JP2015522806A5 - - Google Patents
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- JP2015522806A5 JP2015522806A5 JP2015516071A JP2015516071A JP2015522806A5 JP 2015522806 A5 JP2015522806 A5 JP 2015522806A5 JP 2015516071 A JP2015516071 A JP 2015516071A JP 2015516071 A JP2015516071 A JP 2015516071A JP 2015522806 A5 JP2015522806 A5 JP 2015522806A5
- Authority
- JP
- Japan
- Prior art keywords
- glyca
- nmr
- component
- region
- nmr spectrum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 26
- 238000005481 NMR spectroscopy Methods 0.000 claims 14
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 claims 11
- 238000005259 measurement Methods 0.000 claims 10
- 108010010234 HDL Lipoproteins Proteins 0.000 claims 7
- 102000015779 HDL Lipoproteins Human genes 0.000 claims 7
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 7
- 108010007622 LDL Lipoproteins Proteins 0.000 claims 7
- 102000007330 LDL Lipoproteins Human genes 0.000 claims 7
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 7
- 239000004474 valine Substances 0.000 claims 7
- 108010062497 VLDL Lipoproteins Proteins 0.000 claims 6
- 239000002207 metabolite Substances 0.000 claims 5
- 235000018102 proteins Nutrition 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 239000000523 sample Substances 0.000 claims 5
- 108010004103 Chylomicrons Proteins 0.000 claims 3
- 102000004895 Lipoproteins Human genes 0.000 claims 3
- 108090001030 Lipoproteins Proteins 0.000 claims 3
- 238000004891 communication Methods 0.000 claims 3
- 208000029078 coronary artery disease Diseases 0.000 claims 3
- 238000004590 computer program Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 claims 2
- 239000012491 analyte Substances 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 235000004252 protein component Nutrition 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000001228 spectrum Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657315P | 2012-06-08 | 2012-06-08 | |
| US61/657,315 | 2012-06-08 | ||
| US201261711471P | 2012-10-09 | 2012-10-09 | |
| US61/711,471 | 2012-10-09 | ||
| US201261739305P | 2012-12-19 | 2012-12-19 | |
| US61/739,305 | 2012-12-19 | ||
| US13/830,199 US9470771B2 (en) | 2012-06-08 | 2013-03-14 | NMR measurements of NMR biomarker GlycA |
| US13/830,199 | 2013-03-14 | ||
| PCT/US2013/043343 WO2013184483A1 (en) | 2012-06-08 | 2013-05-30 | Nmr measurements of glyca |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015522806A JP2015522806A (ja) | 2015-08-06 |
| JP2015522806A5 true JP2015522806A5 (https=) | 2016-06-16 |
| JP6177899B2 JP6177899B2 (ja) | 2017-08-09 |
Family
ID=49712504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015516071A Active JP6177899B2 (ja) | 2012-06-08 | 2013-05-30 | ＧｌｙｃＡのＮＭＲ測定 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9470771B2 (https=) |
| EP (3) | EP3839544B1 (https=) |
| JP (1) | JP6177899B2 (https=) |
| CN (1) | CN104508471B (https=) |
| AU (1) | AU2013272014B2 (https=) |
| CA (2) | CA2874550C (https=) |
| FI (1) | FI3839544T3 (https=) |
| SG (1) | SG11201407803TA (https=) |
| WO (1) | WO2013184483A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9076342B2 (en) | 2008-02-19 | 2015-07-07 | Architecture Technology Corporation | Automated execution and evaluation of network-based training exercises |
| US9361429B2 (en) | 2012-06-08 | 2016-06-07 | Liposcience, Inc. | Multi-parameter diabetes risk evaluations |
| US9928345B2 (en) | 2012-06-08 | 2018-03-27 | Liposciences, Inc. | Multiple-marker risk parameters predictive of conversion to diabetes |
| US20140358451A1 (en) * | 2013-06-04 | 2014-12-04 | Arizona Board Of Regents On Behalf Of Arizona State University | Fractional Abundance Estimation from Electrospray Ionization Time-of-Flight Mass Spectrum |
| PT3074775T (pt) * | 2013-11-27 | 2018-10-31 | Inst Dinvestigacio Sanitaria Pere Virgili | Método para a caracterização de lipoproteínas |
| CA2931648C (en) * | 2014-01-06 | 2022-11-29 | Liposcience, Inc. | Multiple-marker risk parameters predictive of conversion to diabetes |
| US9952232B2 (en) * | 2014-09-11 | 2018-04-24 | Liposcience, Inc. | Cardiovascular risk evaluations using a risk parameter that includes an HDL and inflammatory biomarker interaction parameter |
