JP2015523852A5 - - Google Patents
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- Publication number
- JP2015523852A5 JP2015523852A5 JP2015512643A JP2015512643A JP2015523852A5 JP 2015523852 A5 JP2015523852 A5 JP 2015523852A5 JP 2015512643 A JP2015512643 A JP 2015512643A JP 2015512643 A JP2015512643 A JP 2015512643A JP 2015523852 A5 JP2015523852 A5 JP 2015523852A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- antibody
- cdr
- tat194
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 36
- 210000004027 cell Anatomy 0.000 claims 29
- 229920001184 polypeptide Polymers 0.000 claims 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims 15
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 239000000523 sample Substances 0.000 claims 10
- 241000124008 Mammalia Species 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 206010006187 Breast cancer Diseases 0.000 claims 6
- 208000026310 Breast neoplasm Diseases 0.000 claims 6
- 208000020816 lung neoplasm Diseases 0.000 claims 6
- 229940127089 cytotoxic agent Drugs 0.000 claims 5
- 239000002254 cytotoxic agent Substances 0.000 claims 5
- 231100000599 cytotoxic agent Toxicity 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 4
- 201000005202 lung cancer Diseases 0.000 claims 4
- 239000003053 toxin Substances 0.000 claims 4
- 231100000765 toxin Toxicity 0.000 claims 4
- 108700012359 toxins Proteins 0.000 claims 4
- 239000000611 antibody drug conjugate Substances 0.000 claims 2
- 229940049595 antibody-drug conjugate Drugs 0.000 claims 2
- 108010044540 auristatin Proteins 0.000 claims 2
- 239000013068 control sample Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 208000037841 lung tumor Diseases 0.000 claims 2
- 241000894006 Bacteria Species 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 238000010240 RT-PCR analysis Methods 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
- 229930195731 calicheamicin Natural products 0.000 claims 1
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 1
- 230000009918 complex formation Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003966 growth inhibitor Substances 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000002991 immunohistochemical analysis Methods 0.000 claims 1
- 238000011065 in-situ storage Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000001293 nucleolytic effect Effects 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 238000001262 western blot Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261646803P | 2012-05-14 | 2012-05-14 | |
| US61/646,803 | 2012-05-14 | ||
| US201361776603P | 2013-03-11 | 2013-03-11 | |
| US61/776,603 | 2013-03-11 | ||
| PCT/US2013/031547 WO2013172961A1 (en) | 2012-05-14 | 2013-03-14 | Compositions and methods for the diagnosis and treatment of tumor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015523852A JP2015523852A (ja) | 2015-08-20 |
| JP2015523852A5 true JP2015523852A5 (enExample) | 2016-05-12 |
Family
ID=49584135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015512643A Pending JP2015523852A (ja) | 2012-05-14 | 2013-03-14 | 腫瘍の診断と治療のための組成物と方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9580514B2 (enExample) |
| EP (1) | EP2849789A4 (enExample) |
| JP (1) | JP2015523852A (enExample) |
| KR (1) | KR20150013277A (enExample) |
| CN (1) | CN104284677A (enExample) |
| BR (1) | BR112014027905A2 (enExample) |
| CA (1) | CA2871116A1 (enExample) |
| HK (1) | HK1201045A1 (enExample) |
| MX (1) | MX2014013806A (enExample) |
| RU (1) | RU2014145633A (enExample) |
| WO (1) | WO2013172961A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2632647C2 (ru) | 2011-04-22 | 2017-10-06 | Аптево Рисерч Энд Девелопмент Ллс | Белки, связывающие специфический мембранный антиген простаты, и соответствующие композиции и способы |
| US9758591B2 (en) | 2012-08-24 | 2017-09-12 | The Regents Of The University Of California | Antibodies and vaccines for use in treating ROR1 cancers and inhibiting metastasis |
| MX2018003292A (es) | 2015-09-21 | 2018-08-01 | Aptevo Res & Development Llc | Polipéptidos de unión a cd3. |
| US10537633B2 (en) | 2016-03-04 | 2020-01-21 | Jn Biosciences Llc | Antibodies to TIGIT |
