FI3839544T3 - Glycan nmr-mittaukset sepelvaltimotaudin riskin määrittämiseksi - Google Patents
Glycan nmr-mittaukset sepelvaltimotaudin riskin määrittämiseksi Download PDFInfo
- Publication number
- FI3839544T3 FI3839544T3 FIEP20199970.3T FI20199970T FI3839544T3 FI 3839544 T3 FI3839544 T3 FI 3839544T3 FI 20199970 T FI20199970 T FI 20199970T FI 3839544 T3 FI3839544 T3 FI 3839544T3
- Authority
- FI
- Finland
- Prior art keywords
- glyca
- nmr
- risk
- components
- density lipoprotein
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
- A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
- A61B5/0044—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
- A61B5/7271—Specific aspects of physiological measurement analysis
- A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
- G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/46—NMR spectroscopy
- G01R33/465—NMR spectroscopy applied to biological material, e.g. in vitro testing
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2576/00—Medical imaging apparatus involving image processing or analysis
- A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
- A61B2576/023—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the heart
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4728—Details alpha-Glycoproteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- High Energy & Nuclear Physics (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Signal Processing (AREA)
- Hematology (AREA)
- Ecology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Artificial Intelligence (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Physiology (AREA)
- Psychiatry (AREA)
- Urology & Nephrology (AREA)
- Data Mining & Analysis (AREA)
- Databases & Information Systems (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Cardiology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261657315P | 2012-06-08 | 2012-06-08 | |
| US201261711471P | 2012-10-09 | 2012-10-09 | |
| US201261739305P | 2012-12-19 | 2012-12-19 | |
| US13/830,199 US9470771B2 (en) | 2012-06-08 | 2013-03-14 | NMR measurements of NMR biomarker GlycA |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FI3839544T3 true FI3839544T3 (fi) | 2024-12-27 |
Family
ID=49712504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FIEP20199970.3T FI3839544T3 (fi) | 2012-06-08 | 2013-05-30 | Glycan nmr-mittaukset sepelvaltimotaudin riskin määrittämiseksi |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US9470771B2 (https=) |
| EP (3) | EP3839544B1 (https=) |
| JP (1) | JP6177899B2 (https=) |
| CN (1) | CN104508471B (https=) |
| AU (1) | AU2013272014B2 (https=) |
| CA (2) | CA2874550C (https=) |
| FI (1) | FI3839544T3 (https=) |
| SG (1) | SG11201407803TA (https=) |
| WO (1) | WO2013184483A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9076342B2 (en) | 2008-02-19 | 2015-07-07 | Architecture Technology Corporation | Automated execution and evaluation of network-based training exercises |
| US9361429B2 (en) | 2012-06-08 | 2016-06-07 | Liposcience, Inc. | Multi-parameter diabetes risk evaluations |
| US9928345B2 (en) * | 2012-06-08 | 2018-03-27 | Liposciences, Inc. | Multiple-marker risk parameters predictive of conversion to diabetes |