| EP3197045B1 (en) * | 2014-10-31 | 2018-09-19 | Huawei Technologies Co., Ltd. | Curve fitting circuit, analog predistorter and radio frequency signal transmitter |
| US10083624B2 (en) | 2015-07-28 | 2018-09-25 | Architecture Technology Corporation | Real-time monitoring of network-based training exercises |
| US10803766B1 (en) | 2015-07-28 | 2020-10-13 | Architecture Technology Corporation | Modular training of network-based training exercises |
| EP3258285B1 (en) * | 2016-06-14 | 2020-10-21 | Bruker BioSpin GmbH | Method for predicting chemical shift values of nmr spin systems in a sample of a fluid class, in particular in a sample of a biofluid |
| DE102016224691A1 (de) * | 2016-12-12 | 2018-06-14 | Numares Ag | Verfahren zur Analyse eines NMR-Spektrums einer lipoproteinhaltigen Probe |
| FI20177098A1 (fi) * | 2017-08-29 | 2019-03-01 | Leppaeluoto Juhani | Menetelmiä ja laitejärjestelyitä diabeteksen, sydän- ja verisuonisairauksien, tulehdusten, dementian ja kuolleisuuden riskejä vähän liikkuvilla henkilöillä vähentävän liikunnan kynnysarvojen määrittämiseen |
| CA3073827C (en) * | 2017-09-07 | 2023-10-17 | Liposcience, Inc. | Multi-parameter metabolic vulnerability index evaluations |
| CN107796946B (zh) * | 2017-10-20 | 2019-10-25 | 中国医学科学院基础医学研究所 | 尿液中冠心病的蛋白标志物及其用途 |
| US11467171B2 (en) * | 2017-11-10 | 2022-10-11 | Liposcience, Inc. | Methods and systems to detect and quantify the amount of LP-X and other abnormal lipoproteins in a biosample using NMR spectroscopy |
| US20200367795A1 (en) * | 2018-01-18 | 2020-11-26 | New York University | System and method for blood glucose monitoring using magnetic resonance spectroscopy |
| CN109805898B (zh) * | 2019-03-22 | 2024-04-05 | 中国科学院重庆绿色智能技术研究院 | 基于注意力机制时序卷积网络算法的危重症死亡预测方法 |
| US11887505B1 (en) | 2019-04-24 | 2024-01-30 | Architecture Technology Corporation | System for deploying and monitoring network-based training exercises |
| CN116848409A (zh) * | 2021-01-22 | 2023-10-03 | 布鲁克碧奥斯平有限公司 | 使用扩散和弛豫编辑的质子nmr谱的感染诊断和表征 |
| EP4281768A1 (en) * | 2021-01-22 | 2023-11-29 | Bruker BioSpin MRI GmbH | Infection diagnosis and characterization using diffusion and relaxation edited proton nmr spectroscopy |
| FI130189B (fi) * | 2021-02-19 | 2023-04-03 | Nightingale Health Oyj | Menetelmä sappirakon häiriön kehittymisriskin määrittämiseksi kohteelle |
| AU2023320157A1 (en) * | 2022-08-05 | 2025-01-30 | Liposcience, Inc. | Metabolic vulnerability analyzed by nmr |
| DE102023110285B3 (de) | 2023-04-21 | 2024-05-08 | Universität zu Lübeck, Körperschaft des öffentlichen Rechts | Nmr-messung von glykoproteinen |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4529710A (en) | 1981-06-12 | 1985-07-16 | The United States Of America As Represented By The United States Department Of Energy | Method of using a nuclear magnetic resonance spectroscopy standard |
| JPH0698036B2 (ja) | 1986-10-20 | 1994-12-07 | 小野薬品工業株式会社 | アミノ酸の選択的定量法 |
| US4933844A (en) | 1988-09-26 | 1990-06-12 | Otvos James D | Measurement of blood lipoprotein constituents by analysis of data acquired from an NMR spectrometer |
| US6653140B2 (en) * | 1999-02-26 | 2003-11-25 | Liposcience, Inc. | Methods for providing personalized lipoprotein-based risk assessments |
| WO2000051054A1 (en) | 1999-02-26 | 2000-08-31 | Lipomed, Inc. | Methods, systems, and computer program products for analyzing and presenting risk assessment results based on nmr lipoprotein analysis of blood |
| EP1171778B1 (en) | 1999-04-22 | 2006-03-01 | Liposcience, Inc. | Nmr-method for determining the risk of developing type 2 diabetes |
| CA2331116A1 (en) | 2001-01-15 | 2002-07-15 | Chenomx, Inc. | Compound identification and quantitation in liquid mixtures -- method and process using an automated nuclear magnetic resonance measurement system |
| WO2003012416A1 (en) | 2001-08-01 | 2003-02-13 | Liposcience, Inc. | Method of determining presence and concentration of lipoprotein x in blood plasma and serum |
| AU2003232406A1 (en) | 2002-06-14 | 2003-12-31 | Pfizer Inc. | Metabolic phenotyping |
| WO2004040407A2 (en) | 2002-10-25 | 2004-05-13 | Liposcience, Inc. | Methods, systems and computer programs for deconvolving the spectral contribution of chemical constituents with overlapping signals |