| MX2018016330A (es) | 2016-06-27 | 2020-02-17 | Univ California | Combinaciones para tratamiento del cáncer. |
| US11690919B2 (en) * | 2017-01-17 | 2023-07-04 | The Texas A&M University System | Endolysosomal targeting conjugates for improved delivery of cargo molecules to the endolysosomal compartment of target cells |
| CN113332447B (zh) * | 2017-03-17 | 2023-08-15 | 浙江孚诺医药股份有限公司 | 肿瘤靶向多肽、制备方法及其应用 |
| CN109709340B (zh) * | 2018-12-29 | 2022-02-11 | 江苏众红生物工程创药研究院有限公司 | 人中性粒细胞明胶酶相关脂质运载蛋白定量检测卡及其临床应用 |
| CR20220611A (es) | 2020-06-02 | 2023-06-07 | Arcus Biosciences Inc | Anticuerpos anti-tigit |
| CN112457406B (zh) * | 2020-11-27 | 2022-05-31 | 中国科学院上海药物研究所 | 一种抗mmae的单克隆抗体、其编码序列及应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037454A (en) * | 1996-11-27 | 2000-03-14 | Genentech, Inc. | Humanized anti-CD11a antibodies |
| AU2985800A (en) * | 1999-02-09 | 2000-08-29 | Arch Development Corporation | Genes encoding the 5h7 antibody and methods for conferring programmed cell deathproperties to cells |
| US20050272120A1 (en) | 2001-06-20 | 2005-12-08 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| EP1992643A3 (en) | 2001-06-20 | 2008-12-10 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumor |
| EP2143438B1 (en) | 2001-09-18 | 2011-07-13 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of tumors |
| US20050014687A1 (en) * | 2002-03-19 | 2005-01-20 | Anderson David W. | Therapeutic polypeptides, nucleic acids encoding same, and methods of use |
| WO2004048414A2 (en) * | 2002-11-26 | 2004-06-10 | Axis-Shield Asa | Holo-transcobalamins binding partners and their use in cobalamin assay |
| CN107213469A (zh) | 2003-11-06 | 2017-09-29 | 西雅图基因公司 | 能够与配体偶联的单甲基缬氨酸化合物 |
| ZA200707967B (en) * | 2005-04-08 | 2008-11-26 | Genentech Inc | Compositions and methods for the diagnosis and treatment of tumor |
| WO2007049624A1 (ja) * | 2005-10-24 | 2007-05-03 | Takeda Pharmaceutical Company Limited | 癌の予防・治療剤 |
| CN101553255A (zh) * | 2006-08-23 | 2009-10-07 | 奎尔斯根制药有限责任公司 | 天花单克隆抗体 |
| US20110028498A1 (en) * | 2006-09-07 | 2011-02-03 | Anderson Joseph Ryan | Method for evaluating patients for treatment with drugs targeting ret receptor tyrosine kinase |
| US20100036091A1 (en) * | 2006-11-10 | 2010-02-11 | Amgen Inc. | Antibody-based diagnostics and therapeutics |
| WO2008127735A1 (en) * | 2007-04-13 | 2008-10-23 | Stemline Therapeutics, Inc. | Il3ralpha antibody conjugates and uses thereof |
| AU2008272330A1 (en) * | 2007-07-04 | 2009-01-08 | Forerunner Pharma Research Co., Ltd. | Anti-Muc17 antibody |
| PA8849601A1 (es) | 2008-12-05 | 2010-07-27 | Lilly Co Eli | Anticuerpos monoclonales anti-ferroportina 1 y usos de los mismos |
| US8183346B2 (en) * | 2008-12-05 | 2012-05-22 | Eli Lilly And Company | Anti-ferroportin 1 monoclonal antibodies and uses thereof |
| WO2010119704A1 (en) * | 2009-04-17 | 2010-10-21 | Immunas Pharma, Inc. | Antibodies that specifically bind to a beta oligomers and use thereof |
| US8580714B2 (en) * | 2009-10-14 | 2013-11-12 | Janssen Biotech, Inc. | Methods of affinity maturing antibodies |
| CA2805035A1 (en) * | 2010-07-22 | 2012-01-26 | Glaxosmithkline Biologicals S.A. | Novel antigen binding proteins |
| US8790649B2 (en) * | 2010-10-29 | 2014-07-29 | Immunogen, Inc. | EGFR-binding molecules and immunoconjugates thereof |
-
2013
- 2013-03-14 CA CA2871116A patent/CA2871116A1/en not_active Abandoned
- 2013-03-14 RU RU2014145633A patent/RU2014145633A/ru not_active Application Discontinuation
- 2013-03-14 MX MX2014013806A patent/MX2014013806A/es unknown
- 2013-03-14 HK HK15101546.0A patent/HK1201045A1/xx unknown
- 2013-03-14 EP EP13791411.5A patent/EP2849789A4/en not_active Withdrawn
- 2013-03-14 JP JP2015512643A patent/JP2015523852A/ja active Pending
- 2013-03-14 BR BR112014027905A patent/BR112014027905A2/pt unknown
- 2013-03-14 CN CN201380025032.0A patent/CN104284677A/zh active Pending
- 2013-03-14 WO PCT/US2013/031547 patent/WO2013172961A1/en not_active Ceased
- 2013-03-14 KR KR1020147034670A patent/KR20150013277A/ko not_active Withdrawn
- 2013-03-14 US US14/400,684 patent/US9580514B2/en not_active Expired - Fee Related
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