JP2015523855A - Ａｐｏａ１及びａｂｃａ１発現を調節するための組成物及び方法 - Google Patents

Ａｐｏａ１及びａｂｃａ１発現を調節するための組成物及び方法 Download PDF

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JP2015523855A
JP2015523855A JP2015512861A JP2015512861A JP2015523855A JP 2015523855 A JP2015523855 A JP 2015523855A JP 2015512861 A JP2015512861 A JP 2015512861A JP 2015512861 A JP2015512861 A JP 2015512861A JP 2015523855 A JP2015523855 A JP 2015523855A
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nucleotide
oligonucleotide
nucleotides
stranded oligonucleotide
sequence
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アーサー エム． クリーグ，
アーサー エム． クリーグ，
ロメシュ スブラマニアン，
ロメシュ スブラマニアン，
ジェイムズ マクスウィゲン，
ジェイムズ マクスウィゲン，
ジェニー ティー． リー，
ジェニー ティー． リー，
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ラナ セラピューティクス インコーポレイテッド
ラナ セラピューティクス インコーポレイテッド
ザ ジェネラル ホスピタル コーポレイション
ザ ジェネラル ホスピタル コーポレイション
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Publication of JP2015523855A publication Critical patent/JP2015523855A/ja
Publication of JP2015523855A5 publication Critical patent/JP2015523855A5/ja
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

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  • Wood Science & Technology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Physics & Mathematics (AREA)
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  • Heart & Thoracic Surgery (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2015512861A 2012-05-16 2013-05-16 Ａｐｏａ１及びａｂｃａ１発現を調節するための組成物及び方法 Pending JP2015523855A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261647949P 2012-05-16 2012-05-16
US61/647,949 2012-05-16
US201361785778P 2013-03-14 2013-03-14
US61/785,778 2013-03-14
PCT/US2013/041455 WO2013173647A1 (en) 2012-05-16 2013-05-16 Compositions and methods for modulating apoa1 and abca1 expression

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JP2015523855A true JP2015523855A (ja) 2015-08-20
JP2015523855A5 JP2015523855A5 (https=) 2016-06-30

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US (1) US20150191722A1 (https=)
EP (1) EP2849801A4 (https=)
JP (1) JP2015523855A (https=)
CN (1) CN104582737A (https=)
AU (1) AU2013262658A1 (https=)
BR (1) BR112014028645A2 (https=)
CA (1) CA2873801A1 (https=)
EA (1) EA201492119A1 (https=)
WO (1) WO2013173647A1 (https=)

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JP2021514182A (ja) * 2018-02-09 2021-06-10 ジェネンテック， インコーポレイテッド Ｔｍｅｍ１０６ｂ発現を調節するためのオリゴヌクレオチド
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US12319913B2 (en) 2018-10-31 2025-06-03 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11584932B2 (en) 2016-11-01 2023-02-21 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer
US12371693B2 (en) 2016-11-01 2025-07-29 The Research Foundation For The State University Of New York 5-halouracil-modified micrornas and their use in the treatment of cancer
JP2021514182A (ja) * 2018-02-09 2021-06-10 ジェネンテック， インコーポレイテッド Ｔｍｅｍ１０６ｂ発現を調節するためのオリゴヌクレオチド
JP7281474B2 (ja) 2018-02-09 2023-05-25 ジェネンテック， インコーポレイテッド Ｔｍｅｍ１０６ｂ発現を調節するためのオリゴヌクレオチド
US12319913B2 (en) 2018-10-31 2025-06-03 The Research Foundation For The State University Of New York 5-halouracil-modified microRNAs and their use in the treatment of cancer

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CN104582737A (zh) 2015-04-29
AU2013262658A1 (en) 2015-01-22
BR112014028645A2 (pt) 2017-06-27
EP2849801A4 (en) 2016-05-25
EA201492119A1 (ru) 2015-05-29
EP2849801A1 (en) 2015-03-25
CA2873801A1 (en) 2013-11-21
US20150191722A1 (en) 2015-07-09
WO2013173647A1 (en) 2013-11-21

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