| US20140358451A1 (en) * | 2013-06-04 | 2014-12-04 | Arizona Board Of Regents On Behalf Of Arizona State University | Fractional Abundance Estimation from Electrospray Ionization Time-of-Flight Mass Spectrum |
| PT3074775T (pt) * | 2013-11-27 | 2018-10-31 | Inst Dinvestigacio Sanitaria Pere Virgili | Método para a caracterização de lipoproteínas |
| EP3058369B1 (en) * | 2014-01-06 | 2020-06-17 | Liposcience, Inc. | Multiple-marker risk parameters predictive of conversion to diabetes |
| CN107110939B (zh) * | 2014-09-11 | 2021-05-14 | 力保科学公司 | 用于测定心血管疾病或事件的风险参数的系统 |
| WO2016065633A1 (zh) * | 2014-10-31 | 2016-05-06 | 华为技术有限公司 | 一种曲线拟合电路、模拟预失真器和射频信号发射机 |
| US10803766B1 (en) | 2015-07-28 | 2020-10-13 | Architecture Technology Corporation | Modular training of network-based training exercises |
| US10083624B2 (en) | 2015-07-28 | 2018-09-25 | Architecture Technology Corporation | Real-time monitoring of network-based training exercises |
| EP3258285B1 (en) | 2016-06-14 | 2020-10-21 | Bruker BioSpin GmbH | Method for predicting chemical shift values of nmr spin systems in a sample of a fluid class, in particular in a sample of a biofluid |
| DE102016224691A1 (de) * | 2016-12-12 | 2018-06-14 | Numares Ag | Verfahren zur Analyse eines NMR-Spektrums einer lipoproteinhaltigen Probe |
| FI20177098A1 (fi) | 2017-08-29 | 2019-03-01 | Leppaeluoto Juhani | Menetelmiä ja laitejärjestelyitä diabeteksen, sydän- ja verisuonisairauksien, tulehdusten, dementian ja kuolleisuuden riskejä vähän liikkuvilla henkilöillä vähentävän liikunnan kynnysarvojen määrittämiseen |
| JP7341987B2 (ja) | 2017-09-07 | 2023-09-11 | リポサイエンス,インコーポレイテッド | マルチパラメータ代謝脆弱性指数評価 |
| CN107796946B (zh) * | 2017-10-20 | 2019-10-25 | 中国医学科学院基础医学研究所 | 尿液中冠心病的蛋白标志物及其用途 |
| WO2019094879A1 (en) * | 2017-11-10 | 2019-05-16 | Liposcience, Inc. | Methods and systems to detect and quantify the amount of lp-x and other abnormal lipoproteins in a biosample using nmr spectroscopy |
| EP3740127A4 (en) * | 2018-01-18 | 2021-07-21 | New York University | SYSTEM AND METHOD FOR MONITORING BLOOD GLUCOSE USING MAGNETIC RESONANCE SPECTROSCOPY |
| CN109805898B (zh) * | 2019-03-22 | 2024-04-05 | 中国科学院重庆绿色智能技术研究院 | 基于注意力机制时序卷积网络算法的危重症死亡预测方法 |
| US11887505B1 (en) | 2019-04-24 | 2024-01-30 | Architecture Technology Corporation | System for deploying and monitoring network-based training exercises |
| US20240402273A1 (en) * | 2021-01-22 | 2024-12-05 | Bruker Biospin Gmbh | Infection diagnosis and characterization using diffusion and relaxation edited proton nmr spectroscopy |
| CN116848409A (zh) * | 2021-01-22 | 2023-10-03 | 布鲁克碧奥斯平有限公司 | 使用扩散和弛豫编辑的质子nmr谱的感染诊断和表征 |
| FI130189B (fi) * | 2021-02-19 | 2023-04-03 | Nightingale Health Oyj | Menetelmä sappirakon häiriön kehittymisriskin määrittämiseksi kohteelle |
| JP2025525221A (ja) * | 2022-08-05 | 2025-08-01 | ライポサイエンス, インコーポレイテッド | Nmrによって解析される代謝的脆弱性 |
| DE102023110285B3 (de) | 2023-04-21 | 2024-05-08 | Universität zu Lübeck, Körperschaft des öffentlichen Rechts | Nmr-messung von glykoproteinen |
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| US4529710A (en) | 1981-06-12 | 1985-07-16 | The United States Of America As Represented By The United States Department Of Energy | Method of using a nuclear magnetic resonance spectroscopy standard |
