JP2015523337A - フェスチナビルを製造するためのスルフィリミンおよびスルホキシド方法 - Google Patents

フェスチナビルを製造するためのスルフィリミンおよびスルホキシド方法 Download PDF

Info

Publication number
JP2015523337A
JP2015523337A JP2015514142A JP2015514142A JP2015523337A JP 2015523337 A JP2015523337 A JP 2015523337A JP 2015514142 A JP2015514142 A JP 2015514142A JP 2015514142 A JP2015514142 A JP 2015514142A JP 2015523337 A JP2015523337 A JP 2015523337A
Authority
JP
Japan
Prior art keywords
compound
contacted
solution
tms
acetonitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2015514142A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015523337A5 (OSRAM
Inventor
エイドリアン・オーティズ
タマス・ベンコビックス
ジョンピン・シ
プラシャント・ピー・デシュパンデ
ジウェイ・グオ
デイビッド・アール・クローネンタール
クリス・スフォウガタキス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2015523337A publication Critical patent/JP2015523337A/ja
Publication of JP2015523337A5 publication Critical patent/JP2015523337A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/38—Nucleosides
    • C12P19/385—Pyrimidine nucleosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
JP2015514142A 2012-05-23 2013-05-22 フェスチナビルを製造するためのスルフィリミンおよびスルホキシド方法 Pending JP2015523337A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261650553P 2012-05-23 2012-05-23
US61/650,553 2012-05-23
PCT/US2013/042150 WO2013177243A1 (en) 2012-05-23 2013-05-22 Sulfilimine and sulphoxide methods for producing festinavir

Publications (2)

Publication Number Publication Date
JP2015523337A true JP2015523337A (ja) 2015-08-13
JP2015523337A5 JP2015523337A5 (OSRAM) 2016-07-07

Family

ID=48534517

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015514142A Pending JP2015523337A (ja) 2012-05-23 2013-05-22 フェスチナビルを製造するためのスルフィリミンおよびスルホキシド方法

Country Status (5)

Country Link
US (1) US9249171B2 (OSRAM)
EP (1) EP2852583A1 (OSRAM)
JP (1) JP2015523337A (OSRAM)
CN (1) CN104379571A (OSRAM)
WO (1) WO2013177243A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020032152A1 (ja) * 2018-08-09 2020-02-13 ヤマサ醤油株式会社 ４'－置換ヌクレオシド誘導体の立体選択的合成法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2986602A1 (en) 2013-04-16 2016-02-24 Bristol-Myers Squibb Company Method for producing festinavir using 5-methyluridine as starting material
EP3008060A1 (en) 2013-06-13 2016-04-20 Bristol-Myers Squibb Company Tert-butyl-sulphoxide method for producing festinavir
EP3760208B1 (en) 2014-06-25 2024-05-29 The General Hospital Corporation Targeting human satellite ii (hsatii)
AU2020211600A1 (en) 2019-01-25 2021-07-22 Brown University Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders
CN119403815A (zh) * 2022-04-22 2025-02-07 罗梅治疗股份有限公司 二脱氢-3’-脱氧-4’-乙炔基胸苷和相关化合物以及它们在治疗医学疾患中的用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0454193A (ja) * 1990-05-25 1992-02-21 Japan Tobacco Inc ２’，３’―ジデオキシ―２’，３’―ジデヒドロ―β―リボヌクレオシドの製造方法
JP2006528972A (ja) * 2003-02-19 2006-12-28 エール ユニヴァーシティ 抗ウイルスヌクレオシド類似体およびウイルス感染特にｈｉｖ感染の処置方法
WO2009084655A1 (ja) * 2007-12-27 2009-07-09 Oncolys Biopharma Inc. 4'-エチニルd4Tの製造方法
WO2009125841A1 (ja) * 2008-04-10 2009-10-15 浜理薬品工業株式会社 ５－メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法
WO2011099443A1 (ja) * 2010-02-15 2011-08-18 日産化学工業株式会社 β－ジヒドロフラン誘導化合物、β－ジヒドロフラン誘導化合物またはβ－テトラヒドロフラン誘導化合物の製造方法、β－グリコシド化合物、β－グリコシド化合物の製造方法、並びに、４'－エチニルｄ４Ｔ及びその類縁化合物の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009510075A (ja) 2005-09-26 2009-03-12 ファーマセット，インコーポレイティド 抗ウイルス剤としての修飾４’−ヌクレオシド
CN101784532B (zh) 2007-06-29 2014-10-22 韩国化学研究院 Hiv逆转录酶抑制剂
US20090318380A1 (en) 2007-11-20 2009-12-24 Pharmasset, Inc. 2',4'-substituted nucleosides as antiviral agents
JP5485138B2 (ja) 2008-03-28 2014-05-07 浜理薬品工業株式会社 エチニルチミジン化合物の精製方法
DE102009034346B4 (de) 2009-07-23 2013-01-24 Kone Corp. Antriebssystem für eine Personenförderanlage
EP2537851B1 (en) 2010-02-15 2015-06-10 Nissan Chemical Industries, Ltd. Process for preparation of b-glycoside compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0454193A (ja) * 1990-05-25 1992-02-21 Japan Tobacco Inc ２’，３’―ジデオキシ―２’，３’―ジデヒドロ―β―リボヌクレオシドの製造方法
JP2006528972A (ja) * 2003-02-19 2006-12-28 エール ユニヴァーシティ 抗ウイルスヌクレオシド類似体およびウイルス感染特にｈｉｖ感染の処置方法
WO2009084655A1 (ja) * 2007-12-27 2009-07-09 Oncolys Biopharma Inc. 4'-エチニルd4Tの製造方法
WO2009125841A1 (ja) * 2008-04-10 2009-10-15 浜理薬品工業株式会社 ５－メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法
WO2011099443A1 (ja) * 2010-02-15 2011-08-18 日産化学工業株式会社 β－ジヒドロフラン誘導化合物、β－ジヒドロフラン誘導化合物またはβ－テトラヒドロフラン誘導化合物の製造方法、β－グリコシド化合物、β－グリコシド化合物の製造方法、並びに、４'－エチニルｄ４Ｔ及びその類縁化合物の製造方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020032152A1 (ja) * 2018-08-09 2020-02-13 ヤマサ醤油株式会社 ４'－置換ヌクレオシド誘導体の立体選択的合成法
JPWO2020032152A1 (ja) * 2018-08-09 2021-08-10 ヤマサ醤油株式会社 ４’−置換ヌクレオシド誘導体の立体選択的合成法
JP7025064B2 (ja) 2018-08-09 2022-02-24 ヤマサ醤油株式会社 ４’－置換ヌクレオシド誘導体の立体選択的合成法

