821A1 (en) * | 2015-01-08 | 2016-07-14 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
| CN105820103B (zh) * | 2015-01-28 | 2020-11-03 | 北京韩美药品有限公司 | N-苯甲酸基取代的苯并吡咯啉-2-酮类衍生物及其用途 |
| US10385036B2 (en) | 2015-01-30 | 2019-08-20 | Pfizer Inc. | Sulfonamide-substituted indole modulators of RORC2 and methods of use thereof |
| CA2975997A1 (en) | 2015-02-11 | 2016-08-18 | Merck Sharp & Dohme Corp. | Substituted pyrazole compounds as rorgammat inhibitors and uses thereof |
| WO2016128908A1 (en) * | 2015-02-12 | 2016-08-18 | Advinus Therapeutics Limited | Bicyclic compounds, compositions and medicinal applications thereof |
| CN107614062A (zh) | 2015-03-12 | 2018-01-19 | 加利福尼亚大学董事会 | 用RORγ抑制剂治疗癌症的方法 |
| US10421751B2 (en) | 2015-05-05 | 2019-09-24 | Lycera Corporation | Dihydro-2H-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORγ and the treatment of disease |
| WO2016198908A1 (en) * | 2015-06-09 | 2016-12-15 | Abbvie Inc. | Ror nuclear receptor modulators |
| JP6549735B2 (ja) * | 2015-06-09 | 2019-07-24 | アッヴィ・インコーポレイテッド | 核内受容体調節剤 |
| AU2016276947A1 (en) | 2015-06-11 | 2017-12-14 | Lycera Corporation | Aryl dihydro-2h-benzo[b][1,4]oxazine sulfonamide and related compounds for use as agonists of RORy and the treatment of disease |
| DK3331876T3 (da) | 2015-08-05 | 2021-01-11 | Vitae Pharmaceuticals Llc | Modulators of ror-gamma |
| JO3638B1 (ar) * | 2015-09-09 | 2020-08-27 | Lilly Co Eli | مركبات مفيدة في تثبيط ror - جاما- t |
| EP3368535B1 (en) | 2015-10-27 | 2020-12-02 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
| JP2018535958A (ja) * | 2015-10-27 | 2018-12-06 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | ＲＯＲγＴ阻害薬としての置換インダゾール化合物及びその使用 |
| US10344000B2 (en) | 2015-10-27 | 2019-07-09 | Merck Sharp & Dohme Corp. | Substituted bicyclic pyrazole compounds as RORgammaT inhibitors and uses thereof |
| MA53943A (fr) | 2015-11-20 | 2021-08-25 | Vitae Pharmaceuticals Llc | Modulateurs de ror-gamma |
| TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| KR102590848B1 (ko) | 2016-12-28 | 2023-10-19 | 다트 뉴로사이언스, 엘엘씨 | Pde2 억제제로서 치환된 피라졸로피리미디논 화합물 |
| JP2020111510A (ja) * | 2017-03-29 | 2020-07-27 | 科研製薬株式会社 | インダゾール誘導体及びそれを含有する医薬 |
| ES2924359T3 (es) * | 2017-04-11 | 2022-10-06 | Sunshine Lake Pharma Co Ltd | Compuestos de indazol sustituidos con flúor y usos de los mismos |
| TW201906816A (zh) * | 2017-07-06 | 2019-02-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 吲哚甲醯胺類衍生物、其製備方法及其在醫藥上的應用 |
| CN115650976A (zh) | 2017-07-24 | 2023-01-31 | 生命医药有限责任公司 | RORγ的抑制剂 |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
| DK3717488T3 (da) | 2017-11-27 | 2021-12-13 | Dart Neuroscience Llc | Substituerede furanopyrimidinforbindelser som pde1-inhibitorer |
| US20240066027A1 (en) * | 2020-12-03 | 2024-02-29 | Domain Therapeutics | Novel par-2 inhibitors |
| EP4650345A1 (en) * | 2023-01-09 | 2025-11-19 | Kangbaida (Sichuan) Biotechnology Co., Ltd. | Heterocyclic compound and use thereof in medicine |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT95899A (pt) * | 1989-11-17 | 1991-09-13 | Glaxo Group Ltd | Processo para a preparacao de derivados indole |
