JP2015526439A - 体重増加を予防するため、および/または肥満関連疾患を治療するための変異トマトおよびその使用 - Google Patents
体重増加を予防するため、および/または肥満関連疾患を治療するための変異トマトおよびその使用 Download PDFInfo
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Abstract
Description
rin含量の決定
以前に説明された通りに(Kitagawaら、Characterization of tomato fruit ripening and analysis of gen expression in F1-Hybrids of the ripening inhibitor(rin)Mutant. Physiol Plantarium 2005、 123(3):331-338)、RNeasy Plus Mini Kit(Qiagen, Hilden, Germany)を使用して、正常植物(遺伝子型RIN/RIN)(緑熟、桃熟および完熟)を含めた、rin含量が異なる品種、およびこれらの段階に対応する時期のrin変異体植物(rin/rin)のトマト果実から全RNAを抽出し、精製した。PrimeScript II first cDNA strand synthesis kit(Takara Biotech)を使用して全RNAから相補DNAを合成し、次いでリアルタイムPCRに鋳型として適用した。rin遺伝子の発現レベルを、rinに特異的なオリゴヌクレオチドプライマー(GenBank受託番号AF448522)を使用した定量リアルタイム逆転写PCR(qRT-PCR)によって解析した。
新鮮なトマト果実を切って約1×1×1cmの小片にした。果実全体を使用した。小片を凍結乾燥した後、凍結乾燥した材料を、乳棒と乳鉢を使用して粉砕して均一の粉末にした。粉末を抽出溶媒(メタノールまたはメタノール/水 80:20 v/v/ 混合物)で抽出した。一般には、溶媒13mLを使用して粉末1グラムを抽出した。抽出は室温で実施した(超音波を30分、その後、激しい振とうを30分)。抽出混合物を遠心分離し、上清を真空下で乾燥させた。乾燥した抽出物をDMSO(Q:体積?)に再溶解させた後に、脂肪生成アッセイで使用した。抽出物の濃度は、375mg/mlの元の粉末に対応する。
Niwanoら(Niwanoら、Extensive screening for plant foodstuffs in Okinawa、Japan with anti-obese activity on adipocytes in vitro. Plant Foods Hum Nutr. 2009 Mar;64(1):6-10)によって以前に説明されたプロトコールに従ってアッセイを実施した。
Claims (18)
- 哺乳動物において体重増加を予防するため、および/または脂肪生成に関連する疾患を抑制する、予防する、もしくは改善するための方法において使用するためのトマト植物、果実、断片またはその抽出物であって、該トマトが成熟障害変異トマトである、トマト植物、果実、断片またはその抽出物。
- 前記変異トマトがrin、norおよび/またはNr遺伝子を保有する、請求項1に記載の使用のためのトマト植物、果実、断片またはその抽出物。
- 前記トマトがrin遺伝子を保有し、好ましくは前記トマトがrinホモ接合体である、請求項1または2に記載の使用のためのトマト植物、果実、断片またはその抽出物。
- 前記トマトが、品種「Slimmy」、「Mr Tasty」、「Gusto Delight」および「Tomango」からなる群から選択される、請求項3に記載の使用のためのトマト植物、果実、断片またはその抽出物。
- 果実、根またはその抽出物が使用される、請求項1から4のいずれか一項に記載の使用のためのトマト植物、果実、断片またはその抽出物。
- 前記抽出物はアルコール抽出によって調製される、請求項5に記載のトマト果実抽出物。
- 前記哺乳動物が、ヒト個体、好ましくは脂肪生成に関連する疾患が発生するリスクが高いヒト個体である、請求項1から6のいずれか一項に記載の使用のためのトマト植物、果実、断片またはその抽出物。
- 前記ヒト個体が、肥満症、脂質蓄積症、高脂血症、2型糖尿病、心疾患、脳卒中、高血圧症、がん、メタボリックシンドローム、胆嚢疾患、痛風、睡眠時無呼吸、喘息または小児肥満症に罹患している、またはそれが発生する素因がある、請求項7に記載の使用のためのトマト植物、果実、断片またはその抽出物。
- トマト植物、果実またはその断片の抽出物を活性成分として含む抗脂肪生成剤であって、該トマトが成熟障害変異トマトである、抗脂肪生成剤。
- 前記変異トマトがrin、norおよび/またはNr遺伝子を保有し、好ましくは、前記変異トマトがrin遺伝子を保有する、請求項9に記載の抗脂肪生成剤。
- 前記抽出物が、トマト果実または根のアルコール抽出物、好ましくはメタノール抽出物、より好ましくは70:30〜95:5(v/v)の範囲のMeOH/水によって調製された抽出物である、請求項9または10に記載の抗脂肪生成剤。
- トマト植物、果実、断片またはその抽出物を含む医薬品、動物用食品、栄養補給食品または化粧用組成物であって、該トマトが成熟障害変異トマトである、医薬品、動物用食品、栄養補給食品または化粧用組成物。
- トマト植物、果実、断片またはその抽出物を含む医薬品、栄養補給食品、食物、飲料または化粧用組成物であって、該トマトが成熟障害変異トマトであり、少なくとも1つのプロバイオティクスおよび/または少なくとも1つのプレバイオティクスをさらに含む、医薬品、栄養補給食品、食物、飲料または化粧用組成物。
- 前記変異トマトがrin、norおよび/またはNr遺伝子を保有する、請求項12または13に記載の医薬品、栄養補給食品、食物、飲料または化粧用組成物。
- 抗脂肪生成剤を製造するための方法であって、トマト植物、果実またはその断片の原料を溶媒で抽出する工程を含み、該トマトが、成熟障害変異トマト、好ましくはripening inhibitor(rin)変異トマトである方法。