Also Published As

Publication number Publication date
US9249171B2 (en) 2016-02-02
CN104379571A (zh) 2015-02-25
EP2852583A1 (en) 2015-04-01
WO2013177243A1 (en) 2013-11-28
US20150140610A1 (en) 2015-05-21

Similar Documents

Publication Publication Date Title
JP7296882B2 (ja) ホスホラミダイト及びオリゴヌクレオチド合成のための組成物及び方法
JP2015523337A (ja) フェスチナビルを製造するためのスルフィリミンおよびスルホキシド方法
CN107108681B (zh) 制备取代的核苷类似物的方法
WO2009125841A1 (ja) ５－メチルウリジンを出発原料とするエチニルチミジン化合物の製造方法
JP2024528206A (ja) アレーンの触媒的グリコシル化プロセス
WO2020010560A1 (zh) 一种亚磷酰胺类化合物、其制备方法及应用
CN117362374A (zh) 一种含羟基和氨基的化合物中羟基和氨基的保护方法
KR100908363B1 (ko) 트라이-Ｏ-아세틸-5-데옥시-β-Ｄ-라이보퓨라노즈의입체선택적 제조방법 및 이의 분리방법
CN113286802B (zh) 高产率的血管渗漏阻断剂的制备方法
CN103936759A (zh) （3aS,6aR）-1,3-二苄基-四氢-4H-噻吩并[3,4-d]咪唑-2,4-（1H）-二酮的简便制备方法
CN108373491B (zh) 一种奈拉滨的制备方法
CN103087132B (zh) β-核苷的合成
KR101259648B1 (ko) 2′,2′-디플루오로뉴클레오시드 및 중간체의 새로운 제조방법
KR101241321B1 (ko) 수율 및 순도가 개선된 데시타빈의 제조방법
EP2049558B1 (en) Naphthalene 2-carboxylate derivative useful for synthesizing gemcitabine and a method for preparing the same
US7214791B2 (en) Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
WO1995012593A1 (en) 5-0-pyrimidyl-2,3-dideoxy-1-thiofuranoside derivative, process for producing the same, and use thereof
CN107090009B (zh) 一种二糖核苷化合物及其制备方法
CN102603652A (zh) 5-甲酰基嘧啶碳环核苷及制备方法
CN114106043A (zh) 一种化合物及其制备方法、该化合物制备胞磷胆碱的方法、应用
CN120795047A (zh) 一种胞苷类似物的合成方法
CN119654332A (zh) 制备4’-硫代-5-氮杂-2’-脱氧胞苷的方法
JP2014169239A (ja) 核酸誘導体とその製造方法
CN119431334A (zh) 2’OMe修饰的假尿苷和N1甲基假尿苷的制备方法
JPH04103594A (ja) グリセロ糖脂質の製造方法

Legal Events

Date Code Title Description
RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20160218

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160520

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160520

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170124

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20170126

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170421

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20170623

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170926