| AU2109695A (en) * | 1994-03-30 | 1995-10-23 | Novartis Ag | Screening method using the rzr receptor family |
| US5639780A (en) * | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
| US6716452B1 (en) * | 2000-08-22 | 2004-04-06 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| EP1773781A2 (en) * | 2004-08-03 | 2007-04-18 | Wyeth | Indazoles useful in treating cardiovascular diseases |
| WO2006034419A2 (en) * | 2004-09-21 | 2006-03-30 | Athersys, Inc. | Indole acetic acids exhibiting crth2 receptor antagonism and uses thereof |
| EP1828180A4 (en) | 2004-12-08 | 2010-09-15 | Glaxosmithkline Llc | 1H-pyrrolo [2,3-BETA] PYRIDINE |
| EP2181710A1 (en) * | 2008-10-28 | 2010-05-05 | Phenex Pharmaceuticals AG | Ligands for modulation of orphan receptor-gamma (NR1F3) activity |
| EP2459184A1 (en) * | 2009-07-31 | 2012-06-06 | The Brigham and Women's Hospital, Inc. | Modulation of sgk1 expression in th17 cells to modulate th17-mediated immune responses |
| WO2011055270A1 (en) * | 2009-11-04 | 2011-05-12 | Wyeth Llc | Indole based receptor crth2 antagonists |
| EP2487159A1 (en) * | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
| JP2014166961A (ja) * | 2011-06-20 | 2014-09-11 | Dainippon Sumitomo Pharma Co Ltd | 新規インダゾール誘導体 |
| WO2014026327A1 (en) * | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof |
| WO2014026330A1 (en) * | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
| WO2014026329A1 (en) * | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof |
-
2012
- 2012-08-15 WO PCT/CN2012/080133 patent/WO2014026328A1/en not_active Ceased
-
2013
- 2013-08-14 BR BR112015003332A patent/BR112015003332A2/pt not_active IP Right Cessation
- 2013-08-14 WO PCT/US2013/054902 patent/WO2014028597A2/en not_active Ceased
- 2013-08-14 JP JP2015527569A patent/JP6232429B2/ja not_active Expired - Fee Related
- 2013-08-14 LT LTEP13829099.4T patent/LT2884976T/lt unknown
- 2013-08-14 DK DK13829099.4T patent/DK2884976T3/da active
- 2013-08-14 EP EP13829099.4A patent/EP2884976B1/en active Active
- 2013-08-14 SM SM20190580T patent/SMT201900580T1/it unknown
- 2013-08-14 RS RSP20191289 patent/RS59364B1/sr unknown
- 2013-08-14 ES ES13829099T patent/ES2749713T3/es active Active
- 2013-08-14 SI SI201331578T patent/SI2884976T1/sl unknown
- 2013-08-14 ME MEP-2019-276A patent/ME03579B/me unknown
- 2013-08-14 RU RU2015108898A patent/RU2015108898A/ru unknown
- 2013-08-14 KR KR20157006342A patent/KR20150041800A/ko not_active Abandoned
- 2013-08-14 AU AU2013302644A patent/AU2013302644A1/en not_active Abandoned
- 2013-08-14 HU HUE13829099A patent/HUE045379T2/hu unknown
- 2013-08-14 PL PL13829099T patent/PL2884976T3/pl unknown
- 2013-08-14 US US14/421,057 patent/US9487490B2/en active Active
- 2013-08-14 CN CN201380053426.7A patent/CN104822376A/zh active Pending
- 2013-08-14 HR HRP20191654 patent/HRP20191654T1/hr unknown
- 2013-08-14 CA CA2881696A patent/CA2881696A1/en not_active Abandoned
- 2013-08-14 PT PT138290994T patent/PT2884976T/pt unknown
-
2019
- 2019-10-04 CY CY20191101047T patent/CY1122272T1/el unknown
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