JP2015523337A - フェスチナビルを製造するためのスルフィリミンおよびスルホキシド方法 - Google Patents

フェスチナビルを製造するためのスルフィリミンおよびスルホキシド方法 Download PDF

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Publication number
JP2015523337A
JP2015523337A JP2015514142A JP2015514142A JP2015523337A JP 2015523337 A JP2015523337 A JP 2015523337A JP 2015514142 A JP2015514142 A JP 2015514142A JP 2015514142 A JP2015514142 A JP 2015514142A JP 2015523337 A JP2015523337 A JP 2015523337A
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Japan
Prior art keywords
compound
contacted
solution
tms
acetonitrile
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Pending
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JP2015514142A
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Japanese (ja)
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JP2015523337A5 (cg-RX-API-DMAC7.html
Inventor
エイドリアン・オーティズ
タマス・ベンコビックス
ジョンピン・シ
プラシャント・ピー・デシュパンデ
ジウェイ・グオ
デイビッド・アール・クローネンタール
クリス・スフォウガタキス
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Publication of JP2015523337A publication Critical patent/JP2015523337A/ja
Publication of JP2015523337A5 publication Critical patent/JP2015523337A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/385—Pyrimidine nucleosides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
JP2015514142A 2012-05-23 2013-05-22 フェスチナビルを製造するためのスルフィリミンおよびスルホキシド方法 Pending JP2015523337A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261650553P 2012-05-23 2012-05-23
US61/650,553 2012-05-23
PCT/US2013/042150 WO2013177243A1 (en) 2012-05-23 2013-05-22 Sulfilimine and sulphoxide methods for producing festinavir

Publications (2)

Publication Number Publication Date
JP2015523337A true JP2015523337A (ja) 2015-08-13
JP2015523337A5 JP2015523337A5 (cg-RX-API-DMAC7.html) 2016-07-07

Family

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JP2015514142A Pending JP2015523337A (ja) 2012-05-23 2013-05-22 フェスチナビルを製造するためのスルフィリミンおよびスルホキシド方法

Country Status (5)

Country Link
US (1) US9249171B2 (cg-RX-API-DMAC7.html)
EP (1) EP2852583A1 (cg-RX-API-DMAC7.html)
JP (1) JP2015523337A (cg-RX-API-DMAC7.html)
CN (1) CN104379571A (cg-RX-API-DMAC7.html)
WO (1) WO2013177243A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020032152A1 (ja) * 2018-08-09 2020-02-13 ヤマサ醤油株式会社 ４'－置換ヌクレオシド誘導体の立体選択的合成法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160060252A1 (en) 2013-04-16 2016-03-03 Bristol-Myers Squibb Company 5-methyluridine method for producing festinavir
WO2014201122A1 (en) 2013-06-13 2014-12-18 Bristol-Myers Squibb Company Tert-butyl-sulphoxide method for producing festinavir
EP3760208B1 (en) 2014-06-25 2024-05-29 The General Hospital Corporation Targeting human satellite ii (hsatii)
SG11202107145SA (en) 2019-01-25 2021-08-30 Univ Brown Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders
AU2023255774A1 (en) * 2022-04-22 2024-12-05 Rome Therapeutics, Inc. Didehydro-3'-deoxy-4'-ethynylthymidines and related compounds and their use in treating medical conditions

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0454193A (ja) * 1990-05-25 1992-02-21 Japan Tobacco Inc ２’，３’―ジデオキシ―２’，３’―ジデヒドロ―β―リボヌクレオシドの製造方法
JP2006528972A (ja) * 2003-02-19 2006-12-28 エール ユニヴァーシティ 抗ウイルスヌクレオシド類似体およびウイルス感染特にｈｉｖ感染の処置方法
WO2009084655A1 (ja) * 2007-12-27 2009-07-09 Oncolys Biopharma Inc. 4'-エチニルd4Tの製造方法
WO2009125841A1 (ja) * 2008-04-10 2009-10-15 浜理薬品工業株式会社 ５－メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法
WO2011099443A1 (ja) * 2010-02-15 2011-08-18 日産化学工業株式会社 β－ジヒドロフラン誘導化合物、β－ジヒドロフラン誘導化合物またはβ－テトラヒドロフラン誘導化合物の製造方法、β－グリコシド化合物、β－グリコシド化合物の製造方法、並びに、４'－エチニルｄ４Ｔ及びその類縁化合物の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2617582T3 (es) 2005-09-26 2017-06-19 Gilead Pharmasset Llc 4'-Nucleósidos modificados como agentes antivirales
WO2009005674A2 (en) 2007-06-29 2009-01-08 Gilead Sciences, Inc. Novel hiv reverse transcriptase inhibitors
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
WO2009119785A1 (ja) 2008-03-28 2009-10-01 浜理薬品工業株式会社 エチニルチミジン化合物の精製方法
DE102009034346B4 (de) 2009-07-23 2013-01-24 Kone Corp. Antriebssystem für eine Personenförderanlage
EP2537851B1 (en) 2010-02-15 2015-06-10 Nissan Chemical Industries, Ltd. Process for preparation of b-glycoside compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0454193A (ja) * 1990-05-25 1992-02-21 Japan Tobacco Inc ２’，３’―ジデオキシ―２’，３’―ジデヒドロ―β―リボヌクレオシドの製造方法
JP2006528972A (ja) * 2003-02-19 2006-12-28 エール ユニヴァーシティ 抗ウイルスヌクレオシド類似体およびウイルス感染特にｈｉｖ感染の処置方法
WO2009084655A1 (ja) * 2007-12-27 2009-07-09 Oncolys Biopharma Inc. 4'-エチニルd4Tの製造方法
WO2009125841A1 (ja) * 2008-04-10 2009-10-15 浜理薬品工業株式会社 ５－メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法
WO2011099443A1 (ja) * 2010-02-15 2011-08-18 日産化学工業株式会社 β－ジヒドロフラン誘導化合物、β－ジヒドロフラン誘導化合物またはβ－テトラヒドロフラン誘導化合物の製造方法、β－グリコシド化合物、β－グリコシド化合物の製造方法、並びに、４'－エチニルｄ４Ｔ及びその類縁化合物の製造方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020032152A1 (ja) * 2018-08-09 2020-02-13 ヤマサ醤油株式会社 ４'－置換ヌクレオシド誘導体の立体選択的合成法
JPWO2020032152A1 (ja) * 2018-08-09 2021-08-10 ヤマサ醤油株式会社 ４’−置換ヌクレオシド誘導体の立体選択的合成法
JP7025064B2 (ja) 2018-08-09 2022-02-24 ヤマサ醤油株式会社 ４’－置換ヌクレオシド誘導体の立体選択的合成法

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US9249171B2 (en) 2016-02-02
EP2852583A1 (en) 2015-04-01
US20150140610A1 (en) 2015-05-21
CN104379571A (zh) 2015-02-25
WO2013177243A1 (en) 2013-11-28

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