| JPH0698036B2 (ja) | 1986-10-20 | 1994-12-07 | 小野薬品工業株式会社 | アミノ酸の選択的定量法 |
| US4933844A (en) | 1988-09-26 | 1990-06-12 | Otvos James D | Measurement of blood lipoprotein constituents by analysis of data acquired from an NMR spectrometer |
| US6653140B2 (en) * | 1999-02-26 | 2003-11-25 | Liposcience, Inc. | Methods for providing personalized lipoprotein-based risk assessments |
| WO2000051054A1 (en) | 1999-02-26 | 2000-08-31 | Lipomed, Inc. | Methods, systems, and computer program products for analyzing and presenting risk assessment results based on nmr lipoprotein analysis of blood |
| DE60026287T2 (de) | 1999-04-22 | 2006-08-17 | Liposcience, Inc. | Nmr-verfahren zur bestimmung des risikos zur entwicklung von diabetes type 2 |
| CA2331116A1 (en) | 2001-01-15 | 2002-07-15 | Chenomx, Inc. | Compound identification and quantitation in liquid mixtures -- method and process using an automated nuclear magnetic resonance measurement system |
| US6617167B2 (en) | 2001-08-01 | 2003-09-09 | Liposcience, Inc. | Method of determining presence and concentration of lipoprotein X in blood plasma and serum |
| ATE502343T1 (de) | 2002-06-14 | 2011-04-15 | Pfizer | Metabolische phänotypisierung |
| WO2004040407A2 (en) | 2002-10-25 | 2004-05-13 | Liposcience, Inc. | Methods, systems and computer programs for deconvolving the spectral contribution of chemical constituents with overlapping signals |
| WO2004085996A2 (en) | 2003-03-20 | 2004-10-07 | Albert Einstein College Of Medicine Of Yeshiva University | Biomarkers for longevity and disease and uses thereof |
| EP1676137A1 (en) | 2003-10-23 | 2006-07-05 | Liposcience, Inc. | Methods, systems and computer programs for assessing chd risk using mathematical models that consider in vivo concentration gradients of ldl particle subclasses of discrete size |
| AU2005230449B2 (en) | 2004-04-01 | 2010-02-18 | Liposcience, Inc. | NMR clinical analyzers and related methods, systems, modules and computer program products for clinical evaluation of biosamples |
| WO2006057081A1 (en) | 2004-11-24 | 2006-06-01 | Mitsuyo Okazaki | Method for analyzing lipoproteins |
| JP5006524B2 (ja) | 2005-05-13 | 2012-08-22 | 株式会社日立製作所 | 緩和時間特定のためのnmr装置の信号処理方法 |
| JP4358814B2 (ja) | 2005-11-09 | 2009-11-04 | 花王株式会社 | 試料の解析方法 |
| EP2369346B1 (en) | 2006-03-24 | 2014-08-27 | Metanomics GmbH | Method for diagnosing diabetes type II |
| WO2007133593A2 (en) | 2006-05-10 | 2007-11-22 | Liposcience, Inc. | Methods, systems and computer programs for assessing chd risk using weighted hdl particle number measurements |
| WO2008137075A2 (en) | 2007-05-02 | 2008-11-13 | President And Fellows Of Harvard College | Compositions and methods for the treatment of metabolic disorders and inflammation |
| US7923257B2 (en) | 2007-05-04 | 2011-04-12 | Perkinelmer Health Sciences, Inc. | Detecting isomers using differential derivatization mass spectrometry |
| EP2019311A1 (en) | 2007-07-23 | 2009-01-28 | F.Hoffmann-La Roche Ag | A method for detecting a target substance by nuclear magnetic resonance |
| US20110311650A1 (en) | 2008-07-07 | 2011-12-22 | Thomas Wang | Multiplexed biomarkers of insulin resistance |
| EP2344890B1 (en) | 2008-10-20 | 2021-08-11 | Liposcience, Inc. | Lipoprotein insulin resistance indexes and related methods |
