JP2015523852A - 腫瘍の診断と治療のための組成物と方法 - Google Patents

腫瘍の診断と治療のための組成物と方法 Download PDF

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JP2015523852A
JP2015523852A JP2015512643A JP2015512643A JP2015523852A JP 2015523852 A JP2015523852 A JP 2015523852A JP 2015512643 A JP2015512643 A JP 2015512643A JP 2015512643 A JP2015512643 A JP 2015512643A JP 2015523852 A JP2015523852 A JP 2015523852A
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antibody
seq
sequence
polypeptide
cdr
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JP2015523852A5 (enExample
Inventor
スニール バクタ,
スニール バクタ,
メレディス ヘイズン,
メレディス ヘイズン,
ジョ−アン エス. ホンゴー,
ジョ−アン エス. ホンゴー,
ジャガス アール. ジュヌトゥラ,
ジャガス アール. ジュヌトゥラ,
イシドロ ホッツェル,
イシドロ ホッツェル,
ヨンレイ シャン,
ヨンレイ シャン,
シャン−ファン ユイ,
シャン−ファン ユイ,
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Genentech Inc
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Genentech Inc
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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JP2015512643A 2012-05-14 2013-03-14 腫瘍の診断と治療のための組成物と方法 Pending JP2015523852A (ja)

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US201261646803P 2012-05-14 2012-05-14
US61/646,803 2012-05-14
US201361776603P 2013-03-11 2013-03-11
US61/776,603 2013-03-11
PCT/US2013/031547 WO2013172961A1 (en) 2012-05-14 2013-03-14 Compositions and methods for the diagnosis and treatment of tumor

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JP2015523852A true JP2015523852A (ja) 2015-08-20
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EP (1) EP2849789A4 (enExample)
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KR (1) KR20150013277A (enExample)
CN (1) CN104284677A (enExample)
BR (1) BR112014027905A2 (enExample)
CA (1) CA2871116A1 (enExample)
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BR112013027224A8 (pt) 2011-04-22 2018-08-14 Emergent Product Dev Seattle Proteínas de ligação de antígeno de membrana específico de próstata e composições e métodos relacionados
PL3489261T3 (pl) 2012-08-24 2021-08-16 The Regents Of The University Of California Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu
HK1251480A1 (zh) 2015-09-21 2019-02-01 Aptevo Research And Development Llc Cd3结合多肽
MX2018010485A (es) 2016-03-04 2019-01-10 Jn Biosciences Llc Anticuerpos para inmunoreceptor de celulas t con dominios de ig e itim (tigit).
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JP2020518240A (ja) * 2017-01-17 2020-06-25 ザ テキサス エー アンド エム ユニバーシティー システム 標的細胞のエンドリソソーム区画へのカーゴ分子の送達の向上のためのエンドリソソーム標的化コンジュゲート
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CN112457406B (zh) * 2020-11-27 2022-05-31 中国科学院上海药物研究所 一种抗mmae的单克隆抗体、其编码序列及应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005535294A (ja) * 2002-03-19 2005-11-24 キュラジェン コーポレイション 治療ポリペプチド、それをコードする核酸、および使用方法
JP2005536439A (ja) * 2001-09-18 2005-12-02 ジェネンテック・インコーポレーテッド 腫瘍の診断及び治療のための組成物と方法
WO2007049624A1 (ja) * 2005-10-24 2007-05-03 Takeda Pharmaceutical Company Limited 癌の予防・治療剤
JP2010502209A (ja) * 2006-09-07 2010-01-28 アストラゼネカ アクチボラグ Retレセプターチロシンキナーゼを標的とする薬剤による治療のために患者を評価する方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6037454A (en) * 1996-11-27 2000-03-14 Genentech, Inc. Humanized anti-CD11a antibodies
AU2985800A (en) * 1999-02-09 2000-08-29 Arch Development Corporation Genes encoding the 5h7 antibody and methods for conferring programmed cell deathproperties to cells
US20050272120A1 (en) 2001-06-20 2005-12-08 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
EP1409549A4 (en) * 2001-06-20 2007-10-24 Genentech Inc COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF TUMORS
DK1565490T3 (da) * 2002-11-26 2010-08-23 Axis Shield Asa Holo-transcobalamin bindingspartnere og deres anvendelse i cobalamintest
ES2605443T3 (es) 2003-11-06 2017-03-14 Seattle Genetics, Inc. Conjugados de auristatina con anticuerpos anti-HER2 o anti-CD22 y su uso en terapia
MX2007012216A (es) * 2005-04-08 2007-12-06 Genentech Inc Composiciones y metodos para el diagnostico y tratamiento de tumores.
JP2010507362A (ja) * 2006-08-23 2010-03-11 ケルセジーン ファーマ リミテッド ライアビリティ カンパニー 天然痘モノクローナル抗体
US20100036091A1 (en) * 2006-11-10 2010-02-11 Amgen Inc. Antibody-based diagnostics and therapeutics
WO2008127735A1 (en) * 2007-04-13 2008-10-23 Stemline Therapeutics, Inc. Il3ralpha antibody conjugates and uses thereof
AU2008272330A1 (en) * 2007-07-04 2009-01-08 Forerunner Pharma Research Co., Ltd. Anti-Muc17 antibody
PA8849601A1 (es) * 2008-12-05 2010-07-27 Lilly Co Eli Anticuerpos monoclonales anti-ferroportina 1 y usos de los mismos
US8183346B2 (en) * 2008-12-05 2012-05-22 Eli Lilly And Company Anti-ferroportin 1 monoclonal antibodies and uses thereof
JP5812418B2 (ja) * 2009-04-17 2015-11-11 イムナス・ファーマ株式会社 Aβオリゴマーに特異的に結合する抗体およびその利用
US8580714B2 (en) * 2009-10-14 2013-11-12 Janssen Biotech, Inc. Methods of affinity maturing antibodies
US8987423B2 (en) * 2010-07-22 2015-03-24 Glaxosmithkline Biologicals, S.A. MAGE antigen binding proteins
CA2815277A1 (en) * 2010-10-29 2012-05-03 Immunogen, Inc. Novel egfr-binding molecules and immunoconjugates thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005536439A (ja) * 2001-09-18 2005-12-02 ジェネンテック・インコーポレーテッド 腫瘍の診断及び治療のための組成物と方法
JP2005535294A (ja) * 2002-03-19 2005-11-24 キュラジェン コーポレイション 治療ポリペプチド、それをコードする核酸、および使用方法
WO2007049624A1 (ja) * 2005-10-24 2007-05-03 Takeda Pharmaceutical Company Limited 癌の予防・治療剤
JP2010502209A (ja) * 2006-09-07 2010-01-28 アストラゼネカ アクチボラグ Retレセプターチロシンキナーゼを標的とする薬剤による治療のために患者を評価する方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ESSEGHIR, S. ET AL., CANCER RES., vol. 67, no. 24, JPN6017003169, 15 December 2007 (2007-12-15), pages 11732 - 11741, ISSN: 0003491143 *
LE HIR, H. ET AL., ONCOLOGY, vol. 58, no. 4, JPN6017003172, May 2000 (2000-05-01), pages 311 - 318, ISSN: 0003491146 *
MUZZA, M. ET AL., EUR. J. ENDOCRINOL., vol. 162, no. 4, JPN6017003170, April 2010 (2010-04-01), pages 771 - 777, ISSN: 0003491144 *
SKINNER, M. A. ET AL., ANTICANCER RES., vol. Vol.27, No.4B, JPN6017003171, 2008, pages 2019 - 2025, ISSN: 0003491145 *

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