| WO2004085996A2 (en) | 2003-03-20 | 2004-10-07 | Albert Einstein College Of Medicine Of Yeshiva University | Biomarkers for longevity and disease and uses thereof |
| CA2542107A1 (en) | 2003-10-23 | 2005-05-12 | Liposcience, Inc. | Methods, systems and computer programs for assessing chd risk using mathematical models that consider in vivo concentration gradients of ldl particle subclasses of discrete size |
| WO2005098463A2 (en) | 2004-04-01 | 2005-10-20 | Liposcience, Inc. | Nmr clinical analyzers and related methods, systems, modules and computer program products for clinical evaluation of biosamples |
| WO2006057081A1 (en) | 2004-11-24 | 2006-06-01 | Mitsuyo Okazaki | Method for analyzing lipoproteins |
| JP5006524B2 (ja) | 2005-05-13 | 2012-08-22 | 株式会社日立製作所 | 緩和時間特定のためのｎｍｒ装置の信号処理方法 |
| JP4358814B2 (ja) | 2005-11-09 | 2009-11-04 | 花王株式会社 | 試料の解析方法 |
| EP2339346B1 (en) | 2006-03-24 | 2014-09-03 | Metanomics GmbH | Methods for predicting diabetes type II |
| WO2007133593A2 (en) | 2006-05-10 | 2007-11-22 | Liposcience, Inc. | Methods, systems and computer programs for assessing chd risk using weighted hdl particle number measurements |
| WO2008137075A2 (en) | 2007-05-02 | 2008-11-13 | President And Fellows Of Harvard College | Compositions and methods for the treatment of metabolic disorders and inflammation |
| US7923257B2 (en) | 2007-05-04 | 2011-04-12 | Perkinelmer Health Sciences, Inc. | Detecting isomers using differential derivatization mass spectrometry |
| EP2019311A1 (en) | 2007-07-23 | 2009-01-28 | F.Hoffmann-La Roche Ag | A method for detecting a target substance by nuclear magnetic resonance |
| WO2010005982A2 (en) | 2008-07-07 | 2010-01-14 | The General Hospital Corporation | Multiplexed biomarkers of insulin resistance |
| KR20110086074A (ko) | 2008-10-20 | 2011-07-27 | 리포사이언스, 인크. | 지질단백질 인슐린 저항성 지표 및 이와 관련된 방법, 시스템 및 이를 생성하기 위한 컴퓨터 프로그램 |
| US20120122981A1 (en) | 2009-03-31 | 2012-05-17 | Yun Fu Hu | Biomarkers Related to Insulin Resistance and Methods using the Same |
| US8741788B2 (en) | 2009-08-06 | 2014-06-03 | Applied Materials, Inc. | Formation of silicon oxide using non-carbon flowable CVD processes |
| US7935643B2 (en) | 2009-08-06 | 2011-05-03 | Applied Materials, Inc. | Stress management for tensile films |
| US8449942B2 (en) | 2009-11-12 | 2013-05-28 | Applied Materials, Inc. | Methods of curing non-carbon flowable CVD films |
| US20110136241A1 (en) | 2009-12-08 | 2011-06-09 | Stephen Naylor | Type ii diabetes molecular bioprofile and method and system of using the same |
| JP2013517616A (ja) | 2010-01-06 | 2013-05-16 | アプライド マテリアルズ インコーポレイテッド | 酸化物ライナを使用する流動可能な誘電体 |
| AU2011256064B2 (en) | 2010-05-21 | 2016-09-15 | The Governors Of The University Of Alberta | Methods for the assessment of colorectal cancer and colorectal polyps by measurement of metabolites in urine |
| US9361429B2 (en) | 2012-06-08 | 2016-06-07 | Liposcience, Inc. | Multi-parameter diabetes risk evaluations |
| US9928345B2 (en) | 2012-06-08 | 2018-03-27 | Liposciences, Inc. | Multiple-marker risk parameters predictive of conversion to diabetes |
| WO2014059025A1 (en) | 2012-10-09 | 2014-04-17 | Liposcience, Inc. | Nmr quantification of branched chain amino acids |
-
2013
- 2013-03-14 US US13/830,199 patent/US9470771B2/en active Active
- 2013-05-30 WO PCT/US2013/043343 patent/WO2013184483A1/en not_active Ceased
- 2013-05-30 SG SG11201407803TA patent/SG11201407803TA/en unknown
- 2013-05-30 EP EP20199970.3A patent/EP3839544B1/en active Active
- 2013-05-30 CA CA2874550A patent/CA2874550C/en active Active
- 2013-05-30 CN CN201380041876.4A patent/CN104508471B/zh active Active
- 2013-05-30 CA CA3146947A patent/CA3146947A1/en active Pending
- 2013-05-30 AU AU2013272014A patent/AU2013272014B2/en active Active
- 2013-05-30 EP EP13800239.9A patent/EP2859339B1/en active Active
- 2013-05-30 FI FIEP20199970.3T patent/FI3839544T3/fi active
- 2013-05-30 EP EP24189279.3A patent/EP4439587A3/en active Pending
- 2013-05-30 JP JP2015516071A patent/JP6177899B2/ja active Active
-
2016
- 2016-09-14 US US15/264,977 patent/US10852293B2/en active Active
-
2020
- 2020-11-13 US US17/097,640 patent/US11692995B2/en active Active
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