| EP2414535A4 (en) | 2009-03-31 | 2012-12-26 | Metabolon Inc | BIOMARKERS RELATED TO INSULIN RESISTANCE AND METHOD OF USE THEREOF |
| US8741788B2 (en) | 2009-08-06 | 2014-06-03 | Applied Materials, Inc. | Formation of silicon oxide using non-carbon flowable CVD processes |
| US7935643B2 (en) | 2009-08-06 | 2011-05-03 | Applied Materials, Inc. | Stress management for tensile films |
| US8449942B2 (en) | 2009-11-12 | 2013-05-28 | Applied Materials, Inc. | Methods of curing non-carbon flowable CVD films |
| US20110136241A1 (en) | 2009-12-08 | 2011-06-09 | Stephen Naylor | Type ii diabetes molecular bioprofile and method and system of using the same |
| JP2013517616A (ja) | 2010-01-06 | 2013-05-16 | アプライド マテリアルズ インコーポレイテッド | 酸化物ライナを使用する流動可能な誘電体 |
| PT2572193T (pt) | 2010-05-21 | 2018-01-31 | Univ Alberta | Métodos para a examinação de cancro colorretal e pólipos colorretais por medição de metabólitos na urina |
| US9928345B2 (en) | 2012-06-08 | 2018-03-27 | Liposciences, Inc. | Multiple-marker risk parameters predictive of conversion to diabetes |
| US9361429B2 (en) | 2012-06-08 | 2016-06-07 | Liposcience, Inc. | Multi-parameter diabetes risk evaluations |
| SG11201502693SA (en) | 2012-10-09 | 2015-05-28 | Liposcience Inc | Nmr quantification of branched chain amino acids |
-
2013
- 2013-03-14 US US13/830,199 patent/US9470771B2/en active Active
- 2013-05-30 AU AU2013272014A patent/AU2013272014B2/en active Active
- 2013-05-30 WO PCT/US2013/043343 patent/WO2013184483A1/en not_active Ceased
- 2013-05-30 FI FIEP20199970.3T patent/FI3839544T3/fi active
- 2013-05-30 EP EP20199970.3A patent/EP3839544B1/en active Active
- 2013-05-30 CA CA2874550A patent/CA2874550C/en active Active
- 2013-05-30 SG SG11201407803TA patent/SG11201407803TA/en unknown
- 2013-05-30 JP JP2015516071A patent/JP6177899B2/ja active Active
- 2013-05-30 CN CN201380041876.4A patent/CN104508471B/zh active Active
- 2013-05-30 CA CA3146947A patent/CA3146947A1/en active Pending
- 2013-05-30 EP EP24189279.3A patent/EP4439587A3/en active Pending
- 2013-05-30 EP EP13800239.9A patent/EP2859339B1/en active Active
-
2016
- 2016-09-14 US US15/264,977 patent/US10852293B2/en active Active
-
2020
- 2020-11-13 US US17/097,640 patent/US11692995B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104508471A (zh) | 2015-04-08 |
| US10852293B2 (en) | 2020-12-01 |
| EP4439587A2 (en) | 2024-10-02 |
| US20130328561A1 (en) | 2013-12-12 |
| AU2013272014A1 (en) | 2014-12-18 |
| CA2874550A1 (en) | 2013-12-12 |
| HK1207156A1 (en) | 2016-01-22 |
| EP2859339B1 (en) | 2020-10-28 |
| US11692995B2 (en) | 2023-07-04 |
| US20170003269A1 (en) | 2017-01-05 |
| US9470771B2 (en) | 2016-10-18 |
| SG11201407803TA (en) | 2014-12-30 |
| JP6177899B2 (ja) | 2017-08-09 |
| JP2015522806A (ja) | 2015-08-06 |
| EP3839544B1 (en) | 2024-10-02 |
| EP2859339A1 (en) | 2015-04-15 |
| EP4439587A3 (en) | 2024-12-18 |
| WO2013184483A1 (en) | 2013-12-12 |
| CN104508471B (zh) | 2017-09-19 |
| CA3146947A1 (en) | 2013-12-12 |
| CA2874550C (en) | 2022-04-19 |
| US20210080452A1 (en) | 2021-03-18 |
| EP2859339A4 (en) | 2016-08-03 |
| AU2013272014B2 (en) | 2017-05-25 |
| EP3839544A1 (en) | 2021-06-23 |
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