- 前記原料を抽出前に凍結乾燥または噴霧乾燥する、請求項15に記載の方法。
- 前記溶媒が、アルコール溶媒、好ましくはメタノール溶媒、より好ましくは70:30〜95:5(v/v)の範囲のMeOH/水である、請求項15または16に記載の方法。
- 対象における体重減少を誘導するため、および/または体重増加を予防するための方法であって、該対象に、成熟障害トマト植物、果実、断片またはその抽出物、および薬学的に許容される担体を含む医薬製剤を治療有効量で投与することを含む方法。
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NL2009317A NL2009317C2 (en) | 2012-08-13 | 2012-08-13 | Mutant tomatoes and use thereof for preventing weight gain and/or treating obesity-related conditions. |
NL2009317 | 2012-08-13 | ||
PCT/NL2013/050596 WO2014027886A1 (en) | 2012-08-13 | 2013-08-13 | Mutant tomatoes and use thereof for preventing weight gain and/or treating obesity-related conditions |
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JP2011184411A (ja) * | 2010-03-11 | 2011-09-22 | Kyoto Univ | トマト抽出物を含有する生活習慣病改善剤 |
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US20030129292A1 (en) * | 1998-04-02 | 2003-07-10 | Lipton | Tomato paste and sauce and process for preparation |
AU2003258570A1 (en) * | 2002-08-08 | 2004-03-11 | Unilever Plc | Processed tomato products and process for preparing the same |
DE102005043986A1 (de) * | 2005-09-14 | 2007-04-05 | Mark Warnecke | Zusatznahrungsmittel |
ES2336180B8 (es) * | 2008-03-13 | 2011-08-01 | Semillas Fito, S.A. | Procedimiento para producir plantas de tomate con caracteristicas de larga vida. |
US8772606B2 (en) * | 2008-10-10 | 2014-07-08 | Arcadia Biosciences, Inc. | Non-transgenic tomato varieties having increased shelf life post-harvest |
CN101703290A (zh) * | 2009-05-25 | 2010-05-12 | 赵敏 | 一种西红柿益生菌发酵饮料及其制作方法 |
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JP2002080387A (ja) * | 2000-06-28 | 2002-03-19 | Kikkoman Corp | 抗アレルギー剤およびその製造方法 |
JP2011184411A (ja) * | 2010-03-11 | 2011-09-22 | Kyoto Univ | トマト抽出物を含有する生活習慣病改善剤 |
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KITAGAWA M, ET AL.: "Reduction of allergenic proteins by the effect of the ripening inhibitor (rin) mutant gene in an F1", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 70, no. 5, JPN6018012927, 2006, pages 1227 - 1233 * |
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DK2882280T3 (en) | 2018-11-05 |
AU2013303289B2 (en) | 2019-02-21 |
RU2015108679A (ru) | 2016-09-27 |
CA2881810A1 (en) | 2014-02-20 |
US20150313106A1 (en) | 2015-11-05 |
BR112015003312A2 (pt) | 2017-07-04 |
EP2882280B1 (en) | 2018-07-18 |
EP2882280A1 (en) | 2015-06-17 |
WO2014027886A1 (en) | 2014-02-20 |
NL2009317C2 (en) | 2014-02-18 |
CN104837336B (zh) | 2018-03-13 |
AU2013303289A1 (en) | 2015-04-02 |
CN104837336A (zh) | 2015-08-12 |
RU2662935C2 (ru) | 2018-07-31 |
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