JP2015524826A - Ｖｅｇｆｒ３阻害剤 - Google Patents

Ｖｅｇｆｒ３阻害剤 Download PDF

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Publication number
JP2015524826A
JP2015524826A JP2015526836A JP2015526836A JP2015524826A JP 2015524826 A JP2015524826 A JP 2015524826A JP 2015526836 A JP2015526836 A JP 2015526836A JP 2015526836 A JP2015526836 A JP 2015526836A JP 2015524826 A JP2015524826 A JP 2015524826A
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alkyl
compound according
group
compound
methyl
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JP2015526836A
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Japanese (ja)
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JP2015524826A5 (enExample
Inventor
フォイトジーク、リチャード・チャールズ
モロー、ベンジャミン・ジョセフ
ヘムレイ、キャサリン・ファエ
ランニース、ジリアン・エリザベス
キャメリノ、ミッチェル・アング
ガネーム、ダニー
ストゥップル、ポール・アンソニー
レッセン、ロミナ
カーステン、ビルヘルムズ・ヨハネス・アントニウス
ハーベイ、アンドリュー・ジョン
ホルムス、イアン・ピーター
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キャンサー・セラピューティクス・シーアールシー・ピーティーワイ・リミテッド
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Publication of JP2015524826A publication Critical patent/JP2015524826A/ja
Publication of JP2015524826A5 publication Critical patent/JP2015524826A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015526836A 2012-08-17 2013-08-16 Ｖｅｇｆｒ３阻害剤 Pending JP2015524826A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261684202P 2012-08-17 2012-08-17
US61/684,202 2012-08-17
PCT/AU2013/000913 WO2014026243A1 (en) 2012-08-17 2013-08-16 Vegfr3 inhibitors

Publications (2)

Publication Number Publication Date
JP2015524826A true JP2015524826A (ja) 2015-08-27
JP2015524826A5 JP2015524826A5 (enExample) 2016-10-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015526836A Pending JP2015524826A (ja) 2012-08-17 2013-08-16 Ｖｅｇｆｒ３阻害剤

Country Status (8)

Country Link
US (2) US20160009686A1 (enExample)
EP (1) EP2885291A4 (enExample)
JP (1) JP2015524826A (enExample)
CN (1) CN104736533B (enExample)
AU (1) AU2013302320A1 (enExample)
CA (1) CA2882158A1 (enExample)
HK (1) HK1209105A1 (enExample)
WO (1) WO2014026243A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019536766A (ja) * 2016-11-10 2019-12-19 浙江大学Ｚｈｅｊｉａｎｇ Ｕｎｉｖｅｒｓｉｔｙ ２−置換芳香族環−ピリミジン系誘導体及びその調製と医学的用途

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EP2885292A4 (en) * 2012-08-17 2015-07-01 Cancer Therapeutics Crc Pty Ltd VEGFR3 INHIBITORS
WO2015123722A1 (en) * 2014-02-19 2015-08-27 Bionomics Limited Inhibitors
CN112088003B (zh) * 2017-12-20 2023-10-13 戴纳立制药公司 制备嘧啶基-4-氨基吡唑化合物的工艺
BR112020013198A2 (pt) 2017-12-29 2020-12-01 Glycomimetics, Inc. inibidores heterobifuncionais de e-selectina e galectina-3
WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
CN109942616A (zh) * 2019-04-18 2019-06-28 广东工业大学 一种含炔基的芳基酰胺类衍生物及其制备方法和应用
WO2023073148A1 (en) * 2021-10-29 2023-05-04 Janssen Pharmaceutica Nv Vascular endothelial growth factor receptor 3 as biomarker for bace2 activity

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JP2010539094A (ja) * 2007-09-10 2010-12-16 キュリス，インコーポレイテッド 亜鉛結合部分を含むｖｅｇｆｒインヒビター
WO2012022408A1 (de) * 2010-08-18 2012-02-23 Merck Patent Gmbh Pyrimidinderivate als fak inhibitoren
WO2012036919A2 (en) * 2010-09-14 2012-03-22 Glaxosmithkline Llc Combination of braf and vegf inhibitors
JP2012511016A (ja) * 2008-12-05 2012-05-17 アボット・ラボラトリーズ 癌の治療に使用するためのキナーゼ阻害剤としてのチエノ［３，２−ｃ］ピリジン誘導体
JP2012526766A (ja) * 2009-05-14 2012-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 腫瘍性及び線維性疾患の処置における新規な併用療法
JP5937111B2 (ja) * 2011-02-17 2016-06-22 カンサー・セラピューティクス・シーアールシー・プロプライエタリー・リミテッドＣａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｒｃ Ｐｔｙ Ｌｉｍｉｔｅｄ Ｆａｋ阻害剤

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PT885198E (pt) 1996-03-05 2002-06-28 Astrazeneca Ab Derivados de 4-anilinoquinazolina
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010539094A (ja) * 2007-09-10 2010-12-16 キュリス，インコーポレイテッド 亜鉛結合部分を含むｖｅｇｆｒインヒビター
JP2012511016A (ja) * 2008-12-05 2012-05-17 アボット・ラボラトリーズ 癌の治療に使用するためのキナーゼ阻害剤としてのチエノ［３，２−ｃ］ピリジン誘導体
JP2012526766A (ja) * 2009-05-14 2012-11-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 腫瘍性及び線維性疾患の処置における新規な併用療法
WO2012022408A1 (de) * 2010-08-18 2012-02-23 Merck Patent Gmbh Pyrimidinderivate als fak inhibitoren
WO2012036919A2 (en) * 2010-09-14 2012-03-22 Glaxosmithkline Llc Combination of braf and vegf inhibitors
JP5937111B2 (ja) * 2011-02-17 2016-06-22 カンサー・セラピューティクス・シーアールシー・プロプライエタリー・リミテッドＣａｎｃｅｒ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｒｃ Ｐｔｙ Ｌｉｍｉｔｅｄ Ｆａｋ阻害剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019536766A (ja) * 2016-11-10 2019-12-19 浙江大学Ｚｈｅｊｉａｎｇ Ｕｎｉｖｅｒｓｉｔｙ ２−置換芳香族環−ピリミジン系誘導体及びその調製と医学的用途

Also Published As

Publication number Publication date
CA2882158A1 (en) 2014-02-20
US9238644B2 (en) 2016-01-19
US20140073620A1 (en) 2014-03-13
EP2885291A1 (en) 2015-06-24
CN104736533A (zh) 2015-06-24
HK1209105A1 (en) 2016-03-24
EP2885291A4 (en) 2015-11-04
AU2013302320A1 (en) 2015-02-26
US20160009686A1 (en) 2016-01-14
CN104736533B (zh) 2016-12-07
WO2014026243A1 (en) 2014-02-20

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